Items where Author is "Fletcher, Helen"

Year Item Type Full Text

Article

Uniting to end the TB epidemic: advances in disease control from prevention to better diagnosis and treatment. (2016) Abubakar, Ibrahim; Lipman, Marc; McHugh, Timothy D; Fletcher, Helen

Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study. (2017) Andrews, Jason R; Nemes, Elisa; Tameris, Michele; Landry, Bernard S; Mahomed, Hassan; McClain, J Bruce; Fletcher, Helen A; Hanekom, Willem A; Wood, Robin; McShane, Helen; Scriba, Thomas J; Hatherill, Mark

MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines. (2009) Berthoud, Tamara K; Dunachie, Susanna J; Todryk, Stephen; Hill, Adrian VS; Fletcher, Helen A

Comparing human T cell and NK cell responses in viral-based malaria vaccine trials. (2009) Berthoud, Tamara K; Fletcher, Helen; Porter, David; Thompson, Fiona; Hill, Adrian VS; Todryk, Stephen M

Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1. (2011) Berthoud, Tamara K; Hamill, Matthew; Lillie, Patrick J; Hwenda, Lenias; Collins, Katharine A; Ewer, Katie J; Milicic, Anita; Poyntz, Hazel C; Lambe, Teresa; Fletcher, Helen A; Hill, Adrian VS; Gilbert, Sarah C

A comparison of IFNgamma detection methods used in tuberculosis vaccine trials. (2008) Beveridge, Natalie ER; Fletcher, Helen A; Hughes, Jane; Pathan, Ansar A; Scriba, Thomas J; Minassian, Angela; Sander, Clare R; Whelan, Kathryn T; Dockrell, Hazel M; Hill, Adrian VS; Hanekom, Willem A; McShane, Helen

The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project, 2010-2014. (2017) Brennan, Michael J; Tanner, Rachel; Morris, Sheldon; Scriba, Thomas J; Achkar, Jacqueline M; Zelmer, Andrea; Hokey, David A; Izzo, Angelo; Sharpe, Sally; Williams, Ann; Penn-Nicholson, Adam; Erasmus, Mzwandile; Stylianou, Elena; Hoft, Daniel F; McShane, Helen; Fletcher, Helen A

Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa. (2008) Brookes, Roger H; Hill, Philip C; Owiafe, Patrick K; Ibanga, Hannah B; Jeffries, David J; Donkor, Simon A; Fletcher, Helen A; Hammond, Abdulrahman S; Lienhardt, Christian; Adegbola, Richard A; McShane, Helen; Hill, Adrian VS

Serum From Melioidosis Survivors Diminished Intracellular Burkholderia pseudomallei Growth in Macrophages: A Brief Research Report. (2020) Chaichana, Panjaporn; Kronsteiner, Barbara; Rongkard, Patpong; Teparrukkul, Prapit; Limmathurotsakul, Direk; Chantratita, Narisara; Day, Nicholas PJ; Fletcher, Helen A; Dunachie, Susanna J

Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction. (2016) Chen, Tingting; Blanc, Caroline; Eder, Anke Z; Prados-Rosales, Rafael; Souza, Ana Camila Oliveira; Kim, Ryung S; Glatman-Freedman, Aharona; Joe, Maju; Bai, Yu; Lowary, Todd L; Tanner, Rachel; Brennan, Michael J; Fletcher, Helen A; McShane, Helen; Casadevall, Arturo; Achkar, Jacqueline M

The convergent epidemiology of tuberculosis and human cytomegalovirus infection. (2018) Cobelens, Frank; Nagelkerke, Nico; Fletcher, Helen

The convergent epidemiology of tuberculosis and human cytomegalovirus infection. (2018) Cobelens, Frank; Nagelkerke, Nico; Fletcher, Helen

Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2. (2004) Demissie, Abebech; Abebe, Markos; Aseffa, Abraham; Rook, Graham; Fletcher, Helen; Zumla, Alimuddin; Weldingh, Karin; Brock, Inger; Andersen, Peter; Doherty, T Mark; VACSEL Study Group

Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis. (2006) Demissie, Abebech; Leyten, Eliane MS; Abebe, Markos; Wassie, Liya; Aseffa, Abraham; Abate, Getahun; Fletcher, Helen; Owiafe, Patrick; Hill, Philip C; Brookes, Roger; Rook, Graham; Zumla, Alimuddin; Arend, Sandra M; Klein, Michel; Ottenhoff, Tom HM; Andersen, Peter; Doherty, T Mark; VACSEL Study Group

Social determinants and BCG efficacy: a call for a socio-biological approach to TB prevention. (2018) Dowd, Jennifer B; Fletcher, Helen A; Boccia, Delia

MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy. (2010) Dunachie, Susanna J; Berthoud, Tamara; Keating, Sheila M; Hill, Adrian VS; Fletcher, Helen A

Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model. (2015) Dunachie, Susanna; Berthoud, Tamara; Hill, Adrian VS; Fletcher, Helen A

Profiling the host response to malaria vaccination and malaria challenge. (2015) Dunachie, Susanna; Hill, Adrian VS; Fletcher, Helen A

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'. (2014) Dutruel, Céline; Thole, Jelle; Geels, Mark; Mollenkopf, Hans-Joachim; Ottenhoff, Tom; Guzman, Carlos A; Fletcher, Helen A; Leroy, Odile; Kaufmann, Stefan HE

The prospective evaluation of a nested polymerase chain reaction assay for the early detection of Aspergillus infection in patients with leukaemia or undergoing allograft treatment. (2002) Ferns, R Bridget; Fletcher, Helen; Bradley, Susan; Mackinnon, Stephen; Hunt, Chris; Tedder, Richard S

Molecular epidemiology of tuberculosis: recent developments and applications. (2001) Fletcher, HA

Profiling the host immune response to tuberculosis vaccines. (2015) Fletcher, Helen A

Systems approaches to correlates of protection and progression to TB disease. (2018) Fletcher, Helen A

Correlates of immune protection from tuberculosis. (2007) Fletcher, Helen A

Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine. (2016) Fletcher, Helen A

VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy. (2018) Fletcher, Helen A; Chatterjee, Mitali; Cooper, Andrea; Hussell, Tracy; Kaye, Paul M; Prior, Joann; Reljic, Rajko; Vermaak, Samantha; Vordermeier, Martin; Williams, Ann; McShane, Helen

Human biomarkers: can they help us to develop a new tuberculosis vaccine? (2016) Fletcher, Helen A; Dockrell, Hazel M

Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians. (2003) Fletcher, Helen A; Donoghue, Helen D; Holton, John; Pap, Ildikó; Spigelman, Mark

Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians. (2003) Fletcher, Helen A; Donoghue, Helen D; Taylor, G Michael; van der Zanden, Adri GM; Spigelman, Mark

Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study. (2016) Fletcher, Helen A; Filali-Mouhim, Ali; Nemes, Elisa; Hawkridge, Anthony; Keyser, Alana; Njikan, Samuel; Hatherill, Mark; Scriba, Thomas J; Abel, Brian; Kagina, Benjamin M; Veldsman, Ashley; Agudelo, Nancy Marín; Kaplan, Gilla; Hussey, Gregory D; Sekaly, Rafick-Pierre; Hanekom, Willem A; BCG study team

A New Vaccine for Tuberculosis: The Challenges of Development and Deployment. (2009) Fletcher, Helen A; Hawkridge, Tony; McShane, Helen

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth. (2009) Fletcher, Helen A; Keyser, Alana; Bowmaker, Mark; Sayles, Peter C; Kaplan, Gilla; Hussey, Greg; Hill, Adrian VS; Hanekom, Willem A

Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation. (2004) Fletcher, Helen A; Owiafe, Patrick; Jeffries, David; Hill, Philip; Rook, Graham AW; Zumla, Alimuddin; Doherty, T Mark; Brookes, Roger H; Vacsel Study Group

Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1. (2008) Fletcher, Helen A; Pathan, Ansar A; Berthoud, Tamara K; Dunachie, Susanna J; Whelan, Kathryn T; Alder, Nicola C; Sander, Clare R; Hill, Adrian VS; McShane, Helen

TB vaccine development and the End TB Strategy: importance and current status. (2016) Fletcher, Helen A; Schrager, Lewis

T-cell activation is an immune correlate of risk in BCG vaccinated infants. (2016) Fletcher, Helen A; Snowden, Margaret A; Landry, Bernard; Rida, Wasima; Satti, Iman; Harris, Stephanie A; Matsumiya, Magali; Tanner, Rachel; O'Shea, Matthew K; Dheenadhayalan, Veerabadran; Bogardus, Leah; Stockdale, Lisa; Marsay, Leanne; Chomka, Agnieszka; Harrington-Kandt, Rachel; Manjaly-Thomas, Zita-Rose; Naranbhai, Vivek; Stylianou, Elena; Darboe, Fatoumatta; Penn-Nicholson, Adam; Nemes, Elisa; Hatherill, Mark; Hussey, Gregory; Mahomed, Hassan; Tameris, Michele; McClain, J Bruce; Evans, Thomas G; Hanekom, Willem A; Scriba, Thomas J; McShane, Helen

Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG. (2013) Fletcher, Helen A; Tanner, Rachel; Wallis, Robert S; Meyer, Joel; Manjaly, Zita-Rose; Harris, Stephanie; Satti, Iman; Silver, Richard F; Hoft, Dan; Kampmann, Beate; Walker, K Barry; Dockrell, Hazel M; Fruth, Uli; Barker, Lew; Brennan, Michael J; McShane, Helen

Tuberculosis vaccines: current status and future prospects. (2006) Fletcher, Helen; McShane, Helen

Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. (2011) Griffiths, Kristin L; Pathan, Ansar A; Minassian, Angela M; Sander, Clare R; Beveridge, Natalie ER; Hill, Adrian VS; Fletcher, Helen A; McShane, Helen

Cholera toxin enhances vaccine-induced protection against Mycobacterium tuberculosis challenge in mice. (2013) Griffiths, Kristin L; Stylianou, Elena; Poyntz, Hazel C; Betts, Gareth J; Fletcher, Helen A; McShane, Helen

World TB Day 2018: The Challenge of Drug Resistant Tuberculosis. (2018) Gupta-Wright, Ankur; Tomlinson, Gillian S; Rangaka, Molebogeng X; Fletcher, Helen A

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations. (2008) Hanekom, Willem A; Dockrell, Hazel M; Ottenhoff, Tom HM; Doherty, T Mark; Fletcher, Helen; McShane, Helen; Weichold, Frank F; Hoft, Dan F; Parida, Shreemanta K; Fruth, Uli J

Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate tuberculosis vaccine, MVA85A, alone and in combination. (2013) Harris, Stephanie A; Meyer, Joel; Satti, Iman; Marsay, Leanne; Poulton, Ian D; Tanner, Rachel; Minassian, Angela M; Fletcher, Helen A; McShane, Helen

Process of assay selection and optimization for the study of case and control samples from a phase IIb efficacy trial of a candidate tuberculosis vaccine, MVA85A. (2014) Harris, Stephanie A; Satti, Iman; Matsumiya, Magali; Stockdale, Lisa; Chomka, Agnieszka; Tanner, Rachel; O'Shea, Matthew K; Manjaly Thomas, Zita-Rose; Tameris, Michele; Mahomed, Hassan; Scriba, Thomas J; Hanekom, Willem A; Fletcher, Helen A; McShane, Helen

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa. (2008) Hawkridge, Tony; Scriba, Thomas J; Gelderbloem, Sebastian; Smit, Erica; Tameris, Michele; Moyo, Sizulu; Lang, Trudie; Veldsman, Ashley; Hatherill, Mark; Merwe, Linda van der; Fletcher, Helen A; Mahomed, Hassan; Hill, Adrian VS; Hanekom, Willem A; Hussey, Gregory D; McShane, Helen

A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis. (2020) Hayward, Sally E; Dowd, Jennifer B; Fletcher, Helen; Nellums, Laura B; Wurie, Fatima; Boccia, Delia

Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design. (2006) Ibanga, Hannah B; Brookes, Roger H; Hill, Philip C; Owiafe, Patrick K; Fletcher, Helen A; Lienhardt, Christian; Hill, Adrian VS; Adegbola, Richard A; McShane, Helen

T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients. (2015) Jenjaroen, Kemajittra; Chumseng, Suchintana; Sumonwiriya, Manutsanun; Ariyaprasert, Pitchayanant; Chantratita, Narisara; Sunyakumthorn, Piyanate; Hongsuwan, Maliwan; Wuthiekanun, Vanaporn; Fletcher, Helen A; Teparrukkul, Prapit; Limmathurotsakul, Direk; Day, Nicholas PJ; Dunachie, Susanna J

A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis. (2013) Joosten, Simone A; Fletcher, Helen A; Ottenhoff, Tom HM

Sensitivity of IFN-gamma release assay to detect latent tuberculosis infection is retained in HIV-infected patients but dependent on HIV/AIDS progression. (2008) Karam, Farba; Mbow, Fatou; Fletcher, Helen; Senghor, Cheikh S; Coulibaly, Koura D; LeFevre, Andrea M; Ngom Gueye, Ndeye F; Dieye, Tandakha; Sow, Papa S; Mboup, Souleymane; Lienhardt, Christian picture_as_pdf

Identification of Pneumocystis carinii DNA by polymerase chain reaction in necropsy lung samples from children dying of respiratory tract illnesses. (2002) Kasolo, Francis; Lishimpi, Kennedy; Chintu, Chifumbe; Mwaba, Peter; Mudenda, Victor; Maswahu, Daniel; Terunuma, Hiroshi; Fletcher, Helen; Nunn, Andrew; Lucas, Sebastian; Zumla, Alimuddin

