Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives.
Alexander Khrizman;
Jason S Moulthrop;
Susan Little;
Hayley Wharton;
Vanessa Yardley;
Guillermo Moyna;
(2007)
Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives.
Bioorganic & medicinal chemistry letters, 17 (15).
pp. 4183-4186.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2007.05.044
We describe the synthesis and protozoocidal evaluation of a series of diazabicycles based on benzotropolone ethers. Several of the compounds, which can be obtained through a high-yielding hetero Diels-Alder reaction using simple and readily available starting materials, have in vitro activities against Trypanosoma cruzi and Leishmania donovani that are comparable to, and in some cases better than, those of currently used chemotherapies.
| Item Type | Article |
|---|---|
| Keywords | Animals, Antiprotozoal Agents, chemical synthesis, pharmacology, Aza Compounds, chemistry, Bicyclo Compounds, chemistry, Biflavonoids, chemical synthesis, pharmacology, Catechin, analogs & derivatives, chemical synthesis, pharmacology, Leishmania donovani, drug effects, Trypanosoma cruzi, drug effects |
| ISI | 248462300019 |