Items where Author is "Fletcher, Helen"
Number of items: 121.
2021
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. (2021)
Ogbe, Ane; Kronsteiner, Barbara; Skelly, Donal T; Pace, Matthew; Brown, Anthony; Adland, Emily; Adair, Kareena; Akhter, Hossain Delowar; Ali, Mohammad; Ali, Serat-E; Angyal, Adrienn; Ansari, M Azim; Arancibia-Cárcamo, Carolina V; Brown, Helen; Chinnakannan, Senthil; Conlon, Christopher; de Lara, Catherine; de Silva, Thushan; Dold, Christina; Dong, Tao; Donnison, Timothy; Eyre, David; Flaxman, Amy; Fletcher, Helen; Gardner, Joshua; Grist, James T; Hackstein, Carl-Philipp; Jaruthamsophon, Kanoot; Jeffery, Katie; Lambe, Teresa; Lee, Lian; Li, Wenqin; Lim, Nicholas; Matthews, Philippa C; Mentzer, Alexander J; Moore, Shona C; Naisbitt, Dean J; Ogese, Monday; Ogg, Graham; Openshaw, Peter; Pirmohamed, Munir; Pollard, Andrew J; Ramamurthy, Narayan; Rongkard, Patpong; Rowland-Jones, Sarah; Sampson, Oliver; Screaton, Gavin; Sette, Alessandro; Stafford, Lizzie; Thompson, Craig; Thomson, Paul J; Thwaites, Ryan; Vieira, Vinicius; Weiskopf, Daniela; Zacharopoulou, Panagiota; Oxford Immunology Network Covid-19 Response T Cell Consortium; Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinica; Turtle, Lance; Klenerman, Paul; Goulder, Philip; Frater, John; Barnes, Eleanor; Dunachie, Susanna
Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward. (2021)
Olbrich, Laura; Stockdale, Lisa; Basu Roy, Robindra; Song, Rinn; Cicin-Sain, Luka; Whittaker, Elizabeth; Prendergast, Andrew J; Fletcher, Helen; Seddon, James A
Accelerating the preclinical development of effective vaccines for protection against Mycobacterium tuberculosis. (2021)
Painter, HE
Characterization of the Infant Immune System and the Influence and Immunogenicity of BCG Vaccination in Infant and Adult Rhesus Macaques. (2021)
Sarfas, Charlotte; White, Andrew D; Sibley, Laura; Morrison, Alexandra L; Gullick, Jennie; Lawrence, Steve; Dennis, Mike J; Marsh, Philip D; Fletcher, Helen A; Sharpe, Sally A
The in vitro direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells. (2021)
Tanner, Rachel; Hoogkamer, Emily; Bitencourt, Julia; White, Andrew; Boot, Charelle; Sombroek, Claudia C; Harris, Stephanie A; O'Shea, Matthew K; Wright, Daniel; Wittenberg, Rachel; Sarfas, Charlotte; Satti, Iman; Verreck, Frank AW; Sharpe, Sally A; Fletcher, Helen A; McShane, Helen
A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates. (2021)
Tanner, Rachel; White, Andrew D; Boot, Charelle; Sombroek, Claudia C; O'Shea, Matthew K; Wright, Daniel; Hoogkamer, Emily; Bitencourt, Julia; Harris, Stephanie A; Sarfas, Charlotte; Wittenberg, Rachel; Satti, Iman; Fletcher, Helen A; Verreck, Frank AW; Sharpe, Sally A; McShane, Helen
2020
Serum From Melioidosis Survivors Diminished Intracellular Burkholderia pseudomallei Growth in Macrophages: A Brief Research Report. (2020)
Chaichana, Panjaporn; Kronsteiner, Barbara; Rongkard, Patpong; Teparrukkul, Prapit; Limmathurotsakul, Direk; Chantratita, Narisara; Day, Nicholas PJ; Fletcher, Helen A; Dunachie, Susanna J
A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis. (2020)
Hayward, Sally E; Dowd, Jennifer B; Fletcher, Helen; Nellums, Laura B; Wurie, Fatima; Boccia, Delia
Adaption of the ex vivo mycobacterial growth inhibition assay for use with murine lung cells. (2020)
Painter, Hannah; Prabowo, Satria A; Cia, Felipe; Stockdale, Lisa; Tanner, Rachel; Willcocks, Samuel; Reljic, Rajko; Fletcher, Helen A; Zelmer, Andrea
Human Immune Responses to Melioidosis and Cross-Reactivity to Low-Virulence Burkholderia Species, Thailand1. (2020)
Rongkard, Patpong; Kronsteiner, Barbara; Hantrakun, Viriya; Jenjaroen, Kemajittra; Sumonwiriya, Manutsanun; Chaichana, Panjaporn; Chumseng, Suchintana; Chantratita, Narisara; Wuthiekanun, Vanaporn; Fletcher, Helen A; Teparrukkul, Prapit; Limmathurotsakul, Direk; Day, Nicholas PJ; Dunachie, Susanna J
Tools for Assessing the Protective Efficacy of TB Vaccines in Humans: in vitro Mycobacterial Growth Inhibition Predicts Outcome of in vivo Mycobacterial Infection. (2020)
Tanner, Rachel; Satti, Iman; Harris, Stephanie A; O'Shea, Matthew K; Cizmeci, Deniz; O'Connor, Daniel; Chomka, Agnieszka; Matsumiya, Magali; Wittenberg, Rachel; Minassian, Angela M; Meyer, Joel; Fletcher, Helen A; McShane, Helen
2019
How can we improve priority-setting for investments in health research? A case study of tuberculosis. (2019)
Khan, Mishal S; Rahman-Shepherd, Afifah; Painter, Hannah; Fletcher, Helen
In vitro Mycobacterial Growth Inhibition in South Korean Adults With Latent TB Infection. (2019)
Lee, Hyejon; Kim, Jungho; Kang, Young Ae; Kim, Deok Ryun; Sim, Bora; Zelmer, Andrea; Fletcher, Helen A; Dockrell, Hazel M; Smith, Steven G; Cho, Sang-Nae
Cytomegalovirus infection is a risk factor for tuberculosis disease in infants. (2019)
Müller, Julius; Tanner, Rachel; Matsumiya, Magali; Snowden, Margaret A; Landry, Bernard; Satti, Iman; Harris, Stephanie A; O'Shea, Matthew K; Stockdale, Lisa; Marsay, Leanne; Chomka, Agnieszka; Harrington-Kandt, Rachel; Thomas, Zita-Rose Manjaly; Naranbhai, Vivek; Stylianou, Elena; Mbandi, Stanley Kimbung; Hatherill, Mark; Hussey, Gregory; Mahomed, Hassan; Tameris, Michele; McClain, J Bruce; Evans, Thomas G; Hanekom, Willem A; Scriba, Thomas J; McShane, Helen; Fletcher, Helen A
Accelerating Development of Therapeutic Tuberculosis Vaccines Using an Ex Vivo Immune Assay Platform. (2019)
Prabowo, SA
RUTI Vaccination Enhances Inhibition of Mycobacterial Growth ex vivo and Induces a Shift of Monocyte Phenotype in Mice. (2019)
Prabowo, Satria A; Painter, Hannah; Zelmer, Andrea; Smith, Steven G; Seifert, Karin; Amat, Merce; Cardona, Pere-Joan; Fletcher, Helen A
Impact of individual-level factors on Ex vivo mycobacterial growth inhibition: Associations of immune cell phenotype, cytomegalovirus-specific response and sex with immunity following BCG vaccination in humans. (2019)
Prabowo, Satria A; Smith, Steven G; Seifert, Karin; Fletcher, Helen A
Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells. (2019)
Prabowo, Satria A; Zelmer, Andrea; Stockdale, Lisa; Ojha, Utkarsh; Smith, Steven G; Seifert, Karin; Fletcher, Helen A
Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques. (2019)
Sibley, Laura; Gooch, Karen; Wareham, Alice; Gray, Susan; Chancellor, Andrew; Dowall, Stuart; Bate, Simon; Marriott, Anthony; Dennis, Mike; White, Andrew D; Marsh, Philip D; Fletcher, Helen; Sharpe, Sally
Investigation of immune correlates, and impact of human cytomegalovirus and immune activation, on tuberculosis disease risk. (2019)
Stockdale, L
Cytomegalovirus Antibody Responses Associated With Increased Risk of Tuberculosis Disease in Ugandan Adults. (2019)
Stockdale, Lisa; Nash, Stephen; Farmer, Ruth; Raynes, John; Mallikaarjun, Suresh; Newton, Robert; Fletcher, Helen A
2018
The convergent epidemiology of tuberculosis and human cytomegalovirus infection. (2018)
Cobelens, Frank; Nagelkerke, Nico; Fletcher, Helen
The convergent epidemiology of tuberculosis and human cytomegalovirus infection. (2018)
Cobelens, Frank; Nagelkerke, Nico; Fletcher, Helen
Social determinants and BCG efficacy: a call for a socio-biological approach to TB prevention. (2018)
Dowd, Jennifer B; Fletcher, Helen A; Boccia, Delia
Systems approaches to correlates of protection and progression to TB disease. (2018)
Fletcher, Helen A
VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy. (2018)
Fletcher, Helen A; Chatterjee, Mitali; Cooper, Andrea; Hussell, Tracy; Kaye, Paul M; Prior, Joann; Reljic, Rajko; Vermaak, Samantha; Vordermeier, Martin; Williams, Ann; McShane, Helen
World TB Day 2018: The Challenge of Drug Resistant Tuberculosis. (2018)
Gupta-Wright, Ankur; Tomlinson, Gillian S; Rangaka, Molebogeng X; Fletcher, Helen A
Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization. (2018)
Kewcharoenwong, Chidchamai; Prabowo, Satria A; Bancroft, Gregory J; Fletcher, Helen A; Lertmemongkolchai, Ganjana
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin. (2018)
McNeill, Eileen; Stylianou, Elena; Crabtree, Mark J; Harrington-Kandt, Rachel; Kolb, Anna-Lena; Diotallevi, Marina; Hale, Ashley B; Bettencourt, Paulo; Tanner, Rachel; O'Shea, Matthew K; Matsumiya, Magali; Lockstone, Helen; Müller, Julius; Fletcher, Helen A; Greaves, David R; McShane, Helen; Channon, Keith M
The development of a mathematical modelling framework to translate TB vaccine responses between species and predict the most immunogenic dose in humans using animal data. (2018)
Rhodes, SJ
Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making. (2018)
Rhodes, Sophie J; Guedj, Jeremie; Fletcher, Helen A; Lindenstrøm, Thomas; Scriba, Thomas J; Evans, Thomas G; Knight, Gwenan M; White, Richard G
HIV, HCMV and mycobacterial antibody levels: a cross-sectional study in a rural Ugandan cohort. (2018)
Stockdale, Lisa; Nash, Stephen; Nalwoga, Angela; Gibson, Lorna; Painter, Hannah; Raynes, John; Asiki, Gershim; Newton, Robert; Fletcher, Helen
Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort. (2018)
Stockdale, Lisa; Nash, Stephen; Nalwoga, Angela; Painter, Hannah; Asiki, Gershim; Fletcher, Helen; Newton, Robert
Progress and challenges in TB vaccine development. (2018)
Voss, Gerald; Casimiro, Danilo; Neyrolles, Olivier; Williams, Ann; Kaufmann, Stefan HE; McShane, Helen; Hatherill, Mark; Fletcher, Helen A
High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis. (2018)
Zelmer, Andrea; Stockdale, Lisa; Prabowo, Satria A; Cia, Felipe; Spink, Natasha; Gibb, Matthew; Eddaoudi, Ayad; Fletcher, Helen A
High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis. (2018)
Zelmer, Andrea; Stockdale, Lisa; Prabowo, Satria A; Cia, Felipe; Spink, Natasha; Gibb, Matthew; Eddaoudi, Ayad; Fletcher, Helen A
2017
Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study. (2017)
Andrews, Jason R; Nemes, Elisa; Tameris, Michele; Landry, Bernard S; Mahomed, Hassan; McClain, J Bruce; Fletcher, Helen A; Hanekom, Willem A; Wood, Robin; McShane, Helen; Scriba, Thomas J; Hatherill, Mark
The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project, 2010-2014. (2017)
Brennan, Michael J; Tanner, Rachel; Morris, Sheldon; Scriba, Thomas J; Achkar, Jacqueline M; Zelmer, Andrea; Hokey, David A; Izzo, Angelo; Sharpe, Sally; Williams, Ann; Penn-Nicholson, Adam; Erasmus, Mzwandile; Stylianou, Elena; Hoft, Daniel F; McShane, Helen; Fletcher, Helen A
Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods. (2017)
Rhodes, Sophie J; Sarfas, Charlotte; Knight, Gwenan M; White, Andrew; Pathan, Ansar A; McShane, Helen; Evans, Thomas G; Fletcher, Helen; Sharpe, Sally; White, Richard G
Human Immunology of Tuberculosis. (2017)
Scriba, Thomas J; Coussens, Anna K; Fletcher, Helen A
Human Immunology of Tuberculosis. (2017)
Scriba, Thomas J; Coussens, Anna K; Fletcher, Helen A
The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays. (2017)
Tanner, Rachel; O'Shea, Matthew K; White, Andrew D; Müller, Julius; Harrington-Kandt, Rachel; Matsumiya, Magali; Dennis, Mike J; Parizotto, Eneida A; Harris, Stephanie; Stylianou, Elena; Naranbhai, Vivek; Bettencourt, Paulo; Drakesmith, Hal; Sharpe, Sally; Fletcher, Helen A; McShane, Helen
2016
Uniting to end the TB epidemic: advances in disease control from prevention to better diagnosis and treatment. (2016)
Abubakar, Ibrahim; Lipman, Marc; McHugh, Timothy D; Fletcher, Helen
Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction. (2016)
Chen, Tingting; Blanc, Caroline; Eder, Anke Z; Prados-Rosales, Rafael; Souza, Ana Camila Oliveira; Kim, Ryung S; Glatman-Freedman, Aharona; Joe, Maju; Bai, Yu; Lowary, Todd L; Tanner, Rachel; Brennan, Michael J; Fletcher, Helen A; McShane, Helen; Casadevall, Arturo; Achkar, Jacqueline M
Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine. (2016)
Fletcher, Helen A
Human biomarkers: can they help us to develop a new tuberculosis vaccine? (2016)
Fletcher, Helen A; Dockrell, Hazel M
Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study. (2016)
Fletcher, Helen A; Filali-Mouhim, Ali; Nemes, Elisa; Hawkridge, Anthony; Keyser, Alana; Njikan, Samuel; Hatherill, Mark; Scriba, Thomas J; Abel, Brian; Kagina, Benjamin M; Veldsman, Ashley; Agudelo, Nancy Marín; Kaplan, Gilla; Hussey, Gregory D; Sekaly, Rafick-Pierre; Hanekom, Willem A; BCG study team
TB vaccine development and the End TB Strategy: importance and current status. (2016)
Fletcher, Helen A; Schrager, Lewis
T-cell activation is an immune correlate of risk in BCG vaccinated infants. (2016)
Fletcher, Helen A; Snowden, Margaret A; Landry, Bernard; Rida, Wasima; Satti, Iman; Harris, Stephanie A; Matsumiya, Magali; Tanner, Rachel; O'Shea, Matthew K; Dheenadhayalan, Veerabadran; Bogardus, Leah; Stockdale, Lisa; Marsay, Leanne; Chomka, Agnieszka; Harrington-Kandt, Rachel; Manjaly-Thomas, Zita-Rose; Naranbhai, Vivek; Stylianou, Elena; Darboe, Fatoumatta; Penn-Nicholson, Adam; Nemes, Elisa; Hatherill, Mark; Hussey, Gregory; Mahomed, Hassan; Tameris, Michele; McClain, J Bruce; Evans, Thomas G; Hanekom, Willem A; Scriba, Thomas J; McShane, Helen
Investments in tuberculosis research - what are the gaps? (2016)
Khan, Mishal S; Fletcher, Helen; London School of Hygiene and Tropical Medicine TB Centre Steerin; Coker, Richard
World TB Day 2016: an interview with leading experts in tuberculosis research. (2016)
Phillips, Patrick PJ; Fletcher, Helen A; Abubakar, Ibrahim; Lipman, Marc CI; McHugh, Timothy D
The TB vaccine H56+IC31 dose-response curve is peaked not saturating: Data generation for new mathematical modelling methods to inform vaccine dose decisions. (2016)
Rhodes, Sophie J; Zelmer, Andrea; Knight, Gwenan M; Prabowo, Satria Arief; Stockdale, Lisa; Evans, Thomas G; Lindenstrøm, Thomas; White, Richard G; Fletcher, Helen
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Human Immunology of Tuberculosis. (2016)
Scriba, TJ; Coussens, AK; Fletcher, HA
Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants. (2016)
Smith, Steven G; Zelmer, Andrea; Blitz, Rose; Fletcher, Helen A; Dockrell, Hazel M
In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy. (2016)
Tanner, Rachel; O'Shea, Matthew K; Fletcher, Helen A; McShane, Helen
Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points. (2016)
Vainieri, Maria L; Blagborough, Andrew M; MacLean, Adam L; Haltalli, Myriam LR; Ruivo, Nicola; Fletcher, Helen A; Stumpf, Michael PH; Sinden, Robert E; Celso, Cristina Lo
A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis. (2016)
Zelmer, Andrea; Tanner, Rachel; Stylianou, Elena; Damelang, Timon; Morris, Sheldon; Izzo, Angelo; Williams, Ann; Sharpe, Sally; Pepponi, Ilaria; Walker, Barry; Hokey, David A; McShane, Helen; Brennan, Michael; Fletcher, Helen
2015
Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model. (2015)
Dunachie, Susanna; Berthoud, Tamara; Hill, Adrian VS; Fletcher, Helen A
Profiling the host response to malaria vaccination and malaria challenge. (2015)
Dunachie, Susanna; Hill, Adrian VS; Fletcher, Helen A
Profiling the host immune response to tuberculosis vaccines. (2015)
Fletcher, Helen A
T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients. (2015)
Jenjaroen, Kemajittra; Chumseng, Suchintana; Sumonwiriya, Manutsanun; Ariyaprasert, Pitchayanant; Chantratita, Narisara; Sunyakumthorn, Piyanate; Hongsuwan, Maliwan; Wuthiekanun, Vanaporn; Fletcher, Helen A; Teparrukkul, Prapit; Limmathurotsakul, Direk; Day, Nicholas PJ; Dunachie, Susanna J
Big Data in Vaccinology: Introduction and section summaries. (2015)
Kaufmann, Stefan HE; Fletcher, Helen A; Guzmán, Carlos A; Ottenhoff, Tom HM
Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes. (2015)
Naranbhai, Vivek; Fletcher, Helen A; Tanner, Rachel; O'Shea, Matthew K; McShane, Helen; Fairfax, Benjamin P; Knight, Julian C; Hill, Adrian VS
Individual-level factors associated with variation in mycobacterial-specific immune response: Gender and previous BCG vaccination status. (2015)
Rhodes, Sophie J; Knight, Gwenan M; Fielding, Katherine; Scriba, Thomas J; Pathan, Ansar A; McShane, Helen; Fletcher, Helen; White, Richard G
description
Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines. (2015)
Schito, Marco; Migliori, Giovanni Battista; Fletcher, Helen A; McNerney, Ruth; Centis, Rosella; D'Ambrosio, Lia; Bates, Matthew; Kibiki, Gibson; Kapata, Nathan; Corrah, Tumena; Bomanji, Jamshed; Vilaplana, Cris; Johnson, Daniel; Mwaba, Peter; Maeurer, Markus; Zumla, Alimuddin
Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines. (2015)
Smith, Steven G; Smits, Kaatje; Joosten, Simone A; van Meijgaarden, Krista E; Satti, Iman; Fletcher, Helen A; Caccamo, Nadia; Dieli, Francesco; Mascart, Francoise; McShane, Helen; Dockrell, Hazel M; Ottenhoff, Tom HM; TBVI TB Biomarker Working Group
2014
TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'. (2014)
Dutruel, Céline; Thole, Jelle; Geels, Mark; Mollenkopf, Hans-Joachim; Ottenhoff, Tom; Guzman, Carlos A; Fletcher, Helen A; Leroy, Odile; Kaufmann, Stefan HE
Process of assay selection and optimization for the study of case and control samples from a phase IIb efficacy trial of a candidate tuberculosis vaccine, MVA85A. (2014)
Harris, Stephanie A; Satti, Iman; Matsumiya, Magali; Stockdale, Lisa; Chomka, Agnieszka; Tanner, Rachel; O'Shea, Matthew K; Manjaly Thomas, Zita-Rose; Tameris, Michele; Mahomed, Hassan; Scriba, Thomas J; Hanekom, Willem A; Fletcher, Helen A; McShane, Helen
Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response. (2014)
Matsumiya, Magali; Harris, Stephanie A; Satti, Iman; Stockdale, Lisa; Tanner, Rachel; O'Shea, Matthew K; Tameris, Michelle; Mahomed, Hassan; Hatherill, Mark; Scriba, Thomas J; Hanekom, Willem A; McShane, Helen; Fletcher, Helen A
Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model. (2014)
Matsumiya, Magali; Satti, Iman; Chomka, Agnieszka; Harris, Stephanie A; Stockdale, Lisa; Meyer, Joel; Fletcher, Helen A; McShane, Helen
The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life. (2014)
Naranbhai, Vivek; Kim, Soyeon; Fletcher, Helen; Cotton, Mark F; Violari, Avy; Mitchell, Charles; Nachman, Sharon; McSherry, George; McShane, Helen; Hill, Adrian VS; Madhi, Shabir A
The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women. (2014)
Naranbhai, Vivek; Moodley, Dhayendre; Chipato, Tsungai; Stranix-Chibanda, Lynda; Nakabaiito, Clemensia; Kamateeka, Moreen; Musoke, Philippa; Manji, Karim; George, Kathleen; Emel, Lynda M; Richardson, Paul; Andrew, Philip; Fowler, MaryGlenn; Fletcher, Helen; McShane, Helen; Coovadia, Hoosen M; Hill, Adrian VS; HPTN 046 Protocol Team
Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A. (2014)
Tanner, Rachel; Kakalacheva, Kristina; Miller, Ellen; Pathan, Ansar A; Chalk, Rod; Sander, Clare R; Scriba, Tom; Tameris, Michelle; Hawkridge, Tony; Mahomed, Hassan; Hussey, Greg; Hanekom, Willem; Checkley, Anna; McShane, Helen; Fletcher, Helen A
2013
Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG. (2013)
Fletcher, Helen A; Tanner, Rachel; Wallis, Robert S; Meyer, Joel; Manjaly, Zita-Rose; Harris, Stephanie; Satti, Iman; Silver, Richard F; Hoft, Dan; Kampmann, Beate; Walker, K Barry; Dockrell, Hazel M; Fruth, Uli; Barker, Lew; Brennan, Michael J; McShane, Helen
Cholera toxin enhances vaccine-induced protection against Mycobacterium tuberculosis challenge in mice. (2013)
Griffiths, Kristin L; Stylianou, Elena; Poyntz, Hazel C; Betts, Gareth J; Fletcher, Helen A; McShane, Helen
Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate tuberculosis vaccine, MVA85A, alone and in combination. (2013)
Harris, Stephanie A; Meyer, Joel; Satti, Iman; Marsay, Leanne; Poulton, Ian D; Tanner, Rachel; Minassian, Angela M; Fletcher, Helen A; McShane, Helen
A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis. (2013)
Joosten, Simone A; Fletcher, Helen A; Ottenhoff, Tom HM
Mycobacterial growth inhibition in murine splenocytes as a surrogate for protection against Mycobacterium tuberculosis (M. tb). (2013)
Marsay, Leanne; Matsumiya, Magali; Tanner, Rachel; Poyntz, Hazel; Griffiths, Kristin L; Stylianou, Elena; Marsh, Philip D; Williams, Ann; Sharpe, Sally; Fletcher, Helen; McShane, Helen
Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A. (2013)
Matsumiya, Magali; Stylianou, Elena; Griffiths, Kristin; Lang, Zoe; Meyer, Joel; Harris, Stephanie A; Rowland, Rosalind; Minassian, Angela M; Pathan, Ansar A; Fletcher, Helen; McShane, Helen
Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery. (2013)
Meyer, Joel; Harris, Stephanie A; Satti, Iman; Poulton, Ian D; Poyntz, Hazel C; Tanner, Rachel; Rowland, Rosalind; Griffiths, Kristin L; Fletcher, Helen A; McShane, Helen
Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy. (2013)
Naranbhai, Vivek; Hill, Adrian VS; Abdool Karim, Salim S; Naidoo, Kogieleum; Abdool Karim, Quarraisha; Warimwe, George M; McShane, Helen; Fletcher, Helen
Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data. (2013)
Warimwe, George M; Fletcher, Helen A; Olotu, Ally; Agnandji, Selidji T; Hill, Adrian VS; Marsh, Kevin; Bejon, Philip
The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children. (2013)
Warimwe, George M; Murungi, Linda M; Kamuyu, Gathoni; Nyangweso, George M; Wambua, Juliana; Naranbhai, Vivek; Fletcher, Helen A; Hill, Adrian VS; Bejon, Philip; Osier, Faith HA; Marsh, Kevin
2012
Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults. (2012)
Pathan, Ansar A; Minassian, Angela M; Sander, Clare R; Rowland, Rosalind; Porter, David W; Poulton, Ian D; Hill, Adrian VS; Fletcher, Helen A; McShane, Helen
2011
Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1. (2011)
Berthoud, Tamara K; Hamill, Matthew; Lillie, Patrick J; Hwenda, Lenias; Collins, Katharine A; Ewer, Katie J; Milicic, Anita; Poyntz, Hazel C; Lambe, Teresa; Fletcher, Helen A; Hill, Adrian VS; Gilbert, Sarah C
Th1/Th17 cell induction following vaccination with the novel tuberculosis vaccine MVA85A and their role in Mycobacterium tuberculosis challenge
CD4 T cell response to MVA85A vaccination against Mycobacterium tuberculosis in healthy HIV-infected adults SO IMMUNOLOGY CT Annual Congress of the British-Society-for-Immunology CY DEC 05-08, 2011 CL Liverpool, ENGLAND SP British Soc Immunol. (2011)
Griffiths, K; Stylianou, E; Poyntz, H; Betts, G; Fletcher, H; McShane, H; Beveridge, N; Minassian, A; Rowland, R; Poulton, I; Satti, I; Harris, S; Poyntz, H; Hamill, M; Griffiths, K; Sander, C; Ambrozak, D; Price, D; Hill, B; Casazza, J; Douek, D; Koup, R; Roederer, M; Winston, A; Ross, J; Sherrad, J; Rooney, G; Williams, N; Lawrie, A; Fletcher, H; Pathan, A; McShane, H
Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. (2011)
Griffiths, Kristin L; Pathan, Ansar A; Minassian, Angela M; Sander, Clare R; Beveridge, Natalie ER; Hill, Adrian VS; Fletcher, Helen A; McShane, Helen
A molecular assay for sensitive detection of pathogen-specific T-cells. (2011)
Kasprowicz, Victoria O; Mitchell, Jessica E; Chetty, Shivan; Govender, Pamla; Huang, Kuan-Hsiang Gary; Fletcher, Helen A; Webster, Daniel P; Brown, Sebastian; Kasmar, Anne; Millington, Kerry; Day, Cheryl L; Mkhwanazi, Nompumelelo; McClurg, Cheryl; Chonco, Fundisiwe; Lalvani, Ajit; Walker, Bruce D; Ndung'u, Thumbi; Klenerman, Paul
A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults. (2011)
