Items where Author is "Yardley, Vanessa"
Number of items: 106.
Article
In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle. (2001)
Asres, K; Bucar, F; Knauder, E; Yardley, V; Kendrick, H; Croft, SL
Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography. (2013)
Baiocco, Paola; Poce, Giovanna; Alfonso, Salvatore; Cocozza, Martina; Porretta, Giulio Cesare; Colotti, Gianni; Biava, Mariangela; Moraca, Francesca; Botta, Maurizio; Yardley, Vanessa; Fiorillo, Annarita; Lantella, Antonella; Malatesta, Francesco; Ilari, Andrea
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites. (2005)
Baliani, Alessandro; Bueno, Gorka Jimenez; Stewart, Mhairi L; Yardley, Vanessa; Brun, Reto; Barrett, Michael P; Gilbert, Ian H
In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial. (2017)
Basilico, Nicoletta; Parapini, Silvia; Sparatore, Anna; Romeo, Sergio; Misiano, Paola; Vivas, Livia; Yardley, Vanessa; Croft, Simon L; Habluetzel, Annette; Lucantoni, Leonardo; Renia, Laurent; Russell, Bruce; Suwanarusk, Rossarin; Nosten, Francois; Dondio, Giulio; Bigogno, Chiara; Jabes, Daniela; Taramelli, Donatella
A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme. (2006)
Bauer, Holger; Fritz-Wolf, Karin; Winzer, Andreas; Kühner, Sebastian; Little, Susan; Yardley, Vanessa; Vezin, Hervé; Palfey, Bruce; Schirmer, R Heiner; Davioud-Charvet, Elisabeth
Synthesis and antitrypanosomal activities of novel pyridylchalcones. (2017)
Bhambra, AS; Ruparelia, KC; Tan, HL; Tasdemir, D; Burrell-Saward, H; Yardley, V; Beresford, KJ; Arroo, RR
Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes. (2015)
Bhambra, Avninder S; Edgar, Mark; Elsegood, Mark RJ; Li, Yuqi; Weaver, George W; Arroo, Randolph RJ; Yardley, Vanessa; Burrell-Saward, Hollie; Krystof, Vladimir
Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo. (2010)
Blackie, Margaret AL; Yardley, Vanessa; Chibale, Kelly
The Oral Antimalarial Drug Tafenoquine Shows Activity against Trypanosoma brucei. (2015)
Carvalho, Luis; Martínez-García, Marta; Pérez-Victoria, Ignacio; Manzano, José Ignacio; Yardley, Vanessa; Gamarro, Francisco; Pérez-Victoria, José M
Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine. (2001)
Chibale, K; Haupt, H; Kendrick, H; Yardley, V; Saravanamuthu, A; Fairlamb, AH; Croft, SL
An efficient and novel technology for the extraction of parasite genomic DNA from whole blood or culture. (2019)
Clark, David J; Moore, Catherine M; Flanagan, Marc; Bocxlaer, Katrien Van; Piperaki, Evangelia-Theophano; Yardley, Vanessa; Croft, Simon L; Tyson, John; Whitehouse, Sam P; O'Halloran, Jonathan; Krishna, Sanjeev; Staines, Henry M
Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents. (2006)
Coro, Julieta; Atherton, Richard; Little, Susan; Wharton, Hayley; Yardley, Vanessa; Alvarez, Amaury; Súarez, Margarita; Pérez, Rolando; Rodríguez, Hortensia
Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones). (2008)
Coro, Julieta; Little, Susan; Yardley, Vanessa; Suárez, Margarita; Rodríguez, Hortensia; Martín, Nazario; Perez-Pineiro, Rolando
Protein energy malnutrition increases arginase activity in monocytes and macrophages. (2014)
Corware, Karina; Yardley, Vanessa; Mack, Christopher; Schuster, Steffen; Al-Hassi, Hafid; Herath, Shanthi; Bergin, Philip; Modolell, Manuel; Munder, Markus; Müller, Ingrid; Kropf, Pascale
Current scenario of drug development for leishmaniasis. (2006)
Croft, Simon L; Seifert, Karin; Yardley, Vanessa
Chemotherapy of leishmaniasis. (2002)
Croft, Simon L; Yardley, Vanessa
Drug sensitivity of Leishmania species: some unresolved problems. (2002)
Croft, Simon L; Yardley, Vanessa; Kendrick, Howard
QSAR study on the contribution of log P and E(s) to the in vitro antiprotozoal activity of glutathione derivatives. (2001)
Daunes, S; D'Silva, C; Kendrick, H; Yardley, V; Croft, SL
Antiprotozoal glutathione derivatives with flagellar membrane binding activity against T. brucei rhodesiense. (2016)
Daunes, S; Yardley, V; Croft, SL; D'Silva, C
Gene expression profiling of Leishmania (Leishmania) donovani: overcoming technical variation and exploiting biological variation. (2008)
Decuypere, S; Vanaerschot, M; Rijal, S; Yardley, V; Maes, L; de Doncker, S; Chappuis, F; Dujardin, J-C
Differential polyadenylation of ribosomal RNA during post-transcriptional processing in Leishmania. (2005)
Decuypere, S; Vandesompele, J; Yardley, V; De Donckeri, S; Laurent, T; Rijal, S; Llanos-Cuentas, A; Chappuis, F; Arevalo, J; Dujardin, JC
Gene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from Nepal. (2005)
Decuypere, Saskia; Rijal, Suman; Yardley, Vanessa; De Doncker, Simonne; Laurent, Thierry; Khanal, Basudha; Chappuis, François; Dujardin, Jean-Claude
Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice. (2001)
Escobar, P; Yardley, V; Croft, SL
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. (2008)
Fattorusso, Caterina; Campiani, Giuseppe; Kukreja, Gagan; Persico, Marco; Butini, Stefania; Romano, Maria Pia; Altarelli, Maria; Ros, Sindu; Brindisi, Margherita; Savini, Luisa; Novellino, Ettore; Nacci, Vito; Fattorusso, Ernesto; Parapini, Silvia; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Croft, Simon; Borriello, Marianna; Gemma, Sandra
Synthesis, structure, and biological activity of ferrocenyl carbohydrate conjugates. (2006)
Ferreira, Cara L; Ewart, Charles B; Barta, Cheri A; Little, Susan; Yardley, Vanessa; Martins, Candice; Polishchuk, Elena; Smith, Peter J; Moss, John R; Merkel, Michael; Adam, Michael J; Orvig, Chris
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. (2008)
Friebolin, Wolfgang; Jannack, Beate; Wenzel, Nicole; Furrer, Julien; Oeser, Thomas; Sanchez, Cecilia P; Lanzer, Michael; Yardley, Vanessa; Becker, Katja; Davioud-Charvet, Elisabeth
Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. (2009)
Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, Bhupendra P; Kukreja, Gagan; Coccone, Salvatore Sanna; Bernetti, Matteo; Persico, Marco; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Taramelli, Donatella; Basilico, Nicoletta; Parapini, Silvia; Yardley, Vanessa; Croft, Simon; Keller-Maerki, Sonja; Rottmann, Matthias; Brun, Reto; Coletta, Massimiliano; Marini, Stefano; Guiso, Giovanna; Caccia, Silvio; Fattorusso, Caterina
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies. (2008)
Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, Gagan; Coccone, Salvatore Sanna; Joshi, Bhupendra P; Persico, Marco; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Fattorusso, Ernesto; Taglialatela-Scafati, Orazio; Savini, Luisa; Taramelli, Donatella; Basilico, Nicoletta; Parapini, Silvia; Morace, Giulia; Yardley, Vanessa; Croft, Simon; Coletta, Massimiliano; Marini, Stefano; Fattorusso, Caterina
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore. (2007)
Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, Gagan; Joshi, Bhupendra P; Persico, Marco; Catalanotti, Bruno; Novellino, Ettore; Fattorusso, Ernesto; Nacci, Vito; Savini, Luisa; Taramelli, Donatella; Basilico, Nicoletta; Morace, Giulia; Yardley, Vanessa; Fattorusso, Caterina
