Items where Author is "Yardley, Vanessa"
Number of items: 106.
2021
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis. (2021)
Mowbray, Charles E; Braillard, Stéphanie; Glossop, Paul A; Whitlock, Gavin A; Jacobs, Robert T; Speake, Jason; Pandi, Bharathi; Nare, Bakela; Maes, Louis; Yardley, Vanessa; Freund, Yvonne; Wall, Richard J; Carvalho, Sandra; Bello, Davide; Van den Kerkhof, Magali; Caljon, Guy; Gilbert, Ian H; Corpas-Lopez, Victoriano; Lukac, Iva; Patterson, Stephen; Zuccotto, Fabio; Wyllie, Susan
Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug. (2021)
Sanderson, Lisa; da Silva, Marcelo; Sekhar, Gayathri N; Brown, Rachel C; Burrell-Saward, Hollie; Fidanboylu, Mehmet; Liu, Bo; Dailey, Lea Ann; Dreiss, Cécile A; Lorenz, Chris; Christie, Mark; Persaud, Shanta J; Yardley, Vanessa; Croft, Simon L; Valero, Margarita; Thomas, Sarah A
2020
Antileishmanial Activity and Synergistic Effects of Amphotericin B Deoxycholate with Allicin and Andrographolide against Leishmania martiniquensis In Vitro. (2020)
Intakhan, Nuchpicha; Chanmol, Wetpisit; Somboon, Pradya; Bates, Michelle D; Yardley, Vanessa; Bates, Paul A; Jariyapan, Narissara
Novel 2D and 3D Assays to Determine the Activity of Anti-Leishmanial Drugs. (2020)
O'Keeffe, Alec; Hale, Christine; Cotton, James A; Yardley, Vanessa; Gupta, Kapish; Ananthanarayanan, Abhishek; Murdan, Sudaxshina; Croft, Simon L
Insights into the application of chitosan as an anti-leishmanial compound. (2020)
Riezk, A
Activity of Amphotericin B-Loaded Chitosan Nanoparticles against Experimental Cutaneous Leishmaniasis. (2020)
Riezk, Alaa; Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L
2019
An efficient and novel technology for the extraction of parasite genomic DNA from whole blood or culture. (2019)
Clark, David J; Moore, Catherine M; Flanagan, Marc; Bocxlaer, Katrien Van; Piperaki, Evangelia-Theophano; Yardley, Vanessa; Croft, Simon L; Tyson, John; Whitehouse, Sam P; O'Halloran, Jonathan; Krishna, Sanjeev; Staines, Henry M
Activity of Chitosan and Its Derivatives against Leishmania major and Leishmania mexicana In Vitro. (2019)
Riezk, Alaa; Raynes, John G; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L
Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis. (2019)
Van Bocxlaer, Katrien; Caridha, Diana; Black, Chad; Vesely, Brian; Leed, Susan; Sciotti, Richard J; Wijnant, Gert-Jan; Yardley, Vanessa; Braillard, Stéphanie; Mowbray, Charles E; Ioset, Jean-Robert; Croft, Simon L
Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis. (2019)
Wijnant, Gert-Jan; Croft, Simon L; de la Flor, Raul; Alavijeh, Mo; Yardley, Vanessa; Braillard, Stéphanie; Mowbray, Charles; Van Bocxlaer, Katrien
2018
Investigating Permeation Behavior of Flufenamic Acid Cocrystals Using a Dissolution and Permeation System. (2018)
Guo, Minshan; Wang, Ke; Qiao, Ning; Yardley, Vanessa; Li, Mingzhong
Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis. (2018)
Thompson, Andrew M; O'Connor, Patrick D; Marshall, Andrew J; Blaser, Adrian; Yardley, Vanessa; Maes, Louis; Gupta, Suman; Launay, Delphine; Braillard, Stephanie; Chatelain, Eric; Wan, Baojie; Franzblau, Scott G; Ma, Zhenkun; Cooper, Christopher B; Denny, William A
Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles. (2018)
Van Bocxlaer, Katrien; Gaukel, Eric; Hauser, Deirdre; Park, Seong Hee; Schock, Sara; Yardley, Vanessa; Randolph, Ryan; Plattner, Jacob J; Merchant, Tejal; Croft, Simon L; Jacobs, Robert T; Wring, Stephen A
Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B. (2018)
Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Fortes Francisco, Amanda; Yardley, Vanessa; Harris, Andy; Alavijeh, Mo; Murdan, Sudaxshina; Croft, Simon L
Comparative efficacy, toxicity and biodistribution of the liposomal amphotericin B formulations Fungisome® and AmBisome® in murine cutaneous leishmaniasis. (2018)
Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Yardley, Vanessa; Harris, Andy; Alavijeh, Mo; Silva-Pedrosa, Rita; Antunes, Sandra; Mauricio, Isabel; Murdan, Sudaxshina; Croft, Simon L
Chapter 4: Drug Assay Methodology in Leishmaniasis: From the Microplate to Image Analysis. (2018)
Yardley, V; Koniordou, M
2017
In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial. (2017)
Basilico, Nicoletta; Parapini, Silvia; Sparatore, Anna; Romeo, Sergio; Misiano, Paola; Vivas, Livia; Yardley, Vanessa; Croft, Simon L; Habluetzel, Annette; Lucantoni, Leonardo; Renia, Laurent; Russell, Bruce; Suwanarusk, Rossarin; Nosten, Francois; Dondio, Giulio; Bigogno, Chiara; Jabes, Daniela; Taramelli, Donatella
Synthesis and antitrypanosomal activities of novel pyridylchalcones. (2017)
Bhambra, AS; Ruparelia, KC; Tan, HL; Tasdemir, D; Burrell-Saward, H; Yardley, V; Beresford, KJ; Arroo, RR
7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis. (2017)
Thompson, AM; O'Connor, PD; Marshall, AJ; Yardley, V; Maes, L; Gupta, S; Launay, D; Braillard, S; Chatelain, E; Franzblau, SG; Wan, B; Wang, Y; Ma, Z; Cooper, CB; Denny, WA
Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis. (2017)
Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Yardley, Vanessa; Harris, Andy; Murdan, Sudaxshina; Croft, Simon L
Efficacy of Paromomycin-Chloroquine Combination Therapy in Experimental Cutaneous Leishmaniasis. (2017)
Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L
2016
Antiprotozoal glutathione derivatives with flagellar membrane binding activity against T. brucei rhodesiense. (2016)
Daunes, S; Yardley, V; Croft, SL; D'Silva, C
Cutaneous Leishmaniasis in Khyber Pakhtunkhwa Province of Pakistan: Clinical Diversity and Species-Level Diagnosis. (2016)
Khan, Nazma Habib; Bari, Arfan Ul; Hashim, Rizwan; Khan, Inamullah; Muneer, Akhtar; Shah, Akram; Wahid, Sobia; Yardley, Vanessa; O'Neil, Brighid; Sutherland, Colin J
A Replicative In Vitro Assay for Drug Discovery against Leishmania donovani. (2016)
Tegazzini, Diana; Díaz, Rosario; Aguilar, Fernando; Peña, Imanol; Presa, Jesús L; Yardley, Vanessa; Martin, Julio J; Coteron, Jose M; Croft, Simon L; Cantizani, Juan
Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. (2016)
Thompson, Andrew M; O'Connor, Patrick D; Blaser, Adrian; Yardley, Vanessa; Maes, Louis; Gupta, Suman; Launay, Delphine; Martin, Denis; Franzblau, Scott G; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A
Topical formulations of miltefosine for cutaneous leishmaniasis in a BALB/c mouse model. (2016)
Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L
Drug permeation and barrier damage in Leishmania-infected mouse skin. (2016)
Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L
Visceral Leishmaniasis Patients Display Altered Composition and Maturity of Neutrophils as well as Impaired Neutrophil Effector Functions. (2016)
Yizengaw, Endalew; Getahun, Mulusew; Tajebe, Fitsumbrhan; Cruz Cervera, Edward; Adem, Emebet; Mesfin, Getnet; Hailu, Asrat; Van der Auwera, Gert; Yardley, Vanessa; Lemma, Mulualem; Skhedy, Ziv; Diro, Ermias; Yeshanew, Arega; Melkamu, Roma; Mengesha, Bewketu; Modolell, Manuel; Munder, Markus; Müller, Ingrid; Takele, Yegnasew; Kropf, Pascale
