Year Item Type Full Text

Bibliographic data only

Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development. (2003) Bannister, Lawrence H; Hopkins, John M; Dluzewski, Anton R; Margos, Gabriele; Williams, Ian T; Blackman, Michael J; Kocken, Clemens H; Thomas, Alan W; Mitchell, Graham H

Apical organelles of Apicomplexa: biology and isolation by subcellular fractionation. (2001) Blackman, MJ; Bannister, LH

RNAi in protozoan parasites: what hope for the Apicomplexa? (2003) Blackman, Michael J

Proteases in host cell invasion by the malaria parasite. (2004) Blackman, Michael J

Recent insights into apicomplexan parasite egress provide new views to a kill. (2013) Blackman, Michael J; Carruthers, Vern B

Structural and biochemical characterization of a fluorogenic rhodamine-labeled malarial protease substrate. (2002) Blackman, Michael J; Corrie, John ET; Croney, John C; Kelly, Geoff; Eccleston, John F; Jameson, David M

Atomic resolution insight into host cell recognition by Toxoplasma gondii. (2007) Blumenschein, Tharin MA; Friedrich, Nikolas; Childs, Robert A; Saouros, Savvas; Carpenter, Elisabeth P; Campanero-Rhodes, Maria A; Simpson, Peter; Chai, Wengang; Koutroukides, Theodoros; Blackman, Michael J; Feizi, Ten; Soldati-Favre, Dominique; Matthews, Stephen

A new release on life: emerging concepts in proteolysis and parasite invasion. (2005) Carruthers, Vern B; Blackman, Michael J

Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites. (2005) Chesne-Seck, Marie-Laure; Pizarro, Juan Carlos; Vulliez-Le Normand, Brigitte; Collins, Christine R; Blackman, Michael J; Faber, Bart W; Remarque, Edmond J; Kocken, Clemens HM; Thomas, Alan W; Bentley, Graham A

Apicomplexan AMA1 in host cell invasion: a model at the junction? (2011) Collins, Christine R; Blackman, Michael J

Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1. (2007) Collins, Christine R; Withers-Martinez, Chrislaine; Bentley, Graham A; Batchelor, Adrian H; Thomas, Alan W; Blackman, Michael J

A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes. (2013) Deligianni, Elena; Morgan, Rhiannon N; Bertuccini, Lucia; Wirth, Christine C; Silmon de Monerri, Natalie C; Spanos, Lefteris; Blackman, Michael J; Louis, Christos; Pradel, Gabriele; Siden-Kiamos, Inga

Signalling in malaria parasites. The MALSIG consortium. (2009) Doerig, C; Baker, D; Billker, O; Blackman, MJ; Chitnis, C; Dhar Kumar, S; Heussler, V; Holder, AA; Kocken, C; Krishna, S; Langsley, G; Lasonder, E; Menard, R; Meissner, M; Pradel, G; Ranford-Cartwright, L; Sharma, A; Sharma, P; Tardieux, T; Tatu, U; Alano, P

Roles of proteases during invasion and egress by Plasmodium and Toxoplasma. (2008) Dowse, Timothy J; Koussis, Konstantinos; Blackman, Michael J; Soldati-Favre, Dominique

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. (2010) Dvorin, Jeffrey D; Martyn, Derek C; Patel, Saurabh D; Grimley, Joshua S; Collins, Christine R; Hopp, Christine S; Bright, A Taylor; Westenberger, Scott; Winzeler, Elizabeth; Blackman, Michael J; Baker, David A; Wandless, Thomas J; Duraisingh, Manoj T

Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity. (2004) Ersmark, Karolina; Feierberg, Isabella; Bjelic, Sinisa; Hamelink, Elizabeth; Hackett, Fiona; Blackman, Michael J; Hultén, Johan; Samuelsson, Bertil; Aqvist, Johan; Hallberg, Anders

Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. (2005) Ersmark, Karolina; Nervall, Martin; Hamelink, Elizabeth; Janka, Linda K; Clemente, Jose C; Dunn, Ben M; Blackman, Michael J; Samuelsson, Bertil; Aqvist, Johan; Hallberg, Anders

Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum. (2003) Fleck, Suzanne L; Birdsall, Berry; Babon, Jeffrey; Dluzewski, Anton R; Martin, Stephen R; Morgan, William D; Angov, Evelina; Kettleborough, Catherine A; Feeney, James; Blackman, Michael J; Holder, Anthony A

Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites. (2010) Friedrich, Nikolas; Santos, Joana M; Liu, Yan; Palma, Angelina S; Leon, Ester; Saouros, Savvas; Kiso, Makoto; Blackman, Michael J; Matthews, Stephen; Feizi, Ten; Soldati-Favre, Dominique

Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1. (2012) Gemma, Sandra; Giovani, Simone; Brindisi, Margherita; Tripaldi, Pierangela; Brogi, Simone; Savini, Luisa; Fiorini, Isabella; Novellino, Ettore; Butini, Stefania; Campiani, Giuseppe; Penzo, Maria; Blackman, Michael J

Rational design of the first difluorostatone-based PfSUB1 inhibitors. (2014) Giovani, Simone; Penzo, Maria; Brogi, Simone; Brindisi, Margherita; Gemma, Sandra; Novellino, Ettore; Savini, Luisa; Blackman, Michael J; Campiani, Giuseppe; Butini, Stefania

Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. (2014) Grüring, Christof; Moon, Robert W; Lim, Caeul; Holder, Anthony A; Blackman, Michael J; Duraisingh, Manoj T

Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1. (2001) Howell, SA; Withers-Martinez, C; Kocken, CH; Thomas, AW; Blackman, MJ

Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens. (2005) Howell, Steven A; Hackett, Fiona; Jongco, Artemio M; Withers-Martinez, Chrislaine; Kim, Kami; Carruthers, Vern B; Blackman, Michael J

A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavage. (2003) Howell, Steven A; Well, Isabelle; Fleck, Suzanne L; Kettleborough, Catherine; Collins, Christine R; Blackman, Michael J

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit. (2014) Jaudzems, Kristaps; Tars, Kaspars; Maurops, Gundars; Ivdra, Natalija; Otikovs, Martins; Leitans, Janis; Kanepe-Lapsa, Iveta; Domraceva, Ilona; Mutule, Ilze; Trapencieris, Peteris; Blackman, Michael J; Jirgensons, Aigars

Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1. (2003) Jean, Letitia; Hackett, Fiona; Martin, Stephen R; Blackman, Michael J

Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity. (2005) Jean, Létitia; Withers-Martinez, Chrislaine; Hackett, Fiona; Blackman, Michael J

Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs. (2004) Johansson, Per-Ola; Chen, Yantao; Belfrage, Anna Karin; Blackman, Michael J; Kvarnström, Ingemar; Jansson, Katarina; Vrang, Lotta; Hamelink, Elizabeth; Hallberg, Anders; Rosenquist, Asa; Samuelsson, Bertil

Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II. (2005) Johansson, Per-Ola; Lindberg, Jimmy; Blackman, Michael J; Kvarnström, Ingemar; Vrang, Lotta; Hamelink, Elizabeth; Hallberg, Anders; Rosenquist, Asa; Samuelsson, Bertil

High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion. (2002) Kocken, Clemens HM; Withers-Martinez, Chrislaine; Dubbeld, Martin A; van der Wel, Annemarie; Hackett, Fiona; Valderrama, Augusto; Blackman, Michael J; Thomas, Alan W

Inhibition of erythrocyte invasion and Plasmodium falciparum merozoite surface protein 1 processing by human immunoglobulin G1 (IgG1) and IgG3 antibodies. (2009) Lazarou, Maria; Guevara Patiño, José A; Jennings, Richard M; McIntosh, Richard S; Shi, Jianguo; Howell, Steven; Cullen, Eilish; Jones, Tarran; Adame-Gallegos, Jaime R; Chappel, Jonathan A; McBride, Jana S; Blackman, Michael J; Holder, Anthony A; Pleass, Richard J

