Items where Author is "Taylor, Martin C"
Number of items: 83.
2022
Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer. (2022)
Abacha, Yabalu Z; Forkuo, Arnold Donkor; Gbedema, Stephen Y; Mittal, Nimisha; Ottilie, Sabine; Rocamora, Frances; Winzeler, Elizabeth A; van Schalkwyk, Donelly A; Kelly, John M; Taylor, Martin C; Reader, Janette; Birkholtz, Lyn-Marie; Lisgarten, David R; Cockcroft, Jeremy K; Lisgarten, John N; Palmer, Rex A; Talbert, Rosemary C; Shnyder, Steven D; Wright, Colin W
Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi. (2022)
Foscolos, Angeliki Sofia; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; Papanastasiou, Ioannis P
Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor. (2022)
Macleod, Olivia JS; Cook, Alexander D; Webb, Helena; Crow, Mandy; Burns, Roisin; Redpath, Maria; Seisenberger, Stefanie; Trevor, Camilla E; Peacock, Lori; Schwede, Angela; Kimblin, Nicola; Francisco, Amanda F; Pepperl, Julia; Rust, Steve; Voorheis, Paul; Gibson, Wendy; Taylor, Martin C; Higgins, Matthew K; Carrington, Mark
Incomplete Recruitment of Protective T Cells Is Associated with Trypanosoma cruzi Persistence in the Mouse Colon. (2022)
Ward, Alexander I; Lewis, Michael D; Taylor, Martin C; Kelly, John M
2021
Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale. (2021)
Khan, Archie A; Langston, Harry C; Costa, Fernanda C; Olmo, Francisco; Taylor, Martin C; McCann, Conor J; Kelly, John M; Lewis, Michael D
Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles. (2021)
Racané, Livio; Rep, Valentina; Kraljević Pavelić, Sandra; Grbčić, Petra; Zonjić, Iva; Radić Stojković, Marijana; Taylor, Martin C; Kelly, John M; Raić-Malić, Silvana
Trypanosoma cruzi : Where is it? Does it ever sleep? Why is a sterile outcome rarely achieved? (2021)
Ward, A
2020
Challenges in Chagas Disease Drug Development. (2020)
Francisco, Amanda F; Jayawardhana, Shiromani; Olmo, Francisco; Lewis, Michael D; Wilkinson, Shane R; Taylor, Martin C; Kelly, John M
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies. (2020)
Macleod, Olivia JS; Bart, Jean-Mathieu; MacGregor, Paula; Peacock, Lori; Savill, Nicholas J; Hester, Svenja; Ravel, Sophie; Sunter, Jack D; Trevor, Camilla; Rust, Steven; Vaughan, Tristan J; Minter, Ralph; Mohammed, Shabaz; Gibson, Wendy; Taylor, Martin C; Higgins, Matthew K; Carrington, Mark
Exploring the Potential of Vaccination to Combat Trypanosoma cruzi Infection using Bioluminescent Imaging. (2020)
Mann, GS
Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection. (2020)
Mann, Gurdip Singh; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Olmo, Francisco; de Freitas, Elisangela Oliveira; Leoratti, Fabiana MS; López-Camacho, Cesar; Reyes-Sandoval, Arturo; Kelly, John M
Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study. (2020)
Pardali, Vasiliki; Giannakopoulou, Erofili; Balourdas, Dimitrios-Ilias; Myrianthopoulos, Vassilios; Taylor, Martin C; Šekutor, Marina; Mlinarić-Majerski, Kata; Kelly, John M; Zoidis, Grigoris
Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity. (2020)
Taylor, Martin C; Ward, Alexander I; Olmo, Francisco; Francisco, Amanda F; Jayawardhana, Shiromani; Costa, Fernanda C; Lewis, Michael D; Kelly, John M
Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection. (2020)
Taylor, Martin C; Ward, Alexander; Olmo, Francisco; Jayawardhana, Shiromani; Francisco, Amanda F; Lewis, Michael D; Kelly, John M
Editorial: Unravelling T. cruzi Biology. (2020)
Taylor, Martin Craig; Lander, Noelia; Yoshida, Nobuko
In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution. (2020)
Ward, Alexander I; Lewis, Michael D; Khan, Archie A; McCann, Conor J; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Kelly, John M
Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate. (2020)
Ward, Alexander I; Olmo, Francisco; Atherton, Richard L; Taylor, Martin C; Kelly, John M
2019
Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity. (2019)
Foscolos, Angeliki-Sofia; Papanastasiou, Ioannis; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M