2015
Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes. (2015)
Bhambra, Avninder S; Edgar, Mark; Elsegood, Mark RJ; Li, Yuqi; Weaver, George W; Arroo, Randolph RJ; Yardley, Vanessa; Burrell-Saward, Hollie; Krystof, Vladimir
The Oral Antimalarial Drug Tafenoquine Shows Activity against Trypanosoma brucei. (2015)
Carvalho, Luis; Martínez-García, Marta; Pérez-Victoria, Ignacio; Manzano, José Ignacio; Yardley, Vanessa; Gamarro, Francisco; Pérez-Victoria, José M
2014
Protein energy malnutrition increases arginase activity in monocytes and macrophages. (2014)
Corware, Karina; Yardley, Vanessa; Mack, Christopher; Schuster, Steffen; Al-Hassi, Hafid; Herath, Shanthi; Bergin, Philip; Modolell, Manuel; Munder, Markus; Müller, Ingrid; Kropf, Pascale
Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis. (2014)
Gupta, Suman; Yardley, Vanessa; Vishwakarma, Preeti; Shivahare, Rahul; Sharma, Bhawna; Launay, Delphine; Martin, Denis; Puri, Sunil K
Poly(methacrylic acid) complexation of amphotericin B to treat neglected diseases. (2014)
Les, Karolina Alicja; Mohamed-Ahmed, Abeer HA; Balan, Sibu; Choi, Ji-won; Martin, Denis; Yardley, Vanessa; Powell, Keith; Godwin, Antony; Brocchini, Steve
Synthesis of cyclohexapeptides as antimalarial and anti-trypanosomal agents. (2014)
Peña, S; Fagundez, C; Medeiros, A; Comini, M; Scarone, L; Sellanes, D; Manta, E; Tulla-Puche, J; Albericio, F; Stewart, L; Yardley, V; Serra, G
Activity of anti-cancer protein kinase inhibitors against Leishmania spp. (2014)
Sanderson, Lisa; Yardley, Vanessa; Croft, Simon L
2013
Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography. (2013)
Baiocco, Paola; Poce, Giovanna; Alfonso, Salvatore; Cocozza, Martina; Porretta, Giulio Cesare; Colotti, Gianni; Biava, Mariangela; Moraca, Francesca; Botta, Maurizio; Yardley, Vanessa; Fiorillo, Annarita; Lantella, Antonella; Malatesta, Francesco; Ilari, Andrea
Antileishmanial activity, uptake, and biodistribution of an amphotericin B and poly(α-Glutamic Acid) complex. (2013)
Mohamed-Ahmed, Abeer HA; Seifert, Karin; Yardley, Vanessa; Burrell-Saward, Hollie; Brocchini, Stephen; Croft, Simon L
2011
Synthesis of aminoquinoline-based aminoalcohols and oxazolidinones and their antiplasmodial activity. (2011)
Kobarfard, Farzad; Yardley, Vanessa; Little, Susan; Daryaee, Fereidoon; Chibale, Kelly
Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites. (2011)
Müller, Tobias; Johann, Laure; Jannack, Beate; Brückner, Margit; Lanfranchi, Don Antoine; Bauer, Holger; Sanchez, Cecilia; Yardley, Vanessa; Deregnaucourt, Christiane; Schrével, Joseph; Lanzer, Michael; Schirmer, R Heiner; Davioud-Charvet, Elisabeth
2010
Treatment of localised cutaneous Leishmania tropica infection in Aleppo, Syria and drug sensitivity of clinical isolates. (2010)
Abazid, Nizar
Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo. (2010)
Blackie, Margaret AL; Yardley, Vanessa; Chibale, Kelly
Therapeutic glucocorticoid-induced TNF receptor-mediated amplification of CD4+ T cell responses enhances antiparasitic immunity. (2010)
Haque, Ashraful; Stanley, Amanda C; Amante, Fiona H; Rivera, Fabian de Labastida; Zhou, Yonghong; Kuns, Rachel D; Yardley, Vanessa; Sakaguchi, Shimon; Hill, Geoffrey R; Engwerda, Christian R
Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL). (2010)
Yang, Mei; Arai, Chika; Bakar Md, Abu; Lu, Jun; Ge, Jian-Feng; Pudhom, Khanitha; Takasu, Kiyosei; Kasai, Kazuki; Kaiser, Marcel; Brun, Reto; Yardley, Vanessa; Itoh, Isamu; Ihara, Masataka
Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine. (2010)
Yardley, Vanessa; Gamarro, Francisco; Croft, Simon L
2009
Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. (2009)
Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, Bhupendra P; Kukreja, Gagan; Coccone, Salvatore Sanna; Bernetti, Matteo; Persico, Marco; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Taramelli, Donatella; Basilico, Nicoletta; Parapini, Silvia; Yardley, Vanessa; Croft, Simon; Keller-Maerki, Sonja; Rottmann, Matthias; Brun, Reto; Coletta, Massimiliano; Marini, Stefano; Guiso, Giovanna; Caccia, Silvio; Fattorusso, Caterina
A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity. (2009)
Guglielmo, Stefano; Bertinaria, Massimo; Rolando, Barbara; Crosetti, Marco; Fruttero, Roberta; Yardley, Vanessa; Croft, Simon L; Gasco, Alberto
2008
Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones). (2008)
Coro, Julieta; Little, Susan; Yardley, Vanessa; Suárez, Margarita; Rodríguez, Hortensia; Martín, Nazario; Perez-Pineiro, Rolando
Gene expression profiling of Leishmania (Leishmania) donovani: overcoming technical variation and exploiting biological variation. (2008)
Decuypere, S; Vanaerschot, M; Rijal, S; Yardley, V; Maes, L; de Doncker, S; Chappuis, F; Dujardin, J-C
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. (2008)
Fattorusso, Caterina; Campiani, Giuseppe; Kukreja, Gagan; Persico, Marco; Butini, Stefania; Romano, Maria Pia; Altarelli, Maria; Ros, Sindu; Brindisi, Margherita; Savini, Luisa; Novellino, Ettore; Nacci, Vito; Fattorusso, Ernesto; Parapini, Silvia; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Croft, Simon; Borriello, Marianna; Gemma, Sandra
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. (2008)
Friebolin, Wolfgang; Jannack, Beate; Wenzel, Nicole; Furrer, Julien; Oeser, Thomas; Sanchez, Cecilia P; Lanzer, Michael; Yardley, Vanessa; Becker, Katja; Davioud-Charvet, Elisabeth
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies. (2008)
Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, Gagan; Coccone, Salvatore Sanna; Joshi, Bhupendra P; Persico, Marco; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Fattorusso, Ernesto; Taglialatela-Scafati, Orazio; Savini, Luisa; Taramelli, Donatella; Basilico, Nicoletta; Parapini, Silvia; Morace, Giulia; Yardley, Vanessa; Croft, Simon; Coletta, Massimiliano; Marini, Stefano; Fattorusso, Caterina
Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines. (2008)
Musonda, Chitalu C; Yardley, Vanessa; de Souza, Renata C Carvalho; Ncokazi, Kanyile; Egan, Timothy J; Chibale, Kelly
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate. (2008)
Nanayakkara, NP Dhammika; Ager, Arba L; Bartlett, Marilyn S; Yardley, Vanessa; Croft, Simon L; Khan, Ikhlas A; McChesney, James D; Walker, Larry A
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichloropheno xy]quinoline succinate. (2008)
Nanayakkara, NP; Ager, AL; Bartlett, MS; Yardley, V; Croft, SL; Khan, IA; McChesney, JD; Walker, LA
Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity. (2008)
October, Natasha; Watermeyer, Nicholas D; Yardley, Vanessa; Egan, Timothy J; Ncokazi, Kanyile; Chibale, Kelly
2007
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore. (2007)
Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, Gagan; Joshi, Bhupendra P; Persico, Marco; Catalanotti, Bruno; Novellino, Ettore; Fattorusso, Ernesto; Nacci, Vito; Savini, Luisa; Taramelli, Donatella; Basilico, Nicoletta; Morace, Giulia; Yardley, Vanessa; Fattorusso, Caterina
