Impact of bleeding on mortality after percutaneous coronary intervention results from a patient-level pooled analysis of the REPLACE-2 (randomized evaluation of PCI linking angiomax to reduced clinical events), ACUITY (acute catheterization and urgent intervention triage strategy), and HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trials.

Roxana Mehran; Stuart Pocock; Eugenia Nikolsky; George D Dangas; Tim Clayton; Bimmer E Claessen; Adriano Caixeta; Frederick Feit; Steven V Manoukian; Harvey White; +6 more... Michel Bertrand; E Magnus Ohman; Helen Parise; Alexandra J Lansky; A Michael Lincoff; Gregg W Stone; (2011) Impact of bleeding on mortality after percutaneous coronary intervention results from a patient-level pooled analysis of the REPLACE-2 (randomized evaluation of PCI linking angiomax to reduced clinical events), ACUITY (acute catheterization and urgent intervention triage strategy), and HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trials. JACC. Cardiovascular interventions, 4 (6). pp. 654-64. ISSN 1876-7605 https://material-uat.leaf.cosector.com/id/eprint/20523
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Non-CABG-related bleeding within 30 days is strongly associated with an increased risk of subsequent mortality at 1 year in patients undergoing PCI for all indications. A risk score was established to calculate the bleeding risk for patients undergoing PCI, allowing therapeutic decision making to minimize the incidence of bleeding.

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