Items where Author is "Blackman, MJ"
Number of items: 112.
2022
CDC50 Orthologues in Plasmodium falciparum Have Distinct Roles in Merozoite Egress and Trophozoite Maturation. (2022)
Patel, Avnish; Nofal, Stephanie D; Blackman, Michael J; Baker, David A
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite. (2022)
Ramaprasad, Abhinay; Burda, Paul-Christian; Calvani, Enrica; Sait, Aaron J; Palma-Duran, Susana Alejandra; Withers-Martinez, Chrislaine; Hackett, Fiona; Macrae, James; Collinson, Lucy; Gilberger, Tim Wolf; Blackman, Michael J
2021
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG. (2021)
Balestra, Aurélia C; Koussis, Konstantinos; Klages, Natacha; Howell, Steven A; Flynn, Helen R; Bantscheff, Marcus; Pasquarello, Carla; Perrin, Abigail J; Brusini, Lorenzo; Arboit, Patrizia; Sanz, Olalla; Castaño, Laura Peces-Barba; Withers-Martinez, Chrislaine; Hainard, Alexandre; Ghidelli-Disse, Sonja; Snijders, Ambrosius P; Baker, David A; Blackman, Michael J; Brochet, Mathieu
Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1. (2021)
Lidumniece, Elina; Withers-Martinez, Chrislaine; Hackett, Fiona; Collins, Christine R; Perrin, Abigail J; Koussis, Konstantinos; Bisson, Claudine; Blackman, Michael J; Jirgensons, Aigars
Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress. (2021)
Nofal, Stephanie D; Patel, Avnish; Blackman, Michael J; Flueck, Christian; Baker, David A
Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony. (2021)
Perrin, Abigail J; Bisson, Claudine; Faull, Peter A; Renshaw, Matthew J; Lees, Rebecca A; Fleck, Roland A; Saibil, Helen R; Snijders, Ambrosius P; Baker, David A; Blackman, Michael J
Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid. (2021)
Prior, Kimberley F; Middleton, Benita; Owolabi, Alíz TY; Westwood, Mary L; Holland, Jacob; O'Donnell, Aidan J; Blackman, Michael J; Skene, Debra J; Reece, Sarah E
Malaria parasite egress at a glance. (2021)
Tan, Michele SY; Blackman, Michael J
Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor. (2021)
Tan, Michele SY; Koussis, Konstantinos; Withers-Martinez, Chrislaine; Howell, Steven A; Thomas, James A; Hackett, Fiona; Knuepfer, Ellen; Shen, Min; Hall, Matthew D; Snijders, Ambrosius P; Blackman, Michael J
2020
The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion. (2020)
Collins, Christine R; Hackett, Fiona; Howell, Steven A; Snijders, Ambrosius P; Russell, Matthew Rg; Collinson, Lucy M; Blackman, Michael J
Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function. (2020)
Koussis, Konstantinos; Withers-Martinez, Chrislaine; Baker, David A; Blackman, Michael J
The parasitophorous vacuole of the blood-stage malaria parasite. (2020)
Matz, Joachim M; Beck, Josh R; Blackman, Michael J
A lipocalin mediates unidirectional heme biomineralization in malaria parasites. (2020)
Matz, Joachim M; Drepper, Benjamin; Blum, Thorsten B; van Genderen, Eric; Burrell, Alana; Martin, Peer; Stach, Thomas; Collinson, Lucy M; Abrahams, Jan Pieter; Matuschewski, Kai; Blackman, Michael J
cAMP signalling and its role in host cell invasion by malaria parasites. (2020)
Perrin, Abigail J; Patel, Avnish; Flueck, Christian; Blackman, Michael J; Baker, David A
A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1. (2020)
Tarr, Sarah J; Withers-Martinez, Chrislaine; Flynn, Helen R; Snijders, Ambrosius P; Masino, Laura; Koussis, Konstantinos; Conway, David J; Blackman, Michael J
2019
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. (2019)
