The role of cGMP signalling in regulating life cycle progression of Plasmodium.
Christine S Hopp;
Paul W Bowyer;
David A Baker 
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(2012)
The role of cGMP signalling in regulating life cycle progression of Plasmodium.
Microbes and infection / Institut Pasteur, 14 (10).
pp. 831-837.
ISSN 1286-4579
DOI: 10.1016/j.micinf.2012.04.011
;
(2012)
The role of cGMP signalling in regulating life cycle progression of Plasmodium.
Microbes and infection / Institut Pasteur, 14 (10).
pp. 831-837.
ISSN 1286-4579
DOI: 10.1016/j.micinf.2012.04.011
The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and motility, and liver stage schizont development. The current views on potential effector proteins downstream of PKG and the mechanisms that may regulate cyclic nucleotide levels are presented.
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