Associations between nasopharyngeal carriage of Group B Streptococcus and other respiratory pathogens during early infancy.

Ebenezer Foster-Nyarko ORCID logo; Brenda Kwambana; Odutola Aderonke; Fatima Ceesay; Sheikh Jarju; Abdoulie Bojang; Jessica McLellan; James Jafali; Beate Kampmann ORCID logo; Martin O Ota; +2 more... Ifedayo Adetifa ORCID logo; Martin Antonio ORCID logo; (2016) Associations between nasopharyngeal carriage of Group B Streptococcus and other respiratory pathogens during early infancy. BMC microbiology, 16 (1). 97-. ISSN 1471-2180 DOI: 10.1186/s12866-016-0714-7
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BACKGROUND: In West Africa, the carriage of Group B Streptococcus (GBS), among infants is poorly characterised. We investigated co-carriage of GBS with other respiratory pathogens in the infants' nasopharynx in The Gambia. METHODS: We assessed the carriage, serotypes and antibiotic susceptibility of Beta-haemolytic Streptococci (BHS) groups A-G; along with the carriage of Streptococcus pneumoniae; Haemophilus influenzae; Staphylococcus aureus and Moraxella catarrhalis in 1200 two-month old infants. RESULTS: The BHS prevalence was 20.0 % and GBS dominated (13.8 %), particularly serotypes V and II; serotype V being negatively associated with H. Influenzae carriage (OR 0.41 [95 % CI: 0.18-0.93], p = 0.033). Although co-colonization of GBS and other BHS was not seen, colonization with GBS was positively associated with S. aureus (OR 1.89 [95 % CI: 1.33-2.69], P < 0.001) and negatively associated with S. pneumoniae (OR 0.47 [95 % CI: 0.33-0.67], p < 0.001) and M. catarrhalis (OR 0.61 [95 % CI: 0.40-0.92], p = 0.017). ≥ 89 % of GBS isolates were susceptible to most antibiotics tested, except for tetracycline resistance, which was 89 %. CONCLUSION: This study provides baseline data on the carriage of GBS in two month old infants from West Africa. The dominant serotypes of GBS in this setting are serotypes V and II. This may be important for future GBS vaccine development for the West African sub-region.


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