El Bakkouri, Majida; Kouidmi, Imène; Wernimont, Amy K; Amani, Mehrnaz; Hutchinson, Ashley; Loppnau, Peter; Kim, Jeong Joo; Flueck, Christian; Walker, John R; Seitova, Alma; Senisterra, Guillermo; Kakihara, Yoshito; Kim, Choel; Blackman, Michael J; Calmettes, Charles; Baker, David A; Hui, Raymond
Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. (2019)
Flueck, Christian; Drought, Laura G; Jones, Andrew; Patel, Avnish; Perrin, Abigail J; Walker, Eloise M; Nofal, Stephanie D; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A
Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. (2019)
Flueck, Christian; Drought, Laura G; Jones, Andrew; Patel, Avnish; Perrin, Abigail J; Walker, Eloise M; Nofal, Stephanie D; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A
Deletion of Plasmodium falciparum Protein RON3 Affects the Functional Translocation of Exported Proteins and Glucose Uptake. (2019)
Low, Leanne M; Azasi, Yvonne; Sherling, Emma S; Garten, Matthias; Zimmerberg, Joshua; Tsuboi, Takafumi; Brzostowski, Joseph; Mu, Jianbing; Blackman, Michael J; Miller, Louis H
Investigation of the role of GCα in activating cGMP signalling in Plasmodium falciparum and how cyclic nucleotide signalling modulates molecular motor function. (2019)
Nofal, SD
The Plasmodium berghei serine protease PbSUB1 plays an important role in male gamete egress. (2019)
Pace, Tomasino; Grasso, Felicia; Camarda, Grazia; Suarez, Catherine; Blackman, Michael J; Ponzi, Marta; Olivieri, Anna
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery. (2019)
Patel, Avnish; Perrin, Abigail J; Flynn, Helen R; Bisson, Claudine; Withers-Martinez, Chrislaine; Treeck, Moritz; Flueck, Christian; Nicastro, Giuseppe; Martin, Stephen R; Ramos, Andres; Gilberger, Tim W; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A
The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion. (2019)
Sherling, Emma S; Perrin, Abigail J; Knuepfer, Ellen; Russell, Matthew RG; Collinson, Lucy M; Miller, Louis H; Blackman, Michael J
Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D. (2019)
Zogota, Rimants; Kinena, Linda; Withers-Martinez, Chrislaine; Blackman, Michael J; Bobrovs, Raitis; Pantelejevs, Teodors; Kanepe-Lapsa, Iveta; Ozola, Vita; Jaudzems, Kristaps; Suna, Edgars; Jirgensons, Aigars
2018
Essentiality of Plasmodium falciparum plasmepsin V. (2018)
Boonyalai, Nonlawat; Collins, Christine R; Hackett, Fiona; Withers-Martinez, Chrislaine; Blackman, Michael J
Function and essentiality of <i>Plasmodium falciparum</i> plasmepsin V. (2018)
Boonyalai, Nonlawat; Collins, Christine R; Hackett, Fiona; Withers-Martinez, Chrislaine; Blackman, Michael J
Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage. (2018)
Deligianni, Elena; Silmon de Monerri, Natalie C; McMillan, Paul J; Bertuccini, Lucia; Superti, Fabiana; Manola, Maria; Spanos, Lefteris; Louis, Christos; Blackman, Michael J; Tilley, Leann; Siden-Kiamos, Inga
Identification and validation of a novel panel of Plasmodium knowlesi biomarkers of serological exposure. (2018)
Herman, Lou S; Fornace, Kimberly; Phelan, Jody; Grigg, Matthew J; Anstey, Nicholas M; William, Timothy; Moon, Robert W; Blackman, Michael J; Drakeley, Chris J; Tetteh, Kevin KA
The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress. (2018)
Perrin, Abigail J; Collins, Christine R; Russell, Matthew RG; Collinson, Lucy M; Baker, David A; Blackman, Michael J
A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells. (2018)
Thomas, James A; Tan, Michele SY; Bisson, Claudine; Borg, Aaron; Umrekar, Trishant R; Hackett, Fiona; Hale, Victoria L; Vizcay-Barrena, Gema; Fleck, Roland A; Snijders, Ambrosius P; Saibil, Helen R; Blackman, Michael J