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. (2007)
Gemma, Sandra; Kukreja, Gagan; Campiani, Giuseppe; Butini, Stefania; Bernetti, Matteo; Joshi, Bhupendra P; Savini, Luisa; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Bertamino, Alessia; Novellino, Ettore; Persico, Marco; Catalanotti, Bruno; Fattorusso, Caterina
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. (2006)
Gemma, Sandra; Kukreja, Gagan; Fattorusso, Caterina; Persico, Marco; Romano, Maria P; Altarelli, Maria; Savini, Luisa; Campiani, Giuseppe; Fattorusso, Ernesto; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Butini, Stefania
Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity. (2004)
Grant, Karen M; Dunion, Morag H; Yardley, Vanessa; Skaltsounis, Alexios-Leandros; Marko, Doris; Eisenbrand, Gerhard; Croft, Simon L; Meijer, Laurent; Mottram, Jeremy C
New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action. (2006)
Gros, Ludovic; Castillo-Acosta, Victor Manuel; Jiménez Jiménez, Carmen; Sealey-Cardona, Marco; Vargas, Sofia; Manuel Estévez, Antonio; Yardley, Vanessa; Rattray, Lauren; Croft, Simon L; Ruiz-Perez, Luis M; Urbina, Julio A; Gilbert, Ian H; González-Pacanowska, Dolores
Evaluation of azasterols as anti-parasitics. (2006)
Gros, Ludovic; Lorente, Silvia Orenes; Jimenez, Carmen Jimenez; Yardley, Vanessa; Rattray, Lauren; Wharton, Hayley; Little, Susan; Croft, Simon L; Ruiz-Perez, Luis M; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H
A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity. (2009)
Guglielmo, Stefano; Bertinaria, Massimo; Rolando, Barbara; Crosetti, Marco; Fruttero, Roberta; Yardley, Vanessa; Croft, Simon L; Gasco, Alberto
Investigating Permeation Behavior of Flufenamic Acid Cocrystals Using a Dissolution and Permeation System. (2018)
Guo, Minshan; Wang, Ke; Qiao, Ning; Yardley, Vanessa; Li, Mingzhong
Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis. (2014)
Gupta, Suman; Yardley, Vanessa; Vishwakarma, Preeti; Shivahare, Rahul; Sharma, Bhawna; Launay, Delphine; Martin, Denis; Puri, Sunil K
Therapeutic glucocorticoid-induced TNF receptor-mediated amplification of CD4+ T cell responses enhances antiparasitic immunity. (2010)
Haque, Ashraful; Stanley, Amanda C; Amante, Fiona H; Rivera, Fabian de Labastida; Zhou, Yonghong; Kuns, Rachel D; Yardley, Vanessa; Sakaguchi, Shimon; Hill, Geoffrey R; Engwerda, Christian R
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. (2006)
Hudock, Michael P; Sanz-Rodríguez, CE; Song, Yongcheng; Chan, Julian MW; Zhang, Yonghui; Odeh, Sarah; Kosztowski, Thomas; Leon-Rossell, Annette; Concepción, JL; Yardley, Vanessa; Croft, Simon L; Urbina, Julio A; Oldfield, Eric
Antileishmanial Activity and Synergistic Effects of Amphotericin B Deoxycholate with Allicin and Andrographolide against Leishmania martiniquensis In Vitro. (2020)
Intakhan, Nuchpicha; Chanmol, Wetpisit; Somboon, Pradya; Bates, Michelle D; Yardley, Vanessa; Bates, Paul A; Jariyapan, Narissara
Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives. (2004)
Jung, Mankil; Lee, Kyunghoon; Jung, Hochul; Kendrick, Howard; Yardley, Vanessa; Croft, Simon L
Formulation of amphotericin B as nanosuspension for oral administration. (2003)
Kayser, O; Olbrich, C; Yardley, V; Kiderlen, AF; Croft, SL
Cutaneous Leishmaniasis in Khyber Pakhtunkhwa Province of Pakistan: Clinical Diversity and Species-Level Diagnosis. (2016)
