Items where Author is "Baker, David A"
Number of items: 80.
2022
CDC50 Orthologues in Plasmodium falciparum Have Distinct Roles in Merozoite Egress and Trophozoite Maturation. (2022)
Patel, Avnish; Nofal, Stephanie D; Blackman, Michael J; Baker, David A
Plasmodium falciparum Sexual Commitment Rate Variation among Clinical Isolates and Diverse Laboratory-Adapted Lines. (2022)
Stewart, Lindsay B; Freville, Aline; Voss, Till S; Baker, David A; Awandare, Gordon A; Conway, David J
2021
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG. (2021)
Balestra, Aurélia C; Koussis, Konstantinos; Klages, Natacha; Howell, Steven A; Flynn, Helen R; Bantscheff, Marcus; Pasquarello, Carla; Perrin, Abigail J; Brusini, Lorenzo; Arboit, Patrizia; Sanz, Olalla; Castaño, Laura Peces-Barba; Withers-Martinez, Chrislaine; Hainard, Alexandre; Ghidelli-Disse, Sonja; Snijders, Ambrosius P; Baker, David A; Blackman, Michael J; Brochet, Mathieu
Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress. (2021)
Nofal, Stephanie D; Patel, Avnish; Blackman, Michael J; Flueck, Christian; Baker, David A
Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony. (2021)
Perrin, Abigail J; Bisson, Claudine; Faull, Peter A; Renshaw, Matthew J; Lees, Rebecca A; Fleck, Roland A; Saibil, Helen R; Snijders, Ambrosius P; Baker, David A; Blackman, Michael J
2020
Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs. (2020)
Baker, David A; Matralis, Alexios N; Osborne, Simon A; Large, Jonathan M; Penzo, Maria
The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation. (2020)
Henrici, Ryan C; Edwards, Rachel L; Zoltner, Martin; van Schalkwyk, Donelly A; Hart, Melissa N; Mohring, Franziska; Moon, Robert W; Nofal, Stephanie D; Patel, Avnish; Flueck, Christian; Baker, David A; Odom John, Audrey R; Field, Mark C; Sutherland, Colin J
The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation. (2020)
Henrici, Ryan C; Edwards, Rachel L; Zoltner, Martin; van Schalkwyk, Donelly A; Hart, Melissa N; Mohring, Franziska; Moon, Robert W; Nofal, Stephanie D; Patel, Avnish; Flueck, Christian; Baker, David A; Odom John, Audrey R; Field, Mark C; Sutherland, Colin J
Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function. (2020)
Koussis, Konstantinos; Withers-Martinez, Chrislaine; Baker, David A; Blackman, Michael J
An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi. (2020)
Marr, Edward J; Milne, Rachel M; Anar, Burcu; Girling, Gareth; Schwach, Frank; Mooney, Jason P; Nahrendorf, Wiebke; Spence, Philip J; Cunningham, Deirdre; Baker, David A; Langhorne, Jean; Rayner, Julian C; Billker, Oliver; Bushell, Ellen S; Thompson, Joanne
CRISPR-Cas9 Genome Editing of Plasmodium knowlesi. (2020)
Mohring, Franziska; Hart, Melissa N; Patel, Avnish; Baker, David A; Moon, Robert W
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cAMP signalling and its role in host cell invasion by malaria parasites. (2020)
Perrin, Abigail J; Patel, Avnish; Flueck, Christian; Blackman, Michael J; Baker, David A
Use of a highly specific kinase inhibitor for rapid, simple and precise synchronization of Plasmodium falciparum and Plasmodium knowlesi asexual blood-stage parasites. (2020)
Ressurreição, Margarida; Thomas, James A; Nofal, Stephanie D; Flueck, Christian; Moon, Robert W; Baker, David A; van Ooij, Christiaan
Differential IL-18 Dependence of Canonical and Adaptive NK Cells for Antibody Dependent Responses to P. falciparum. (2020)
Sherratt, Samuel; Patel, Avnish; Baker, David A; Riley, Eleanor M; Goodier, Martin R
2019
Antimalarial activity of primaquine operates via a two-step biochemical relay. (2019)
Camarda, Grazia; Jirawatcharadech, Piyaporn; Priestley, Richard S; Saif, Ahmed; March, Sandra; Wong, Michael HL; Leung, Suet; Miller, Alex B; Baker, David A; Alano, Pietro; Paine, Mark JI; Bhatia, Sangeeta N; O'Neill, Paul M; Ward, Stephen A; Biagini, Giancarlo A
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. (2019)
El Bakkouri, Majida; Kouidmi, Imène; Wernimont, Amy K; Amani, Mehrnaz; Hutchinson, Ashley; Loppnau, Peter; Kim, Jeong Joo; Flueck, Christian; Walker, John R; Seitova, Alma; Senisterra, Guillermo; Kakihara, Yoshito; Kim, Choel; Blackman, Michael J; Calmettes, Charles; Baker, David A; Hui, Raymond
Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. (2019)
Flueck, Christian; Drought, Laura G; Jones, Andrew; Patel, Avnish; Perrin, Abigail J; Walker, Eloise M; Nofal, Stephanie D; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A
Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. (2019)
Flueck, Christian; Drought, Laura G; Jones, Andrew; Patel, Avnish; Perrin, Abigail J; Walker, Eloise M; Nofal, Stephanie D; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A
Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty. (2019)
Large, Jonathan M; Birchall, Kristian; Bouloc, Nathalie S; Merritt, Andy T; Smiljanic-Hurley, Ela; Tsagris, Denise J; Wheldon, Mary C; Ansell, Keith H; Coombs, Peter J; Kettleborough, Catherine A; Whalley, David; Stewart, Lindsay B; Bowyer, Paul W; Baker, David A; Osborne, Simon A
Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites. (2019)
Matralis, Alexios N; Malik, Adnan; Penzo, Maria; Moreno, Inmaculada; Almela, Maria J; Camino, Isabel; Crespo, Benigno; Saadeddin, Anas; Ghidelli-Disse, Sonja; Rueda, Lourdes; Calderon, Felix; Osborne, Simon A; Drewes, Gerard; Böesche, Markus; Fernández-Álvaro, Elena; Martin Hernando, Jose Ignacio; Baker, David A
Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research. (2019)
Mohring, Franziska; Hart, Melissa Natalie; Rawlinson, Thomas A; Henrici, Ryan; Charleston, James A; Diez Benavente, Ernest; Patel, Avnish; Hall, Joanna; Almond, Neil; Campino, Susana; Clark, Taane G; Sutherland, Colin J; Baker, David A; Draper, Simon J; Moon, Robert William
Investigation of the role of GCα in activating cGMP signalling in Plasmodium falciparum and how cyclic nucleotide signalling modulates molecular motor function. (2019)
Nofal, SD
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery. (2019)
Patel, Avnish; Perrin, Abigail J; Flynn, Helen R; Bisson, Claudine; Withers-Martinez, Chrislaine; Treeck, Moritz; Flueck, Christian; Nicastro, Giuseppe; Martin, Stephen R; Ramos, Andres; Gilberger, Tim W; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A
High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites. (2019)
Penzo, Maria; de Las Heras-Dueña, Laura; Mata-Cantero, Lydia; Diaz-Hernandez, Beatriz; Vazquez-Muñiz, Maria-Jesus; Ghidelli-Disse, Sonja; Drewes, Gerard; Fernandez-Alvaro, Elena; Baker, David A
An analysis of large structural variation in global Plasmodium falciparum isolates identifies a novel duplication of the chloroquine resistance associated gene. (2019)
Ravenhall, Matt; Benavente, Ernest Diez; Sutherland, Colin J; Baker, David A; Campino, Susana; Clark, Taane G
2018
Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development. (2018)