Novel 2,6-diketopiperazine-derived acetohydroxamic acids as promising anti-Trypanosoma brucei agents. (2019)
Fytas, George; Zoidis, Grigoris; Taylor, Martin C; Kelly, John M; Tsatsaroni, Alexandra; Tsotinis, Andrew
Synthesis of diphenoxyadamantane alkylamines with pharmacological interest. (2019)
Georgiadis, Markos-Orestis; Kourbeli, Violeta; Ioannidou, Vaya; Karakitsios, Evangelos; Papanastasiou, Ioannis; Tsotinis, Andrew; Komiotis, Dimitri; Vocat, Anthony; Cole, Stewart T; Taylor, Martin C; Kelly, John M
Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei. (2019)
Georgiadis, Markos-Orestis; Kourbeli, Violeta; Papanastasiou, Ioannis P; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M
Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species. (2019)
Giannakopoulou, Erofili; Pardali, Vasiliki; Frakolaki, Efseveia; Siozos, Vasileios; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Taylor, Martin C; Kelly, John M; Vassilaki, Niki; Zoidis, Grigoris
A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis. (2019)
MacGregor, Paula; Gonzalez-Munoz, Andrea L; Jobe, Fatoumatta; Taylor, Martin C; Rust, Steven; Sandercock, Alan M; Macleod, Olivia JS; Van Bocxlaer, Katrien; Francisco, Amanda F; D'Hooge, Francois; Tiberghien, Arnaud; Barry, Conor S; Howard, Philip; Higgins, Matthew K; Vaughan, Tristan J; Minter, Ralph; Carrington, Mark
Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity. (2019)
Popov, A Bistrović; Stolić, I; Krstulović, L; Taylor, MC; Kelly, JM; Tomić, S; Tumir, L; Bajić, M; Raić-Malić, S
Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions. (2019)
Taylor, Martin C; Francisco, Amanda F; Jayawardhana, Shiromani; Mann, Gurdip Singh; Ward, Alexander I; Olmo, Francisco; Lewis, Michael D; Kelly, John M
2018
Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA. (2018)
Bistrović, Andrea; Krstulović, Luka; Stolić, Ivana; Drenjančević, Domagoj; Talapko, Jasminka; Taylor, Martin C; Kelly, John M; Bajić, Miroslav; Raić-Malić, Silvana
Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping. (2018)
Costa, Fernanda Cristina; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Calderano, Simone Guedes; Lewis, Michael D; Olmo, Francisco; Beneke, Tom; Gluenz, Eva; Sunter, Jack; Dean, Samuel; Kelly, John Morrison; Taylor, Martin Craig
Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease. (2018)
Francisco, Amanda Fortes; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Kelly, John M
Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases. (2018)
Ghashghaei, Ouldouz; Kielland, Nicola; Revés, Marc; Taylor, Martin C; Kelly, John M; Di Pietro, Ornella; Muñoz-Torrero, Diego; Pérez, Belén; Lavilla, Rodolfo
Imaging the development of chronic Chagas disease after oral transmission. (2018)
Lewis, Michael D; Francisco, Amanda F; Jayawardhana, Shiromani; Langston, Harry; Taylor, Martin C; Kelly, John M
Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation. (2018)
Olmo, Francisco; Costa, Fernanda C; Mann, Gurdip Singh; Taylor, Martin C; Kelly, John M
2017
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole. (2017)
Campos, Mônica C; Phelan, Jody; Francisco, Amanda F; Taylor, Martin C; Lewis, Michael D; Pain, Arnab; Clark, Taane G; Kelly, John M
Biological factors that impinge on Chagas disease drug development. (2017)
Francisco, Amanda F; Jayawardhana, Shiromani; Lewis, Michael D; Taylor, Martin C; Kelly, John M
Pathogen imaging applications. (2017)
Taylor, Martin C; Ward, Theresa H
Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study. (2017)
Zoidis, Grigoris; Tsotinis, Andrew; Tsatsaroni, Alexandra; Taylor, Martin C; Kelly, John M; Efstathiou, Antonia; Smirlis, Despina; Fytas, George
2016
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy. (2016)
Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Jayawardhana, Shiromani; Kelly, John M
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. (2016)
Sola, Irene; Artigas, Albert; Taylor, Martin C; Pérez-Areales, F Javier; Viayna, Elisabet; Clos, M Victòria; Pérez, Belén; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego
