Updated estimate of the duration of the meningo-encephalitic stage in gambiense human African trypanosomiasis.

Francesco Checchi ORCID logo; Sebastian Funk ORCID logo; Daniel Chandramohan ORCID logo; Daniel T Haydon; François Chappuis; (2015) Updated estimate of the duration of the meningo-encephalitic stage in gambiense human African trypanosomiasis. BMC research notes, 8 (1). 292-. ISSN 1756-0500 DOI: 10.1186/s13104-015-1244-3
Copy

BACKGROUND: The duration of the stages of HAT is an important factor in epidemiological studies and intervention planning. Previously, we published estimates of the duration of the haemo-lymphatic stage 1 and meningo-encephalitic stage 2 of the gambiense form of human African trypanosomiasis (HAT), in the absence of treatment. Here we revise the estimate of stage 2 duration, computed based on data from Uganda and South Sudan, by adjusting observed infection prevalence for incomplete case detection coverage and diagnostic inaccuracy. FINDINGS: The revised best estimate for the mean duration of stage 2 is 252 days (95% CI 171-399), about half of our initial best estimate, giving a total mean duration of untreated gambiense HAT infection of approximately 2 years and 2 months. CONCLUSIONS: Our new estimate provides improved information on the transmission dynamics of this neglected tropical disease in Uganda and South Sudan. We stress that there remains considerable variability around the estimated mean values, and that one must be cautious in applying these results to other foci.


picture_as_pdf
Updated estimate of the duration of the meningo-encephalitic stage in gambiense human African trypanosomiasis_GOLD VoR.pdf
subject
Published Version
Available under Creative Commons: 3.0

View Download

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads