Items where Author is "Kelly, John M"

Year Item Type Full Text

2023

Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection. (2023) Tawaraishi, Taisuke; Ochida, Atsuko; Akao, Yuichiro; Itono, Sachiko; Kamaura, Masahiro; Akther, Thamina; Shimada, Mitsuyuki; Canan, Stacie; Chowdhury, Sanjoy; Cao, Yafeng; Condroski, Kevin; Engkvist, Ola; Francisco, Amanda; Ghosh, Sunil; Kaki, Rina; Kelly, John M; Kimura, Chiaki; Kogej, Thierry; Nagaoka, Kazuya; Naito, Akira; Pairaudeau, Garry; Radu, Constantin; Roberts, Ieuan; Shum, David; Watanabe, Nao-Aki; Xie, Huanxu; Yonezawa, Shuji; Yoshida, Osamu; Yoshida, Ryu; Mowbray, Charles; Perry, Benjamin

2022

Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi. (2022) Foscolos, Angeliki Sofia; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; Papanastasiou, Ioannis P

Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitological cure. (2022) Francisco, Amanda Fortes; Saade, Ursula; Jayawardhana, Shiromani; Pottel, Hans; Scandale, Ivan; Chatelain, Eric; Liehl, Peter; Kelly, John M; Zrein, Maan

Incomplete Recruitment of Protective T Cells Is Associated with Trypanosoma cruzi Persistence in the Mouse Colon. (2022) Ward, Alexander I; Lewis, Michael D; Taylor, Martin C; Kelly, John M

2021

Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease. (2021) Beltran-Hortelano, Iván; Atherton, Richard L; Rubio-Hernández, Mercedes; Sanz-Serrano, Julen; Alcolea, Verónica; Kelly, John M; Pérez-Silanes, Silvia; Olmo, Francisco

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale. (2021) Khan, Archie A; Langston, Harry C; Costa, Fernanda C; Olmo, Francisco; Taylor, Martin C; McCann, Conor J; Kelly, John M; Lewis, Michael D

Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles. (2021) Racané, Livio; Rep, Valentina; Kraljević Pavelić, Sandra; Grbčić, Petra; Zonjić, Iva; Radić Stojković, Marijana; Taylor, Martin C; Kelly, John M; Raić-Malić, Silvana

Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against Trypanosoma cruzi. (2021) Scarim, Cauê Benito; Olmo, Francisco; Ferreira, Elizabeth Igne; Chin, Chung Man; Kelly, John M; Fortes Francisco, Amanda

Trypanosoma cruzi : Where is it? Does it ever sleep? Why is a sterile outcome rarely achieved? (2021) Ward, A

2020

Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery. (2020) Fesser, Anna F; Braissant, Olivier; Olmo, Francisco; Kelly, John M; Mäser, Pascal; Kaiser, Marcel

Challenges in Chagas Disease Drug Development. (2020) Francisco, Amanda F; Jayawardhana, Shiromani; Olmo, Francisco; Lewis, Michael D; Wilkinson, Shane R; Taylor, Martin C; Kelly, John M

Exploring the Potential of Vaccination to Combat Trypanosoma cruzi Infection using Bioluminescent Imaging. (2020) Mann, GS

Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection. (2020) Mann, Gurdip Singh; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Olmo, Francisco; de Freitas, Elisangela Oliveira; Leoratti, Fabiana MS; López-Camacho, Cesar; Reyes-Sandoval, Arturo; Kelly, John M

Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study. (2020) Pardali, Vasiliki; Giannakopoulou, Erofili; Balourdas, Dimitrios-Ilias; Myrianthopoulos, Vassilios; Taylor, Martin C; Šekutor, Marina; Mlinarić-Majerski, Kata; Kelly, John M; Zoidis, Grigoris

Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity. (2020) Taylor, Martin C; Ward, Alexander I; Olmo, Francisco; Francisco, Amanda F; Jayawardhana, Shiromani; Costa, Fernanda C; Lewis, Michael D; Kelly, John M