A molecular assay for sensitive detection of pathogen-specific T-cells. (2011) Kasprowicz, Victoria O; Mitchell, Jessica E; Chetty, Shivan; Govender, Pamla; Huang, Kuan-Hsiang Gary; Fletcher, Helen A; Webster, Daniel P; Brown, Sebastian; Kasmar, Anne; Millington, Kerry; Day, Cheryl L; Mkhwanazi, Nompumelelo; McClurg, Cheryl; Chonco, Fundisiwe; Lalvani, Ajit; Walker, Bruce D; Ndung'u, Thumbi; Klenerman, Paul

Big Data in Vaccinology: Introduction and section summaries. (2015) Kaufmann, Stefan HE; Fletcher, Helen A; Guzmán, Carlos A; Ottenhoff, Tom HM

Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization. (2018) Kewcharoenwong, Chidchamai; Prabowo, Satria A; Bancroft, Gregory J; Fletcher, Helen A; Lertmemongkolchai, Ganjana

Investments in tuberculosis research - what are the gaps? (2016) Khan, Mishal S; Fletcher, Helen; London School of Hygiene and Tropical Medicine TB Centre Steerin; Coker, Richard

How can we improve priority-setting for investments in health research? A case study of tuberculosis. (2019) Khan, Mishal S; Rahman-Shepherd, Afifah; Painter, Hannah; Fletcher, Helen

In vitro Mycobacterial Growth Inhibition in South Korean Adults With Latent TB Infection. (2019) Lee, Hyejon; Kim, Jungho; Kang, Young Ae; Kim, Deok Ryun; Sim, Bora; Zelmer, Andrea; Fletcher, Helen A; Dockrell, Hazel M; Smith, Steven G; Cho, Sang-Nae

Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal. (2010) Lienhardt, Christian; Fielding, Katherine; Hane, Abdoul A; Niang, Aliou; Ndao, Cheikh T; Karam, Farba; Fletcher, Helen; Mbow, Fatou; Gomis, Jules-François; Diadhiou, Raymond; Toupane, Maxime; Dieye, Tandakha; Mboup, Souleymane

Mycobacterial growth inhibition in murine splenocytes as a surrogate for protection against Mycobacterium tuberculosis (M. tb). (2013) Marsay, Leanne; Matsumiya, Magali; Tanner, Rachel; Poyntz, Hazel; Griffiths, Kristin L; Stylianou, Elena; Marsh, Philip D; Williams, Ann; Sharpe, Sally; Fletcher, Helen; McShane, Helen

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response. (2014) Matsumiya, Magali; Harris, Stephanie A; Satti, Iman; Stockdale, Lisa; Tanner, Rachel; O'Shea, Matthew K; Tameris, Michelle; Mahomed, Hassan; Hatherill, Mark; Scriba, Thomas J; Hanekom, Willem A; McShane, Helen; Fletcher, Helen A

Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model. (2014) Matsumiya, Magali; Satti, Iman; Chomka, Agnieszka; Harris, Stephanie A; Stockdale, Lisa; Meyer, Joel; Fletcher, Helen A; McShane, Helen

Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A. (2013) Matsumiya, Magali; Stylianou, Elena; Griffiths, Kristin; Lang, Zoe; Meyer, Joel; Harris, Stephanie A; Rowland, Rosalind; Minassian, Angela M; Pathan, Ansar A; Fletcher, Helen; McShane, Helen

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin. (2018) McNeill, Eileen; Stylianou, Elena; Crabtree, Mark J; Harrington-Kandt, Rachel; Kolb, Anna-Lena; Diotallevi, Marina; Hale, Ashley B; Bettencourt, Paulo; Tanner, Rachel; O'Shea, Matthew K; Matsumiya, Magali; Lockstone, Helen; Müller, Julius; Fletcher, Helen A; Greaves, David R; McShane, Helen; Channon, Keith M

Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials. (2005) McShane, Helen; Pathan, Ansar A; Sander, Clare R; Goonetilleke, Nilu P; Fletcher, Helen A; Hill, Adrian VS

Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. (2004) McShane, Helen; Pathan, Ansar A; Sander, Clare R; Keating, Sheila M; Gilbert, Sarah C; Huygen, Kris; Fletcher, Helen A; Hill, Adrian VS

Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery. (2013) Meyer, Joel; Harris, Stephanie A; Satti, Iman; Poulton, Ian D; Poyntz, Hazel C; Tanner, Rachel; Rowland, Rosalind; Griffiths, Kristin L; Fletcher, Helen A; McShane, Helen

