New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.
María D Duque;
Pelayo Camps;
Eva Torres;
Elena Valverde;
Francesc X Sureda;
Marta López-Querol;
Antoni Camins;
S Radhika Prathalingam;
John M Kelly 
;
Santiago Vázquez;
(2010)
New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.
Bioorganic & medicinal chemistry, 18 (1).
pp. 46-57.
ISSN 0968-0896
DOI: 10.1016/j.bmc.2009.11.017
;
Santiago Vázquez;
(2010)
New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.
Bioorganic & medicinal chemistry, 18 (1).
pp. 46-57.
ISSN 0968-0896
DOI: 10.1016/j.bmc.2009.11.017
The synthesis of several (1,2,3,5,6,7-hexahydro-1,5:3,7-dimethano-4-benzoxonin-3-yl)amines and related compounds is reported. Several of them display very similar activity to memantine as NMDA receptor antagonists. Several derivatives showed a significant level of trypanocidal activity.
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