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection. (2020) Taylor, Martin C; Ward, Alexander; Olmo, Francisco; Jayawardhana, Shiromani; Francisco, Amanda F; Lewis, Michael D; Kelly, John M

Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy. (2020) Thompson, Andrew M; O'Connor, Patrick D; Marshall, Andrew J; Francisco, Amanda F; Kelly, John M; Riley, Jennifer; Read, Kevin D; Perez, Catherine J; Cornwall, Scott; Thompson, RC Andrew; Keenan, Martine; White, Karen L; Charman, Susan A; Zulfiqar, Bilal; Sykes, Melissa L; Avery, Vicky M; Chatelain, Eric; Denny, William A description

In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution. (2020) Ward, Alexander I; Lewis, Michael D; Khan, Archie A; McCann, Conor J; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Kelly, John M

Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate. (2020) Ward, Alexander I; Olmo, Francisco; Atherton, Richard L; Taylor, Martin C; Kelly, John M

2019

Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity. (2019) Foscolos, Angeliki-Sofia; Papanastasiou, Ioannis; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M

Novel 2,6-diketopiperazine-derived acetohydroxamic acids as promising anti-Trypanosoma brucei agents. (2019) Fytas, George; Zoidis, Grigoris; Taylor, Martin C; Kelly, John M; Tsatsaroni, Alexandra; Tsotinis, Andrew

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest. (2019) Georgiadis, Markos-Orestis; Kourbeli, Violeta; Ioannidou, Vaya; Karakitsios, Evangelos; Papanastasiou, Ioannis; Tsotinis, Andrew; Komiotis, Dimitri; Vocat, Anthony; Cole, Stewart T; Taylor, Martin C; Kelly, John M

Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei. (2019) Georgiadis, Markos-Orestis; Kourbeli, Violeta; Papanastasiou, Ioannis P; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M

Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species. (2019) Giannakopoulou, Erofili; Pardali, Vasiliki; Frakolaki, Efseveia; Siozos, Vasileios; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Taylor, Martin C; Kelly, John M; Vassilaki, Niki; Zoidis, Grigoris

Metabolomics, lipidomics and proteomics profiling of myoblasts infected with Trypanosoma cruzi after treatment with different drugs against Chagas disease. (2019) Hennig, K; Abi-Ghanem, J; Bunescu, A; Meniche, X; Biliaut, E; Ouattara, AD; Lewis, MD; Kelly, JM; Braillard, S; Courtemanche, G; Chatelain, E; Béquet, F

Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity. (2019) Popov, A Bistrović; Stolić, I; Krstulović, L; Taylor, MC; Kelly, JM; Tomić, S; Tumir, L; Bajić, M; Raić-Malić, S

Drug Discovery for Kinetoplastid Diseases: Future Directions. (2019) Rao, Srinivasa PS; Barrett, Michael P; Dranoff, Glenn; Faraday, Christopher J; Gimpelewicz, Claudio R; Hailu, Asrat; Jones, Catherine L; Kelly, John M; Lazdins-Helds, Janis K; Mäser, Pascal; Mengel, Jose; Mottram, Jeremy C; Mowbray, Charles E; Sacks, David L; Scott, Phillip; Späth, Gerald F; Tarleton, Rick L; Spector, Jonathan M; Diagana, Thierry T

Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions. (2019) Taylor, Martin C; Francisco, Amanda F; Jayawardhana, Shiromani; Mann, Gurdip Singh; Ward, Alexander I; Olmo, Francisco; Lewis, Michael D; Kelly, John M

2018

Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations. (2018) Adjogatse, Eyram; Erskine, Peter; Wells, Stephen A; Kelly, John M; Wilden, Jonathan D; Chan, AW Edith; Selwood, David; Coker, Alun; Wood, Steve; Cooper, Jonathan B

Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA. (2018) Bistrović, Andrea; Krstulović, Luka; Stolić, Ivana; Drenjančević, Domagoj; Talapko, Jasminka; Taylor, Martin C; Kelly, John M; Bajić, Miroslav; Raić-Malić, Silvana

Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping. (2018) Costa, Fernanda Cristina; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Calderano, Simone Guedes; Lewis, Michael D; Olmo, Francisco; Beneke, Tom; Gluenz, Eva; Sunter, Jack; Dean, Samuel; Kelly, John Morrison; Taylor, Martin Craig

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease. (2018) Francisco, Amanda Fortes; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Kelly, John M

Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases. (2018) Ghashghaei, Ouldouz; Kielland, Nicola; Revés, Marc; Taylor, Martin C; Kelly, John M; Di Pietro, Ornella; Muñoz-Torrero, Diego; Pérez, Belén; Lavilla, Rodolfo

Imaging the development of chronic Chagas disease after oral transmission. (2018) Lewis, Michael D; Francisco, Amanda F; Jayawardhana, Shiromani; Langston, Harry; Taylor, Martin C; Kelly, John M

Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation. (2018) Olmo, Francisco; Costa, Fernanda C; Mann, Gurdip Singh; Taylor, Martin C; Kelly, John M

2017

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. (2017) Brand, Stephen; Ko, Eun Jung; Viayna, Elisabet; Thompson, Stephen; Spinks, Daniel; Thomas, Michael; Sandberg, Lars; Francisco, Amanda F; Jayawardhana, Shiromani; Smith, Victoria C; Jansen, Chimed; De Rycker, Manu; Thomas, John; MacLean, Lorna; Osuna-Cabello, Maria; Riley, Jennifer; Scullion, Paul; Stojanovski, Laste; Simeons, Frederick RC; Epemolu, Ola; Shishikura, Yoko; Crouch, Sabrinia D; Bakshi, Tania S; Nixon, Christopher J; Reid, Iain H; Hill, Alan P; Underwood, Tim Z; Hindley, Sean J; Robinson, Sharon A; Kelly, John M; Fiandor, Jose M; Wyatt, Paul G; Marco, Maria; Miles, Timothy J; Read, Kevin D; Gilbert, Ian H

Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole. (2017) Campos, Mônica C; Phelan, Jody; Francisco, Amanda F; Taylor, Martin C; Lewis, Michael D; Pain, Arnab; Clark, Taane G; Kelly, John M

Biological factors that impinge on Chagas disease drug development. (2017) Francisco, Amanda F; Jayawardhana, Shiromani; Lewis, Michael D; Taylor, Martin C; Kelly, John M

Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study. (2017) Zoidis, Grigoris; Tsotinis, Andrew; Tsatsaroni, Alexandra; Taylor, Martin C; Kelly, John M; Efstathiou, Antonia; Smirlis, Despina; Fytas, George

2016

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage. (2016) Francisco, Amanda Fortes; Jayawardhana, Shiromani; Lewis, Michael D; White, Karen L; Shackleford, David M; Chen, Gong; Saunders, Jessica; Osuna-Cabello, Maria; Read, Kevin D; Charman, Susan A; Chatelain, Eric; Kelly, John M

Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds. (2016) Kishore, Kranti G; Ghashghaei, Ouldouz; Estarellas, Carolina; Mestre, M Mar; Monturiol, Cristina; Kielland, Nicola; Kelly, John M; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Muñoz-Torrero, Diego; Pérez, Belén; Luque, F Javier; Gámez-Montaño, Rocío; Lavilla, Rodolfo

Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds. (2016) Kishore, Kranti G; Ghashghaei, Ouldouz; Estarellas, Carolina; Mestre, M Mar; Monturiol, Cristina; Kielland, Nicola; Kelly, John M; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Muñoz-Torrero, Diego; Pérez, Belén; Luque, F Javier; Gámez-Montaño, Rocío; Lavilla, Rodolfo

Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy. (2016) Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Jayawardhana, Shiromani; Kelly, John M

Putting Infection Dynamics at the Heart of Chagas Disease. (2016) Lewis, Michael D; Kelly, John M

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. (2016) Sola, Irene; Artigas, Albert; Taylor, Martin C; Pérez-Areales, F Javier; Viayna, Elisabet; Clos, M Victòria; Pérez, Belén; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego

2015

"Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert'' [Mol. Biochem. Parasit. (2014) 193, 17-19]. (2015) Campos, MCO; Leon, LL; Taylor, MC; Kelly, JM

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity. (2015) Di Pietro, Ornella; Vicente-García, Esther; Taylor, Martin C; Berenguer, Diana; Viayna, Elisabet; Lanzoni, Anna; Sola, Irene; Sayago, Helena; Riera, Cristina; Fisa, Roser; Clos, M Victòria; Pérez, Belén; Kelly, John M; Lavilla, Rodolfo; Muñoz-Torrero, Diego

Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs". (2015) Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M

Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. (2015) Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. (2015) Sola, Irene; Castellà, Sílvia; Viayna, Elisabet; Galdeano, Carles; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Jones, Deuan C; Fairlamb, Alan H; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego

The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence. (2015) Taylor, Martin C; Lewis, Michael D; Fortes Francisco, Amanda; Wilkinson, Shane R; Kelly, John M

2014

Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert. (2014) Campos, Mônica CO; Leon, Leonor L; Taylor, Martin C; Kelly, John M

Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection. (2014) Lewis, Michael D; Fortes Francisco, Amanda; Taylor, Martin C; Burrell-Saward, Hollie; McLatchie, Alex P; Miles, Michael A; Kelly, John M

A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging. (2014) Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Kelly, John M

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. (2014) Sola, Irene; Artigas, Albert; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego

Optimizing bioluminescence imaging to study protozoan parasite infections. (2014) Taylor, Martin C; Kelly, John M

2013

Genetic dissection of drug resistance in trypanosomes. (2013) Alsford, Sam; Kelly, John M; Baker, Nicola; Horn, David

Synthesis and trypanocidal action of new adamantane substituted imidazolines. (2013) Koperniku, Ana; Papanastasiou, Ioannis; Foscolos, George B; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M

Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase. (2013) McLatchie, Alex P; Burrell-Saward, Hollie; Myburgh, Elmarie; Lewis, Michael D; Ward, Theresa H; Mottram, Jeremy C; Croft, Simon L; Kelly, John M; Taylor, Martin C

Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue. (2013) Taylor, Martin C; McLatchie, Alex P; Kelly, John M

An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids. (2013) Tsatsaroni, Alexandra; Zoidis, Grigoris; Zoumpoulakis, Panagiotis; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; Fytas, George

2012

Centromere-associated repeat arrays on Trypanosoma brucei chromosomes are much more extensive than predicted. (2012) Echeverry, Maria C; Bot, Christopher; Obado, Samson O; Taylor, Martin C; Kelly, John M

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei. (2012) Kelly, John M; Taylor, Martin C; Horn, David; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik

Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population. (2012) Mejia, Ana Maria; Hall, Belinda S; Taylor, Martin C; Gómez-Palacio, Andrés; Wilkinson, Shane R; Triana-Chávez, Omar; Kelly, John M

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities. (2012) Torres, Eva; Duque, María D; López-Querol, Marta; Taylor, Martin C; Naesens, Lieve; Ma, Chunlong; Pinto, Lawrence H; Sureda, Francesc X; Kelly, John M; Vázquez, Santiago

2011

Huprines as a new family of dual acting trypanocidal-antiplasmodial agents. (2011) Defaux, Julien; Sala, Marta; Formosa, Xavier; Galdeano, Carles; Taylor, Martin C; Alobaid, Waleed AA; Kelly, John M; Wright, Colin W; Camps, Pelayo; Muñoz-Torrero, Diego picture_as_pdf

Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity. (2011) Fytas, Christos; Zoidis, Grigoris; Tzoutzas, Nikolaos; Taylor, Martin C; Fytas, George; Kelly, John M

Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei. (2011) Obado, Samson O; Bot, Christopher; Echeverry, Maria C; Bayona, Julio C; Alvarez, Vanina E; Taylor, Martin C; Kelly, John M

Genetic techniques in Trypanosoma cruzi. (2011) Taylor, Martin C; Huang, Huan; Kelly, John M

Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives. (2011) Wilkinson, Shane R; Bot, Christopher; Kelly, John M; Hall, Belinda S

2010

New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities. (2010) Duque, María D; Camps, Pelayo; Torres, Eva; Valverde, Elena; Sureda, Francesc X; López-Querol, Marta; Camins, Antoni; Prathalingam, S Radhika; Kelly, John M; Vázquez, Santiago

Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I). (2010) Patel, Shreenal; Hussain, Syeed; Harris, Richard; Sardiwal, Sunita; Kelly, John M; Wilkinson, Shane R; Driscoll, Paul C; Djordjevic, Snezana

Iron metabolism in trypanosomatids, and its crucial role in infection. (2010) Taylor, MC; Kelly, JM

Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines. (2010) Zoidis, Grigoris; Kolocouris, Nicolas; Kelly, John M; Prathalingam, S Radhika; Naesens, Lieve; De Clercq, Erik

2009

Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines. (2009) Duque, María D; Camps, Pelayo; Profire, Lenuta; Montaner, Silvia; Vázquez, Santiago; Sureda, Francesc X; Mallol, Jordi; López-Querol, Marta; Naesens, Lieve; De Clercq, Erik; Prathalingam, S Radhika; Kelly, John M

Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones. (2009) Papanastasiou, Ioannis; Tsotinis, Andrew; Zoidis, Grigoris; Kolocouris, Nicolas; Prathalingam, S Radhika; Kelly, John M

Trypanocidal drugs: mechanisms, resistance and new targets. (2009) Wilkinson, Shane R; Kelly, John M

2008

Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs. (2008) Camps, Pelayo; Duque, María D; Vázquez, Santiago; Naesens, Lieve; De Clercq, Erik; Sureda, Francesc X; López-Querol, Marta; Camins, Antoni; Pallàs, Mercè; Prathalingam, S Radhika; Kelly, John M; Romero, Vanessa; Ivorra, Dolores; Cortés, Diego

Synthesis of conformationally constrained adamantane imidazolines with trypanocidal activity. (2008) Papanastasiou, Ioannis; Tsotinis, Andrew; Foscolos, George B; Prathalingam, S Radhika; Kelly, John M

Design, synthesis, and trypanocidal activity of new aminoadamantane derivatives. (2008) Papanastasiou, Ioannis; Tsotinis, Andrew; Kolocouris, Nicolas; Prathalingam, S Radhika; Kelly, John M

Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite. (2008) Piacenza, Lucía; Peluffo, Gonzalo; Alvarez, María Noel; Kelly, John M; Wilkinson, Shane R; Radi, Rafael

Validation of spermidine synthase as a drug target in African trypanosomes. (2008) Taylor, Martin C; Kaur, Harparkash; Blessington, Bernard; Kelly, John M; Wilkinson, Shane R

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. (2008) Wilkinson, Shane R; Taylor, Martin C; Horn, David; Kelly, John M; Cheeseman, Ian

Design and synthesis of bioactive 1,2-annulated adamantane derivatives. (2008) Zoidis, Grigoris; Tsotinis, Andrew; Kolocouris, Nicolas; Kelly, John M; Prathalingam, S Radhika; Naesens, Lieve; De Clercq, Erik

2007

The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements. (2007) Gluenz, Eva; Taylor, Martin C; Kelly, John M picture_as_pdf

Design and synthesis of bioactive adamantane spiro heterocycles. (2007) Kolocouris, Nicolas; Zoidis, Grigoris; Foscolos, George B; Fytas, George; Prathalingham, S Radhika; Kelly, John M; Naesens, Lieve; De Clercq, Erik

The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase. (2007) Logan, Flora J; Taylor, Martin C; Wilkinson, Shane R; Kaur, Harparkash; Kelly, John M

Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. (2007) Obado, Samson O; Bot, Christopher; Nilsson, Daniel; Andersson, Bjorn; Kelly, John M picture_as_pdf

Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. (2007) Piacenza, Lucía; Irigoín, Florencia; Alvarez, María Noel; Peluffo, Gonzalo; Taylor, Martin C; Kelly, John M; Wilkinson, Shane R; Radi, Rafael

Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole. (2007) Prathalingham, S Radhika; Wilkinson, Shane R; Horn, David; Kelly, John M

Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole. (2007) Prathalingham, SR; Wilkinson, SR; Horn, D; Kelly, JM

Chromosome structure and dynamics. (2007) Renauld, H; Kelly, JM; Horn, D

2006

Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage. (2006) Kelly, John M; McRobert, Louisa; Baker, David A

The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology. (2006) MacRae, James I; Obado, Samson O; Turnock, Daniel C; Roper, Janine R; Kierans, Martin; Kelly, John M; Ferguson, Michael AJ

pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi. (2006) Taylor, Martin C; Kelly, John M

Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. (2006) Wilkinson, Shane R; Prathalingam, S Radhika; Taylor, Martin C; Ahmed, Aiyaz; Horn, David; Kelly, John M

2005

Developmentally regulated genes in Trypansoma Cruzi. (2005) Gluenz, E

Trypanosoma cruzi. (2005) Kelly, JM; Taylor, MC; Wilkinson, SR

Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature. (2005) Obado, Samson O; Taylor, Martin C; Wilkinson, Shane R; Bromley, Elizabeth V; Kelly, John M

Vitamin C biosynthesis in trypanosomes: a role for the glycosome. (2005) Wilkinson, Shane R; Prathalingam, S Radhika; Taylor, Martin C; Horn, David; Kelly, John M

2004

Structure, function and evolution of microbial adenylyl and guanylyl cyclases. (2004) Baker, David A; Kelly, John M

Purine nucleotide cyclases in the malaria parasite. (2004) Baker, David A; Kelly, John M

The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal. (2004) Bromley, Elizabeth V; Taylor, Martin C; Wilkinson, Shane R; Kelly, John M

Functional mapping of an American trypanosome centromere [Abstract]. (2004) Kelly, JM; Obado, SO; Taylor, MC

2003

Molecular Mechanisms in the Pathogenesis of Chagas? Disease. (2003) Kelly, JM

Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. (2003) Muhia, David K; Swales, Claire A; Eckstein-Ludwig, Ursula; Saran, Shweta; Polley, Spencer D; Kelly, John M; Schaap, Pauline; Krishna, Sanjeev; Baker, David A

How does Trypanosoma cruzi survive the toxic effects of reactive oxygen species? (2003) Wilkinson, SR; Kelly, JM

RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome. (2003) Wilkinson, Shane R; Horn, David; Prathalingam, S Radhika; Kelly, John M

The role of glutathione peroxidases in trypanosomatids. (2003) Wilkinson, Shane R; Kelly, John M

2002

Chromosome fragmentation as an approach to whole-genome analysis in trypanosomes. (2002) Kelly, JM; Obado, S

Intracellular signalling. (2002) Ruben, L; Kelly, JM; Chakrabarti, D

Functional dissection of the Trypanosoma cruzi genome: New approaches in a new era. (2002) Taylor, MC; Kelly, JM

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. (2002) Wilkinson, Shane R; Meyer, David J; Taylor, Martin C; Bromley, Elizabeth V; Miles, Michael A; Kelly, John M

Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum. (2002) Wilkinson, Shane R; Obado, Samson O; Mauricio, Isabel L; Kelly, John M

TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum. (2002) Wilkinson, Shane R; Taylor, Martin C; Touitha, Said; Mauricio, Isabel L; Meyer, David J; Kelly, John M

2001

Trypanosoma cruzi: mucin pseudogenes organized in a tandem array. (2001) Allen, CL; Kelly, JM

In vitro and in vivo activities of aminoadamantane and aminoalkylcyclohexane derivatives against Trypanosoma brucei. (2001) Kelly, JM; Quack, G; Miles, MM

The gametocyte-activating factor xanthurenic acid stimulates an increase in membrane-associated guanylyl cyclase activity in the human malaria parasite Plasmodium falciparum. (2001) Muhia, DK; Swales, CA; Deng, W; Kelly, JM; Baker, DA