Items where Author is "Douglas, I"

Year Item Type Full Text

2022

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform. (2022) Bhaskaran, Krishnan; Rentsch, Christopher T; Hickman, George; Hulme, William J; Schultze, Anna; Curtis, Helen J; Wing, Kevin; Warren-Gash, Charlotte; Tomlinson, Laurie; Bates, Chris J; Mathur, Rohini; MacKenna, Brian; Mahalingasivam, Viyaasan; Wong, Angel; Walker, Alex J; Morton, Caroline E; Grint, Daniel; Mehrkar, Amir; Eggo, Rosalind M; Inglesby, Peter; Douglas, Ian J; McDonald, Helen I; Cockburn, Jonathan; Williamson, Elizabeth J; Evans, David; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen Jw; Bacon, Sebastian; Smeeth, Liam; Goldacre, Ben

Recording of 'COVID-19 vaccine declined': a cohort study on 57.9 million National Health Service patients' records in situ using OpenSAFELY, England, 8 December 2020 to 25 May 2021. (2022) Curtis, Helen J; Inglesby, Peter; MacKenna, Brian; Croker, Richard; Hulme, William J; Rentsch, Christopher T; Bhaskaran, Krishnan; Mathur, Rohini; Morton, Caroline E; Bacon, Sebastian Cj; Smith, Rebecca M; Evans, David; Mehrkar, Amir; Tomlinson, Laurie; Walker, Alex J; Bates, Christopher; Hickman, George; Ward, Tom; Morley, Jessica; Cockburn, Jonathan; Davy, Simon; Williamson, Elizabeth J; Eggo, Rosalind M; Parry, John; Hester, Frank; Harper, Sam; O'Hanlon, Shaun; Eavis, Alex; Jarvis, Richard; Avramov, Dima; Griffiths, Paul; Fowles, Aaron; Parkes, Nasreen; Evans, Stephen Jw; Douglas, Ian J; Smeeth, Liam; Goldacre, Ben

Comparative effectiveness of ChAdOx1 versus BNT162b2 covid-19 vaccines in health and social care workers in England: cohort study using OpenSAFELY. (2022) Hulme, William J; Williamson, Elizabeth J; Green, Amelia CA; Bhaskaran, Krishnan; McDonald, Helen I; Rentsch, Christopher T; Schultze, Anna; Tazare, John; Curtis, Helen J; Walker, Alex J; Tomlinson, Laurie A; Palmer, Tom; Horne, Elsie MF; MacKenna, Brian; Morton, Caroline E; Mehrkar, Amir; Morley, Jessica; Fisher, Louis; Bacon, Sebastian CJ; Evans, David; Inglesby, Peter; Hickman, George; Davy, Simon; Ward, Tom; Croker, Richard; Eggo, Rosalind M; Wong, Angel YS; Mathur, Rohini; Wing, Kevin; Forbes, Harriet; Grint, Daniel J; Douglas, Ian J; Evans, Stephen JW; Smeeth, Liam; Bates, Chris; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Sterne, Jonathan AC; Hernán, Miguel A; Goldacre, Ben

Risk of severe COVID-19 outcomes associated with immune-mediated inflammatory diseases and immune-modifying therapies: a nationwide cohort study in the OpenSAFELY platform. (2022) MacKenna, Brian; Kennedy, Nicholas A; Mehrkar, Amir; Rowan, Anna; Galloway, James; Matthewman, Julian; Mansfield, Kathryn E; Bechman, Katie; Yates, Mark; Brown, Jeremy; Schultze, Anna; Norton, Sam; Walker, Alex J; Morton, Caroline E; Harrison, David; Bhaskaran, Krishnan; Rentsch, Christopher T; Williamson, Elizabeth; Croker, Richard; Bacon, Seb; Hickman, George; Ward, Tom; Davy, Simon; Green, Amelia; Fisher, Louis; Hulme, William; Bates, Chris; Curtis, Helen J; Tazare, John; Eggo, Rosalind M; Evans, David; Inglesby, Peter; Cockburn, Jonathan; McDonald, Helen I; Tomlinson, Laurie A; Mathur, Rohini; Wong, Angel YS; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian J; Smeeth, Liam; Lees, Charlie W; Evans, Stephen JW; Goldacre, Ben; Smith, Catherine H; Langan, Sinéad M

Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY. (2022) OpenSAFELY Collaborative; Green, Amelia; Curtis, Helen; Hulme, William; Williamson, Elizabeth; McDonald, Helen; Bhaskaran, Krishnan; Rentsch, Christopher; Schultze, Anna; MacKenna, Brian; Mahalingasivam, Viyaasan; Tomlinson, Laurie; Walker, Alex; Fisher, Louis; Massey, Jon; Andrews, Colm; Hopcroft, Lisa; Morton, Caroline; Croker, Richard; Morley, Jessica; Mehrkar, Amir; Bacon, Seb; Evans, David; Inglesby, Peter; Hickman, George; Ward, Tom; Davy, Simon; Mathur, Rohini; Tazare, John; Eggo, Rosalind; Wing, Kevin; Wong, Angel; Forbes, Harriet; Bates, Chris; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian; Evans, Stephen; Smeeth, Liam; Goldacre, Ben

Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic: an observational study of 4.3 million adults over the age of 65. (2022) Schultze, Anna; Nightingale, Emily; Evans, David; Hulme, William; Rosello, Alicia; Bates, Chris; Cockburn, Jonathan; MacKenna, Brian; Curtis, Helen J; Morton, Caroline E; Croker, Richard; Bacon, Seb; McDonald, Helen I; Rentsch, Christopher T; Bhaskaran, Krishnan; Mathur, Rohini; Tomlinson, Laurie A; Williamson, Elizabeth J; Forbes, Harriet; Tazare, John; Grint, Daniel; Walker, Alex J; Inglesby, Peter; DeVito, Nicholas J; Mehrkar, Amir; Hickman, George; Davy, Simon; Ward, Tom; Fisher, Louis; Green, Amelia Ca; Wing, Kevin; Wong, Angel Ys; McManus, Robert; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen Jw; Douglas, Ian J; Smeeth, Liam; Eggo, Rosalind M; Goldacre, Ben; Leon, David A

High-dimensional propensity scores for data-driven confounder adjustment in UK electronic health records. (2022) Tazare, JR

Safety of COVID-19 vaccination and acute neurological events: A self-controlled case series in England using the OpenSAFELY platform. (2022) Walker, Jemma L; Schultze, Anna; Tazare, John; Tamborska, Arina; Singh, Bhagteshwar; Donegan, Katherine; Stowe, Julia; Morton, Caroline E; Hulme, William J; Curtis, Helen J; Williamson, Elizabeth J; Mehrkar, Amir; Eggo, Rosalind M; Rentsch, Christopher T; Mathur, Rohini; Bacon, Sebastian; Walker, Alex J; Davy, Simon; Evans, David; Inglesby, Peter; Hickman, George; MacKenna, Brian; Tomlinson, Laurie; Ca Green, Amelia; Fisher, Louis; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Bates, Christopher; Evans, Stephen Jw; Solomon, Tom; Andrews, Nick J; Douglas, Ian J; Goldacre, Ben; Smeeth, Liam; McDonald, Helen I

Association between household composition and severe COVID-19 outcomes in older people by ethnicity: an observational cohort study using the OpenSAFELY platform. (2022) Wing, Kevin; Grint, Daniel J; Mathur, Rohini; Gibbs, Hamish P; Hickman, George; Nightingale, Emily; Schultze, Anna; Forbes, Harriet; Nafilyan, Vahé; Bhaskaran, Krishnan; Williamson, Elizabeth; House, Thomas; Pellis, Lorenzo; Herrett, Emily; Gautam, Nileesa; Curtis, Helen J; Rentsch, Christopher T; Wong, Angel YS; MacKenna, Brian; Mehrkar, Amir; Bacon, Seb; Douglas, Ian J; Evans, Stephen JW; Tomlinson, Laurie; Goldacre, Ben; Eggo, Rosalind M

Association between oral anticoagulants and COVID-19-related outcomes: a population-based cohort study. (2022) Wong, Angel Ys; Tomlinson, Laurie; Brown, Jeremy P; Elson, William; Walker, Alex J; Schultze, Anna; Morton, Caroline E; Evans, David; Inglesby, Peter; MacKenna, Brian; Bhaskaran, Krishnan; Rentsch, Christopher T; Powell, Emma; Williamson, Elizabeth; Croker, Richard; Bacon, Seb; Hulme, William; Bates, Chris; Curtis, Helen J; Mehrkar, Amir; Cockburn, Jonathan; McDonald, Helen I; Mathur, Rohini; Wing, Kevin; Forbes, Harriet; Eggo, Rosalind M; Evans, Stephen Jw; Smeeth, Liam; Goldacre, Ben; Douglas, Ian J; (The OpenSAFELY Collaborative)

