Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones).
Julieta Coro;
Susan Little;
Vanessa Yardley;
Margarita Suárez;
Hortensia Rodríguez;
Nazario Martín;
Rolando Perez-Pineiro;
(2008)
Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones).
Archiv der Pharmazie, 341 (11).
pp. 708-713.
ISSN 0365-6233
DOI: 10.1002/ardp.200800011
The synthesis and in-vitro antiprotozoal evaluation of novel N(4)-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thione) (bis-THTT) derivatives from N(4)-(benzyl)spermidine is disclosed. Several of the new bis-THTT have in-vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.
| Item Type | Article |
|---|---|
| Keywords | Protozoocidal activity, Spermidine, 1, 3, 5-Thiadiazinane-2-thione, TRYPANOTHIONE REDUCTASE, TRYPANOSOMA-CRUZI, IN-VITRO, ANTIMICROBIAL, ACTIVITY, TRYPANOCIDAL AGENTS, CHAGAS-DISEASE, DERIVATIVES, INHIBITORS, CHEMOTHERAPY, BRUCEI |
| ISI | 261440800005 |