Emergence of Low-level Delamanid and Bedaquiline Resistance During Extremely Drug-resistant Tuberculosis Treatment.

Silke Polsfuss; Sabine Hofmann-Thiel; Matthias Merker; David Krieger; Stefan Niemann; Holger Rüssmann; Nicolas Schönfeld; Harald Hoffmann; Katharina Kranzer ORCID logo; (2019) Emergence of Low-level Delamanid and Bedaquiline Resistance During Extremely Drug-resistant Tuberculosis Treatment. CLINICAL INFECTIOUS DISEASES, 69 (7). pp. 1229-1231. ISSN 1058-4838 DOI: 10.1093/cid/ciz074
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Two new drugs, delamanid and bedaquiline, have recently been approved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis. Here, we report a case of clofazimine, bedaquiline, and low-level delamanid resistances acquired during treatment of a patient with XDR tuberculosis.


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