A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults. (2011) Minassian, Angela M; Rowland, Rosalind; Beveridge, Natalie ER; Poulton, Ian D; Satti, Iman; Harris, Stephanie; Poyntz, Hazel; Hamill, Matthew; Griffiths, Kristin; Sander, Clare R; Ambrozak, David R; Price, David A; Hill, Brenna J; Casazza, Joseph P; Douek, Daniel C; Koup, Richard A; Roederer, Mario; Winston, Alan; Ross, Jonathan; Sherrard, Jackie; Rooney, Guy; Williams, Nicola; Lawrie, Alison M; Fletcher, Helen A; Pathan, Ansar A; McShane, Helen

Quantitative PCR evaluation of cellular immune responses in Kenyan children vaccinated with a candidate malaria vaccine. (2009) Mwacharo, Jedidah; Dunachie, Susanna J; Kai, Oscar; Hill, Adrian VS; Bejon, Philip; Fletcher, Helen A

Cytomegalovirus infection is a risk factor for tuberculosis disease in infants. (2019) Müller, Julius; Tanner, Rachel; Matsumiya, Magali; Snowden, Margaret A; Landry, Bernard; Satti, Iman; Harris, Stephanie A; O'Shea, Matthew K; Stockdale, Lisa; Marsay, Leanne; Chomka, Agnieszka; Harrington-Kandt, Rachel; Thomas, Zita-Rose Manjaly; Naranbhai, Vivek; Stylianou, Elena; Mbandi, Stanley Kimbung; Hatherill, Mark; Hussey, Gregory; Mahomed, Hassan; Tameris, Michele; McClain, J Bruce; Evans, Thomas G; Hanekom, Willem A; Scriba, Thomas J; McShane, Helen; Fletcher, Helen A

Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes. (2015) Naranbhai, Vivek; Fletcher, Helen A; Tanner, Rachel; O'Shea, Matthew K; McShane, Helen; Fairfax, Benjamin P; Knight, Julian C; Hill, Adrian VS

Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy. (2013) Naranbhai, Vivek; Hill, Adrian VS; Abdool Karim, Salim S; Naidoo, Kogieleum; Abdool Karim, Quarraisha; Warimwe, George M; McShane, Helen; Fletcher, Helen

The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life. (2014) Naranbhai, Vivek; Kim, Soyeon; Fletcher, Helen; Cotton, Mark F; Violari, Avy; Mitchell, Charles; Nachman, Sharon; McSherry, George; McShane, Helen; Hill, Adrian VS; Madhi, Shabir A

The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women. (2014) Naranbhai, Vivek; Moodley, Dhayendre; Chipato, Tsungai; Stranix-Chibanda, Lynda; Nakabaiito, Clemensia; Kamateeka, Moreen; Musoke, Philippa; Manji, Karim; George, Kathleen; Emel, Lynda M; Richardson, Paul; Andrew, Philip; Fowler, MaryGlenn; Fletcher, Helen; McShane, Helen; Coovadia, Hoosen M; Hill, Adrian VS; HPTN 046 Protocol Team

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. (2021) Ogbe, Ane; Kronsteiner, Barbara; Skelly, Donal T; Pace, Matthew; Brown, Anthony; Adland, Emily; Adair, Kareena; Akhter, Hossain Delowar; Ali, Mohammad; Ali, Serat-E; Angyal, Adrienn; Ansari, M Azim; Arancibia-Cárcamo, Carolina V; Brown, Helen; Chinnakannan, Senthil; Conlon, Christopher; de Lara, Catherine; de Silva, Thushan; Dold, Christina; Dong, Tao; Donnison, Timothy; Eyre, David; Flaxman, Amy; Fletcher, Helen; Gardner, Joshua; Grist, James T; Hackstein, Carl-Philipp; Jaruthamsophon, Kanoot; Jeffery, Katie; Lambe, Teresa; Lee, Lian; Li, Wenqin; Lim, Nicholas; Matthews, Philippa C; Mentzer, Alexander J; Moore, Shona C; Naisbitt, Dean J; Ogese, Monday; Ogg, Graham; Openshaw, Peter; Pirmohamed, Munir; Pollard, Andrew J; Ramamurthy, Narayan; Rongkard, Patpong; Rowland-Jones, Sarah; Sampson, Oliver; Screaton, Gavin; Sette, Alessandro; Stafford, Lizzie; Thompson, Craig; Thomson, Paul J; Thwaites, Ryan; Vieira, Vinicius; Weiskopf, Daniela; Zacharopoulou, Panagiota; Oxford Immunology Network Covid-19 Response T Cell Consortium; Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinica; Turtle, Lance; Klenerman, Paul; Goulder, Philip; Frater, John; Barnes, Eleanor; Dunachie, Susanna

Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward. (2021) Olbrich, Laura; Stockdale, Lisa; Basu Roy, Robindra; Song, Rinn; Cicin-Sain, Luka; Whittaker, Elizabeth; Prendergast, Andrew J; Fletcher, Helen; Seddon, James A

