Year Item Type Full Text

Article

The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei. (2003) Alsford, NS; Navarro, M; Jamnadass, HR; Dunbar, H; Ackroyd, M; Murphy, NB; Gull, K; Ersfeld, K

Diversity and dynamics of the minichromosomal karyotype in Trypanosoma brucei. (2001) Alsford, S; Wickstead, B; Ersfeld, K; Gull, K

Subverting lysosomal function in Trypanosoma brucei. (2015) Alsford, Sam

Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis. (2014) Alsford, Sam

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. (2014) Alsford, Sam; Currier, Rachel B; Guerra-Assunção, José Afonso; Clark, Taane G; Horn, David

High-throughput decoding of antitrypanosomal drug efficacy and resistance. (2012) Alsford, Sam; Eckert, Sabine; Baker, Nicola; Glover, Lucy; Sanchez-Flores, Alejandro; Leung, Ka Fai; Turner, Daniel J; Field, Mark C; Berriman, Matthew; Horn, David

Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy. (2013) Alsford, Sam; Field, Mark C; Horn, David

Multiplex analysis of RNA interference defects in Trypanosoma brucei. (2005) Alsford, Sam; Glover, Lucy; Horn, David

Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei. (2012) Alsford, Sam; Horn, David

Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes. (2011) Alsford, Sam; Horn, David

Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei. (2008) Alsford, Sam; Horn, David

RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei. (2007) Alsford, Sam; Horn, David picture_as_pdf

Trypanosomatid histones. (2004) Alsford, Sam; Horn, David

DNA breaks as triggers for antigenic variation in African trypanosomes. (2009) Alsford, Sam; Horn, David; Glover, Lucy

Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects. (2005) Alsford, Sam; Kawahara, Taemi; Glover, Lucy; Horn, David

A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation. (2007) Alsford, Sam; Kawahara, Taemi; Isamah, Cyril; Horn, David

Genetic dissection of drug resistance in trypanosomes. (2013) Alsford, Sam; Kelly, John M; Baker, Nicola; Horn, David

RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease. (2010) Alsford, Sam; Kemp, Louise E; Kawahara, Taemi; Horn, David picture_as_pdf

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. (2011) Alsford, Sam; Turner, Daniel J; Obado, Samson O; Sanchez-Flores, Alejandro; Glover, Lucy; Berriman, Matthew; Hertz-Fowler, Christiane; Horn, David

Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes. (2012) Alsford, Sam; duBois, Kelly; Horn, David; Field, Mark C

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6. (2010) Baker, Nicola; Alsford, Sam; Horn, David

Synthetic biology tools for engineering Goodwin oscillation in Trypanosoma brucei brucei. (2022) Borg, Yanika; Alsford, Sam; Pavlika, Vasos; Zaikin, Alexei; Nesbeth, Darren N

Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite <i>Trypanosoma brucei</i>. (2019) Collett, Clare F; Kitson, Carl; Baker, Nicola; Steele-Stallard, Heather B; Santrot, Marie-Victoire; Hutchinson, Sebastian; Horn, David; Alsford, Sam

Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei. (2019) Collett, Clare F; Kitson, Carl; Baker, Nicola; Steele-Stallard, Heather B; Santrot, Marie-Victoire; Hutchinson, Sebastian; Horn, David; Alsford, Sam

Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1. (2018) Currier, Rachel B; Cooper, Anneli; Burrell-Saward, Hollie; MacLeod, Annette; Alsford, Sam

TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei. (2021) Davies, Carys; Ooi, Cher-Pheng; Sioutas, Georgios; Hall, Belinda S; Sidhu, Haneesh; Butter, Falk; Alsford, Sam; Wickstead, Bill; Rudenko, Gloria

NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions. (2012) DuBois, Kelly N; Alsford, Sam; Holden, Jennifer M; Buisson, Johanna; Swiderski, Michal; Bart, Jean-Mathieu; Ratushny, Alexander V; Wan, Yakun; Bastin, Philippe; Barry, J David; Navarro, Miguel; Horn, David; Aitchison, John D; Rout, Michael P; Field, Mark C

Telomeres, tethers and trypanosomes. (2012) Field, Mark C; Horn, David; Alsford, Sam; Koreny, Ludek; Rout, Michael P

Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes. (2014) Glover, Lucy; Alsford, Sam; Baker, Nicola; Turner, Daniel J; Sanchez-Flores, Alejandro; Hutchinson, Sebastian; Hertz-Fowler, Christiane; Berriman, Matthew; Horn, David

Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest. (2007) Glover, Lucy; Alsford, Sam; Beattie, Caroline; Horn, David

DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. (2013) Glover, Lucy; Alsford, Sam; Horn, David

VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes. (2016) Glover, Lucy; Hutchinson, Sebastian; Alsford, Sam; Horn, David

Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control. (2013) Glover, Lucy; Hutchinson, Sebastian; Alsford, Sam; McCulloch, Richard; Field, Mark C; Horn, David

Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA. (2013) Gould, Matthew K; Bachmaier, Sabine; Ali, Juma AM; Alsford, Sam; Tagoe, Daniel NA; Munday, Jane C; Schnaufer, Achim C; Horn, David; Boshart, Michael; de Koning, Harry P

Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes. (2008) Kawahara, Taemi; Siegel, T Nicolai; Ingram, Alexandra K; Alsford, Sam; Cross, George AM; Horn, David picture_as_pdf

Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei. (2017) Macedo, Juan P; Currier, Rachel B; Wirdnam, Corina; Horn, David; Alsford, Sam; Rentsch, Doris

Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression. (2016) Maishman, Luke; Obado, Samson O; Alsford, Sam; Bart, Jean-Mathieu; Chen, Wei-Ming; Ratushny, Alexander V; Navarro, Miguel; Horn, David; Aitchison, John D; Chait, Brian T; Rout, Michael P; Field, Mark C

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs. (2017) Meredith, Emma Louise; Kumar, Ambika; Konno, Aya; Szular, Joanna; Alsford, Sam; Seifert, Karin; Horn, David; Wilkinson, Shane R

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. (2017) Stortz, Jennifer A; Serafim, Tiago D; Alsford, Sam; Wilkes, Jonathan; Fernandez-Cortes, Fernando; Hamilton, Graham; Briggs, Emma; Lemgruber, Leandro; Horn, David; Mottram, Jeremy C; McCulloch, Richard

Insights into antitrypanosomal drug mode-of-action from cytology-based profiling. (2018) Thomas, James A; Baker, Nicola; Hutchinson, Sebastian; Dominicus, Caia; Trenaman, Anna; Glover, Lucy; Alsford, Sam; Horn, David

Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes. (2015) Zoltner, Martin; Leung, Ka Fai; Alsford, Sam; Horn, David; Field, Mark C