[Protective activity of a bacterial plasmid, bearing the gene for the tick-borne encephalitis virus NS1 nonstructural protein].
AV Timofeev;
Iu Iu Kondrat'eva;
GG Karganova;
J Stephenson;
(2001)
[Protective activity of a bacterial plasmid, bearing the gene for the tick-borne encephalitis virus NS1 nonstructural protein].
Voprosy virusologii, 46 (1).
pp. 22-24.
ISSN 0507-4088
https://material-uat.leaf.cosector.com/id/eprint/18489
Three intramuscular injections (50 micrograms each) with bacterial plasmid pMV45 carrying nonstructural gene of NS1 protein of tick-borne encephalitis (TBE) virus protected 88% Balb/c mice from lethal challenge with the virus. Antibodies to NS1 nonstructural protein were detected in the sera of vaccinated mice after the challenge. Absence of antibodies to E structural protein indicated absence of manifest infectious process in mice vaccinated with plasmid and challenged with a lethal dose of TBE virus.
| Item Type | Article |
|---|---|
| Keywords | Animal, Antibodies, Viral, blood, Cercopithecus aethiops, Encephalitis Viruses, Tick-Borne, genetics, English Abstract, Mice, Mice, Inbred BALB C, Plasmids, administration & dosage, Vero Cells, Viral Envelope Proteins, immunology, Viral Nonstructural Proteins, genetics, immunology, Viral Vaccines, administration & dosage |