Adaption of the ex vivo mycobacterial growth inhibition assay for use with murine lung cells. (2020) Painter, Hannah; Prabowo, Satria A; Cia, Felipe; Stockdale, Lisa; Tanner, Rachel; Willcocks, Samuel; Reljic, Rajko; Fletcher, Helen A; Zelmer, Andrea

Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults. (2012) Pathan, Ansar A; Minassian, Angela M; Sander, Clare R; Rowland, Rosalind; Porter, David W; Poulton, Ian D; Hill, Adrian VS; Fletcher, Helen A; McShane, Helen

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials. (2007) Pathan, Ansar A; Sander, Clare R; Fletcher, Helen A; Poulton, Ian; Alder, Nicola C; Beveridge, Natalie ER; Whelan, Kathryn T; Hill, Adrian VS; McShane, Helen

World TB Day 2016: an interview with leading experts in tuberculosis research. (2016) Phillips, Patrick PJ; Fletcher, Helen A; Abubakar, Ibrahim; Lipman, Marc CI; McHugh, Timothy D

RUTI Vaccination Enhances Inhibition of Mycobacterial Growth ex vivo and Induces a Shift of Monocyte Phenotype in Mice. (2019) Prabowo, Satria A; Painter, Hannah; Zelmer, Andrea; Smith, Steven G; Seifert, Karin; Amat, Merce; Cardona, Pere-Joan; Fletcher, Helen A

Impact of individual-level factors on Ex vivo mycobacterial growth inhibition: Associations of immune cell phenotype, cytomegalovirus-specific response and sex with immunity following BCG vaccination in humans. (2019) Prabowo, Satria A; Smith, Steven G; Seifert, Karin; Fletcher, Helen A

Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells. (2019) Prabowo, Satria A; Zelmer, Andrea; Stockdale, Lisa; Ojha, Utkarsh; Smith, Steven G; Seifert, Karin; Fletcher, Helen A

Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making. (2018) Rhodes, Sophie J; Guedj, Jeremie; Fletcher, Helen A; Lindenstrøm, Thomas; Scriba, Thomas J; Evans, Thomas G; Knight, Gwenan M; White, Richard G

Individual-level factors associated with variation in mycobacterial-specific immune response: Gender and previous BCG vaccination status. (2015) Rhodes, Sophie J; Knight, Gwenan M; Fielding, Katherine; Scriba, Thomas J; Pathan, Ansar A; McShane, Helen; Fletcher, Helen; White, Richard G description

Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods. (2017) Rhodes, Sophie J; Sarfas, Charlotte; Knight, Gwenan M; White, Andrew; Pathan, Ansar A; McShane, Helen; Evans, Thomas G; Fletcher, Helen; Sharpe, Sally; White, Richard G

The TB vaccine H56+IC31 dose-response curve is peaked not saturating: Data generation for new mathematical modelling methods to inform vaccine dose decisions. (2016) Rhodes, Sophie J; Zelmer, Andrea; Knight, Gwenan M; Prabowo, Satria Arief; Stockdale, Lisa; Evans, Thomas G; Lindenstrøm, Thomas; White, Richard G; Fletcher, Helen description

Human Immune Responses to Melioidosis and Cross-Reactivity to Low-Virulence Burkholderia Species, Thailand1. (2020) Rongkard, Patpong; Kronsteiner, Barbara; Hantrakun, Viriya; Jenjaroen, Kemajittra; Sumonwiriya, Manutsanun; Chaichana, Panjaporn; Chumseng, Suchintana; Chantratita, Narisara; Wuthiekanun, Vanaporn; Fletcher, Helen A; Teparrukkul, Prapit; Limmathurotsakul, Direk; Day, Nicholas PJ; Dunachie, Susanna J

Characterization of the Infant Immune System and the Influence and Immunogenicity of BCG Vaccination in Infant and Adult Rhesus Macaques. (2021) Sarfas, Charlotte; White, Andrew D; Sibley, Laura; Morrison, Alexandra L; Gullick, Jennie; Lawrence, Steve; Dennis, Mike J; Marsh, Philip D; Fletcher, Helen A; Sharpe, Sally A

Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines. (2015) Schito, Marco; Migliori, Giovanni Battista; Fletcher, Helen A; McNerney, Ruth; Centis, Rosella; D'Ambrosio, Lia; Bates, Matthew; Kibiki, Gibson; Kapata, Nathan; Corrah, Tumena; Bomanji, Jamshed; Vilaplana, Cris; Johnson, Daniel; Mwaba, Peter; Maeurer, Markus; Zumla, Alimuddin

