Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity.
Ruqaiyyah Siddiqui;
Abdul Matin;
David Warhurst;
Monique Stins;
Naveed Ahmed Khan;
(2007)
Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity.
Antimicrobial agents and chemotherapy, 51 (12).
pp. 4471-4473.
ISSN 0066-4804
DOI: 10.1128/AAC.00373-07
Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.
| Item Type | Article |
|---|---|
| ISI | 251472100038 |
Explore Further
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168013 (OA Location)
- 10.1128/AAC.00373-07 (DOI)
- 17875991 (PubMed)