A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii. (2001) Miller, SA; Binder, EM; Blackman, MJ; Carruthers, VB; Kim, K

TgSUB2 is a Toxoplasma gondii rhoptry organelle processing proteinase. (2003) Miller, Steven A; Thathy, Vandana; Ajioka, James W; Blackman, Michael J; Kim, Kami

A conserved subtilisin protease identified in Babesia divergens merozoites. (2006) Montero, Estrella; Gonzalez, Luis Miguel; Rodriguez, Marilis; Oksov, Yelena; Blackman, Michael J; Lobo, Cheryl A

Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes. (2012) Moon, Robert W; Hall, Joanna; Rangkuti, Farania; Ho, Yung Shwen; Almond, Neil; Mitchell, Graham H; Pain, Arnab; Holder, Anthony A; Blackman, Michael J

The role of malaria merozoite proteases in red blood cell invasion. (2005) O'Donnell, Rebecca A; Blackman, Michael J

Crystal structure of the malaria vaccine candidate apical membrane antigen 1. (2005) Pizarro, Juan Carlos; Vulliez-Le Normand, Brigitte; Chesne-Seck, Marie-Laure; Collins, Christine R; Withers-Martinez, Chrislaine; Hackett, Fiona; Blackman, Michael J; Faber, Bart W; Remarque, Edmond J; Kocken, Clemens HM; Thomas, Alan W; Bentley, Graham A

A role for poly(dA)poly(dT) tracts in directing activity of the Plasmodium falciparum calmodulin gene promoter. (2005) Polson, Hannah EJ; Blackman, Michael J

Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode. (2011) Santos, Joana M; Ferguson, David JP; Blackman, Michael J; Soldati-Favre, Dominique

Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition. (2008) Sawmynaden, Kovilen; Saouros, Savvas; Friedrich, Nikolas; Marchant, Jan; Simpson, Peter; Bleijlevens, Boris; Blackman, Michael J; Soldati-Favre, Dominique; Matthews, Stephen

Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease. (2011) Silmon de Monerri, Natalie C; Flynn, Helen R; Campos, Marta G; Hackett, Fiona; Koussis, Konstantinos; Withers-Martinez, Chrislaine; Skehel, J Mark; Blackman, Michael J

A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites. (2004) Silvie, Olivier; Franetich, Jean-François; Charrin, Stéphanie; Mueller, Markus S; Siau, Anthony; Bodescot, Myriam; Rubinstein, Eric; Hannoun, Laurent; Charoenvit, Yupin; Kocken, Clemens H; Thomas, Alan W; Van Gemert, Geert-Jan; Sauerwein, Robert W; Blackman, Michael J; Anders, Robin F; Pluschke, Gerd; Mazier, Dominique

Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro. (2009) Wanyiri, Jane W; Techasintana, Patsharaporn; O'Connor, Roberta M; Blackman, Michael J; Kim, Kami; Ward, Honorine D

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface. (2008) Withers-Martinez, Chrislaine; Haire, Lesley F; Hackett, Fiona; Walker, Philip A; Howell, Steven A; Smerdon, Stephen J; Dodson, Guy G; Blackman, Michael J

Subtilisin-like proteases of the malaria parasite. (2004) Withers-Martinez, Chrislaine; Jean, Létitia; Blackman, Michael J

Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling. (2002) Withers-Martinez, Chrislaine; Saldanha, José W; Ely, Barry; Hackett, Fiona; O'Connor, Tony; Blackman, Michael J

Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex. (2004) Zhou, Xing W; Blackman, Michael J; Howell, Steven A; Carruthers, Vern B

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Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG. (2021) Balestra, Aurélia C; Koussis, Konstantinos; Klages, Natacha; Howell, Steven A; Flynn, Helen R; Bantscheff, Marcus; Pasquarello, Carla; Perrin, Abigail J; Brusini, Lorenzo; Arboit, Patrizia; Sanz, Olalla; Castaño, Laura Peces-Barba; Withers-Martinez, Chrislaine; Hainard, Alexandre; Ghidelli-Disse, Sonja; Snijders, Ambrosius P; Baker, David A; Blackman, Michael J; Brochet, Mathieu