Minassian, Angela M; Rowland, Rosalind; Beveridge, Natalie ER; Poulton, Ian D; Satti, Iman; Harris, Stephanie; Poyntz, Hazel; Hamill, Matthew; Griffiths, Kristin; Sander, Clare R; Ambrozak, David R; Price, David A; Hill, Brenna J; Casazza, Joseph P; Douek, Daniel C; Koup, Richard A; Roederer, Mario; Winston, Alan; Ross, Jonathan; Sherrard, Jackie; Rooney, Guy; Williams, Nicola; Lawrie, Alison M; Fletcher, Helen A; Pathan, Ansar A; McShane, Helen
Single Nucleotide Polymorphisms in the Toll-Like Receptor 3 and CD44 Genes Are Associated with Persistence of Vaccine-Induced Immunity to the Serogroup C Meningococcal Conjugate Vaccine. (2011)
Moore, CE; Hennig, BJ; Perrett, KP; Hoe, JC; Lee, SJ; Fletcher, H; Brocklebank, D; O'Connor, D; Snape, MD; Hall, AJ; Segal, S; Hill, AVS; Pollard, AJ
2010
MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy. (2010)
Dunachie, Susanna J; Berthoud, Tamara; Keating, Sheila M; Hill, Adrian VS; Fletcher, Helen A
Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal. (2010)
Lienhardt, Christian; Fielding, Katherine; Hane, Abdoul A; Niang, Aliou; Ndao, Cheikh T; Karam, Farba; Fletcher, Helen; Mbow, Fatou; Gomis, Jules-François; Diadhiou, Raymond; Toupane, Maxime; Dieye, Tandakha; Mboup, Souleymane
Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A. (2010)
de Cassan, Simone C; Pathan, Ansar A; Sander, Clare R; Minassian, Angela; Rowland, Rosalind; Hill, Adrian VS; McShane, Helen; Fletcher, Helen A
2009
MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines. (2009)
Berthoud, Tamara K; Dunachie, Susanna J; Todryk, Stephen; Hill, Adrian VS; Fletcher, Helen A
Comparing human T cell and NK cell responses in viral-based malaria vaccine trials. (2009)
Berthoud, Tamara K; Fletcher, Helen; Porter, David; Thompson, Fiona; Hill, Adrian VS; Todryk, Stephen M
A New Vaccine for Tuberculosis: The Challenges of Development and Deployment. (2009)
Fletcher, Helen A; Hawkridge, Tony; McShane, Helen
Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth. (2009)
Fletcher, Helen A; Keyser, Alana; Bowmaker, Mark; Sayles, Peter C; Kaplan, Gilla; Hussey, Greg; Hill, Adrian VS; Hanekom, Willem A
Quantitative PCR evaluation of cellular immune responses in Kenyan children vaccinated with a candidate malaria vaccine. (2009)
Mwacharo, Jedidah; Dunachie, Susanna J; Kai, Oscar; Hill, Adrian VS; Bejon, Philip; Fletcher, Helen A
Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A. (2009)
Whelan, Kathryn T; Pathan, Ansar A; Sander, Clare R; Fletcher, Helen A; Poulton, Ian; Alder, Nicola C; Hill, Adrian VS; McShane, Helen
2008
A comparison of IFNgamma detection methods used in tuberculosis vaccine trials. (2008)
Beveridge, Natalie ER; Fletcher, Helen A; Hughes, Jane; Pathan, Ansar A; Scriba, Thomas J; Minassian, Angela; Sander, Clare R; Whelan, Kathryn T; Dockrell, Hazel M; Hill, Adrian VS; Hanekom, Willem A; McShane, Helen
Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa. (2008)
Brookes, Roger H; Hill, Philip C; Owiafe, Patrick K; Ibanga, Hannah B; Jeffries, David J; Donkor, Simon A; Fletcher, Helen A; Hammond, Abdulrahman S; Lienhardt, Christian; Adegbola, Richard A; McShane, Helen; Hill, Adrian VS
Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1. (2008)
Fletcher, Helen A; Pathan, Ansar A; Berthoud, Tamara K; Dunachie, Susanna J; Whelan, Kathryn T; Alder, Nicola C; Sander, Clare R; Hill, Adrian VS; McShane, Helen
Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations. (2008)
Hanekom, Willem A; Dockrell, Hazel M; Ottenhoff, Tom HM; Doherty, T Mark; Fletcher, Helen; McShane, Helen; Weichold, Frank F; Hoft, Dan F; Parida, Shreemanta K; Fruth, Uli J
Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa. (2008)
Hawkridge, Tony; Scriba, Thomas J; Gelderbloem, Sebastian; Smit, Erica; Tameris, Michele; Moyo, Sizulu; Lang, Trudie; Veldsman, Ashley; Hatherill, Mark; Merwe, Linda van der; Fletcher, Helen A; Mahomed, Hassan; Hill, Adrian VS; Hanekom, Willem A; Hussey, Gregory D; McShane, Helen
