Genomic history of the seventh pandemic of cholera in Africa.
;
Daryl Domman ;
Elisabeth Njamkepo ;
Cheryl Tarr ;
Jean Rauzier;
Nizar Fawal ;
Karen H Keddy ;
Henrik Salje ;
Sandra Moore;
Asish K Mukhopadhyay;
+31 more...
Raymond Bercion ;
Francisco J Luquero ;
Antoinette Ngandjio ;
Mireille Dosso ;
Elena Monakhova ;
Benoit Garin;
Christiane Bouchier ;
Carlo Pazzani ;
Ankur Mutreja;
Roland Grunow ;
Fati Sidikou ;
Laurence Bonte;
Sébastien Breurec;
Maria Damian;
Berthe-Marie Njanpop-Lafourcade ;
Guillaume Sapriel;
Anne-Laure Page ;
Monzer Hamze;
Myriam Henkens;
Goutam Chowdhury;
Martin Mengel;
Jean-Louis Koeck ;
Jean-Michel Fournier;
Gordon Dougan ;
Patrick AD Grimont ;
Julian Parkhill ;
Kathryn E Holt ;
Renaud Piarroux ;
Thandavarayan Ramamurthy;
Marie-Laure Quilici;
Nicholas R Thomson ;
(2017)
Genomic history of the seventh pandemic of cholera in Africa.
Science (New York, NY), 358 (6364).
pp. 785-789.
ISSN 0036-8075
DOI: 10.1126/science.aad5901
The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.