2015
"Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert'' [Mol. Biochem. Parasit. (2014) 193, 17-19]. (2015)
Campos, MCO; Leon, LL; Taylor, MC; Kelly, JM
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity. (2015)
Di Pietro, Ornella; Vicente-García, Esther; Taylor, Martin C; Berenguer, Diana; Viayna, Elisabet; Lanzoni, Anna; Sola, Irene; Sayago, Helena; Riera, Cristina; Fisa, Roser; Clos, M Victòria; Pérez, Belén; Kelly, John M; Lavilla, Rodolfo; Muñoz-Torrero, Diego
Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs". (2015)
Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. (2015)
Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. (2015)
Sola, Irene; Castellà, Sílvia; Viayna, Elisabet; Galdeano, Carles; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Jones, Deuan C; Fairlamb, Alan H; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego
The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence. (2015)
Taylor, Martin C; Lewis, Michael D; Fortes Francisco, Amanda; Wilkinson, Shane R; Kelly, John M
2014
Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert. (2014)
Campos, Mônica CO; Leon, Leonor L; Taylor, Martin C; Kelly, John M
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection. (2014)
Lewis, Michael D; Fortes Francisco, Amanda; Taylor, Martin C; Burrell-Saward, Hollie; McLatchie, Alex P; Miles, Michael A; Kelly, John M
A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging. (2014)
Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Kelly, John M
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. (2014)
Shameer, Sanu; Logan-Klumpler, Flora J; Vinson, Florence; Cottret, Ludovic; Merlet, Benjamin; Achcar, Fiona; Boshart, Michael; Berriman, Matthew; Breitling, Rainer; Bringaud, Frédéric; Bütikofer, Peter; Cattanach, Amy M; Bannerman-Chukualim, Bridget; Creek, Darren J; Crouch, Kathryn; de Koning, Harry P; Denise, Hubert; Ebikeme, Charles; Fairlamb, Alan H; Ferguson, Michael AJ; Ginger, Michael L; Hertz-Fowler, Christiane; Kerkhoven, Eduard J; Mäser, Pascal; Michels, Paul AM; Nayak, Archana; Nes, David W; Nolan, Derek P; Olsen, Christian; Silva-Franco, Fatima; Smith, Terry K; Taylor, Martin C; Tielens, Aloysius GM; Urbaniak, Michael D; van Hellemond, Jaap J; Vincent, Isabel M; Wilkinson, Shane R; Wyllie, Susan; Opperdoes, Fred R; Barrett, Michael P; Jourdan, Fabien
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. (2014)
Sola, Irene; Artigas, Albert; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego
Optimizing bioluminescence imaging to study protozoan parasite infections. (2014)
Taylor, Martin C; Kelly, John M
2013
Synthesis and trypanocidal action of new adamantane substituted imidazolines. (2013)
Koperniku, Ana; Papanastasiou, Ioannis; Foscolos, George B; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M
Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase. (2013)
McLatchie, Alex P; Burrell-Saward, Hollie; Myburgh, Elmarie; Lewis, Michael D; Ward, Theresa H; Mottram, Jeremy C; Croft, Simon L; Kelly, John M; Taylor, Martin C
In Vivo Imaging of Trypanosome-Brain Interactions and Development of a Rapid Screening Test for Drugs against CNS Stage Trypanosomiasis. (2013)
Myburgh, E; Coles, J; Ritchie, R; Kennedy, PGE; McLatchie, AP; Rodgers, R; Taylor, MC; Barrett, MP; Brewer, JM; Mottram, JC
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In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. (2013)
Myburgh, Elmarie; Coles, Jonathan A; Ritchie, Ryan; Kennedy, Peter GE; McLatchie, Alex P; Rodgers, Jean; Taylor, Martin C; Barrett, Michael P; Brewer, James M; Mottram, Jeremy C
Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue. (2013)
Taylor, Martin C; McLatchie, Alex P; Kelly, John M
An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids. (2013)
Tsatsaroni, Alexandra; Zoidis, Grigoris; Zoumpoulakis, Panagiotis; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; Fytas, George
2012