Benavente, Ernest Diez; Oresegun, Damilola R; de Sessions, Paola Florez; Walker, Eloise M; Roper, Cally; Dombrowski, Jamille G; de Souza, Rodrigo M; Marinho, Claudio RF; Sutherland, Colin J; Hibberd, Martin L; Mohareb, Fady; Baker, David A; Clark, Taane G; Campino, Susana
Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites. (2018)
Fang, Hanwei; Gomes, Ana Rita; Klages, Natacha; Pino, Paco; Maco, Bohumil; Walker, Eloise M; Zenonos, Zenon A; Angrisano, Fiona; Baum, Jake; Doerig, Christian; Baker, David A; Billker, Oliver; Brochet, Mathieu
Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines. (2018)
Large, Jonathan M; Birchall, Kristian; Bouloc, Nathalie S; Merritt, Andy T; Smiljanic-Hurley, Ela; Tsagris, Denise J; Wheldon, Mary C; Ansell, Keith H; Coombs, Peter J; Kettleborough, Catherine A; Whalley, David; Stewart, Lindsay B; Bowyer, Paul W; Baker, David A; Osborne, Simon A
Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites. (2018)
Meerstein-Kessel, Lisette; van der Lee, Robin; Stone, Will; Lanke, Kjerstin; Baker, David A; Alano, Pietro; Silvestrini, Francesco; Janse, Chris J; Khan, Shahid M; van de Vegte-Bolmer, Marga; Graumans, Wouter; Siebelink-Stoter, Rianne; Kooij, Taco WA; Marti, Matthias; Drakeley, Chris; Campo, Joseph J; van Dam, Teunis JP; Sauerwein, Robert; Bousema, Teun; Huynen, Martijn A
The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress. (2018)
Perrin, Abigail J; Collins, Christine R; Russell, Matthew RG; Collinson, Lucy M; Baker, David A; Blackman, Michael J
Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG). (2018)
Tsagris, Denise J; Birchall, Kristian; Bouloc, Nathalie; Large, Jonathan M; Merritt, Andy; Smiljanic-Hurley, Ela; Wheldon, Mary; Ansell, Keith H; Kettleborough, Catherine; Whalley, David; Stewart, Lindsay B; Bowyer, Paul W; Baker, David A; Osborne, Simon A
Investigation of the Relationship between CGMP Signalling and Calcium Mobilisation in Plasmodium Falciparum with a Focus on the Role of Phosphodiesterases in Sexual Development. (2018)
Walker, EM
2017
Cyclic nucleotide signalling in malaria parasites. (2017)
Baker, David A; Drought, Laura G; Flueck, Christian; Nofal, Stephanie D; Patel, Avnish; Penzo, Maria; Walker, Eloise M
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission. (2017)
Baker, David A; Stewart, Lindsay B; Large, Jonathan M; Bowyer, Paul W; Ansell, Keith H; Jiménez-Díaz, María B; El Bakkouri, Majida; Birchall, Kristian; Dechering, Koen J; Bouloc, Nathalie S; Coombs, Peter J; Whalley, David; Harding, Denise J; Smiljanic-Hurley, Ela; Wheldon, Mary C; Walker, Eloise M; Dessens, Johannes T; Lafuente, María José; Sanz, Laura M; Gamo, Francisco-Javier; Ferrer, Santiago B; Hui, Raymond; Bousema, Teun; Angulo-Barturén, Iñigo; Merritt, Andy T; Croft, Simon L; Gutteridge, Winston E; Kettleborough, Catherine A; Osborne, Simon A
Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. (2017)
Ganter, M; Goldberg, JM; Dvorin, JD; Paulo, JA; King, JG; Tripathi, AK; Paul, AS; Yang, J; Coppens, I; Jiang, RH; Elsworth, B; Baker, DA; Dinglasan, RR; Gygi, SP; Duraisingh, MT
2016
Genomic variation in two gametocyte non-producing Plasmodium falciparum clonal lines. (2016)
Campino, Susana; Benavente, Ernest Diez; Assefa, Samuel; Thompson, Eloise; Drought, Laura G; Taylor, Catherine J; Gorvett, Zaria; Carret, Celine K; Flueck, Christian; Ivens, Al C; Kwiatkowski, Dominic P; Alano, Pietro; Baker, David A; Clark, Taane G
2015
May 2015 - predicting pandemics, the impact of cold weather, and using viagra to control malaria. (2015)
UNSPECIFIED