A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line. (2017) Benavente, Ernest Diez; de Sessions, Paola Florez; Moon, Robert W; Grainger, Munira; Holder, Anthony A; Blackman, Michael J; Roper, Cally; Drakeley, Christopher J; Pain, Arnab; Sutherland, Colin J; Hibberd, Martin L; Campino, Susana; Clark, Taane G

Malarial proteases and host cell egress: an 'emerging' cascade. (2008) Blackman, Michael J

Essentiality of Plasmodium falciparum plasmepsin V. (2018) Boonyalai, Nonlawat; Collins, Christine R; Hackett, Fiona; Withers-Martinez, Chrislaine; Blackman, Michael J

Function and essentiality of <i>Plasmodium falciparum</i> plasmepsin V. (2018) Boonyalai, Nonlawat; Collins, Christine R; Hackett, Fiona; Withers-Martinez, Chrislaine; Blackman, Michael J

Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth. (2010) Child, Matthew A; Epp, Christian; Bujard, Hermann; Blackman, Michael J

Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2. (2013) Child, Matthew A; Harris, Philippa K; Collins, Christine R; Withers-Martinez, Chrislaine; Yeoh, Sharon; Blackman, Michael J

Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle. (2013) Collins, Christine R; Das, Sujaan; Wong, Eleanor H; Andenmatten, Nicole; Stallmach, Robert; Hackett, Fiona; Herman, Jean-Paul; Müller, Sylke; Meissner, Markus; Blackman, Michael J

The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes. (2017) Collins, Christine R; Hackett, Fiona; Atid, Jonathan; Tan, Michele Ser Ying; Blackman, Michael J

The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion. (2020) Collins, Christine R; Hackett, Fiona; Howell, Steven A; Snijders, Ambrosius P; Russell, Matthew Rg; Collinson, Lucy M; Blackman, Michael J

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. (2013) Collins, Christine R; Hackett, Fiona; Strath, Malcolm; Penzo, Maria; Withers-Martinez, Chrislaine; Baker, David A; Blackman, Michael J

An inhibitory antibody blocks interactions between components of the malarial invasion machinery. (2009) Collins, Christine R; Withers-Martinez, Chrislaine; Hackett, Fiona; Blackman, Michael J

Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites. (2012) Cruz, Laura Nogueira; Juliano, Maria Aparecida; Budu, Alexandre; Juliano, Luiz; Holder, Anthony A; Blackman, Michael J; Garcia, Célia Rs

Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs. (2015) Das, Sujaan; Hertrich, Nadine; Perrin, Abigail J; Withers-Martinez, Chrislaine; Collins, Christine R; Jones, Matthew L; Watermeyer, Jean M; Fobes, Elmar T; Martin, Stephen R; Saibil, Helen R; Wright, Gavin J; Treeck, Moritz; Epp, Christian; Blackman, Michael J

Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage. (2018) Deligianni, Elena; Silmon de Monerri, Natalie C; McMillan, Paul J; Bertuccini, Lucia; Superti, Fabiana; Manola, Maria; Spanos, Lefteris; Louis, Christos; Blackman, Michael J; Tilley, Leann; Siden-Kiamos, Inga

Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations. (2017) Diez Benavente, Ernest; Florez de Sessions, Paola; Moon, Robert W; Holder, Anthony A; Blackman, Michael J; Roper, Cally; Drakeley, Christopher J; Pain, Arnab; Sutherland, Colin J; Hibberd, Martin L; Campino, Susana; Clark, Taane G

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. (2019) El Bakkouri, Majida; Kouidmi, Imène; Wernimont, Amy K; Amani, Mehrnaz; Hutchinson, Ashley; Loppnau, Peter; Kim, Jeong Joo; Flueck, Christian; Walker, John R; Seitova, Alma; Senisterra, Guillermo; Kakihara, Yoshito; Kim, Choel; Blackman, Michael J; Calmettes, Charles; Baker, David A; Hui, Raymond

