Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi
Angeliki Sofia Foscolos
;
Andrew Tsotinis
;
Martin C Taylor
;
John M Kelly
;
Ioannis P Papanastasiou
;
(2022)
Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi.
Molbank, 2022 (2).
M1363-M1363.
ISSN 1422-8599
DOI: 10.3390/m1363
<jats:p>In this work, we present the synthesis and the anti-trypanosomal activity of the 2-(4-(adamant-1-yl)phenyl)-N-hydroxyarylamides, 1a,b and the 2-(4-(adamant-1-yl)phenoxy)-N-hydroxyacetamide, 1c. The 4-(adamant-1-yl)phenyl- and 4-(adamant-1-yl)phenoxy- moieties, which are endowed with promising drug-like properties, are functionalized at the side chain termini as hydroxamic acids. The phenoxy acetohydroxamic derivative, 1c, shows the most interesting profile in terms of activity and toxicity against trypanosomes and merits further investigation.</jats:p>
Item Type | Article |
---|---|
Elements ID | 179702 |
ORCID: https://orcid.org/0000-0001-8123-5060
ORCID: https://orcid.org/0000-0002-4334-4810
ORCID: https://orcid.org/0000-0003-4147-0693
ORCID: https://orcid.org/0000-0003-4305-5258
ORCID: https://orcid.org/0000-0001-6974-2561