Items where Author is "Alsford, Sam"
Number of items: 41.
2019
Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite <i>Trypanosoma brucei</i>. (2019)
Collett, Clare F; Kitson, Carl; Baker, Nicola; Steele-Stallard, Heather B; Santrot, Marie-Victoire; Hutchinson, Sebastian; Horn, David; Alsford, Sam
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Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei. (2019)
Collett, Clare F; Kitson, Carl; Baker, Nicola; Steele-Stallard, Heather B; Santrot, Marie-Victoire; Hutchinson, Sebastian; Horn, David; Alsford, Sam
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2018
Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1. (2018)
Currier, Rachel B; Cooper, Anneli; Burrell-Saward, Hollie; MacLeod, Annette; Alsford, Sam
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Insights into antitrypanosomal drug mode-of-action from cytology-based profiling. (2018)
Thomas, James A; Baker, Nicola; Hutchinson, Sebastian; Dominicus, Caia; Trenaman, Anna; Glover, Lucy; Alsford, Sam; Horn, David
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2017
Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei. (2017)
Macedo, Juan P; Currier, Rachel B; Wirdnam, Corina; Horn, David; Alsford, Sam; Rentsch, Doris
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Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs. (2017)
Meredith, Emma Louise; Kumar, Ambika; Konno, Aya; Szular, Joanna; Alsford, Sam; Seifert, Karin; Horn, David; Wilkinson, Shane R
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Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. (2017)
Stortz, Jennifer A; Serafim, Tiago D; Alsford, Sam; Wilkes, Jonathan; Fernandez-Cortes, Fernando; Hamilton, Graham; Briggs, Emma; Lemgruber, Leandro; Horn, David; Mottram, Jeremy C; McCulloch, Richard
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2016
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes. (2016)
Glover, Lucy; Hutchinson, Sebastian; Alsford, Sam; Horn, David
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Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression. (2016)
Maishman, Luke; Obado, Samson O; Alsford, Sam; Bart, Jean-Mathieu; Chen, Wei-Ming; Ratushny, Alexander V; Navarro, Miguel; Horn, David; Aitchison, John D; Chait, Brian T; Rout, Michael P; Field, Mark C
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2014
Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis. (2014)
Alsford, Sam
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Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. (2014)
Alsford, Sam; Currier, Rachel B; Guerra-Assunção, José Afonso; Clark, Taane G; Horn, David
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Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes. (2014)
Glover, Lucy; Alsford, Sam; Baker, Nicola; Turner, Daniel J; Sanchez-Flores, Alejandro; Hutchinson, Sebastian; Hertz-Fowler, Christiane; Berriman, Matthew; Horn, David
2013
Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy. (2013)
Alsford, Sam; Field, Mark C; Horn, David
Genetic dissection of drug resistance in trypanosomes. (2013)
Alsford, Sam; Kelly, John M; Baker, Nicola; Horn, David
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DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. (2013)
Glover, Lucy; Alsford, Sam; Horn, David
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Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control. (2013)
Glover, Lucy; Hutchinson, Sebastian; Alsford, Sam; McCulloch, Richard; Field, Mark C; Horn, David
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Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA. (2013)
Gould, Matthew K; Bachmaier, Sabine; Ali, Juma AM; Alsford, Sam; Tagoe, Daniel NA; Munday, Jane C; Schnaufer, Achim C; Horn, David; Boshart, Michael; de Koning, Harry P
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2012
High-throughput decoding of antitrypanosomal drug efficacy and resistance. (2012)
Alsford, Sam; Eckert, Sabine; Baker, Nicola; Glover, Lucy; Sanchez-Flores, Alejandro; Leung, Ka Fai; Turner, Daniel J; Field, Mark C; Berriman, Matthew; Horn, David
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Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei. (2012)
Alsford, Sam; Horn, David
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Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes. (2012)
Alsford, Sam; duBois, Kelly; Horn, David; Field, Mark C
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions. (2012)
DuBois, Kelly N; Alsford, Sam; Holden, Jennifer M; Buisson, Johanna; Swiderski, Michal; Bart, Jean-Mathieu; Ratushny, Alexander V; Wan, Yakun; Bastin, Philippe; Barry, J David; Navarro, Miguel; Horn, David; Aitchison, John D; Rout, Michael P; Field, Mark C
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Telomeres, tethers and trypanosomes. (2012)
Field, Mark C; Horn, David; Alsford, Sam; Koreny, Ludek; Rout, Michael P
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2011
Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes. (2011)
Alsford, Sam; Horn, David
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High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. (2011)
Alsford, Sam; Turner, Daniel J; Obado, Samson O; Sanchez-Flores, Alejandro; Glover, Lucy; Berriman, Matthew; Hertz-Fowler, Christiane; Horn, David
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2007
RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei. (2007)
Alsford, Sam; Horn, David
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A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation. (2007)
Alsford, Sam; Kawahara, Taemi; Isamah, Cyril; Horn, David
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Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest. (2007)
Glover, Lucy; Alsford, Sam; Beattie, Caroline; Horn, David
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