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. (2007)
Gemma, Sandra; Kukreja, Gagan; Campiani, Giuseppe; Butini, Stefania; Bernetti, Matteo; Joshi, Bhupendra P; Savini, Luisa; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Bertamino, Alessia; Novellino, Ettore; Persico, Marco; Catalanotti, Bruno; Fattorusso, Caterina
Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives. (2007)
Khrizman, Alexander; Moulthrop, Jason S; Little, Susan; Wharton, Hayley; Yardley, Vanessa; Moyna, Guillermo
Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives. (2007)
Khrizman, Alexander; Slack, Rachel D; Remsing, Richard C; Little, Susan; Yardley, Vanessa; Moyna, Guillermo
Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro. (2007)
Musonda, Chitalu C; Little, Susan; Yardley, Vanessa; Chibale, Kelly
Antimonial treatment of visceral leishmaniasis: are current in vitro susceptibility assays adequate for prognosis of in vivo therapy outcome? (2007)
Rijal, Suman; Yardley, Vanessa; Chappuis, François; Decuypere, Saskia; Khanal, Basudha; Singh, Rupa; Boelaert, Marleen; De Doncker, Simonne; Croft, Simon; Dujardin, Jean-Claude
Anti-malarial activity of N6-modified purine analogues. (2007)
Too, Kathleen; Brown, Daniel M; Bongard, Emily; Yardley, Vanessa; Vivas, Livia; Loakes, David
2006
A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme. (2006)
Bauer, Holger; Fritz-Wolf, Karin; Winzer, Andreas; Kühner, Sebastian; Little, Susan; Yardley, Vanessa; Vezin, Hervé; Palfey, Bruce; Schirmer, R Heiner; Davioud-Charvet, Elisabeth
Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents. (2006)
Coro, Julieta; Atherton, Richard; Little, Susan; Wharton, Hayley; Yardley, Vanessa; Alvarez, Amaury; Súarez, Margarita; Pérez, Rolando; Rodríguez, Hortensia
Current scenario of drug development for leishmaniasis. (2006)
Croft, Simon L; Seifert, Karin; Yardley, Vanessa
Synthesis, structure, and biological activity of ferrocenyl carbohydrate conjugates. (2006)
Ferreira, Cara L; Ewart, Charles B; Barta, Cheri A; Little, Susan; Yardley, Vanessa; Martins, Candice; Polishchuk, Elena; Smith, Peter J; Moss, John R; Merkel, Michael; Adam, Michael J; Orvig, Chris
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. (2006)
Gemma, Sandra; Kukreja, Gagan; Fattorusso, Caterina; Persico, Marco; Romano, Maria P; Altarelli, Maria; Savini, Luisa; Campiani, Giuseppe; Fattorusso, Ernesto; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Butini, Stefania
New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action. (2006)
Gros, Ludovic; Castillo-Acosta, Victor Manuel; Jiménez Jiménez, Carmen; Sealey-Cardona, Marco; Vargas, Sofia; Manuel Estévez, Antonio; Yardley, Vanessa; Rattray, Lauren; Croft, Simon L; Ruiz-Perez, Luis M; Urbina, Julio A; Gilbert, Ian H; González-Pacanowska, Dolores
Evaluation of azasterols as anti-parasitics. (2006)
Gros, Ludovic; Lorente, Silvia Orenes; Jimenez, Carmen Jimenez; Yardley, Vanessa; Rattray, Lauren; Wharton, Hayley; Little, Susan; Croft, Simon L; Ruiz-Perez, Luis M; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. (2006)
Hudock, Michael P; Sanz-Rodríguez, CE; Song, Yongcheng; Chan, Julian MW; Zhang, Yonghui; Odeh, Sarah; Kosztowski, Thomas; Leon-Rossell, Annette; Concepción, JL; Yardley, Vanessa; Croft, Simon L; Urbina, Julio A; Oldfield, Eric
Epidemiological dynamics of antimonial resistance in Leishmania donovani: genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal. (2006)