Frailty and rate of fractures in patients initiating antihypertensive medications: a cohort study in primary care. (2022) Österdahl, Marc F; Sinnott, Sarah-Jo; Douglas, Ian; Clegg, Andrew; Tomlinson, Laurie; Wong, Angel

2021

Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform. (2021) Bhaskaran, Krishnan; Bacon, Sebastian; Evans, Stephen Jw; Bates, Chris J; Rentsch, Christopher T; MacKenna, Brian; Tomlinson, Laurie; Walker, Alex J; Schultze, Anna; Morton, Caroline E; Grint, Daniel; Mehrkar, Amir; Eggo, Rosalind M; Inglesby, Peter; Douglas, Ian J; McDonald, Helen I; Cockburn, Jonathan; Williamson, Elizabeth J; Evans, David; Curtis, Helen J; Hulme, William J; Parry, John; Hester, Frank; Harper, Sam; Spiegelhalter, David; Smeeth, Liam; Goldacre, Ben

Protocol for an observational cohort study investigating personalised medicine for intensification of treatment in people with type 2 diabetes mellitus: the PERMIT study. (2021) Bidulka, Patrick; O'Neill, Stephen; Basu, Anirban; Wilkinson, Samantha; Silverwood, Richard J; Charlton, Paul; Briggs, Andrew; Adler, Amanda I; Khunti, Kamlesh; Tomlinson, Laurie A; Smeeth, Liam; Douglas, Ian J; Grieve, Richard

Proton pump inhibitors and risk of all-cause and cause-specific mortality: A cohort study. (2021) Brown, Jeremy P; Tazare, John R; Williamson, Elizabeth; Mansfield, Kathryn E; Evans, Stephen J; Tomlinson, Laurie A; Bhaskaran, Krishnan; Smeeth, Liam; Wing, Kevin; Douglas, Ian J

Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients’ primary care records in situ using OpenSAFELY. (2021) Curtis, Helen J; Inglesby, Peter; Morton, Caroline E; MacKenna, Brian; Green, Amelia; Hulme, William; Walker, Alex J; Morley, Jessica; Mehrkar, Amir; Bacon, Seb; Hickman, George; Bates, Chris; Croker, Richard; Evans, David; Ward, Tom; Cockburn, Jonathan; Davy, Simon; Bhaskaran, Krishnan; Schultze, Anna; Rentsch, Christopher T; Williamson, Elizabeth J; Rowan, Anna; Fisher, Louis; McDonald, Helen I; Tomlinson, Laurie; Mathur, Rohini; Drysdale, Henry; Eggo, Rosalind M; Wing, Kevin; Wong, Angel Ys; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; O'Hanlon, Shaun; Eavis, Alex; Jarvis, Richard; Avramov, Dima; Griffiths, Paul; Fowles, Aaron; Parkes, Nasreen; Douglas, Ian J; Evans, Stephen Jw; Smeeth, Liam; Goldacre, Ben; (The OpenSAFELY Collaborative)

OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19. (2021) Curtis, Helen J; MacKenna, Brian; Croker, Richard; Inglesby, Peter; Walker, Alex J; Morley, Jessica; Mehrkar, Amir; Morton, Caroline E; Bacon, Seb; Hickman, George; Bates, Chris; Evans, David; Ward, Tom; Cockburn, Jonathan; Davy, Simon; Bhaskaran, Krishnan; Schultze, Anna; Rentsch, Christopher T; Williamson, Elizabeth J; Hulme, William J; McDonald, Helen I; Tomlinson, Laurie; Mathur, Rohini; Drysdale, Henry; Eggo, Rosalind M; Wing, Kevin; Wong, Angel Ys; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen Jw; Douglas, Ian J; Smeeth, Liam; Goldacre, Ben; (The OpenSAFELY Collaborative)

Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England. (2021) Forbes, Harriet; Morton, Caroline E; Bacon, Seb; McDonald, Helen I; Minassian, Caroline; Brown, Jeremy P; Rentsch, Christopher T; Mathur, Rohini; Schultze, Anna; DeVito, Nicholas J; MacKenna, Brian; Hulme, William J; Croker, Richard; Walker, Alex J; Williamson, Elizabeth J; Bates, Chris; Mehrkar, Amir; Curtis, Helen J; Evans, David; Wing, Kevin; Inglesby, Peter; Drysdale, Henry; Wong, Angel YS; Cockburn, Jonathan; McManus, Robert; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian J; Smeeth, Liam; Evans, Stephen JW; Bhaskaran, Krishnan; Eggo, Rosalind M; Goldacre, Ben; Tomlinson, Laurie A

Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England. (2021) Grint, Daniel J; Wing, Kevin; Houlihan, Catherine; Gibbs, Hamish P; Evans, Stephen JW; Williamson, Elizabeth; McDonald, Helen I; Bhaskaran, Krishnan; Evans, David; Walker, Alex J; Hickman, George; Nightingale, Emily; Schultze, Anna; Rentsch, Christopher T; Bates, Chris; Cockburn, Jonathan; Curtis, Helen J; Morton, Caroline E; Bacon, Sebastian; Davy, Simon; Wong, Angel YS; Mehrkar, Amir; Tomlinson, Laurie; Douglas, Ian J; Mathur, Rohini; MacKenna, Brian; Ingelsby, Peter; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; DeVito, Nicholas J; Hulme, Will; Tazare, John; Smeeth, Liam; Goldacre, Ben; Eggo, Rosalind M

Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February. (2021) Grint, Daniel J; Wing, Kevin; Williamson, Elizabeth; McDonald, Helen I; Bhaskaran, Krishnan; Evans, David; Evans, Stephen Jw; Walker, Alex J; Hickman, George; Nightingale, Emily; Schultze, Anna; Rentsch, Christopher T; Bates, Chris; Cockburn, Jonathan; Curtis, Helen J; Morton, Caroline E; Bacon, Sebastian; Davy, Simon; Wong, Angel Ys; Mehrkar, Amir; Tomlinson, Laurie; Douglas, Ian J; Mathur, Rohini; Blomquist, Paula; MacKenna, Brian; Ingelsby, Peter; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; DeVito, Nicholas J; Hulme, Will; Tazare, John; Goldacre, Ben; Smeeth, Liam; Eggo, Rosalind M

Blood cholesterol and risk of dementia in more than 1·8 million people over two decades: a retrospective cohort study. (2021) Iwagami, Masao; Qizilbash, Nawab; Gregson, John; Douglas, Ian; Johnson, Michelle; Pearce, Neil; Evans, Stephen; Pocock, Stuart

Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform. (2021) Mathur, Rohini; Rentsch, Christopher T; Morton, Caroline E; Hulme, William J; Schultze, Anna; MacKenna, Brian; Eggo, Rosalind M; Bhaskaran, Krishnan; Wong, Angel YS; Williamson, Elizabeth J; Forbes, Harriet; Wing, Kevin; McDonald, Helen I; Bates, Chris; Bacon, Seb; Walker, Alex J; Evans, David; Inglesby, Peter; Mehrkar, Amir; Curtis, Helen J; DeVito, Nicholas J; Croker, Richard; Drysdale, Henry; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian J; Tomlinson, Laurie; Evans, Stephen JW; Grieve, Richard; Harrison, David; Rowan, Kathy; Khunti, Kamlesh; Chaturvedi, Nishi; Smeeth, Liam; Goldacre, Ben

OpenSAFELY: impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic. (2021) OpenSAFELY Collaborative; Curtis, Helen J; MacKenna, Brian; Walker, Alex J; Croker, Richard; Mehrkar, Amir; Morton, Caroline; Bacon, Seb; Hickman, George; Inglesby, Peter; Bates, Chris; Evans, David; Ward, Tom; Cockburn, Jonathan; Davy, Simon; Bhaskaran, Krishnan; Schultze, Anna; Rentsch, Christopher T; Williamson, Elizabeth; Hulme, William; Tomlinson, Laurie; Mathur, Rohini; Drysdale, Henry; Eggo, Rosalind M; Wong, Angel Yun; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian; Smeeth, Liam; Goldacre, Ben

Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants: population-based cohort study. (2021) OpenSAFELY Collaborative; Wong, Angel YS; Tomlinson, Laurie A; Brown, Jeremy P; Elson, William; Walker, Alex J; Schultze, Anna; Morton, Caroline E; Evans, David; Inglesby, Peter; MacKenna, Brian; Bhaskaran, Krishnan; Rentsch, Christopher T; Powell, Emma; Williamson, Elizabeth; Croker, Richard; Bacon, Seb; Hulme, William; Bates, Chris; Curtis, Helen J; Mehrkar, Amir; Cockburn, Jonathan; McDonald, Helen I; Mathur, Rohini; Wing, Kevin; Forbes, Harriet; Eggo, Rosalind M; Evans, Stephen JW; Smeeth, Liam; Goldacre, Ben; Douglas, Ian J

Real-world effects of medications for stroke prevention in atrial fibrillation: protocol for a UK population-based non-interventional cohort study with validation against randomised trial results. (2021) Powell, Emma Maud; Douglas, Ian J; Gungabissoon, Usha; Smeeth, Liam; Wing, Kevin

Unicompartmental compared with total knee replacement for patients with multimorbidities: a cohort study using propensity score stratification and inverse probability weighting. (2021) Prats-Uribe, Albert; Kolovos, Spyros; Berencsi, Klara; Carr, Andrew; Judge, Andrew; Silman, Alan; Arden, Nigel; Petersen, Irene; Douglas, Ian J; Wilkinson, J Mark; Murray, David; Valderas, Jose M; Beard, David J; Lamb, Sarah E; Ali, M Sanni; Pinedo-Villanueva, Rafael; Strauss, Victoria Y; Prieto-Alhambra, Daniel

Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study. (2021) Rentsch, Christopher T; Beckman, Joshua A; Tomlinson, Laurie; Gellad, Walid F; Alcorn, Charles; Kidwai-Khan, Farah; Skanderson, Melissa; Brittain, Evan; King, Joseph T; Ho, Yuk-Lam; Eden, Svetlana; Kundu, Suman; Lann, Michael F; Greevy, Robert A; Ho, P Michael; Heidenreich, Paul A; Jacobson, Daniel A; Douglas, Ian J; Tate, Janet P; Evans, Stephen JW; Atkins, David; Justice, Amy C; Freiberg, Matthew S

Hydroxychloroquine treatment does not reduce COVID-19 mortality; underdosing to the wrong patients? - Authors' reply. (2021) Rentsch, Christopher T; DeVito, Nicholas J; MacKenna, Brian; Morton, Caroline E; Bhaskaran, Krishnan; Brown, Jeremy P; Schultze, Anna; Hulme, William J; Croker, Richard; Walker, Alex J; Williamson, Elizabeth J; Bates, Chris; Bacon, Seb; Mehrkar, Amir; Curtis, Helen J; Evans, David; Wing, Kevin; Inglesby, Peter; Mathur, Rohini; Drysdale, Henry; Wong, Angel YS; McDonald, Helen I; Cockburn, Jonathan; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Smeeth, Liam; Douglas, Ian J; Dixon, William G; Evans, Stephen JW; Tomlinson, Laurie; Goldacre, Ben

Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19: a descriptive cohort study within the OpenSAFELY platform. (2021) Tazare, John; Walker, Alex J; Tomlinson, Laurie; Hickman, George; Rentsch, Christopher T; Williamson, Elizabeth J; Bhaskaran, Krishnan; Evans, David; Wing, Kevin; Mathur, Rohini; Wong, Angel YS; Schultze, Anna; Bacon, Seb; Bates, Chris; Morton, Caroline E; Curtis, Helen J; Nightingale, Emily; McDonald, Helen I; Mehrkar, Amir; Inglesby, Peter; Davy, Simon; MacKenna, Brian; Cockburn, Jonathan; Hulme, William J; Warren-Gash, Charlotte; Bhate, Ketaki; Nitsch, Dorothea; Powell, Emma; Mulick, Amy; Forbes, Harriet; Minassian, Caroline; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Eggo, Rosalind M; Evans, Stephen JW; Smeeth, Liam; Douglas, Ian J; Goldacre, Ben

Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY. (2021) Walker, Alex J; MacKenna, Brian; Inglesby, Peter; Tomlinson, Laurie; Rentsch, Christopher T; Curtis, Helen J; Morton, Caroline E; Morley, Jessica; Mehrkar, Amir; Bacon, Seb; Hickman, George; Bates, Chris; Croker, Richard; Evans, David; Ward, Tom; Cockburn, Jonathan; Davy, Simon; Bhaskaran, Krishnan; Schultze, Anna; Williamson, Elizabeth J; Hulme, William J; McDonald, Helen I; Mathur, Rohini; Eggo, Rosalind M; Wing, Kevin; Wong, Angel Ys; Forbes, Harriet; Tazare, John; Parry, John; Hester, Frank; Harper, Sam; O'Hanlon, Shaun; Eavis, Alex; Jarvis, Richard; Avramov, Dima; Griffiths, Paul; Fowles, Aaron; Parkes, Nasreen; Douglas, Ian J; Evans, Stephen Jw; (The OpenSAFELY Collaborative)

Changes in the rate of cardiometabolic and pulmonary events during the COVID-19 pandemic. (2021) Walker, Alex J; Tazare, John; Hickman, George; Rentsch, Christopher T; Williamson, Elizabeth J; Bhaskaran, Krishnan; Evans, David; Wing, Kevin; Mathur, Rohini; Wong, Angel YS; Schultze, Anna; Bacon, Sebastian CJ; Bates, Chris; Morton, Caroline E; Curtis, Helen J; Nightingale, Emily; McDonald, Helen I; Mehrkar, Amir; Inglesby, Peter; MacKenna, Brian; Cockburn, Jonathan; Hulme, William J; Forbes, Harriet; Minassian, Caroline; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Eggo, Rosalind M; Evans, Stephen JW; Smeeth, Liam; Douglas, Ian J; Tomlinson, Laurie; Goldacre, Ben

UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records. (2021) Walker, Jemma L; Grint, Daniel J; Strongman, Helen; Eggo, Rosalind M; Peppa, Maria; Minassian, Caroline; Mansfield, Kathryn E; Rentsch, Christopher T; Douglas, Ian J; Mathur, Rohini; Wong, Angel YS; Quint, Jennifer K; Andrews, Nick; Bernal, Jamie Lopez; Scott, J Anthony; Ramsay, Mary; Smeeth, Liam; McDonald, Helen I

Risks of covid-19 hospital admission and death for people with learning disability: population based cohort study using the OpenSAFELY platform. (2021) Williamson, Elizabeth J; McDonald, Helen I; Bhaskaran, Krishnan; Walker, Alex J; Bacon, Sebastian; Davy, Simon; Schultze, Anna; Tomlinson, Laurie; Bates, Chris; Ramsay, Mary; Curtis, Helen J; Forbes, Harriet; Wing, Kevin; Minassian, Caroline; Tazare, John; Morton, Caroline E; Nightingale, Emily; Mehrkar, Amir; Evans, Dave; Inglesby, Peter; MacKenna, Brian; Cockburn, Jonathan; Rentsch, Christopher T; Mathur, Rohini; Wong, Angel YS; Eggo, Rosalind M; Hulme, William; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian J; Evans, Stephen JW; Smeeth, Liam; Goldacre, Ben; Kuper, Hannah

OpenSAFELY: Risks of COVID-19 hospital admission and death for people with learning disabilities - a cohort study. (2021) Williamson, Elizabeth J; McDonald, Helen I; Bhaskaran, Krishnan; Walker, Alex J; Bacon, Sebastian; Davy, Simon; Schultze, Anna; Tomlinson, Laurie; Bates, Chris; Ramsay, Mary; Curtis, Helen J; Forbes, Harriet; Wing, Kevin; Minassian, Caroline; Tazare, John; Morton, Caroline E; Nightingale, Emily; Mehrkar, Amir; Evans, Dave; Inglesby, Peter; MacKenna, Brian; Cockburn, Jonathan; Rentsch, Christopher T; Mathur, Rohini; Wong, Angel YS; Eggo, Rosalind M; Hulme, Will; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian J; Evans, Stephen JW; Smeeth, Liam; Goldacre, Ben; Kuper, Hannah

Predicting COVID-19 related death using the OpenSAFELY platform. (2021) Williamson, Elizabeth J; Tazare, John; Bhaskaran, Krishnan; McDonald, Helen I; Walker, Alex J; Tomlinson, Laurie; Wing, Kevin; Bacon, Sebastian; Bates, Chris; Curtis, Helen J; Forbes, Harriet; Minassian, Caroline; Morton, Caroline E; Nightingale, Emily; Mehrkar, Amir; Evans, Dave; Nicholson, Brian D; Leon, Dave; Inglesby, Peter; MacKenna, Brian; Davies, Nicholas G; DeVito, Nicholas J; Drysdale, Henry; Cockburn, Jonathan; Hulme, Will; Morley, Jess; Douglas, Ian; Rentsch, Christopher T; Mathur, Rohini; Wong, Angel; Schultze, Anna; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Grieve, Richard; Harrison, David A; Steyerberg, Ewout W; Eggo, Rosalind M; Diaz-Ordaz, Karla; Keogh, Ruth; Evans, Stephen JW; Smeeth, Liam; Goldacre, Ben

