Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.

Daniel J Grint ORCID logo; Kevin Wing ORCID logo; Elizabeth Williamson ORCID logo; Helen I McDonald ORCID logo; Krishnan Bhaskaran ORCID logo; DavidEvans; Stephen Jw Evans ORCID logo; Alex JWalker; GeorgeHickman; Emily Nightingale ORCID logo; +26 more... Anna Schultze ORCID logo; Christopher T Rentsch ORCID logo; ChrisBates; JonathanCockburn; Helen JCurtis; Caroline EMorton; SebastianBacon; SimonDavy; Angel Ys Wong ORCID logo; AmirMehrkar; Laurie Tomlinson ORCID logo; Ian J Douglas ORCID logo; Rohini Mathur ORCID logo; PaulaBlomquist; BrianMacKenna; PeterIngelsby; RichardCroker; JohnParry; FrankHester; SamHarper; Nicholas JDeVito; WillHulme; John Tazare ORCID logo; Ben Goldacre ORCID logo; Liam Smeeth ORCID logo; Rosalind M Eggo ORCID logo; (2021) Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February. Eurosurveillance, 26 (11). pp. 10-15. ISSN 1025-7917 DOI: 10.2807/1560-7917.ES.2021.26.11.2100256
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The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.



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