2017
A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line. (2017)
Benavente, Ernest Diez; de Sessions, Paola Florez; Moon, Robert W; Grainger, Munira; Holder, Anthony A; Blackman, Michael J; Roper, Cally; Drakeley, Christopher J; Pain, Arnab; Sutherland, Colin J; Hibberd, Martin L; Campino, Susana; Clark, Taane G
The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes. (2017)
Collins, Christine R; Hackett, Fiona; Atid, Jonathan; Tan, Michele Ser Ying; Blackman, Michael J
Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations. (2017)
Diez Benavente, Ernest; Florez de Sessions, Paola; Moon, Robert W; Holder, Anthony A; Blackman, Michael J; Roper, Cally; Drakeley, Christopher J; Pain, Arnab; Sutherland, Colin J; Hibberd, Martin L; Campino, Susana; Clark, Taane G
Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress. (2017)
Hale, Victoria L; Watermeyer, Jean M; Hackett, Fiona; Vizcay-Barrena, Gema; van Ooij, Christiaan; Thomas, James A; Spink, Matthew C; Harkiolaki, Maria; Duke, Elizabeth; Fleck, Roland A; Blackman, Michael J; Saibil, Helen R
A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress. (2017)
Pino, P; Caldelari, R; Mukherjee, B; Vahokoski, J; Klages, N; Maco, B; Collins, CR; Blackman, MJ; Kursula, I; Heussler, V; Brochet, M; Soldati-Favre, D
The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake. (2017)
Sherling, Emma S; Knuepfer, Ellen; Brzostowski, Joseph A; Miller, Louis H; Blackman, Michael J; van Ooij, Christiaan
2016
Regulation and Essentiality of the StAR-related Lipid Transfer (START) Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites. (2016)
Hill, Ross J; Ringel, Alessa; Knuepfer, Ellen; Moon, Robert W; Blackman, Michael J; van Ooij, Christiaan
A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum. (2016)
Jones, Matthew L; Das, Sujaan; Belda, Hugo; Collins, Christine R; Blackman, Michael J; Treeck, Moritz
Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi. (2016)
Moon, RW; Sharaf, H; Hastings, CH; Ho, YS; Nair, MB; Rchiad, Z; Knuepfer, E; Ramaprasad, A; Mohring, F; Amir, A; Yusuf, NA; Hall, J; Almond, N; Lau, YL; Pain, A; Blackman, MJ; Holder, AA
description
Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum. (2016)
Thomas, James A; Collins, Christine R; Das, Sujaan; Hackett, Fiona; Graindorge, Arnault; Bell, Donald; Deu, Edgar; Blackman, Michael J
2015
Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs. (2015)
Das, Sujaan; Hertrich, Nadine; Perrin, Abigail J; Withers-Martinez, Chrislaine; Collins, Christine R; Jones, Matthew L; Watermeyer, Jean M; Fobes, Elmar T; Martin, Stephen R; Saibil, Helen R; Wright, Gavin J; Treeck, Moritz; Epp, Christian; Blackman, Michael J
Conditional U1 Gene Silencing in Toxoplasma gondii. (2015)
Pieperhoff, Manuela S; Pall, Gurman S; Jiménez-Ruiz, Elena; Das, Sujaan; Melatti, Carmen; Gow, Matthew; Wong, Eleanor H; Heng, Joanne; Müller, Sylke; Blackman, Michael J; Meissner, Markus
Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle. (2015)
Stallmach, Robert; Kavishwar, Manoli; Withers-Martinez, Chrislaine; Hackett, Fiona; Collins, Christine R; Howell, Steven A; Yeoh, Sharon; Knuepfer, Ellen; Atid, Avshalom J; Holder, Anthony A; Blackman, Michael J
A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes. (2015)
Watermeyer, Jean M; Hale, Victoria L; Hackett, Fiona; Clare, Daniel K; Cutts, Erin E; Vakonakis, Ioannis; Fleck, Roland A; Blackman, Michael J; Saibil, Helen R
2014
Rational design of the first difluorostatone-based PfSUB1 inhibitors. (2014)
Giovani, Simone; Penzo, Maria; Brogi, Simone; Brindisi, Margherita; Gemma, Sandra; Novellino, Ettore; Savini, Luisa; Blackman, Michael J; Campiani, Giuseppe; Butini, Stefania
Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. (2014)
Grüring, Christof; Moon, Robert W; Lim, Caeul; Holder, Anthony A; Blackman, Michael J; Duraisingh, Manoj T
Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit. (2014)
Jaudzems, Kristaps; Tars, Kaspars; Maurops, Gundars; Ivdra, Natalija; Otikovs, Martins; Leitans, Janis; Kanepe-Lapsa, Iveta; Domraceva, Ilona; Mutule, Ilze; Trapencieris, Peteris; Blackman, Michael J; Jirgensons, Aigars
Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1. (2014)
Kher, Samir S; Penzo, Maria; Fulle, Simone; Finn, Paul W; Blackman, Michael J; Jirgensons, Aigars
description
The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin. (2014)
Withers-Martinez, Chrislaine; Strath, Malcolm; Hackett, Fiona; Haire, Lesley F; Howell, Steven A; Walker, Philip A; Christodoulou, Evangelos; Dodson, Guy G; Blackman, Michael J
2013
Recent insights into apicomplexan parasite egress provide new views to a kill. (2013)
Blackman, Michael J; Carruthers, Vern B
Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2. (2013)
Child, Matthew A; Harris, Philippa K; Collins, Christine R; Withers-Martinez, Chrislaine; Yeoh, Sharon; Blackman, Michael J
Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle. (2013)
Collins, Christine R; Das, Sujaan; Wong, Eleanor H; Andenmatten, Nicole; Stallmach, Robert; Hackett, Fiona; Herman, Jean-Paul; Müller, Sylke; Meissner, Markus; Blackman, Michael J
Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. (2013)
Collins, Christine R; Hackett, Fiona; Strath, Malcolm; Penzo, Maria; Withers-Martinez, Chrislaine; Baker, David A; Blackman, Michael J
A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes. (2013)
Deligianni, Elena; Morgan, Rhiannon N; Bertuccini, Lucia; Wirth, Christine C; Silmon de Monerri, Natalie C; Spanos, Lefteris; Blackman, Michael J; Louis, Christos; Pradel, Gabriele; Siden-Kiamos, Inga
Molecular determinants of binding to the Plasmodium subtilisin-like protease 1. (2013)
Fulle, Simone; Withers-Martinez, Chrislaine; Blackman, Michael J; Morris, Garrett M; Finn, Paul W
The malarial serine protease SUB1 plays an essential role in parasite liver stage development. (2013)
Suarez, Catherine; Volkmann, Katrin; Gomes, Ana Rita; Billker, Oliver; Blackman, Michael J
Identification of a Plasmodium falciparum phospholipid transfer protein. (2013)
van Ooij, Christiaan; Withers-Martinez, Chrislaine; Ringel, Alessa; Cockcroft, Shamshad; Haldar, Kasturi; Blackman, Michael J
2012
Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites. (2012)
Cruz, Laura Nogueira; Juliano, Maria Aparecida; Budu, Alexandre; Juliano, Luiz; Holder, Anthony A; Blackman, Michael J; Garcia, Célia Rs
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1. (2012)
Gemma, Sandra; Giovani, Simone; Brindisi, Margherita; Tripaldi, Pierangela; Brogi, Simone; Savini, Luisa; Fiorini, Isabella; Novellino, Ettore; Butini, Stefania; Campiani, Giuseppe; Penzo, Maria; Blackman, Michael J
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes. (2012)
Moon, Robert W; Hall, Joanna; Rangkuti, Farania; Ho, Yung Shwen; Almond, Neil; Mitchell, Graham H; Pain, Arnab; Holder, Anthony A; Blackman, Michael J
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte. (2012)
Ruecker, Andrea; Shea, Michael; Hackett, Fiona; Suarez, Catherine; Hirst, Elizabeth MA; Milutinovic, Katarina; Withers-Martinez, Chrislaine; Blackman, Michael J
Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target. (2012)