Medications for chronic obstructive pulmonary disease: a historical non-interventional cohort study with validation against RCT results. (2021) Wing, Kevin; Williamson, Elizabeth; Carpenter, James R; Wise, Lesley; Schneeweiss, Sebastian; Smeeth, Liam; Quint, Jennifer K; Douglas, Ian

Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19: an OpenSAFELY cohort analysis based on two cohorts. (2021) Wong, Angel Ys; MacKenna, Brian; Morton, Caroline E; Schultze, Anna; Walker, Alex J; Bhaskaran, Krishnan; Brown, Jeremy P; Rentsch, Christopher T; Williamson, Elizabeth; Drysdale, Henry; Croker, Richard; Bacon, Seb; Hulme, William; Bates, Chris; Curtis, Helen J; Mehrkar, Amir; Evans, David; Inglesby, Peter; Cockburn, Jonathan; McDonald, Helen I; Tomlinson, Laurie; Mathur, Rohini; Wing, Kevin; Forbes, Harriet; Eggo, Rosalind M; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen Jw; Smeeth, Liam; Douglas, Ian J; Goldacre, Ben; OpenSAFELY Collaborative

2020

Comparisons of Staphylococcus aureus infection and other outcomes between users of angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers: lessons for COVID-19 from a nationwide cohort study. (2020) Bidulka, Patrick; Iwagami, Masao; Mansfield, Kathryn E; Kalogirou, Fotini; Wong, Angel YS; Douglas, Ian J; Smeeth, Liam; Summers, Charlotte; Tomlinson, Laurie A

COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis. (2020) Boddington, Nicola L; Charlett, Andre; Elgohari, Suzanne; Walker, Jemma L; Mcdonald, Helen; Byers, Chloe; Coughlan, Laura; Garcia Vilaplana, Tatiana; Whillock, Rosie; Sinnathamby, Mary; Panagiotopoulos, Nikolaos; Letley, Louise; MacDonald, Pauline; Vivancos, Roberto; Edeghere, Obaghe; Shingleton, Joseph; Bennett, Emma; Grint, Daniel J; Strongman, Helen; Mansfield, Kathryn E; Rentsch, Christopher; Minassian, Caroline; Douglas, Ian J; Mathur, Rohini; Peppa, Maria; Cottrell, Simon; McMenamin, Jim; Zambon, Maria; Ramsay, Mary; Dabrera, Gavin; Saliba, Vanessa; Lopez Bernal, Jamie

OpenSAFELY: impact of national guidance on switching from warfarin to direct oral anticoagulants (DOACs) in early phase of COVID-19 pandemic in England. (2020) Curtis, Helen J; MacKenna, Brian; Walker, Alex J; Croker, Richard; Mehrkar, Amir; Morton, Caroline E; Bacon, Seb; Hickman, George; Inglesby, Peter; Bates, Chris; Evans, David; Ward, Tom; Cockburn, Jonathan; Davy, Simon; Bhaskaran, Krishnan; Schultze, Anna; Rentsch, Christopher T; Williamson, Elizabeth; Hulme, William; McDonald, Helen I; Tomlinson, Laurie; Mathur, Rohini; Drysdale, Henry; Eggo, Rosalind M; Wing, Kevin; Wong, Angel YS; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen JW; Douglas, Ian J; Smeeth, Liam; Goldacre, Ben

Approaches for combining primary care electronic health record data from multiple sources: a systematic review of observational studies. (2020) Dedman, Daniel; Cabecinha, Melissa; Williams, Rachael; Evans, Stephen JW; Bhaskaran, Krishnan; Douglas, Ian J

Risk of herpes zoster after exposure to varicella to explore the exogenous boosting hypothesis: self controlled case series study using UK electronic healthcare data. (2020) Forbes, Harriet; Douglas, Ian; Finn, Adam; Breuer, Judith; Bhaskaran, Krishnan; Smeeth, Liam; Packer, Simon; Langan, Sinéad M; Mansfield, Kathryn E; Marlow, Robin; Whitaker, Heather; Warren-Gash, Charlotte

Association between living with children and outcomes from COVID-19: an OpenSAFELY cohort study of 12 million adults in England. (2020) Forbes, Harriet; Morton, Caroline E; Bacon, Seb; McDonald, Helen I; Minassian, Caroline; Brown, Jeremy P; Rentsch, Christopher T; Mathur, Rohini; Schultze, Anna; DeVito, Nicholas J; MacKenna, Brian; Hulme, William J; Croker, Richard; Walker, Alex J; Williamson, Elizabeth J; Bates, Chris; Mehrkar, Amir; Curtis, Helen J; Evans, David; Wing, Kevin; Inglesby, Peter; Drysdale, Henry; Wong, Angel YS; Cockburn, Jonathan; McManus, Robert; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian J; Smeeth, Liam; Evans, Stephen JW; Bhaskaran, Krishnan; Eggo, Rosalind M; Goldacre, Ben; Tomlinson, Laurie A

Ethnic disparities in initiation and intensification of diabetes treatment in adults with type 2 diabetes in the UK, 1990-2017: A cohort study. (2020) Mathur, Rohini; Farmer, Ruth E; Eastwood, Sophie V; Chaturvedi, Nish; Douglas, Ian; Smeeth, Liam

Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform. (2020) Mathur, Rohini; Rentsch, Christopher T; Morton, Caroline E; Hulme, William J; Schultze, Anna; MacKenna, Brian; Eggo, Rosalind M; Bhaskaran, Krishnan; Wong, Angel YS; Williamson, Elizabeth J; Forbes, Harriet; Wing, Kevin; McDonald, Helen I; Bates, Chris; Bacon, Seb; Walker, Alex J; Evans, David; Inglesby, Peter; Mehrkar, Amir; Curtis, Helen J; DeVito, Nicholas J; Croker, Richard; Drysdale, Henry; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian J; Tomlinson, Laurie; Evans, Stephen JW; Grieve, Richard; Harrison, David; Rowan, Kathy; Khunti, Kamlesh; Chaturvedi, Nishi; Smeeth, Liam; Goldacre, Ben; OpenSAFELY Collaborative

Early initiation of prophylactic anticoagulation for prevention of COVID-19 mortality: a nationwide cohort study of hospitalized patients in the United States. (2020) Rentsch, Christopher T; Beckman, Joshua A; Tomlinson, Laurie; Gellad, Walid F; Alcorn, Charles; Kidwai-Khan, Farah; Skanderson, Melissa; Brittain, Evan; King, Joseph T; Ho, Yuk-Lam; Eden, Svetlana; Kundu, Suman; Lann, Michael F; Greevy, Robert A; Ho, P Michael; Heidenreich, Paul A; Jacobson, Daniel A; Douglas, Ian J; Tate, Janet P; Evans, Stephen Jw; Atkins, David; Justice, Amy C; Freiberg, Matthew S

Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform. (2020) Rentsch, Christopher T; DeVito, Nicholas J; MacKenna, Brian; Morton, Caroline E; Bhaskaran, Krishnan; Brown, Jeremy P; Schultze, Anna; Hulme, William J; Croker, Richard; Walker, Alex J; Williamson, Elizabeth J; Bates, Chris; Bacon, Seb; Mehrkar, Amir; Curtis, Helen J; Evans, David; Wing, Kevin; Inglesby, Peter; Mathur, Rohini; Drysdale, Henry; Wong, Angel YS; McDonald, Helen I; Cockburn, Jonathan; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Smeeth, Liam; Douglas, Ian J; Dixon, William G; Evans, Stephen JW; Tomlinson, Laurie; Goldacre, Ben

Hydroxychloroquine for prevention of COVID-19 mortality: a population-based cohort study. (2020) Rentsch, Christopher T; DeVito, Nicholas J; MacKenna, Brian; Morton, Caroline E; Bhaskaran, Krishnan; Brown, Jeremy P; Schultze, Anna; J Hulme, William; Croker, Richard; Walker, Alex J; Williamson, Elizabeth J; Bates, Chris; Bacon, Seb; Mehrkar, Amir; Curtis, Helen J; Evans, David; Wing, Kevin; Inglesby, Peter; Mathur, Rohini; Drysdale, Henry; Wong, Angel YS; McDonald, Helen I; Cockburn, Jonathan; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Smeeth, Liam; Douglas, Ian J; Dixon, William G; Evans, Stephen JW; Tomlinson, Laurie; Goldacre, Ben