Khan, Nazma Habib; Bari, Arfan Ul; Hashim, Rizwan; Khan, Inamullah; Muneer, Akhtar; Shah, Akram; Wahid, Sobia; Yardley, Vanessa; O'Neil, Brighid; Sutherland, Colin J
Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives. (2007)
Khrizman, Alexander; Moulthrop, Jason S; Little, Susan; Wharton, Hayley; Yardley, Vanessa; Moyna, Guillermo
Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives. (2007)
Khrizman, Alexander; Slack, Rachel D; Remsing, Richard C; Little, Susan; Yardley, Vanessa; Moyna, Guillermo
Synthesis of aminoquinoline-based aminoalcohols and oxazolidinones and their antiplasmodial activity. (2011)
Kobarfard, Farzad; Yardley, Vanessa; Little, Susan; Daryaee, Fereidoon; Chibale, Kelly
Toxicity and antileishmanial activity of a new stable lipid suspension of amphotericin B. (2003)
Larabi, Malika; Yardley, Vanessa; Loiseau, Philippe M; Appel, Martine; Legrand, Philippe; Gulik, Annette; Bories, Christian; Croft, Simon L; Barratt, Gillian
Epidemiological dynamics of antimonial resistance in Leishmania donovani: genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal. (2006)
Laurent, Thierry; Rijal, Suman; Yardley, Vanessa; Croft, Simon; De Doncker, Simonne; Decuypere, Saskia; Khanal, Basudha; Singh, Rupa; Schönian, Gabriele; Kuhls, Katrin; Chappuis, François; Dujardin, Jean-Claude
New World cutaneous leishmaniasis in returned travellers: treatment failures using intravenous sodium stibogluconate. (2003)
Lawn, SD; Yardley, V; Vega-Lopez, F; Watson, J; Lockwood, DN
Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. (2005)
Lee, Brittany; Bauer, Holger; Melchers, Johannes; Ruppert, Thomas; Rattray, Lauren; Yardley, Vanessa; Davioud-Charvet, Elisabeth; Krauth-Siegel, R Luise
Poly(methacrylic acid) complexation of amphotericin B to treat neglected diseases. (2014)
Les, Karolina Alicja; Mohamed-Ahmed, Abeer HA; Balan, Sibu; Choi, Ji-won; Martin, Denis; Yardley, Vanessa; Powell, Keith; Godwin, Antony; Brocchini, Steve
Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics. (2005)
Lorente, Silvia Orenes; Jimenez, Carmen Jimenez; Gros, Ludovic; Yardley, Vanessa; de Luca-Fradley, Kate; Croft, Simon L; A Urbina, Julio; Ruiz-Perez, Luis M; Pacanowska, Dolores Gonzalez; Gilbert, Ian H
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis. (2004)
Lorente, Silvia Orenes; Rodrigues, Juliany CF; Jiménez Jiménez, Carmen; Joyce-Menekse, Miranda; Rodrigues, Carlos; Croft, Simon L; Yardley, Vanessa; de Luca-Fradley, Kate; Ruiz-Pérez, Luis M; Urbina, Julio; de Souza, Wanderley; González Pacanowska, Dolores; Gilbert, Ian H
Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi. (2003)
Magaraci, Filippo; Jimenez, Carmen Jimenez; Rodrigues, Carlos; Rodrigues, Juliany CF; Braga, Marina Vianna; Yardley, Vanessa; de Luca-Fradley, Kate; Croft, Simon L; de Souza, Wanderley; Ruiz-Perez, Luis M; Urbina, Julio; Gonzalez Pacanowska, Dolores; Gilbert, Ian H
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. (2001)
Martin, MB; Grimley, JS; Lewis, JC; Heath, HT; Bailey, BN; Kendrick, H; Yardley, V; Caldera, A; Lira, R; Urbina, JA; Moreno, SN; Docampo, R; Croft, SL; Oldfield, E
Antileishmanial activity, uptake, and biodistribution of an amphotericin B and poly(α-Glutamic Acid) complex. (2013)
Mohamed-Ahmed, Abeer HA; Seifert, Karin; Yardley, Vanessa; Burrell-Saward, Hollie; Brocchini, Stephen; Croft, Simon L
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis. (2021)
