An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.
Alexandra Tsatsaroni;
Grigoris Zoidis;
Panagiotis Zoumpoulakis;
Andrew Tsotinis;
Martin C Taylor 
;
John M Kelly ;
George Fytas;
(2013)
An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.
Tetrahedron letters, 54 (25).
pp. 3238-3240.
ISSN 0040-4039
DOI: 10.1016/j.tetlet.2013.03.128
;
John M Kelly ;
George Fytas;
(2013)
An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.
Tetrahedron letters, 54 (25).
pp. 3238-3240.
ISSN 0040-4039
DOI: 10.1016/j.tetlet.2013.03.128
An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners 1a and 2, based on their E/Z conformational behaviour in DMSO, is presented.
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