Impact of pre-exposure time bias in self-controlled case series when the event conditions the exposure: Hip/femur fracture and use of benzodiazepines as a case study. (2020) Requena, Gema; Douglas, Ian J; Huerta, Consuelo; de Abajo, Francisco

Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform. (2020) Schultze, Anna; Walker, Alex J; MacKenna, Brian; Morton, Caroline E; Bhaskaran, Krishnan; Brown, Jeremy P; Rentsch, Christopher T; Williamson, Elizabeth; Drysdale, Henry; Croker, Richard; Bacon, Seb; Hulme, William; Bates, Chris; Curtis, Helen J; Mehrkar, Amir; Evans, David; Inglesby, Peter; Cockburn, Jonathan; McDonald, Helen I; Tomlinson, Laurie; Mathur, Rohini; Wing, Kevin; Wong, Angel YS; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen JW; Quint, Jennifer; Smeeth, Liam; Douglas, Ian J; Goldacre, Ben; OpenSAFELY Collaborative

Inhaled corticosteroid use and risk COVID-19 related death among 966,461 patients with COPD or asthma: an OpenSAFELY analysis. (2020) Schultze, Anna; Walker, Alex J; MacKenna, Brian; Morton, Caroline E; Bhaskaran, Krishnan; Brown, Jeremy P; Rentsch, Christopher T; Williamson, Elizabeth; Drysdale, Henry; Croker, Richard; Bacon, Seb; Hulme, William; Bates, Chris; Curtis, Helen J; Mehrkar, Amir; Evans, David; Inglesby, Peter; Cockburn, Jonathan; McDonald, Helen I; Tomlinson, Laurie; Mathur, Rohini; Wing, Kevin; Wong, Angel YS; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen JW; Quint, Jennifer; Smeeth, Liam; Douglas, Ian J; Goldacre, Ben

First line drug treatment for hypertension and reductions in blood pressure according to age and ethnicity: cohort study in UK primary care. (2020) Sinnott, Sarah-Jo; Douglas, Ian J; Smeeth, Liam; Williamson, Elizabeth; Tomlinson, Laurie A

Implementing high-dimensional propensity score principles to improve confounder adjustment in UK electronic health records. (2020) Tazare, John; Smeeth, Liam; Evans, Stephen JW; Williamson, Elizabeth; Douglas, Ian J

Transparency of high-dimensional propensity score analyses: Guidance for diagnostics and reporting. (2020) Tazare, John; Wyss, Richard; Franklin, Jessica M; Smeeth, Liam; Evans, Stephen JW; Wang, Shirley V; Schneeweiss, Sebastian; Douglas, Ian J; Williamson, Elizabeth; Gagne, Joshua J

UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records. (2020) Walker, Jemma L; Grint, Daniel J; Strongman, Helen; Eggo, Rosalind M; Peppa, Maria; Minassian, Caroline; Mansfield, Kathryn E; Rentsch, Christopher T; Douglas, Ian J; Mathur, Rohini; Wong, Angel YS; Quint, Jennifer K; Andrews, Nick; Bernal, Jamie Lopez; Scott, J Anthony; Ramsay, Mary; Smeeth, Liam; McDonald, Helen

Comparative effects of sulphonylureas, dipeptidyl peptidase-4 inhibitors and sodium-glucose co-transporter-2 inhibitors added to metformin monotherapy: a propensity-score matched cohort study in UK primary care. (2020) Wilkinson, Samantha; Williamson, Elizabeth; Pokrajac, Ana; Fogarty, Damian; Stirnadel-Farrant, Heide; Smeeth, Liam; Douglas, Ian J; Tomlinson, Laurie A

Study protocol: Comparison of different risk prediction modelling approaches for COVID-19 related death using the OpenSAFELY platform. (2020) Williamson, Elizabeth J; Tazare, John; Bhaskaran, Krishnan; Walker, Alex J; McDonald, Helen I; Tomlinson, Laurie; Bacon, Sebastian; Bates, Chris; Curtis, Helen J; Forbes, Harriet; Minassian, Caroline; Morton, Caroline E; Nightingale, Emily; Mehrkar, Amir; Evans, Dave; Nicholson, Brian D; Leon, David; Inglesby, Peter; MacKenna, Brian; Cockburn, Jonathan; Davies, Nicholas G; Hulme, William; Morley, Jessica; Douglas, Ian J; Rentsch, Christopher T; Mathur, Rohini; Wong, Angel; Schultze, Anna; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Perera, Rafael; Grieve, Richard; Harrison, David; Steyerberg, Ewout; Eggo, Rosalind M; Diaz-Ordaz, Karla; Keogh, Ruth; Evans, Stephen JW; Smeeth, Liam; Goldacre, Ben

Factors associated with COVID-19-related death using OpenSAFELY. (2020) Williamson, Elizabeth J; Walker, Alex J; Bhaskaran, Krishnan; Bacon, Seb; Bates, Chris; Morton, Caroline E; Curtis, Helen J; Mehrkar, Amir; Evans, David; Inglesby, Peter; Cockburn, Jonathan; McDonald, Helen I; MacKenna, Brian; Tomlinson, Laurie; Douglas, Ian J; Rentsch, Christopher T; Mathur, Rohini; Wong, Angel YS; Grieve, Richard; Harrison, David; Forbes, Harriet; Schultze, Anna; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Perera, Rafael; Evans, Stephen JW; Smeeth, Liam; Goldacre, Ben

OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients. (2020) Williamson, Elizabeth; Walker, Alex J; Bhaskaran, Krishnan; Bacon, Seb; Bates, Chris; Morton, Caroline E; Curtis, Helen J; Mehrkar, Amir; Evans, David; Inglesby, Peter; Cockburn, Jonathan; McDonald, Helen I; MacKenna, Brian; Tomlinson, Laurie; Douglas, Ian J; Rentsch, Christopher T; Mathur, Rohini; Wong, Angel; Grieve, Richard; Harrison, David; Forbes, Harriet; Schultze, Anna; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Perera, Raf; Evans, Stephen; Smeeth, Liam; Goldacre, Ben

Real world effects of COPD medications: a cohort study with validation against results from randomised controlled trials. (2020) Wing, Kevin; Williamson, Elizabeth; Carpenter, James R; Wise, Lesley; Schneeweiss, Sebastian; Smeeth, Liam; Quint, Jennifer K; Douglas, Ian

OpenSAFELY: Do adults prescribed non-steroidal anti-inflammatory drugs have an increased risk of death from COVID-19? (2020) Wong, Angel YS; MacKenna, Brian; Morton, Caroline E; Schultze, Anna; Walker, Alex J; Bhaskaran, Krishnan; Brown, Jeremy P; Rentsch, Christopher T; Williamson, Elizabeth; Drysdale, Henry; Croker, Richard; Bacon, Seb; Hulme, William; Bates, Chris; Curtis, Helen J; Mehrkar, Amir; Evans, David; Inglesby, Peter; Cockburn, Jonathan; McDonald, Helen I; Tomlinson, Laurie; Mathur, Rohini; Wing, Kevin; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen JW; Smeeth, Liam; Douglas, Ian J; Goldacre, Ben

2019

Cost saving of switching to equivalent inhalers and its effect on health outcomes. (2019) Bloom, Chloe I; Douglas, Ian; Olney, Jack; D'Ancona, Grainne; Smeeth, Liam; Quint, Jennifer K

Use of real-world evidence in postmarketing medicines regulation in the European Union: a systematic assessment of European Medicines Agency referrals 2013-2017. (2019) Brown, Jeremy Philip; Wing, Kevin; Evans, Stephen J; Bhaskaran, Krishnan; Smeeth, Liam; Douglas, Ian J

Blood pressure and risk of dementia and its subtypes: a historical cohort study with long-term follow-up in 2.6 million people. (2019) Gregson, J; Qizilbash, N; Iwagami, M; Douglas, I; Johnson, M; Pearce, N; Pocock, S

Thromboembolic, bleeding, and mortality risks among patients with nonvalvular atrial fibrillation treated with dual antiplatelet therapy versus oral anticoagulants: A population-based study. (2019) Lau, Wallis CY; Douglas, Ian J; Wong, Ian CK; Smeeth, Liam; Lip, Gregory YH; Leung, Wai K; Siu, Chung-Wah; Cheung, Bernard MY; Mok, Michael TC; Chan, Esther W

Asthma in electronic health records: validity and phenotyping. (2019) Nissen, FW

Clinical profile of predefined asthma phenotypes in a large cohort of UK primary care patients (Clinical Practice Research Datalink). (2019) Nissen, Francis; Douglas, Ian J; Müllerová, Hana; Pearce, Neil; Bloom, Chloe I; Smeeth, Liam; Quint, Jennifer K