Mowbray, Charles E; Braillard, Stéphanie; Glossop, Paul A; Whitlock, Gavin A; Jacobs, Robert T; Speake, Jason; Pandi, Bharathi; Nare, Bakela; Maes, Louis; Yardley, Vanessa; Freund, Yvonne; Wall, Richard J; Carvalho, Sandra; Bello, Davide; Van den Kerkhof, Magali; Caljon, Guy; Gilbert, Ian H; Corpas-Lopez, Victoriano; Lukac, Iva; Patterson, Stephen; Zuccotto, Fabio; Wyllie, Susan
Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol. (2006)
Musonda, Chitalu C; Gut, Jiri; Rosenthal, Philip J; Yardley, Vanessa; Carvalho de Souza, Renata C; Chibale, Kelly
Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro. (2007)
Musonda, Chitalu C; Little, Susan; Yardley, Vanessa; Chibale, Kelly
Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines. (2008)
Musonda, Chitalu C; Yardley, Vanessa; de Souza, Renata C Carvalho; Ncokazi, Kanyile; Egan, Timothy J; Chibale, Kelly
Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites. (2011)
Müller, Tobias; Johann, Laure; Jannack, Beate; Brückner, Margit; Lanfranchi, Don Antoine; Bauer, Holger; Sanchez, Cecilia; Yardley, Vanessa; Deregnaucourt, Christiane; Schrével, Joseph; Lanzer, Michael; Schirmer, R Heiner; Davioud-Charvet, Elisabeth
N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. (2001)
Nan, A; Nanayakkara, NP; Walker, LA; Yardley, V; Croft, SL; Ghandehari, H
Targetable water-soluble polymer-drug conjugates for the treatment of visceral leishmaniasis. (2004)
Nan, Anjan; Croft, Simon L; Yardley, Vanessa; Ghandehari, Hamidreza
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate. (2008)
Nanayakkara, NP Dhammika; Ager, Arba L; Bartlett, Marilyn S; Yardley, Vanessa; Croft, Simon L; Khan, Ikhlas A; McChesney, James D; Walker, Larry A
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichloropheno xy]quinoline succinate. (2008)
Nanayakkara, NP; Ager, AL; Bartlett, MS; Yardley, V; Croft, SL; Khan, IA; McChesney, JD; Walker, LA
Novel 2D and 3D Assays to Determine the Activity of Anti-Leishmanial Drugs. (2020)
O'Keeffe, Alec; Hale, Christine; Cotton, James A; Yardley, Vanessa; Gupta, Kapish; Ananthanarayanan, Abhishek; Murdan, Sudaxshina; Croft, Simon L
Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity. (2008)
October, Natasha; Watermeyer, Nicholas D; Yardley, Vanessa; Egan, Timothy J; Ncokazi, Kanyile; Chibale, Kelly
Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa. (2005)
Orenes Lorente, Silvia; Gómez, Rosario; Jiménez, Carmen; Cammerer, Simon; Yardley, Vanessa; de Luca-Fradley, Kate; Croft, Simon L; Ruiz Perez, Luis M; Urbina, Julio; Gonzalez Pacanowska, Dolores; Gilbert, Ian H
Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide. (2005)
Parveen, Seheli; Khan, Mohammed OF; Austin, Susan E; Croft, Simon L; Yardley, Vanessa; Rock, Peter; Douglas, Kenneth T
2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase. (2003)
Pez, Didier; Leal, Isabel; Zuccotto, Fabio; Boussard, Cyrille; Brun, Reto; Croft, Simon L; Yardley, Vanessa; Ruiz Perez, Luis M; Gonzalez Pacanowska, Dolores; Gilbert, Ian H
Synthesis of cyclohexapeptides as antimalarial and anti-trypanosomal agents. (2014)
Peña, S; Fagundez, C; Medeiros, A; Comini, M; Scarone, L; Sellanes, D; Manta, E; Tulla-Puche, J; Albericio, F; Stewart, L; Yardley, V; Serra, G
Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity. (2012)
Peña, Stella; Scarone, Laura; Manta, Eduardo; Stewart, Lindsay; Yardley, Vanessa; Croft, Simon; Serra, Gloria
Design, synthesis, and biological evaluation of a series of simple and novel potential antimalarial compounds. (2001)
Ren, H; Grady, S; Gamenara, D; Heinzen, H; Moyna, P; Croft, SL; Kendrick, H; Yardley, V; Moyna, G
Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines. (2003)
Ren, Hongyu; Grady, Shannon; Banghart, Matthew; Moulthrop, Jason S; Kendrick, Howard; Yardley, Vanessa; Croft, Simon L; Moyna, Guillermo
Activity of Chitosan and Its Derivatives against Leishmania major and Leishmania mexicana In Vitro. (2019)
Riezk, Alaa; Raynes, John G; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L
Activity of Amphotericin B-Loaded Chitosan Nanoparticles against Experimental Cutaneous Leishmaniasis. (2020)
Riezk, Alaa; Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L
Antimonial treatment of visceral leishmaniasis: are current in vitro susceptibility assays adequate for prognosis of in vivo therapy outcome? (2007)
Rijal, Suman; Yardley, Vanessa; Chappuis, François; Decuypere, Saskia; Khanal, Basudha; Singh, Rupa; Boelaert, Marleen; De Doncker, Simonne; Croft, Simon; Dujardin, Jean-Claude
2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity. (2001)
Salmon-Chemin, L; Buisine, E; Yardley, V; Kohler, S; Debreu, MA; Landry, V; Sergheraert, C; Croft, SL; Krauth-Siegel, RL; Davioud-Charvet, E
Activity of anti-cancer protein kinase inhibitors against Leishmania spp. (2014)
Sanderson, Lisa; Yardley, Vanessa; Croft, Simon L
Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug. (2021)
Sanderson, Lisa; da Silva, Marcelo; Sekhar, Gayathri N; Brown, Rachel C; Burrell-Saward, Hollie; Fidanboylu, Mehmet; Liu, Bo; Dailey, Lea Ann; Dreiss, Cécile A; Lorenz, Chris; Christie, Mark; Persaud, Shanta J; Yardley, Vanessa; Croft, Simon L; Valero, Margarita; Thomas, Sarah A
Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies. (2006)
Tasdemir, Deniz; Brun, Reto; Yardley, Vanessa; Franzblau, Scott G; Rüedi, Peter
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. (2006)
Tasdemir, Deniz; Kaiser, Marcel; Brun, Reto; Yardley, Vanessa; Schmidt, Thomas J; Tosun, Fatma; Rüedi, Peter
A Replicative In Vitro Assay for Drug Discovery against Leishmania donovani. (2016)
Tegazzini, Diana; Díaz, Rosario; Aguilar, Fernando; Peña, Imanol; Presa, Jesús L; Yardley, Vanessa; Martin, Julio J; Coteron, Jose M; Croft, Simon L; Cantizani, Juan
7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis. (2017)
Thompson, AM; O'Connor, PD; Marshall, AJ; Yardley, V; Maes, L; Gupta, S; Launay, D; Braillard, S; Chatelain, E; Franzblau, SG; Wan, B; Wang, Y; Ma, Z; Cooper, CB; Denny, WA
Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. (2016)
Thompson, Andrew M; O'Connor, Patrick D; Blaser, Adrian; Yardley, Vanessa; Maes, Louis; Gupta, Suman; Launay, Delphine; Martin, Denis; Franzblau, Scott G; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A
Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis. (2018)
Thompson, Andrew M; O'Connor, Patrick D; Marshall, Andrew J; Blaser, Adrian; Yardley, Vanessa; Maes, Louis; Gupta, Suman; Launay, Delphine; Braillard, Stephanie; Chatelain, Eric; Wan, Baojie; Franzblau, Scott G; Ma, Zhenkun; Cooper, Christopher B; Denny, William A
Anti-malarial activity of N6-modified purine analogues. (2007)
Too, Kathleen; Brown, Daniel M; Bongard, Emily; Yardley, Vanessa; Vivas, Livia; Loakes, David
Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis. (2019)
Van Bocxlaer, Katrien; Caridha, Diana; Black, Chad; Vesely, Brian; Leed, Susan; Sciotti, Richard J; Wijnant, Gert-Jan; Yardley, Vanessa; Braillard, Stéphanie; Mowbray, Charles E; Ioset, Jean-Robert; Croft, Simon L
Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles. (2018)