Centromere-associated repeat arrays on Trypanosoma brucei chromosomes are much more extensive than predicted. (2012)
Echeverry, Maria C; Bot, Christopher; Obado, Samson O; Taylor, Martin C; Kelly, John M
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei. (2012)
Kelly, John M; Taylor, Martin C; Horn, David; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik
Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population. (2012)
Mejia, Ana Maria; Hall, Belinda S; Taylor, Martin C; Gómez-Palacio, Andrés; Wilkinson, Shane R; Triana-Chávez, Omar; Kelly, John M
Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities. (2012)
Torres, Eva; Duque, María D; López-Querol, Marta; Taylor, Martin C; Naesens, Lieve; Ma, Chunlong; Pinto, Lawrence H; Sureda, Francesc X; Kelly, John M; Vázquez, Santiago
2011
Huprines as a new family of dual acting trypanocidal-antiplasmodial agents. (2011)
Defaux, Julien; Sala, Marta; Formosa, Xavier; Galdeano, Carles; Taylor, Martin C; Alobaid, Waleed AA; Kelly, John M; Wright, Colin W; Camps, Pelayo; Muñoz-Torrero, Diego
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Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity. (2011)
Fytas, Christos; Zoidis, Grigoris; Tzoutzas, Nikolaos; Taylor, Martin C; Fytas, George; Kelly, John M
Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei. (2011)
Obado, Samson O; Bot, Christopher; Echeverry, Maria C; Bayona, Julio C; Alvarez, Vanina E; Taylor, Martin C; Kelly, John M
Genetic techniques in Trypanosoma cruzi. (2011)
Taylor, Martin C; Huang, Huan; Kelly, John M
2008
Validation of spermidine synthase as a drug target in African trypanosomes. (2008)
Taylor, Martin C; Kaur, Harparkash; Blessington, Bernard; Kelly, John M; Wilkinson, Shane R
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. (2008)
Wilkinson, Shane R; Taylor, Martin C; Horn, David; Kelly, John M; Cheeseman, Ian
2007
The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements. (2007)
Gluenz, Eva; Taylor, Martin C; Kelly, John M
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The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase. (2007)
Logan, Flora J; Taylor, Martin C; Wilkinson, Shane R; Kaur, Harparkash; Kelly, John M
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. (2007)
Piacenza, Lucía; Irigoín, Florencia; Alvarez, María Noel; Peluffo, Gonzalo; Taylor, Martin C; Kelly, John M; Wilkinson, Shane R; Radi, Rafael
2005
Trypanosoma cruzi. (2005)
Kelly, JM; Taylor, MC; Wilkinson, SR
Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature. (2005)
Obado, Samson O; Taylor, Martin C; Wilkinson, Shane R; Bromley, Elizabeth V; Kelly, John M
Vitamin C biosynthesis in trypanosomes: a role for the glycosome. (2005)
Wilkinson, Shane R; Prathalingam, S Radhika; Taylor, Martin C; Horn, David; Kelly, John M
2004
The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal. (2004)
Bromley, Elizabeth V; Taylor, Martin C; Wilkinson, Shane R; Kelly, John M
Functional mapping of an American trypanosome centromere [Abstract]. (2004)
Kelly, JM; Obado, SO; Taylor, MC
Distinct trafficking and localization of STEVOR proteins in three stages of the Plasmodium falciparum life cycle. (2004)
McRobert, Louisa; Preiser, Peter; Sharp, Sarah; Jarra, William; Kaviratne, Mallika; Taylor, Martin C; Renia, Laurent; Sutherland, Colin J
2003
Mechanism of genetic exchange in American trypanosomes. (2003)
Gaunt, Michael W; Yeo, Matthew; Frame, Iain A; Stothard, J Russell; Carrasco, Hernan J; Taylor, Martin C; Mena, Susana Solis; Veazey, Paul; Miles, Graham AJ; Acosta, Nidia; de Arias, Antonieta Rojas; Miles, Michael A
2002
Functional dissection of the Trypanosoma cruzi genome: New approaches in a new era. (2002)
Taylor, MC; Kelly, JM
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. (2002)
Wilkinson, Shane R; Meyer, David J; Taylor, Martin C; Bromley, Elizabeth V; Miles, Michael A; Kelly, John M
TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum. (2002)
Wilkinson, Shane R; Taylor, Martin C; Touitha, Said; Mauricio, Isabel L; Meyer, David J; Kelly, John M