Laurent, Thierry; Rijal, Suman; Yardley, Vanessa; Croft, Simon; De Doncker, Simonne; Decuypere, Saskia; Khanal, Basudha; Singh, Rupa; Schönian, Gabriele; Kuhls, Katrin; Chappuis, François; Dujardin, Jean-Claude
Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol. (2006)
Musonda, Chitalu C; Gut, Jiri; Rosenthal, Philip J; Yardley, Vanessa; Carvalho de Souza, Renata C; Chibale, Kelly
Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies. (2006)
Tasdemir, Deniz; Brun, Reto; Yardley, Vanessa; Franzblau, Scott G; Rüedi, Peter
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. (2006)
Tasdemir, Deniz; Kaiser, Marcel; Brun, Reto; Yardley, Vanessa; Schmidt, Thomas J; Tosun, Fatma; Rüedi, Peter
American tegumentary leishmaniasis: Is antimonial treatment outcome related to parasite drug susceptibility? (2006)
Yardley, Vanessa; Ortuno, Nimer; Llanos-Cuentas, Alejandro; Chappuis, Francois; Doncker, Simonne De; Ramirez, Luis; Croft, Simon; Arevalo, Jorge; Adaui, Vanessa; Bermudez, Hernan; Decuypere, Saskia; Dujardin, Jean-Claude
2005
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites. (2005)
Baliani, Alessandro; Bueno, Gorka Jimenez; Stewart, Mhairi L; Yardley, Vanessa; Brun, Reto; Barrett, Michael P; Gilbert, Ian H
Differential polyadenylation of ribosomal RNA during post-transcriptional processing in Leishmania. (2005)
Decuypere, S; Vandesompele, J; Yardley, V; De Donckeri, S; Laurent, T; Rijal, S; Llanos-Cuentas, A; Chappuis, F; Arevalo, J; Dujardin, JC
Gene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from Nepal. (2005)
Decuypere, Saskia; Rijal, Suman; Yardley, Vanessa; De Doncker, Simonne; Laurent, Thierry; Khanal, Basudha; Chappuis, François; Dujardin, Jean-Claude
Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. (2005)
Lee, Brittany; Bauer, Holger; Melchers, Johannes; Ruppert, Thomas; Rattray, Lauren; Yardley, Vanessa; Davioud-Charvet, Elisabeth; Krauth-Siegel, R Luise
Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics. (2005)
Lorente, Silvia Orenes; Jimenez, Carmen Jimenez; Gros, Ludovic; Yardley, Vanessa; de Luca-Fradley, Kate; Croft, Simon L; A Urbina, Julio; Ruiz-Perez, Luis M; Pacanowska, Dolores Gonzalez; Gilbert, Ian H
Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa. (2005)
Orenes Lorente, Silvia; Gómez, Rosario; Jiménez, Carmen; Cammerer, Simon; Yardley, Vanessa; de Luca-Fradley, Kate; Croft, Simon L; Ruiz Perez, Luis M; Urbina, Julio; Gonzalez Pacanowska, Dolores; Gilbert, Ian H
Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide. (2005)
Parveen, Seheli; Khan, Mohammed OF; Austin, Susan E; Croft, Simon L; Yardley, Vanessa; Rock, Peter; Douglas, Kenneth T
The sensitivity of clinical isolates of Leishmania from Peru and Nepal to miltefosine. (2005)
Yardley, Vanessa; Croft, Simon L; De Doncker, Simonne; Dujardin, Jean-Claude; Koirala, Siddhartha; Rijal, Suman; Miranda, Cesar; Llanos-Cuentas, Alejandro; Chappuis, Francois
2004
Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity. (2004)
Grant, Karen M; Dunion, Morag H; Yardley, Vanessa; Skaltsounis, Alexios-Leandros; Marko, Doris; Eisenbrand, Gerhard; Croft, Simon L; Meijer, Laurent; Mottram, Jeremy C
Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives. (2004)
Jung, Mankil; Lee, Kyunghoon; Jung, Hochul; Kendrick, Howard; Yardley, Vanessa; Croft, Simon L
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis. (2004)
Lorente, Silvia Orenes; Rodrigues, Juliany CF; Jiménez Jiménez, Carmen; Joyce-Menekse, Miranda; Rodrigues, Carlos; Croft, Simon L; Yardley, Vanessa; de Luca-Fradley, Kate; Ruiz-Pérez, Luis M; Urbina, Julio; de Souza, Wanderley; González Pacanowska, Dolores; Gilbert, Ian H
