Genomic and epidemiological monitoring of yellow fever virus transmission potential.
;
MUG Kraemer ;
SC Hill ;
J Goes de Jesus ;
RS Aguiar ;
FCM Iani ;
J Xavier ;
J Quick;
L du Plessis ;
S Dellicour ;
+71 more...
J Thézé;
RDO Carvalho;
G Baele ;
C-H Wu;
PP Silveira;
MB Arruda;
MA Pereira;
GC Pereira;
J Lourenço ;
U Obolski;
L Abade ;
TI Vasylyeva;
M Giovanetti;
D Yi;
DJ Weiss ;
GRW Wint ;
FM Shearer;
S Funk ;
B Nikolay ;
V Fonseca ;
TER Adelino ;
MAA Oliveira;
MVF Silva;
L Sacchetto ;
PO Figueiredo;
IM Rezende ;
EM Mello ;
RFC Said;
DA Santos;
ML Ferraz ;
MG Brito ;
LF Santana ;
MT Menezes ;
RM Brindeiro ;
A Tanuri ;
FCP Dos Santos;
MS Cunha;
JS Nogueira;
IM Rocco ;
AC da Costa ;
SCV Komninakis ;
V Azevedo ;
AO Chieppe;
ESM Araujo;
MCL Mendonça;
CC Dos Santos;
CD Dos Santos;
AM Mares-Guia;
RMR Nogueira;
PC Sequeira ;
RG Abreu ;
MHO Garcia ;
AL Abreu;
O Okumoto;
EG Kroon ;
CFC de Albuquerque;
K Lewandowski;
ST Pullan ;
M Carroll;
T de Oliveira;
EC Sabino ;
RP Souza ;
MA Suchard ;
P Lemey ;
GS Trindade;
BP Drumond;
AMB Filippis;
NJ Loman;
S Cauchemez;
LCJ Alcantara ;
OG Pybus ;
(2018)
Genomic and epidemiological monitoring of yellow fever virus transmission potential.
Science (New York, NY), 361 (6405).
pp. 894-899.
ISSN 0036-8075
DOI: 10.1126/science.aat7115
The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.
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picture_as_pdf - Genomic-and-epidemiological-monitoring.pdf
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subject - Accepted Version
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- Available under Creative Commons: NC-ND 3.0