Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi

Angeliki Sofia Foscolos ORCID logo; Andrew Tsotinis ORCID logo; Martin C Taylor ORCID logo; John M Kelly ORCID logo; Ioannis P Papanastasiou ORCID logo; (2022) Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi. Molbank, 2022 (2). M1363-M1363. ISSN 1422-8599 DOI: 10.3390/m1363
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<jats:p>In this work, we present the synthesis and the anti-trypanosomal activity of the 2-(4-(adamant-1-yl)phenyl)-N-hydroxyarylamides, 1a,b and the 2-(4-(adamant-1-yl)phenoxy)-N-hydroxyacetamide, 1c. The 4-(adamant-1-yl)phenyl- and 4-(adamant-1-yl)phenoxy- moieties, which are endowed with promising drug-like properties, are functionalized at the side chain termini as hydroxamic acids. The phenoxy acetohydroxamic derivative, 1c, shows the most interesting profile in terms of activity and toxicity against trypanosomes and merits further investigation.</jats:p>


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