Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae.

Janine T Bossé; Yanwen Li; Tom G Atherton; Stephanie Walker; Susanna M Williamson; Jon Rogers; Roy R Chaudhuri; Lucy A Weinert; Matthew TG Holden; Duncan J Maskell; +5 more... Alexander W Tucker; Brendan W Wren ORCID logo; Andrew N Rycroft; Paul R Langford; BRaDP1T consortium; (2015) Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae. Veterinary microbiology, 178 (3-4). pp. 279-282. ISSN 0378-1135 DOI: 10.1016/j.vetmic.2015.05.020
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The complete nucleotide sequence of a 7.7kb mobilisable plasmid (pM3446F), isolated from a florfenicol resistant isolate of Actinobacillus pleuropneumoniae, showed extended similarity to plasmids found in other members of the Pasteurellaceae containing the floR gene as well as replication and mobilisation genes. Mobilisation into other Pasteurellaceae species confirmed that this plasmid can be transferred horizontally.


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