Microevolution and Patterns of Transmission of Shigella sonnei within Cyclic Outbreaks Shigellosis, Israel.

Adi Behar; Kate Susan Baker; Ravit Bassal; Analia Ezernitchi; Lea Valinsky; Nicholas R Thomson ORCID logo; Daniel Cohen; (2018) Microevolution and Patterns of Transmission of Shigella sonnei within Cyclic Outbreaks Shigellosis, Israel. EMERGING INFECTIOUS DISEASES, 24 (7). pp. 1335-1339. ISSN 1080-6040 DOI: 10.3201/eid2407.171313
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Whole-genome sequencing unveiled host and environment-related insights to Shigella sonnei transmission within cyclic epidemics during 2000-2012 in Israel. The Israeli reservoir contains isolates belonging to S. sonnei lineage III but of different origin, shows loss of tetracycline resistance genes, and little genetic variation within the O antigen: highly relevant for Shigella vaccine development.


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