How to validate a diagnosis recorded in electronic health records. (2019) Nissen, Francis; Quint, Jennifer K; Morales, Daniel R; Douglas, Ian J

Association of Relative Age in the School Year With Diagnosis of Intellectual Disability, Attention-Deficit/Hyperactivity Disorder, and Depression. (2019) Root, Adrian; Brown, Jeremy P; Forbes, Harriet J; Bhaskaran, Krishnan; Hayes, Joseph; Smeeth, Liam; Douglas, Ian J

The comparative effectiveness of fourth-line drugs in resistant hypertension: An application in electronic health record data. (2019) Sinnott, Sarah-Jo; Smeeth, Liam; Williamson, Elizabeth; Perel, Pablo; Nitsch, Dorothea; Tomlinson, Laurie A; Douglas, Ian J

2018

Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3·6 million adults in the UK. (2018) Bhaskaran, Krishnan; Dos-Santos-Silva, Isabel; Leon, David A; Douglas, Ian J; Smeeth, Liam

Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study. (2018) Crellin, Elizabeth; Mansfield, Kathryn E; Leyrat, Clémence; Nitsch, Dorothea; Douglas, Ian J; Root, Adrian; Williamson, Elizabeth; Smeeth, Liam; Tomlinson, Laurie A

Gastrointestinal bleeding risk of selective serotonin reuptake inhibitors by level of kidney function: A population-based cohort study. (2018) Iwagami, Masao; Tomlinson, Laurie A; Mansfield, Kathryn E; Douglas, Ian J; Smeeth, Liam; Nitsch, Dorothea

Long-term effects of bariatric surgery on acute kidney injury: a propensity-matched cohort in the UK Clinical Practice Research Datalink. (2018) Koppe, Uwe; Nitsch, Dorothea; Mansfield, Kathryn E; Mathur, Rohini; Bhaskaran, Krishnan; Batterham, Rachel L; Smeeth, Liam; Douglas, Ian J

Acute kidney injury and infections in patients taking antihypertensive drugs: a self-controlled case series analysis. (2018) Mansfield, Kathryn E; Douglas, Ian J; Nitsch, Dorothea; Thomas, Sara L; Smeeth, Liam; Tomlinson, Laurie A

Concomitant diagnosis of asthma and COPD: a quantitative study in UK primary care. (2018) Nissen, Francis; Morales, Daniel R; Mullerova, Hana; Smeeth, Liam; Douglas, Ian J; Quint, Jennifer K

Myocardial Infarction and Ischemic Stroke after Exacerbations of Chronic Obstructive Pulmonary Disease. (2018) Rothnie, Kieran J; Connell, Olivia; Müllerová, Hana; Smeeth, Liam; Pearce, Neil; Douglas, Ian; Quint, Jennifer K

A systematic review comparing the evidence for kidney function outcomes between oral antidiabetic drugs for type 2 diabetes. (2018) Wilkinson, Samantha V; Tomlinson, Laurie A; Iwagami, Masao; Stirnadel-Farrant, Heide A; Smeeth, Liam; Douglas, Ian

Factors associated with choice of intensification treatment for type 2 diabetes after metformin monotherapy: a cohort study in UK primary care. (2018) Wilkinson, Samantha; Douglas, Ian J; Williamson, Elizabeth; Stirnadel-Farrant, Heide A; Fogarty, Damian; Pokrajac, Ana; Smeeth, Liam; Tomlinson, Laurie A

Changing use of antidiabetic drugs in the UK: trends in prescribing 2000-2017. (2018) Wilkinson, Samantha; Douglas, Ian; Stirnadel-Farrant, Heide; Fogarty, Damian; Pokrajac, Ana; Smeeth, Liam; Tomlinson, Laurie

Real-world effects of medications for chronic obstructive pulmonary disease: protocol for a UK population-based non-interventional cohort study with validation against randomised trial results. (2018) Wing, Kevin; Williamson, Elizabeth; Carpenter, James R; Wise, Lesley; Schneeweiss, Sebastian; Smeeth, Liam; Quint, Jennifer K; Douglas, Ian

Signal Detection for Recently Approved Products: Adapting and Evaluating Self-Controlled Case Series Method Using a US Claims and UK Electronic Medical Records Database. (2018) Zhou, Xiaofeng; Douglas, Ian J; Shen, Rongjun; Bate, Andrew

2017

Exacerbation risk and characterisation of the UK's asthma population from infants to old age. (2017) Bloom, Chloe I; Nissen, Francis; Douglas, Ian J; Smeeth, Liam; Cullinan, Paul; Quint, Jennifer K

Self-controlled case series with multiple event types. (2017) Ghebremichael-Weldeselassie, Yonas; Whitaker, Heather J; Douglas, Ian J; Smeeth, Liam; Farrington, C Paddy

Propensity score analysis with partially observed covariates: How should multiple imputation be used? (2017) Leyrat, C; Seaman, SR; White, IR; Douglas, I; Smeeth, L; Kim, J; Resche-Rigon, M; Carpenter, JR; Williamson, EJ

Population trends in the 10-year incidence and prevalence of diabetic retinopathy in the UK: a cohort study in the Clinical Practice Research Datalink 2004-2014. (2017) Mathur, Rohini; Bhaskaran, Krishnan; Edwards, Emma; Lee, Helen; Chaturvedi, Nishi; Smeeth, Liam; Douglas, Ian

Cardiovascular Outcomes after a Respiratory Tract Infection among Adults with Non-Cystic Fibrosis Bronchiectasis: A General Population-based Study. (2017) Navaratnam, Vidya; Root, Adrian A; Douglas, Ian; Smeeth, Liam; Hubbard, Richard B; Quint, Jennifer K

Validation of asthma recording in the Clinical Practice Research Datalink (CPRD). (2017) Nissen, Francis; Morales, Daniel R; Mullerova, Hana; Smeeth, Liam; Douglas, Ian J; Quint, Jennifer K

Validation of asthma recording in electronic health records: a systematic review. (2017) Nissen, Francis; Quint, Jennifer K; Wilkinson, Samantha; Mullerova, Hana; Smeeth, Liam; Douglas, Ian J

Validation of asthma recording in electronic health records: protocol for a systematic review. (2017) Nissen, Francis; Quint, Jennifer K; Wilkinson, Samantha; Mullerova, Hana; Smeeth, Liam; Douglas, Ian J

Re: Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues. (2017) Root, Adrian; Douglas, Ian; Evans, Stephen

Trends for prevalence and incidence of resistant hypertension: population based cohort study in the UK 1995-2015. (2017) Sinnott, Sarah-Jo; Smeeth, Liam; Williamson, Elizabeth; Douglas, Ian J

Pharmacoepidemiology for nephrologists: do proton pump inhibitors cause chronic kidney disease? (2017) Tomlinson, Laurie A; Fogarty, Damian G; Douglas, Ian; Nitsch, Dorothea

Reporting to Improve Reproducibility and Facilitate Validity Assessment for Healthcare Database Studies V1.0. (2017) Wang, Shirley V; Schneeweiss, Sebastian; Berger, Marc L; Brown, Jeffrey; de Vries, Frank; Douglas, Ian; Gagne, Joshua J; Gini, Rosa; Klungel, Olaf; Mullins, C Daniel; Nguyen, Michael D; Rassen, Jeremy A; Smeeth, Liam; Sturkenboom, Miriam; joint ISPE-ISPOR Special Task Force on Real World Evidence in He

Reporting to Improve Reproducibility and Facilitate Validity Assessment for Healthcare Database Studies V1.0. (2017) Wang, Shirley V; Schneeweiss, Sebastian; Berger, Marc L; Brown, Jeffrey; de Vries, Frank; Douglas, Ian; Gagne, Joshua J; Gini, Rosa; Klungel, Olaf; Mullins, C Daniel; Nguyen, Michael D; Rassen, Jeremy A; Smeeth, Liam; Sturkenboom, Miriam; joint ISPE‐ISPOR Special Task Force on Real World Evidence in He

Investigating the assumptions of the self-controlled case series method. (2017) Whitaker, Heather J; Ghebremichael-Weldeselassie, Yonas; Douglas, Ian J; Smeeth, Liam; Farrington, C Paddy

Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study. (2017) Wing, Kevin; Bhaskaran, Krishnan; Pealing, Louise; Root, Adrian; Smeeth, Liam; van Staa, Tjeerd P; Klungel, Olaf H; Reynolds, Robert F; Douglas, Ian

Lansoprazole use and tuberculosis incidence in the United Kingdom Clinical Practice Research Datalink: A population based cohort. (2017) Yates, Tom A; Tomlinson, Laurie A; Bhaskaran, Krishnan; Langan, Sinead; Thomas, Sara; Smeeth, Liam; Douglas, Ian J