Human Immunology of Tuberculosis. (2016) Scriba, TJ; Coussens, AK; Fletcher, HA

Human Immunology of Tuberculosis. (2017) Scriba, Thomas J; Coussens, Anna K; Fletcher, Helen A

Human Immunology of Tuberculosis. (2017) Scriba, Thomas J; Coussens, Anna K; Fletcher, Helen A

Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques. (2019) Sibley, Laura; Gooch, Karen; Wareham, Alice; Gray, Susan; Chancellor, Andrew; Dowall, Stuart; Bate, Simon; Marriott, Anthony; Dennis, Mike; White, Andrew D; Marsh, Philip D; Fletcher, Helen; Sharpe, Sally

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines. (2015) Smith, Steven G; Smits, Kaatje; Joosten, Simone A; van Meijgaarden, Krista E; Satti, Iman; Fletcher, Helen A; Caccamo, Nadia; Dieli, Francesco; Mascart, Francoise; McShane, Helen; Dockrell, Hazel M; Ottenhoff, Tom HM; TBVI TB Biomarker Working Group

Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants. (2016) Smith, Steven G; Zelmer, Andrea; Blitz, Rose; Fletcher, Helen A; Dockrell, Hazel M

Cytomegalovirus Antibody Responses Associated With Increased Risk of Tuberculosis Disease in Ugandan Adults. (2019) Stockdale, Lisa; Nash, Stephen; Farmer, Ruth; Raynes, John; Mallikaarjun, Suresh; Newton, Robert; Fletcher, Helen A

HIV, HCMV and mycobacterial antibody levels: a cross-sectional study in a rural Ugandan cohort. (2018) Stockdale, Lisa; Nash, Stephen; Nalwoga, Angela; Gibson, Lorna; Painter, Hannah; Raynes, John; Asiki, Gershim; Newton, Robert; Fletcher, Helen

Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort. (2018) Stockdale, Lisa; Nash, Stephen; Nalwoga, Angela; Painter, Hannah; Asiki, Gershim; Fletcher, Helen; Newton, Robert

The in vitro direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells. (2021) Tanner, Rachel; Hoogkamer, Emily; Bitencourt, Julia; White, Andrew; Boot, Charelle; Sombroek, Claudia C; Harris, Stephanie A; O'Shea, Matthew K; Wright, Daniel; Wittenberg, Rachel; Sarfas, Charlotte; Satti, Iman; Verreck, Frank AW; Sharpe, Sally A; Fletcher, Helen A; McShane, Helen

Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A. (2014) Tanner, Rachel; Kakalacheva, Kristina; Miller, Ellen; Pathan, Ansar A; Chalk, Rod; Sander, Clare R; Scriba, Tom; Tameris, Michelle; Hawkridge, Tony; Mahomed, Hassan; Hussey, Greg; Hanekom, Willem; Checkley, Anna; McShane, Helen; Fletcher, Helen A

In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy. (2016) Tanner, Rachel; O'Shea, Matthew K; Fletcher, Helen A; McShane, Helen

The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays. (2017) Tanner, Rachel; O'Shea, Matthew K; White, Andrew D; Müller, Julius; Harrington-Kandt, Rachel; Matsumiya, Magali; Dennis, Mike J; Parizotto, Eneida A; Harris, Stephanie; Stylianou, Elena; Naranbhai, Vivek; Bettencourt, Paulo; Drakesmith, Hal; Sharpe, Sally; Fletcher, Helen A; McShane, Helen

Tools for Assessing the Protective Efficacy of TB Vaccines in Humans: in vitro Mycobacterial Growth Inhibition Predicts Outcome of in vivo Mycobacterial Infection. (2020) Tanner, Rachel; Satti, Iman; Harris, Stephanie A; O'Shea, Matthew K; Cizmeci, Deniz; O'Connor, Daniel; Chomka, Agnieszka; Matsumiya, Magali; Wittenberg, Rachel; Minassian, Angela M; Meyer, Joel; Fletcher, Helen A; McShane, Helen

A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates. (2021) Tanner, Rachel; White, Andrew D; Boot, Charelle; Sombroek, Claudia C; O'Shea, Matthew K; Wright, Daniel; Hoogkamer, Emily; Bitencourt, Julia; Harris, Stephanie A; Sarfas, Charlotte; Wittenberg, Rachel; Satti, Iman; Fletcher, Helen A; Verreck, Frank AW; Sharpe, Sally A; McShane, Helen

Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points. (2016) Vainieri, Maria L; Blagborough, Andrew M; MacLean, Adam L; Haltalli, Myriam LR; Ruivo, Nicola; Fletcher, Helen A; Stumpf, Michael PH; Sinden, Robert E; Celso, Cristina Lo