Targetable water-soluble polymer-drug conjugates for the treatment of visceral leishmaniasis. (2004)
Nan, Anjan; Croft, Simon L; Yardley, Vanessa; Ghandehari, Hamidreza
In vitro antiprotozoal and cytotoxic activities of some alkaloids, quinones, flavonoids, and coumarins. (2004)
del Rayo Camacho, Maria; Phillipson, J David; Croft, Simon L; Yardley, Vanesa; Solis, Pablo N
2003
Formulation of amphotericin B as nanosuspension for oral administration. (2003)
Kayser, O; Olbrich, C; Yardley, V; Kiderlen, AF; Croft, SL
Toxicity and antileishmanial activity of a new stable lipid suspension of amphotericin B. (2003)
Larabi, Malika; Yardley, Vanessa; Loiseau, Philippe M; Appel, Martine; Legrand, Philippe; Gulik, Annette; Bories, Christian; Croft, Simon L; Barratt, Gillian
New World cutaneous leishmaniasis in returned travellers: treatment failures using intravenous sodium stibogluconate. (2003)
Lawn, SD; Yardley, V; Vega-Lopez, F; Watson, J; Lockwood, DN
Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi. (2003)
Magaraci, Filippo; Jimenez, Carmen Jimenez; Rodrigues, Carlos; Rodrigues, Juliany CF; Braga, Marina Vianna; Yardley, Vanessa; de Luca-Fradley, Kate; Croft, Simon L; de Souza, Wanderley; Ruiz-Perez, Luis M; Urbina, Julio; Gonzalez Pacanowska, Dolores; Gilbert, Ian H
2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase. (2003)
Pez, Didier; Leal, Isabel; Zuccotto, Fabio; Boussard, Cyrille; Brun, Reto; Croft, Simon L; Yardley, Vanessa; Ruiz Perez, Luis M; Gonzalez Pacanowska, Dolores; Gilbert, Ian H
Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines. (2003)
Ren, Hongyu; Grady, Shannon; Banghart, Matthew; Moulthrop, Jason S; Kendrick, Howard; Yardley, Vanessa; Croft, Simon L; Moyna, Guillermo
2002
Chemotherapy of leishmaniasis. (2002)
Croft, Simon L; Yardley, Vanessa
Drug sensitivity of Leishmania species: some unresolved problems. (2002)
Croft, Simon L; Yardley, Vanessa; Kendrick, Howard
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. (2002)
Yardley, Vanessa; Khan, Anis A; Martin, Michael B; Slifer, Teri R; Araujo, Fausto G; Moreno, Silvia NJ; Docampo, Roberto; Croft, Simon L; Oldfield, Eric
2001
In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle. (2001)
Asres, K; Bucar, F; Knauder, E; Yardley, V; Kendrick, H; Croft, SL
Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine. (2001)
Chibale, K; Haupt, H; Kendrick, H; Yardley, V; Saravanamuthu, A; Fairlamb, AH; Croft, SL
QSAR study on the contribution of log P and E(s) to the in vitro antiprotozoal activity of glutathione derivatives. (2001)
Daunes, S; D'Silva, C; Kendrick, H; Yardley, V; Croft, SL
Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice. (2001)
Escobar, P; Yardley, V; Croft, SL
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. (2001)
Martin, MB; Grimley, JS; Lewis, JC; Heath, HT; Bailey, BN; Kendrick, H; Yardley, V; Caldera, A; Lira, R; Urbina, JA; Moreno, SN; Docampo, R; Croft, SL; Oldfield, E
N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. (2001)
Nan, A; Nanayakkara, NP; Walker, LA; Yardley, V; Croft, SL; Ghandehari, H
Design, synthesis, and biological evaluation of a series of simple and novel potential antimalarial compounds. (2001)
Ren, H; Grady, S; Gamenara, D; Heinzen, H; Moyna, P; Croft, SL; Kendrick, H; Yardley, V; Moyna, G
2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity. (2001)
Salmon-Chemin, L; Buisine, E; Yardley, V; Kohler, S; Debreu, MA; Landry, V; Sergheraert, C; Croft, SL; Krauth-Siegel, RL; Davioud-Charvet, E