Van Bocxlaer, Katrien; Gaukel, Eric; Hauser, Deirdre; Park, Seong Hee; Schock, Sara; Yardley, Vanessa; Randolph, Ryan; Plattner, Jacob J; Merchant, Tejal; Croft, Simon L; Jacobs, Robert T; Wring, Stephen A
Topical formulations of miltefosine for cutaneous leishmaniasis in a BALB/c mouse model. (2016)
Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L
Drug permeation and barrier damage in Leishmania-infected mouse skin. (2016)
Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L
Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis. (2019)
Wijnant, Gert-Jan; Croft, Simon L; de la Flor, Raul; Alavijeh, Mo; Yardley, Vanessa; Braillard, Stéphanie; Mowbray, Charles; Van Bocxlaer, Katrien
Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B. (2018)
Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Fortes Francisco, Amanda; Yardley, Vanessa; Harris, Andy; Alavijeh, Mo; Murdan, Sudaxshina; Croft, Simon L
Comparative efficacy, toxicity and biodistribution of the liposomal amphotericin B formulations Fungisome® and AmBisome® in murine cutaneous leishmaniasis. (2018)
Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Yardley, Vanessa; Harris, Andy; Alavijeh, Mo; Silva-Pedrosa, Rita; Antunes, Sandra; Mauricio, Isabel; Murdan, Sudaxshina; Croft, Simon L
Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis. (2017)
Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Yardley, Vanessa; Harris, Andy; Murdan, Sudaxshina; Croft, Simon L
Efficacy of Paromomycin-Chloroquine Combination Therapy in Experimental Cutaneous Leishmaniasis. (2017)
Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L
Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL). (2010)
Yang, Mei; Arai, Chika; Bakar Md, Abu; Lu, Jun; Ge, Jian-Feng; Pudhom, Khanitha; Takasu, Kiyosei; Kasai, Kazuki; Kaiser, Marcel; Brun, Reto; Yardley, Vanessa; Itoh, Isamu; Ihara, Masataka
The sensitivity of clinical isolates of Leishmania from Peru and Nepal to miltefosine. (2005)
Yardley, Vanessa; Croft, Simon L; De Doncker, Simonne; Dujardin, Jean-Claude; Koirala, Siddhartha; Rijal, Suman; Miranda, Cesar; Llanos-Cuentas, Alejandro; Chappuis, Francois
Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine. (2010)
Yardley, Vanessa; Gamarro, Francisco; Croft, Simon L
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. (2002)
Yardley, Vanessa; Khan, Anis A; Martin, Michael B; Slifer, Teri R; Araujo, Fausto G; Moreno, Silvia NJ; Docampo, Roberto; Croft, Simon L; Oldfield, Eric
American tegumentary leishmaniasis: Is antimonial treatment outcome related to parasite drug susceptibility? (2006)
Yardley, Vanessa; Ortuno, Nimer; Llanos-Cuentas, Alejandro; Chappuis, Francois; Doncker, Simonne De; Ramirez, Luis; Croft, Simon; Arevalo, Jorge; Adaui, Vanessa; Bermudez, Hernan; Decuypere, Saskia; Dujardin, Jean-Claude
Visceral Leishmaniasis Patients Display Altered Composition and Maturity of Neutrophils as well as Impaired Neutrophil Effector Functions. (2016)
Yizengaw, Endalew; Getahun, Mulusew; Tajebe, Fitsumbrhan; Cruz Cervera, Edward; Adem, Emebet; Mesfin, Getnet; Hailu, Asrat; Van der Auwera, Gert; Yardley, Vanessa; Lemma, Mulualem; Skhedy, Ziv; Diro, Ermias; Yeshanew, Arega; Melkamu, Roma; Mengesha, Bewketu; Modolell, Manuel; Munder, Markus; Müller, Ingrid; Takele, Yegnasew; Kropf, Pascale
In vitro antiprotozoal and cytotoxic activities of some alkaloids, quinones, flavonoids, and coumarins. (2004)
del Rayo Camacho, Maria; Phillipson, J David; Croft, Simon L; Yardley, Vanesa; Solis, Pablo N