Post-Viral Fatigue Following SARS-CoV-2 Infection during Pregnancy: A Longitudinal Comparative Study.

Ana Maria da Silva Sousa Oliveira; Mariana Azevedo Carvalho ORCID logo; Luis Nacul ORCID logo; Fábio Roberto Cabar ORCID logo; Amanda Wictky Fabri; Stela Verzinhasse Peres ORCID logo; Tatiana Assuncao Zaccara; Shennae O'Boyle; Neal Alexander ORCID logo; Nilton Hideto Takiuti; +3 more... Philippe Mayaud ORCID logo; Maria de Lourdes Brizot; Rossana Pulcineli Vieira Francisco ORCID logo; (2022) Post-Viral Fatigue Following SARS-CoV-2 Infection during Pregnancy: A Longitudinal Comparative Study. International journal of environmental research and public health, 19 (23). p. 15735. ISSN 1661-7827 DOI: 10.3390/ijerph192315735
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Studies reported post-COVID-19 fatigue in the general population, but not among pregnant women. Our objectives were to determine prevalence, duration, and risk factors of post-viral fatigue among pregnant women with SARS-CoV-2. This study involved 588 pregnant women with SARS-CoV-2 during pregnancy or delivery in Brazil. Three groups were investigated: G1 (n = 259, symptomatic infection during pregnancy); G2 (n = 131, positive serology at delivery); G3 (n = 198, negative serology at delivery). We applied questionnaires investigating fatigue at determined timepoints after infection for G1, and after delivery for all groups; fatigue prevalence was then determined. Cox regression was used to estimate hazard ratio (HR) and 95% CI of the risk of remaining with fatigue in G1. Overall fatigue prevalence in G1 at six weeks, three months and six months were 40.6%, 33.6%, and 27.8%, respectively. Cumulative risk of remaining with fatigue increased over time, with HR of 1.69 (95% CI: 0.89-3.20) and 2.43 (95% CI: 1.49-3.95) for women with moderate and severe symptoms, respectively. Multivariate analysis showed cough and myalgia as independent risk factors in G1. Fatigue prevalence was significantly higher in G1 compared to G2 and G3. Post-viral fatigue prevalence is higher in women infected during pregnancy; fatigue's risk and duration increased with the severity of infection.


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