Withers-Martinez, Chrislaine; Suarez, Catherine; Fulle, Simone; Kher, Samir; Penzo, Maria; Ebejer, Jean-Paul; Koussis, Kostas; Hackett, Fiona; Jirgensons, Aigars; Finn, Paul; Blackman, Michael J
2011
Apicomplexan AMA1 in host cell invasion: a model at the junction? (2011)
Collins, Christine R; Blackman, Michael J
Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies. (2011)
Olivieri, Anna; Collins, Christine R; Hackett, Fiona; Withers-Martinez, Chrislaine; Marshall, Joshua; Flynn, Helen R; Skehel, J Mark; Blackman, Michael J
Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode. (2011)
Santos, Joana M; Ferguson, David JP; Blackman, Michael J; Soldati-Favre, Dominique
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease. (2011)
Silmon de Monerri, Natalie C; Flynn, Helen R; Campos, Marta G; Hackett, Fiona; Koussis, Konstantinos; Withers-Martinez, Chrislaine; Skehel, J Mark; Blackman, Michael J
2010
Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth. (2010)
Child, Matthew A; Epp, Christian; Bujard, Hermann; Blackman, Michael J
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. (2010)
Dvorin, Jeffrey D; Martyn, Derek C; Patel, Saurabh D; Grimley, Joshua S; Collins, Christine R; Hopp, Christine S; Bright, A Taylor; Westenberger, Scott; Winzeler, Elizabeth; Blackman, Michael J; Baker, David A; Wandless, Thomas J; Duraisingh, Manoj T
Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites. (2010)
Friedrich, Nikolas; Santos, Joana M; Liu, Yan; Palma, Angelina S; Leon, Ester; Saouros, Savvas; Kiso, Makoto; Blackman, Michael J; Matthews, Stephen; Feizi, Ten; Soldati-Favre, Dominique
Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion. (2010)
Woehlbier, Ute; Epp, Christian; Hackett, Fiona; Blackman, Michael J; Bujard, Hermann
2009
An inhibitory antibody blocks interactions between components of the malarial invasion machinery. (2009)
Collins, Christine R; Withers-Martinez, Chrislaine; Hackett, Fiona; Blackman, Michael J
Signalling in malaria parasites. The MALSIG consortium. (2009)
Doerig, C; Baker, D; Billker, O; Blackman, MJ; Chitnis, C; Dhar Kumar, S; Heussler, V; Holder, AA; Kocken, C; Krishna, S; Langsley, G; Lasonder, E; Menard, R; Meissner, M; Pradel, G; Ranford-Cartwright, L; Sharma, A; Sharma, P; Tardieux, T; Tatu, U; Alano, P
A multifunctional serine protease primes the malaria parasite for red blood cell invasion. (2009)
Koussis, Konstantinos; Withers-Martinez, Chrislaine; Yeoh, Sharon; Child, Matthew; Hackett, Fiona; Knuepfer, Ellen; Juliano, Luiz; Woehlbier, Ute; Bujard, Hermann; Blackman, Michael J
Inhibition of erythrocyte invasion and Plasmodium falciparum merozoite surface protein 1 processing by human immunoglobulin G1 (IgG1) and IgG3 antibodies. (2009)
Lazarou, Maria; Guevara Patiño, José A; Jennings, Richard M; McIntosh, Richard S; Shi, Jianguo; Howell, Steven; Cullen, Eilish; Jones, Tarran; Adame-Gallegos, Jaime R; Chappel, Jonathan A; McBride, Jana S; Blackman, Michael J; Holder, Anthony A; Pleass, Richard J
Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro. (2009)
Wanyiri, Jane W; Techasintana, Patsharaporn; O'Connor, Roberta M; Blackman, Michael J; Kim, Kami; Ward, Honorine D
2008
Malarial proteases and host cell egress: an 'emerging' cascade. (2008)
Blackman, Michael J
Roles of proteases during invasion and egress by Plasmodium and Toxoplasma. (2008)
Dowse, Timothy J; Koussis, Konstantinos; Blackman, Michael J; Soldati-Favre, Dominique
Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition. (2008)
Sawmynaden, Kovilen; Saouros, Savvas; Friedrich, Nikolas; Marchant, Jan; Simpson, Peter; Bleijlevens, Boris; Blackman, Michael J; Soldati-Favre, Dominique; Matthews, Stephen
Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface. (2008)
Withers-Martinez, Chrislaine; Haire, Lesley F; Hackett, Fiona; Walker, Philip A; Howell, Steven A; Smerdon, Stephen J; Dodson, Guy G; Blackman, Michael J
2007
Atomic resolution insight into host cell recognition by Toxoplasma gondii. (2007)
Blumenschein, Tharin MA; Friedrich, Nikolas; Childs, Robert A; Saouros, Savvas; Carpenter, Elisabeth P; Campanero-Rhodes, Maria A; Simpson, Peter; Chai, Wengang; Koutroukides, Theodoros; Blackman, Michael J; Feizi, Ten; Soldati-Favre, Dominique; Matthews, Stephen
Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1. (2007)
Collins, Christine R; Withers-Martinez, Chrislaine; Bentley, Graham A; Batchelor, Adrian H; Thomas, Alan W; Blackman, Michael J
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes. (2007)
Yeoh, Sharon; O'Donnell, Rebecca A; Koussis, Konstantinos; Dluzewski, Anton R; Ansell, Keith H; Osborne, Simon A; Hackett, Fiona; Withers-Martinez, Chrislaine; Mitchell, Graham H; Bannister, Lawrence H; Bryans, Justin S; Kettleborough, Catherine A; Blackman, Michael J
2006
A conserved subtilisin protease identified in Babesia divergens merozoites. (2006)
Montero, Estrella; Gonzalez, Luis Miguel; Rodriguez, Marilis; Oksov, Yelena; Blackman, Michael J; Lobo, Cheryl A
Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite. (2006)
O'Donnell, Rebecca A; Hackett, Fiona; Howell, Steven A; Treeck, Moritz; Struck, Nicole; Krnajski, Zita; Withers-Martinez, Chrislaine; Gilberger, Tim W; Blackman, Michael J
2005
A new release on life: emerging concepts in proteolysis and parasite invasion. (2005)
Carruthers, Vern B; Blackman, Michael J
Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites. (2005)
Chesne-Seck, Marie-Laure; Pizarro, Juan Carlos; Vulliez-Le Normand, Brigitte; Collins, Christine R; Blackman, Michael J; Faber, Bart W; Remarque, Edmond J; Kocken, Clemens HM; Thomas, Alan W; Bentley, Graham A
Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. (2005)
Ersmark, Karolina; Nervall, Martin; Hamelink, Elizabeth; Janka, Linda K; Clemente, Jose C; Dunn, Ben M; Blackman, Michael J; Samuelsson, Bertil; Aqvist, Johan; Hallberg, Anders
Molecular identification of a malaria merozoite surface sheddase. (2005)
Harris, Philippa K; Yeoh, Sharon; Dluzewski, Anton R; O'Donnell, Rebecca A; Withers-Martinez, Chrislaine; Hackett, Fiona; Bannister, Lawrence H; Mitchell, Graham H; Blackman, Michael J
Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens. (2005)
Howell, Steven A; Hackett, Fiona; Jongco, Artemio M; Withers-Martinez, Chrislaine; Kim, Kami; Carruthers, Vern B; Blackman, Michael J
Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity. (2005)
Jean, Létitia; Withers-Martinez, Chrislaine; Hackett, Fiona; Blackman, Michael J
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II. (2005)
Johansson, Per-Ola; Lindberg, Jimmy; Blackman, Michael J; Kvarnström, Ingemar; Vrang, Lotta; Hamelink, Elizabeth; Hallberg, Anders; Rosenquist, Asa; Samuelsson, Bertil
The role of malaria merozoite proteases in red blood cell invasion. (2005)
O'Donnell, Rebecca A; Blackman, Michael J
Crystal structure of the malaria vaccine candidate apical membrane antigen 1. (2005)
Pizarro, Juan Carlos; Vulliez-Le Normand, Brigitte; Chesne-Seck, Marie-Laure; Collins, Christine R; Withers-Martinez, Chrislaine; Hackett, Fiona; Blackman, Michael J; Faber, Bart W; Remarque, Edmond J; Kocken, Clemens HM; Thomas, Alan W; Bentley, Graham A
A role for poly(dA)poly(dT) tracts in directing activity of the Plasmodium falciparum calmodulin gene promoter. (2005)
Polson, Hannah EJ; Blackman, Michael J
2004
Proteases in host cell invasion by the malaria parasite. (2004)
Blackman, Michael J
Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity. (2004)
Ersmark, Karolina; Feierberg, Isabella; Bjelic, Sinisa; Hamelink, Elizabeth; Hackett, Fiona; Blackman, Michael J; Hultén, Johan; Samuelsson, Bertil; Aqvist, Johan; Hallberg, Anders
Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs. (2004)
Johansson, Per-Ola; Chen, Yantao; Belfrage, Anna Karin; Blackman, Michael J; Kvarnström, Ingemar; Jansson, Katarina; Vrang, Lotta; Hamelink, Elizabeth; Hallberg, Anders; Rosenquist, Asa; Samuelsson, Bertil
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites. (2004)
Silvie, Olivier; Franetich, Jean-François; Charrin, Stéphanie; Mueller, Markus S; Siau, Anthony; Bodescot, Myriam; Rubinstein, Eric; Hannoun, Laurent; Charoenvit, Yupin; Kocken, Clemens H; Thomas, Alan W; Van Gemert, Geert-Jan; Sauerwein, Robert W; Blackman, Michael J; Anders, Robin F; Pluschke, Gerd; Mazier, Dominique
Subtilisin-like proteases of the malaria parasite. (2004)
Withers-Martinez, Chrislaine; Jean, Létitia; Blackman, Michael J
Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex. (2004)
Zhou, Xing W; Blackman, Michael J; Howell, Steven A; Carruthers, Vern B
2003
Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development. (2003)
Bannister, Lawrence H; Hopkins, John M; Dluzewski, Anton R; Margos, Gabriele; Williams, Ian T; Blackman, Michael J; Kocken, Clemens H; Thomas, Alan W; Mitchell, Graham H
RNAi in protozoan parasites: what hope for the Apicomplexa? (2003)
Blackman, Michael J
Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum. (2003)
Fleck, Suzanne L; Birdsall, Berry; Babon, Jeffrey; Dluzewski, Anton R; Martin, Stephen R; Morgan, William D; Angov, Evelina; Kettleborough, Catherine A; Feeney, James; Blackman, Michael J; Holder, Anthony A
A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavage. (2003)
Howell, Steven A; Well, Isabelle; Fleck, Suzanne L; Kettleborough, Catherine; Collins, Christine R; Blackman, Michael J
Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1. (2003)
Jean, Letitia; Hackett, Fiona; Martin, Stephen R; Blackman, Michael J
TgSUB2 is a Toxoplasma gondii rhoptry organelle processing proteinase. (2003)
Miller, Steven A; Thathy, Vandana; Ajioka, James W; Blackman, Michael J; Kim, Kami
2002
Structural and biochemical characterization of a fluorogenic rhodamine-labeled malarial protease substrate. (2002)
Blackman, Michael J; Corrie, John ET; Croney, John C; Kelly, Geoff; Eccleston, John F; Jameson, David M
High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion. (2002)
Kocken, Clemens HM; Withers-Martinez, Chrislaine; Dubbeld, Martin A; van der Wel, Annemarie; Hackett, Fiona; Valderrama, Augusto; Blackman, Michael J; Thomas, Alan W
Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling. (2002)
Withers-Martinez, Chrislaine; Saldanha, José W; Ely, Barry; Hackett, Fiona; O'Connor, Tony; Blackman, Michael J
2001
Apical organelles of Apicomplexa: biology and isolation by subcellular fractionation. (2001)
Blackman, MJ; Bannister, LH
Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1. (2001)
Howell, SA; Withers-Martinez, C; Kocken, CH; Thomas, AW; Blackman, MJ
A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii. (2001)
Miller, SA; Binder, EM; Blackman, MJ; Carruthers, VB; Kim, K