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. (2019) Flueck, Christian; Drought, Laura G; Jones, Andrew; Patel, Avnish; Perrin, Abigail J; Walker, Eloise M; Nofal, Stephanie D; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. (2019) Flueck, Christian; Drought, Laura G; Jones, Andrew; Patel, Avnish; Perrin, Abigail J; Walker, Eloise M; Nofal, Stephanie D; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A

Molecular determinants of binding to the Plasmodium subtilisin-like protease 1. (2013) Fulle, Simone; Withers-Martinez, Chrislaine; Blackman, Michael J; Morris, Garrett M; Finn, Paul W

Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress. (2017) Hale, Victoria L; Watermeyer, Jean M; Hackett, Fiona; Vizcay-Barrena, Gema; van Ooij, Christiaan; Thomas, James A; Spink, Matthew C; Harkiolaki, Maria; Duke, Elizabeth; Fleck, Roland A; Blackman, Michael J; Saibil, Helen R

Molecular identification of a malaria merozoite surface sheddase. (2005) Harris, Philippa K; Yeoh, Sharon; Dluzewski, Anton R; O'Donnell, Rebecca A; Withers-Martinez, Chrislaine; Hackett, Fiona; Bannister, Lawrence H; Mitchell, Graham H; Blackman, Michael J

Identification and validation of a novel panel of Plasmodium knowlesi biomarkers of serological exposure. (2018) Herman, Lou S; Fornace, Kimberly; Phelan, Jody; Grigg, Matthew J; Anstey, Nicholas M; William, Timothy; Moon, Robert W; Blackman, Michael J; Drakeley, Chris J; Tetteh, Kevin KA

Regulation and Essentiality of the StAR-related Lipid Transfer (START) Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites. (2016) Hill, Ross J; Ringel, Alessa; Knuepfer, Ellen; Moon, Robert W; Blackman, Michael J; van Ooij, Christiaan

A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum. (2016) Jones, Matthew L; Das, Sujaan; Belda, Hugo; Collins, Christine R; Blackman, Michael J; Treeck, Moritz

Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1. (2014) Kher, Samir S; Penzo, Maria; Fulle, Simone; Finn, Paul W; Blackman, Michael J; Jirgensons, Aigars description

Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function. (2020) Koussis, Konstantinos; Withers-Martinez, Chrislaine; Baker, David A; Blackman, Michael J

A multifunctional serine protease primes the malaria parasite for red blood cell invasion. (2009) Koussis, Konstantinos; Withers-Martinez, Chrislaine; Yeoh, Sharon; Child, Matthew; Hackett, Fiona; Knuepfer, Ellen; Juliano, Luiz; Woehlbier, Ute; Bujard, Hermann; Blackman, Michael J

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1. (2021) Lidumniece, Elina; Withers-Martinez, Chrislaine; Hackett, Fiona; Collins, Christine R; Perrin, Abigail J; Koussis, Konstantinos; Bisson, Claudine; Blackman, Michael J; Jirgensons, Aigars

Deletion of Plasmodium falciparum Protein RON3 Affects the Functional Translocation of Exported Proteins and Glucose Uptake. (2019) Low, Leanne M; Azasi, Yvonne; Sherling, Emma S; Garten, Matthias; Zimmerberg, Joshua; Tsuboi, Takafumi; Brzostowski, Joseph; Mu, Jianbing; Blackman, Michael J; Miller, Louis H

The parasitophorous vacuole of the blood-stage malaria parasite. (2020) Matz, Joachim M; Beck, Josh R; Blackman, Michael J

A lipocalin mediates unidirectional heme biomineralization in malaria parasites. (2020) Matz, Joachim M; Drepper, Benjamin; Blum, Thorsten B; van Genderen, Eric; Burrell, Alana; Martin, Peer; Stach, Thomas; Collinson, Lucy M; Abrahams, Jan Pieter; Matuschewski, Kai; Blackman, Michael J

Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi. (2016) Moon, RW; Sharaf, H; Hastings, CH; Ho, YS; Nair, MB; Rchiad, Z; Knuepfer, E; Ramaprasad, A; Mohring, F; Amir, A; Yusuf, NA; Hall, J; Almond, N; Lau, YL; Pain, A; Blackman, MJ; Holder, AA description

Investigation of the role of GCα in activating cGMP signalling in Plasmodium falciparum and how cyclic nucleotide signalling modulates molecular motor function. (2019) Nofal, SD

Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress. (2021) Nofal, Stephanie D; Patel, Avnish; Blackman, Michael J; Flueck, Christian; Baker, David A

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite. (2006) O'Donnell, Rebecca A; Hackett, Fiona; Howell, Steven A; Treeck, Moritz; Struck, Nicole; Krnajski, Zita; Withers-Martinez, Chrislaine; Gilberger, Tim W; Blackman, Michael J

Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies. (2011) Olivieri, Anna; Collins, Christine R; Hackett, Fiona; Withers-Martinez, Chrislaine; Marshall, Joshua; Flynn, Helen R; Skehel, J Mark; Blackman, Michael J

The Plasmodium berghei serine protease PbSUB1 plays an important role in male gamete egress. (2019) Pace, Tomasino; Grasso, Felicia; Camarda, Grazia; Suarez, Catherine; Blackman, Michael J; Ponzi, Marta; Olivieri, Anna

CDC50 Orthologues in Plasmodium falciparum Have Distinct Roles in Merozoite Egress and Trophozoite Maturation. (2022) Patel, Avnish; Nofal, Stephanie D; Blackman, Michael J; Baker, David A

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery. (2019) Patel, Avnish; Perrin, Abigail J; Flynn, Helen R; Bisson, Claudine; Withers-Martinez, Chrislaine; Treeck, Moritz; Flueck, Christian; Nicastro, Giuseppe; Martin, Stephen R; Ramos, Andres; Gilberger, Tim W; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A

Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony. (2021) Perrin, Abigail J; Bisson, Claudine; Faull, Peter A; Renshaw, Matthew J; Lees, Rebecca A; Fleck, Roland A; Saibil, Helen R; Snijders, Ambrosius P; Baker, David A; Blackman, Michael J

The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress. (2018) Perrin, Abigail J; Collins, Christine R; Russell, Matthew RG; Collinson, Lucy M; Baker, David A; Blackman, Michael J

cAMP signalling and its role in host cell invasion by malaria parasites. (2020) Perrin, Abigail J; Patel, Avnish; Flueck, Christian; Blackman, Michael J; Baker, David A

Conditional U1 Gene Silencing in Toxoplasma gondii. (2015) Pieperhoff, Manuela S; Pall, Gurman S; Jiménez-Ruiz, Elena; Das, Sujaan; Melatti, Carmen; Gow, Matthew; Wong, Eleanor H; Heng, Joanne; Müller, Sylke; Blackman, Michael J; Meissner, Markus

A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress. (2017) Pino, P; Caldelari, R; Mukherjee, B; Vahokoski, J; Klages, N; Maco, B; Collins, CR; Blackman, MJ; Kursula, I; Heussler, V; Brochet, M; Soldati-Favre, D

Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid. (2021) Prior, Kimberley F; Middleton, Benita; Owolabi, Alíz TY; Westwood, Mary L; Holland, Jacob; O'Donnell, Aidan J; Blackman, Michael J; Skene, Debra J; Reece, Sarah E

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite. (2022) Ramaprasad, Abhinay; Burda, Paul-Christian; Calvani, Enrica; Sait, Aaron J; Palma-Duran, Susana Alejandra; Withers-Martinez, Chrislaine; Hackett, Fiona; Macrae, James; Collinson, Lucy; Gilberger, Tim Wolf; Blackman, Michael J

Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte. (2012) Ruecker, Andrea; Shea, Michael; Hackett, Fiona; Suarez, Catherine; Hirst, Elizabeth MA; Milutinovic, Katarina; Withers-Martinez, Chrislaine; Blackman, Michael J

