Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro.
Chitalu C Musonda;
Susan Little;
Vanessa Yardley;
Kelly Chibale;
(2007)
Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro.
Bioorganic & medicinal chemistry letters, 17 (17).
pp. 4733-4736.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2007.06.070
The synthesis and antimalarial activity of a novel series of first generation 4-aminoquinoline-containing 2,4,5-trisubstituted aminoxazoles against two strains of the Plasmodium falciparum parasite in vitro is described. A number of compounds significantly more potent than the standard drug chloroquine were identified.
| Item Type | Article |
|---|---|
| Keywords | Aminoquinolines, chemistry, Animals, Antimalarials, chemical synthesis, pharmacology, Chemistry, Pharmaceutical, methods, Drug Design, Drug Evaluation, Preclinical, Inhibitory Concentration 50, Oxazoles, chemistry, Parasitic Sensitivity Tests, Plasmodium, metabolism, Plasmodium falciparum, drug effects, Structure-Activity Relationship |
| ISI | 249151700002 |