Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives.
AlexanderKhrizman;
Rachel DSlack;
Richard CRemsing;
SusanLittle;
VanessaYardley;
GuillermoMoyna;
(2007)
Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives.
Archiv der Pharmazie, 340 (11).
pp. 569-576.
ISSN 0365-6233
DOI: 10.1002/ardp.200700143
The synthesis and in vitro antiparasitic activity of twenty-seven novel diazabicycles based on tropolone ethers is presented. The compounds can be readily prepared by means of a high-yielding hetero Diels-Alder reaction using simple and readily available starting materials. Several of the new diazabicycles have in vitro activities against Trypanosoma cruzi, Leishmania donovani, Trypanosoma brucei rhodesiense, and chloroquine-resistant Plasmodium falciparum that are comparable or superior to those of currently employed protozoocidal agents.
Item Type | Article |
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ISI | 251202400001 |
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