2016

Latest trends in ADHD drug prescribing patterns in children in the UK: prevalence, incidence and persistence. (2016) Beau-Lejdstrom, Raphaelle; Douglas, Ian; Evans, Stephen JW; Smeeth, Liam

Association between oral fluoroquinolones and seizures: A self-controlled case series study. (2016) Chui, Celine SL; Chan, Esther W; Wong, Angel YS; Root, Adrian; Douglas, Ian J; Wong, Ian CK

Oral Fluoroquinolone Use and Retinal Detachment. (2016) Douglas, Ian J; Root, Adrian; Krishnan, Bhaskaran

Phosphodiesterase Type 5 Inhibitors and Risk of Malignant Melanoma: Matched Cohort Study Using Primary Care Data from the UK Clinical Practice Research Datalink. (2016) Matthews, Anthony; Langan, Sinéad M; Douglas, Ian J; Smeeth, Liam; Bhaskaran, Krishnan

Self controlled case series methods: an alternative to standard epidemiological study designs. (2016) Petersen, Irene; Douglas, Ian; Whitaker, Heather

The Prevalence of Huntington's Disease. (2016) Rawlins, Michael D; Wexler, Nancy S; Wexler, Alice R; Tabrizi, Sarah J; Douglas, Ian; Evans, Stephen JW; Smeeth, Liam

Methodological issues in electronic healthcare database studies of drug cancer associations: identification of cancer, and drivers of discrepant results. (2016) Rañopa, ME

Evaluation of the risk of cardiovascular events with clarithromycin using both propensity score and self-controlled study designs. (2016) Root, AA; Wong, AY; Ghebremichael-Weldeselassie, Y; Smeeth, L; Bhaskaran, K; Evans, SJ; Brauer, R; Wong, IC; Navaratnam, V; Douglas, I

OS 04-07 THE COMPARATIVE EFFECTIVENESS OF 4TH LINE ANTI-HYPERTENSIVE AGENTS IN PATIENTS WITH RESISTANT HYPERTENSION: A META-ANALYSIS. (2016) Sinnott, SJ; Root, A; Mathur, R; Mansfield, K; Tomlinson, L; Douglas, I

OS 04-07 THE COMPARATIVE EFFECTIVENESS OF 4TH LINE ANTI-HYPERTENSIVE AGENTS IN PATIENTS WITH RESISTANT HYPERTENSION: A META-ANALYSIS. (2016) Sinnott, SJ; Root, A; Mathur, R; Mansfield, K; Tomlinson, L; Douglas, I

Comparative effectiveness of fourth-line anti-hypertensive agents in resistant hypertension: A systematic review and meta-analysis. (2016) Sinnott, SJ; Tomlinson, LA; Root, AA; Mathur, R; Mansfield, KE; Smeeth, L; Douglas, IJ

Incidence of adult Huntington's disease in the UK: a UK-based primary care study and a systematic review. (2016) Wexler, Nancy S; Collett, Laura; Wexler, Alice R; Rawlins, Michael D; Tabrizi, Sarah J; Douglas, Ian; Smeeth, Liam; Evans, Stephen J

Improving the measurement and detection of serious adverse drug reactions in databases of stored electronic health records. (2016) Wing, Kevin

Optimising case detection within UK electronic health records: use of multiple linked databases for detecting liver injury. (2016) Wing, Kevin; Bhaskaran, Krishnan; Smeeth, Liam; van Staa, Tjeerd P; Klungel, Olaf H; Reynolds, Robert F; Douglas, Ian

Cardiovascular outcomes associated with use of clarithromycin: population based study. (2016) Wong, Angel YS; Root, Adrian; Douglas, Ian J; Chui, Celine SL; Chan, Esther W; Ghebremichael-Weldeselassie, Yonas; Siu, Chung-Wah; Smeeth, Liam; Wong, Ian CK

Case-only designs for studying the association of antidepressants and hip or femur fracture. (2016) de Groot, MC; Candore, G; Uddin, MJ; Souverein, PC; Ali, MS; Belitser, SV; Huerta, C; Groenwold, RH; Alvarez, Y; Slattery, J; Korevaar, J; Hoes, AW; Roes, KC; de Boer, A; Douglas, IJ; Schlienger, RG; Reynolds, R; Klungel, OH; Gardarsdottir, H

2015

Glitazone Treatment and Incidence of Parkinson's Disease among People with Diabetes: A Retrospective Cohort Study. (2015) Brauer, Ruth; Bhaskaran, Krishnan; Chaturvedi, Nishi; Dexter, David T; Smeeth, Liam; Douglas, Ian

Risk of acute liver injury associated with use of antibiotics. Comparative cohort and nested case-control studies using two primary care databases in Europe. (2015) Brauer, Ruth; Douglas, Ian; Garcia Rodriguez, Luis Alberto; Downey, Gerald; Huerta, Consuelo; de Abajo, Francisco; Bate, Andrew; Feudjo Tepie, Maurille; de Groot, Mark CH; Schlienger, Raymond; Reynolds, Robert; Smeeth, Liam; Klungel, Olaf; Ruigómez, Ana

Prevalence of antibiotic use: a comparison across various European health care data sources. (2015) Brauer, Ruth; Ruigómez, Ana; Downey, Gerry; Bate, Andrew; Garcia Rodriguez, Luis Alberto; Huerta, Consuelo; Gil, Miguel; de Abajo, Francisco; Requena, Gema; Alvarez, Yolanda; Slattery, Jim; de Groot, Mark; Souverein, Patrick; Hesse, Ulrik; Rottenkolber, Marietta; Schmiedl, Sven; de Vries, Frank; Tepie, Maurille Feudjo; Schlienger, Raymond; Smeeth, Liam; Douglas, Ian; Reynolds, Robert; Klungel, Olaf

The risk of acute liver injury among users of antibiotic medications: a comparison of case-only studies. (2015) Brauer, Ruth; Ruigómez, Ana; Klungel, Olaf; Reynolds, Robert; Feudjo Tepie, Maurille; Smeeth, Liam; Douglas, Ian

Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care. (2015) Douglas, Ian J; Bhaskaran, Krishnan; Batterham, Rachel L; Smeeth, Liam

The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort. (2015) Douglas, Ian J; Bhaskaran, Krishnan; Batterham, Rachel L; Smeeth, Liam

The effect of sibutramine prescribing in routine clinical practice on cardiovascular outcomes: a cohort study in the United Kingdom. (2015) Hayes, JF; Bhaskaran, K; Batterham, R; Smeeth, L; Douglas, I

Herpes zoster, acute cardiovascular events and the role of zoster vaccination. (2015) Minassian, C; Thomas, S; Smeeth, L; Douglas, I; Brauer, R; Langan, S

Acute Cardiovascular Events after Herpes Zoster: A Self-Controlled Case Series Analysis in Vaccinated and Unvaccinated Older Residents of the United States. (2015) Minassian, Caroline; Thomas, Sara L; Smeeth, Liam; Douglas, Ian; Brauer, Ruth; Langan, Sinéad M

BMI and risk of dementia in two million people over two decades: a retrospective cohort study. (2015) Qizilbash, Nawab; Gregson, John; Johnson, Michelle E; Pearce, Neil; Douglas, Ian; Wing, Kevin; Evans, Stephen JW; Pocock, Stuart J

Do case-only designs yield consistent results across design and different databases? A case study of hip fractures and benzodiazepines. (2015) Requena, Gema; Logie, John; Martin, Elisa; Boudiaf, Nada; González González, Rocío; Huerta, Consuelo; Alvarez, Arturo; Webb, David; Bate, Andrew; García Rodríguez, Luis A; Reynolds, Robert; Schlienger, Raymond; Gardarsdottir, Helga; de Groot, Mark; Klungel, Olaf H; de Abajo, Fancisco; Douglas, Ian J

Risk of pancreatic cancer associated with use of incretin-based therapy and other glucose-lowering agents: a nationwide case-control study in Denmark. (2015) Thomsen, RW; Christensen, DH; Kahlert, J; Knudsen, ST; Pedersen, L; Norrelund, H; Dekkers, OM; Douglas, I; Marchesini, G; Smeeth, L; Moller, N; Beck-Nielsen, H; Jorgensen, JO; Sorensen, HT

2014

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults. (2014) Bhaskaran, Krishnan; Douglas, Ian; Forbes, Harriet; dos-Santos-Silva, Isabel; Leon, David A; Smeeth, Liam

Antipsychotic drugs and risks of myocardial infarction: a self-controlled case series study. (2014) Brauer, Ruth; Smeeth, Liam; Anaya-Izquierdo, Karim; Timmis, Adam; Denaxas, Spiros C; Farrington, C Paddy; Whitaker, Heather; Hemingway, Harry; Douglas, Ian

Angiotensin receptor blockers and risk of dementia: cohort study in UK Clinical Practice Research Datalink. (2014) Goh, Kah L; Bhaskaran, Krishnan; Minassian, Caroline; Evans, Stephen JW; Smeeth, Liam; Douglas, Ian J

Statins and the risk of type 2 diabetes mellitus: cohort study using the UK clinical practice pesearch datalink. (2014) Macedo, Ana Filipa; Douglas, Ian; Smeeth, Liam; Forbes, Harriet; Ebrahim, Shah

Methylphenidate and the risk of trauma. (2014) Man, Kenneth KC; Chan, Esther W; Coghill, David; Douglas, Ian; Ip, Patrick; Leung, Ling-Pong; Tsui, Matthew SH; Wong, Wilfred HS; Wong, Ian CK

Red blood cell transfusion and mortality in trauma patients: risk-stratified analysis of an observational study. (2014) Perel, Pablo; Clayton, Tim; Altman, Doug G; Croft, Peter; Douglas, Ian; Hemingway, Harry; Hingorani, Aroon; Morley, Katherine I; Riley, Richard; Timmis, Adam; Van der Windt, Danielle; Roberts, Ian; PROGRESS Partnership

The identification of incident cancers in UK primary care databases: a systematic review. (2014) Rañopa, Michael; Douglas, Ian; van Staa, Tjeerd; Smeeth, Liam; Klungel, Olaf; Reynolds, Robert; Bhaskaran, Krishnan

2013

Representativeness and optimal use of body mass index (BMI) in the UK Clinical Practice Research Datalink (CPRD). (2013) Bhaskaran, Krishnan; Forbes, Harriet J; Douglas, Ian; Leon, David A; Smeeth, Liam

Orlistat and the risk of acute liver injury: self controlled case series study in UK Clinical Practice Research Datalink. (2013) Douglas, Ian J; Langham, Julia; Bhaskaran, Krishnan; Brauer, Ruth; Smeeth, Liam

Juvenile Huntington's disease: a population-based study using the General Practice Research Database. (2013) Douglas, Ian; Evans, Stephen; Rawlins, Michael D; Smeeth, Liam; Tabrizi, Sarah J; Wexler, Nancy S

Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records. (2013) Evans, Stephen JW; Douglas, Ian; Rawlins, Michael D; Wexler, Nancy S; Tabrizi, Sarah J; Smeeth, Liam

The association between Parkinson's disease and anti-epilepsy drug carbamazepine: a case-control study using the UK General Practice Research Database. (2013) Skow, Aine; Douglas, Ian; Smeeth, Liam

Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records. (2013) Wing, Kevin; Douglas, Ian; Bhaskaran, Krishnan; Klungel, Olaf H; Reynolds, Robert F; Pirmohamed, Munir; Smeeth, Liam; van Staa, Tjeerd P

2012

Angiotensin receptor blockers and risk of cancer: cohort study among people receiving antihypertensive drugs in UK General Practice Research Database. (2012) Bhaskaran, Krishnan; Douglas, Ian; Evans, Stephen; van Staa, Tjeerd; Smeeth, Liam

A Comparison between the Standard Self Controlled Case Series Design and a Modification To Account for Events That Censor the Observation Period. (2012) Brauer, R; Smeeth, L; Anaya-Izquierdo, K; Farrington, CP; Whitaker, H; Douglas, I

Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs. (2012) Douglas, Ian J; Evans, Stephen JW; Hingorani, Aroon D; Grosso, Anthony M; Timmis, Adam; Hemingway, Harry; Smeeth, Liam

2011

How Long Do Children Stay on Antiepileptic Treatments in the UK? (2011) Beau, R; Douglas, I; Evans, S; Clayton, T; Smeeth, L

Comparison of Retention Rates of First Line Antiepileptic Drugs in Children in the UK. (2011) Beau, R; Douglas, I; Stephen, E; Clayton, T; Smeeth, L

The Risk of Cancer Associated with Angiotensin-II Receptor Blockers. (2011) Bhaskaran, K; Douglas, I; Evans, S; van Staa, T; Smeeth, L

Using the Self Controlled Case Series Method To Assess the Risk of Myocardial Infarction in GPRD-Registered Users of Antipsychotic Agents. (2011) Brauer, R; Douglas, I; Smeeth, L

The association between antipsychotic agents and the risk of myocardial infarction: a systematic review. (2011) Brauer, Ruth; Douglas, Ian; Smeeth, Liam

A Cohort Study Using GPRD and MINAP Data To Investigate the Possible Drug Interaction between Clopidogrel and Cytochrome P450 2C19 Inhibitors. (2011) Douglas, I; Smeeth, L; Hingorani, A; Grosso, A; Evans, S

Effect of statin treatment on short term mortality after pneumonia episode: cohort study. (2011) Douglas, Ian; Evans, Stephen; Smeeth, Liam

The use of antidepressants and the risk of haemorrhagic stroke: a nested case control study. (2011) Douglas, Ian; Smeeth, Liam; Irvine, David

Self-Controlled Case Series Analysis With Event-Dependent Observation Periods. (2011) Farrington, C Paddy; Anaya-Izquierdo, Karim; Whitaker, Heather J; Hocine, Mounia N; Douglas, Ian; Smeeth, Liam

Use of the self-controlled case series method in drug safety assessment. (2011) Grosso, Anthony; Douglas, Ian; MacAllister, Raymond; Petersen, Irene; Smeeth, Liam; Hingorani, Aroon D

Abstracts of the 27th International Conference on Pharmacoepidemiology & Therapeutic Risk Management. Chicago, Illinois, USA. August 14-17, 2011. (2011) Langham, Julia; Douglas, Ian; Brauer, Ruth; Bhaskaran, Krishnan; Smeeth, Liam

Cutting feedback in Bayesian regression adjustment for the propensity score. (2011) McCandless, Lawrence C; Douglas, Ian J; Evans, Stephen J; Smeeth, Liam

2009

The risk of fractures associated with thiazolidinediones: a self-controlled case-series study. (2009) Douglas, Ian J; Evans, Stephen J; Pocock, Stuart; Smeeth, Liam

Inhaled tiotropium bromide and risk of stroke. (2009) Grosso, Anthony; Douglas, Ian; Hingorani, Aroon D; MacAllister, Raymond; Hubbard, Richard; Smeeth, Liam

Oral bisphosphonates and risk of atrial fibrillation and flutter in women: a self-controlled case-series safety analysis. (2009) Grosso, Anthony; Douglas, Ian; Hingorani, Aroon; MacAllister, Raymond; Smeeth, Liam

THE APPLICATION OF DISCRETE EVENT SIMULATION TO QUANTITATIVE RISK BENEFIT ANALYSIS. (2009) Maguire, A; Douglas, I; Blak, BT

Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials. (2009) Smeeth, Liam; Douglas, Ian; Hall, Andrew J; Hubbard, Richard; Evans, Stephen

2008

Exposure to antipsychotics and risk of stroke: self controlled case series study. (2008) Douglas, Ian J; Smeeth, Liam

Post-marketing assessment of the safety of strontium ranelate; a novel case-only approach to the early detection of adverse drug reactions. (2008) Grosso, Anthony; Douglas, Ian; Hingorani, Aroon; MacAllister, Raymond; Smeeth, Liam

Age-related macular degeneration and complement activation-related diseases: a population-based case-control study. (2008) Nitsch, Dorothea; Douglas, Ian; Smeeth, Liam; Fletcher, Astrid

2007

A propensity score controlled cohort study to investigate the effects of statins. (2007) Douglas, IJ; Smeeth, L; Evans, SJ

A case-control study of drug risk factors for age-related macular degeneration. (2007) Douglas, Ian J; Cook, Claire; Chakravarthy, Usha; Hubbard, Richard; Fletcher, Astrid E; Smeeth, Liam

Patterns of cholesterol levels in patients treated with lipid lowering drugs in UK primary care. (2007) Maguire, A; Douglas, I; Smeeth, L

Determinants of cholesterol and triglycerides recording in patients treated with lipid lowering therapy in UK primary care. (2007) Maguire, A; Douglas, I; Smeeth, L; Thompson, M

Classification of hyperlipidemia from automated primary care data in the UK and France. (2007) Maguire, A; Schwalm, MS; Douglas, I; Smeeth, L

2006

Commentary: we still need observational studies of drugs--they just need to be better. (2006) Smeeth, Liam; Douglas, Ian; Hubbard, Richard