David Baker - Using Viagra to control malaria. (2015)
UNSPECIFIED
Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion. (2015)
Alam, Mahmood M; Solyakov, Lev; Bottrill, Andrew R; Flueck, Christian; Siddiqui, Faiza A; Singh, Shailja; Mistry, Sharad; Viskaduraki, Maria; Lee, Kate; Hopp, Christine S; Chitnis, Chetan E; Doerig, Christian; Moon, Robert W; Green, Judith L; Holder, Anthony A; Baker, David A; Tobin, Andrew B
Investigations into Phosphodieterases as Targets for Antimalarial Drug Discovery. (2015)
Drought, LG
Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development. (2015)
Green, Judith L; Moon, Robert W; Whalley, David; Bowyer, Paul W; Wallace, Claire; Rochani, Ankit; Nageshan, Rishi K; Howell, Steven A; Grainger, Munira; Jones, Hayley M; Ansell, Keith H; Chapman, Timothy M; Taylor, Debra L; Osborne, Simon A; Baker, David A; Tatu, Utpal; Holder, Anthony A
Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vγ9Vδ2 T Cells. (2015)
Guenot, Marianne; Loizon, Séverine; Howard, Jennifer; Costa, Giulia; Baker, David A; Mohabeer, Shaneel Y; Troye-Blomberg, Marita; Moreau, Jean-François; Déchanet-Merville, Julie; Mercereau-Puijalon, Odile; Mamani-Matsuda, Maria; Behr, Charlotte
The Mu subunit of Plasmodium falciparum clathrin-associated adaptor protein 2 modulates in vitro parasite response to artemisinin and quinine. (2015)
Henriques, Gisela; van Schalkwyk, Donelly A; Burrow, Rebekah; Warhurst, David C; Thompson, Eloise; Baker, David A; Fidock, David A; Hallett, Rachel; Flueck, Christian; Sutherland, Colin J
Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress. (2015)
Kim, Jeong Joo; Flueck, Christian; Franz, Eugen; Sanabria-Figueroa, Eduardo; Thompson, Eloise; Lorenz, Robin; Bertinetti, Daniela; Baker, David A; Herberg, Friedrich W; Kim, Choel
cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. (2015)
Ramdani, Ghania; Naissant, Bernina; Thompson, Eloise; Breil, Florence; Lorthiois, Audrey; Dupuy, Florian; Cummings, Ross; Duffier, Yoann; Corbett, Yolanda; Mercereau-Puijalon, Odile; Vernick, Kenneth; Taramelli, Donatella; Baker, David A; Langsley, Gordon; Lavazec, Catherine
2014
Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites. (2014)
Brochet, Mathieu; Collins, Mark O; Smith, Terry K; Thompson, Eloise; Sebastian, Sarah; Volkmann, Katrin; Schwach, Frank; Chappell, Lia; Gomes, Ana Rita; Berriman, Matthew; Rayner, Julian C; Baker, David A; Choudhary, Jyoti; Billker, Oliver
Malaria parasite epigenetics: when virulence and romance collide. (2014)
Flueck, Christian; Baker, David A
A transcriptional switch underlies commitment tosexual development in malaria parasites. (2014)
Kafsack, BF; Rovira-Graells, N; Clark, TG; Bancells, C; Crowley, VM; Campino, SG; Williams, AE; Drought, LG; Kwiatkowski, DP; Baker, DA; Cortés, A; Llinás, M
A transcriptional switch underlies commitment to sexual development in malaria parasites. (2014)
Kafsack, Björn FC; Rovira-Graells, Núria; Clark, Taane G; Bancells, Cristina; Crowley, Valerie M; Campino, Susana G; Williams, April E; Drought, Laura G; Kwiatkowski, Dominic P; Baker, David A; Cortés, Alfred; Llinás, Manuel
Targeting Plasmodium falciparum protein kinases with adenosine analogue-oligoarginine conjugates. (2014)
Lavogina, Darja; Budu, Alexandre; Enkvist, Erki; Hopp, Christine S; Baker, David A; Langsley, Gordon; Garcia, Celia RS; Uri, Asko
Development of a transgenic Plasmodium berghei line (Pb pfpkg) expressing the P. falciparum cGMP-dependent protein kinase, a novel antimalarial drug target. (2014)