Progress and challenges in TB vaccine development. (2018) Voss, Gerald; Casimiro, Danilo; Neyrolles, Olivier; Williams, Ann; Kaufmann, Stefan HE; McShane, Helen; Hatherill, Mark; Fletcher, Helen A

Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. (2005) Walther, Michael; Tongren, Jon Eric; Andrews, Laura; Korbel, Daniel; King, Elizabeth; Fletcher, Helen; Andersen, Rikke F; Bejon, Philip; Thompson, Fiona; Dunachie, Susanna J; Edele, Fanny; de Souza, J Brian; Sinden, Robert E; Gilbert, Sarah C; Riley, Eleanor M; Hill, Adrian VS

Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data. (2013) Warimwe, George M; Fletcher, Helen A; Olotu, Ally; Agnandji, Selidji T; Hill, Adrian VS; Marsh, Kevin; Bejon, Philip

The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children. (2013) Warimwe, George M; Murungi, Linda M; Kamuyu, Gathoni; Nyangweso, George M; Wambua, Juliana; Naranbhai, Vivek; Fletcher, Helen A; Hill, Adrian VS; Bejon, Philip; Osier, Faith HA; Marsh, Kevin

Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A. (2009) Whelan, Kathryn T; Pathan, Ansar A; Sander, Clare R; Fletcher, Helen A; Poulton, Ian; Alder, Nicola C; Hill, Adrian VS; McShane, Helen

High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis. (2018) Zelmer, Andrea; Stockdale, Lisa; Prabowo, Satria A; Cia, Felipe; Spink, Natasha; Gibb, Matthew; Eddaoudi, Ayad; Fletcher, Helen A

High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis. (2018) Zelmer, Andrea; Stockdale, Lisa; Prabowo, Satria A; Cia, Felipe; Spink, Natasha; Gibb, Matthew; Eddaoudi, Ayad; Fletcher, Helen A

A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis. (2016) Zelmer, Andrea; Tanner, Rachel; Stylianou, Elena; Damelang, Timon; Morris, Sheldon; Izzo, Angelo; Williams, Ann; Sharpe, Sally; Pepponi, Ilaria; Walker, Barry; Hokey, David A; McShane, Helen; Brennan, Michael; Fletcher, Helen

Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A. (2010) de Cassan, Simone C; Pathan, Ansar A; Sander, Clare R; Minassian, Angela; Rowland, Rosalind; Hill, Adrian VS; McShane, Helen; Fletcher, Helen A

Conference or Workshop Item

Th1/Th17 cell induction following vaccination with the novel tuberculosis vaccine MVA85A and their role in Mycobacterium tuberculosis challenge CD4 T cell response to MVA85A vaccination against Mycobacterium tuberculosis in healthy HIV-infected adults SO IMMUNOLOGY CT Annual Congress of the British-Society-for-Immunology CY DEC 05-08, 2011 CL Liverpool, ENGLAND SP British Soc Immunol. (2011) Griffiths, K; Stylianou, E; Poyntz, H; Betts, G; Fletcher, H; McShane, H; Beveridge, N; Minassian, A; Rowland, R; Poulton, I; Satti, I; Harris, S; Poyntz, H; Hamill, M; Griffiths, K; Sander, C; Ambrozak, D; Price, D; Hill, B; Casazza, J; Douek, D; Koup, R; Roederer, M; Winston, A; Ross, J; Sherrad, J; Rooney, G; Williams, N; Lawrie, A; Fletcher, H; Pathan, A; McShane, H

Single Nucleotide Polymorphisms in the Toll-Like Receptor 3 and CD44 Genes Are Associated with Persistence of Vaccine-Induced Immunity to the Serogroup C Meningococcal Conjugate Vaccine. (2011) Moore, CE; Hennig, BJ; Perrett, KP; Hoe, JC; Lee, SJ; Fletcher, H; Brocklebank, D; O'Connor, D; Snape, MD; Hall, AJ; Segal, S; Hill, AVS; Pollard, AJ

New tuberculosis vaccines can diminish as well as enhance BCG induced protection: Results from a murine model SO THORAX CT Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF). (2006) Sander, CR; Tchilian, E; Dahm-Vicker, M; Fletcher, H; McShane, H; Hill, AVS

Thesis

Accelerating the preclinical development of effective vaccines for protection against Mycobacterium tuberculosis. (2021) Painter, HE

Accelerating Development of Therapeutic Tuberculosis Vaccines Using an Ex Vivo Immune Assay Platform. (2019) Prabowo, SA

The development of a mathematical modelling framework to translate TB vaccine responses between species and predict the most immunogenic dose in humans using animal data. (2018) Rhodes, SJ

Investigation of immune correlates, and impact of human cytomegalovirus and immune activation, on tuberculosis disease risk. (2019) Stockdale, L