Sensitivity of IFN-gamma release assay to detect latent tuberculosis infection is retained in HIV-infected patients but dependent on HIV/AIDS progression. (2008)
Karam, Farba; Mbow, Fatou; Fletcher, Helen; Senghor, Cheikh S; Coulibaly, Koura D; LeFevre, Andrea M; Ngom Gueye, Ndeye F; Dieye, Tandakha; Sow, Papa S; Mboup, Souleymane; Lienhardt, Christian
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2007
Correlates of immune protection from tuberculosis. (2007)
Fletcher, Helen A
Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials. (2007)
Pathan, Ansar A; Sander, Clare R; Fletcher, Helen A; Poulton, Ian; Alder, Nicola C; Beveridge, Natalie ER; Whelan, Kathryn T; Hill, Adrian VS; McShane, Helen
2006
Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis. (2006)
Demissie, Abebech; Leyten, Eliane MS; Abebe, Markos; Wassie, Liya; Aseffa, Abraham; Abate, Getahun; Fletcher, Helen; Owiafe, Patrick; Hill, Philip C; Brookes, Roger; Rook, Graham; Zumla, Alimuddin; Arend, Sandra M; Klein, Michel; Ottenhoff, Tom HM; Andersen, Peter; Doherty, T Mark; VACSEL Study Group
Tuberculosis vaccines: current status and future prospects. (2006)
Fletcher, Helen; McShane, Helen
Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design. (2006)
Ibanga, Hannah B; Brookes, Roger H; Hill, Philip C; Owiafe, Patrick K; Fletcher, Helen A; Lienhardt, Christian; Hill, Adrian VS; Adegbola, Richard A; McShane, Helen
New tuberculosis vaccines can diminish as well as enhance BCG induced protection: Results from a murine model SO THORAX CT Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF). (2006)
Sander, CR; Tchilian, E; Dahm-Vicker, M; Fletcher, H; McShane, H; Hill, AVS
2005
Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials. (2005)
McShane, Helen; Pathan, Ansar A; Sander, Clare R; Goonetilleke, Nilu P; Fletcher, Helen A; Hill, Adrian VS
Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. (2005)
Walther, Michael; Tongren, Jon Eric; Andrews, Laura; Korbel, Daniel; King, Elizabeth; Fletcher, Helen; Andersen, Rikke F; Bejon, Philip; Thompson, Fiona; Dunachie, Susanna J; Edele, Fanny; de Souza, J Brian; Sinden, Robert E; Gilbert, Sarah C; Riley, Eleanor M; Hill, Adrian VS
2004
Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2. (2004)
Demissie, Abebech; Abebe, Markos; Aseffa, Abraham; Rook, Graham; Fletcher, Helen; Zumla, Alimuddin; Weldingh, Karin; Brock, Inger; Andersen, Peter; Doherty, T Mark; VACSEL Study Group
Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation. (2004)
Fletcher, Helen A; Owiafe, Patrick; Jeffries, David; Hill, Philip; Rook, Graham AW; Zumla, Alimuddin; Doherty, T Mark; Brookes, Roger H; Vacsel Study Group
Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. (2004)
McShane, Helen; Pathan, Ansar A; Sander, Clare R; Keating, Sheila M; Gilbert, Sarah C; Huygen, Kris; Fletcher, Helen A; Hill, Adrian VS
2003
Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians. (2003)
Fletcher, Helen A; Donoghue, Helen D; Holton, John; Pap, Ildikó; Spigelman, Mark
Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians. (2003)
Fletcher, Helen A; Donoghue, Helen D; Taylor, G Michael; van der Zanden, Adri GM; Spigelman, Mark
2002
The prospective evaluation of a nested polymerase chain reaction assay for the early detection of Aspergillus infection in patients with leukaemia or undergoing allograft treatment. (2002)
Ferns, R Bridget; Fletcher, Helen; Bradley, Susan; Mackinnon, Stephen; Hunt, Chris; Tedder, Richard S
Identification of Pneumocystis carinii DNA by polymerase chain reaction in necropsy lung samples from children dying of respiratory tract illnesses. (2002)
Kasolo, Francis; Lishimpi, Kennedy; Chintu, Chifumbe; Mwaba, Peter; Mudenda, Victor; Maswahu, Daniel; Terunuma, Hiroshi; Fletcher, Helen; Nunn, Andrew; Lucas, Sebastian; Zumla, Alimuddin