Advances in mode of action of antimalarials and resistance mechanisms - part 2 of 2

1. Introduction 2. Drug resistance mechanisms 3. Chloroquine-resistance in falciparum malaria 4. Chloroquine-resistance caused raised fatality 5. Resistance mechanisms 6. PfCRT (coded on chromosome 7) 7. PfCRT based on structure of E. coli 1PW5 8. The ancestor of PfCRT may be a thiol carrier CLT 9. Activity of D-AQ in CQ-R 10. AQ selected the SVMNT CQ-resistance variant 11. Can CQ become useful once more? 12. Resistance to artemisinin 13. Mutations in Pgh-1 14. PgH-1 15. Modeled PgH-1 transporter 16. Mouse PgH-1 transporter model 17. Mutated protein pumps more HF into the DV 18. Resistance mechanisms summary 19. Rationale for ACT 20. UBP-1 changes associated with drug-resistance 21. Piperaquine and dihydroartemisinin combination 22. Life cycle stage as drug target - summary (1) 23. Life cycle stage as drug target - summary (2) 24. Controlling the spread of resistance 25. Approach to urgent treatment for severe malaria 26. Intermittent preventive treatment: IPT 27. END