Tewari, Rita; Patzewitz, Eva-Maria; Poulin, Benoit; Stewart, Lindsay; Baker, David A
2010
Cyclic nucleotide signalling in malaria parasites. (2010)
Baker, David A
Malaria gametocytogenesis. (2010)
Baker, David A
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. (2010)
Dvorin, Jeffrey D; Martyn, Derek C; Patel, Saurabh D; Grimley, Joshua S; Collins, Christine R; Hopp, Christine S; Bright, A Taylor; Westenberger, Scott; Winzeler, Elizabeth; Blackman, Michael J; Baker, David A; Wandless, Thomas J; Duraisingh, Manoj T
2009
Signalling in malaria parasites. The MALSIG consortium. (2009)
Doerig, C; Baker, D; Billker, O; Blackman, MJ; Chitnis, C; Dhar Kumar, S; Heussler, V; Holder, AA; Kocken, C; Krishna, S; Langsley, G; Lasonder, E; Menard, R; Meissner, M; Pradel, G; Ranford-Cartwright, L; Sharma, A; Sharma, P; Tardieux, T; Tatu, U; Alano, P
A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum. (2009)
Leber, Werner; Skippen, Alison; Fivelman, Quinton L; Bowyer, Paul W; Cockcroft, Shamshad; Baker, David A
A cyclic GMP signalling module that regulates gliding motility in a malaria parasite. (2009)
Moon, Robert W; Taylor, Cathy J; Bex, Claudia; Schepers, Rebecca; Goulding, David; Janse, Chris J; Waters, Andrew P; Baker, David A; Billker, Oliver
Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages. (2009)
Schnick, Claudia; Polley, Spencer D; Fivelman, Quinton L; Ranford-Cartwright, Lisa C; Wilkinson, Shane R; Brannigan, James A; Wilkinson, Anthony J; Baker, David A
The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony. (2009)
Taylor, Helen M; McRobert, Louisa; Grainger, Munira; Sicard, Audrey; Dluzewski, Anton R; Hopp, Christine S; Holder, Anthony A; Baker, David A
2008
P-falciparum gametogenesis is mediated by cGMPdependent protein kinase. (2008)
McRobert, L; Taylor, CJ; Deng, W; Fivelman, Q; Cummings, R; Billker, O; Baker, DA
Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase. (2008)
McRobert, Louisa; Taylor, Cathy J; Deng, Wensheng; Fivelman, Quinton L; Cummings, Ross M; Polley, Spencer D; Billker, Oliver; Baker, David A
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Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis. (2008)
Taylor, Cathy J; McRobert, Louisa; Baker, David A
Plasmodium falciparum cGMP-dependent protein kinase plays a central role in schizogony. (2008)
Taylor, HM; McRobert, L; Grainger, M; Holder, AA; Baker, DA
2006
Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage. (2006)
Kelly, John M; McRobert, Louisa; Baker, David A
Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes. (2006)
Sharp, Sarah; Lavstsen, Thomas; Fivelman, Quinton L; Saeed, Maha; McRobert, Louisa; Templeton, Thomas J; Jensen, Anja TR; Baker, David A; Theander, Thor G; Sutherland, Colin J
2005
Cyclic GMP-dependent protein kinases in protozoa. (2005)
Baker, David A; Deng, Wensheng
The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. (2005)
Young, Jason A; Fivelman, Quinton L; Blair, Peter L; de la Vega, Patricia; Le Roch, Karine G; Zhou, Yingyao; Carucci, Daniel J; Baker, David A; Winzeler, Elizabeth A
2003
The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum. (2003)
Deng, Wensheng; Parbhu-Patel, Asha; Meyer, David J; Baker, David A
Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. (2003)
Muhia, David K; Swales, Claire A; Eckstein-Ludwig, Ursula; Saran, Shweta; Polley, Spencer D; Kelly, John M; Schaap, Pauline; Krishna, Sanjeev; Baker, David A