The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake. (2017) Sherling, Emma S; Knuepfer, Ellen; Brzostowski, Joseph A; Miller, Louis H; Blackman, Michael J; van Ooij, Christiaan

The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion. (2019) Sherling, Emma S; Perrin, Abigail J; Knuepfer, Ellen; Russell, Matthew RG; Collinson, Lucy M; Miller, Louis H; Blackman, Michael J

Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle. (2015) Stallmach, Robert; Kavishwar, Manoli; Withers-Martinez, Chrislaine; Hackett, Fiona; Collins, Christine R; Howell, Steven A; Yeoh, Sharon; Knuepfer, Ellen; Atid, Avshalom J; Holder, Anthony A; Blackman, Michael J

The malarial serine protease SUB1 plays an essential role in parasite liver stage development. (2013) Suarez, Catherine; Volkmann, Katrin; Gomes, Ana Rita; Billker, Oliver; Blackman, Michael J

Malaria parasite egress at a glance. (2021) Tan, Michele SY; Blackman, Michael J

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor. (2021) Tan, Michele SY; Koussis, Konstantinos; Withers-Martinez, Chrislaine; Howell, Steven A; Thomas, James A; Hackett, Fiona; Knuepfer, Ellen; Shen, Min; Hall, Matthew D; Snijders, Ambrosius P; Blackman, Michael J

A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1. (2020) Tarr, Sarah J; Withers-Martinez, Chrislaine; Flynn, Helen R; Snijders, Ambrosius P; Masino, Laura; Koussis, Konstantinos; Conway, David J; Blackman, Michael J

Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum. (2016) Thomas, James A; Collins, Christine R; Das, Sujaan; Hackett, Fiona; Graindorge, Arnault; Bell, Donald; Deu, Edgar; Blackman, Michael J

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells. (2018) Thomas, James A; Tan, Michele SY; Bisson, Claudine; Borg, Aaron; Umrekar, Trishant R; Hackett, Fiona; Hale, Victoria L; Vizcay-Barrena, Gema; Fleck, Roland A; Snijders, Ambrosius P; Saibil, Helen R; Blackman, Michael J

A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes. (2015) Watermeyer, Jean M; Hale, Victoria L; Hackett, Fiona; Clare, Daniel K; Cutts, Erin E; Vakonakis, Ioannis; Fleck, Roland A; Blackman, Michael J; Saibil, Helen R

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin. (2014) Withers-Martinez, Chrislaine; Strath, Malcolm; Hackett, Fiona; Haire, Lesley F; Howell, Steven A; Walker, Philip A; Christodoulou, Evangelos; Dodson, Guy G; Blackman, Michael J

Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target. (2012) Withers-Martinez, Chrislaine; Suarez, Catherine; Fulle, Simone; Kher, Samir; Penzo, Maria; Ebejer, Jean-Paul; Koussis, Kostas; Hackett, Fiona; Jirgensons, Aigars; Finn, Paul; Blackman, Michael J

Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion. (2010) Woehlbier, Ute; Epp, Christian; Hackett, Fiona; Blackman, Michael J; Bujard, Hermann

Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes. (2007) Yeoh, Sharon; O'Donnell, Rebecca A; Koussis, Konstantinos; Dluzewski, Anton R; Ansell, Keith H; Osborne, Simon A; Hackett, Fiona; Withers-Martinez, Chrislaine; Mitchell, Graham H; Bannister, Lawrence H; Bryans, Justin S; Kettleborough, Catherine A; Blackman, Michael J

Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D. (2019) Zogota, Rimants; Kinena, Linda; Withers-Martinez, Chrislaine; Blackman, Michael J; Bobrovs, Raitis; Pantelejevs, Teodors; Kanepe-Lapsa, Iveta; Ozola, Vita; Jaudzems, Kristaps; Suna, Edgars; Jirgensons, Aigars

Identification of a Plasmodium falciparum phospholipid transfer protein. (2013) van Ooij, Christiaan; Withers-Martinez, Chrislaine; Ringel, Alessa; Cockcroft, Shamshad; Haldar, Kasturi; Blackman, Michael J