Burkholderia pseudomallei: animal models of infection.

Richard W Titball; Paul Russell; Jon Cuccui ORCID logo; Anna Easton; Ashraful Haque; Tim Atkins; Mitali Sarkar-Tyson; Vicki Harley; Brendan Wren ORCID logo; Gregory J Bancroft ORCID logo; (2008) Burkholderia pseudomallei: animal models of infection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102 Su (SUPPL.). S111-S116. ISSN 0035-9203 DOI: 10.1016/S0035-9203(08)70026-9
Copy

A range of animal models of Burkholderia pseudomallei infection have been reported, and the host species differ widely both in their susceptibility to infection and in the pathogenesis of disease. In mice, and depending on the route of infection, dose, and mouse strain, the disease can range from a chronic, and in some cases, an apparently latent infection to an acute fulminant disease. Alternative small animal models of infection include diabetic rats or hamsters. Larger animal models of disease have not yet been fully developed. It is not clear which of the small animal models of melioidosis most accurately reflect disease in humans. However, the findings that diabetic rats are susceptible to infection, that some strains of mice can develop persistent subclinical infections that can spontaneously reactivate, and that inhalation exposure generally results in more acute disease suggest that these different models mimic different aspects of human melioidosis.

Full text not available from this repository.

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads