In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.

Vanessa Yardley; Anis A Khan; Michael B Martin; Teri R Slifer; Fausto G Araujo; Silvia NJ Moreno; Roberto Docampo; Simon L Croft ORCID logo; Eric Oldfield; (2002) In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrobial agents and chemotherapy, 46 (3). pp. 929-931. ISSN 0066-4804 DOI: 10.1128/AAC.46.3.929-931.2002
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The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.
Item Type Article
Keywords Administration, Oral, Alendronate/pharmacology, Alkyl and Aryl Transferases/*antagonists & inhibitors, Animal, Diphosphonates/administration & dosage/*therapeutic use, Enzyme Inhibitors/administration & dosage/adverse effects/*therapeutic use, Female, Hamsters, Injections, Intraperitoneal, Leishmania donovani/*drug effects/*enzymology, Leishmaniasis, Visceral/*drug therapy/*parasitology, Mesocricetus, Mice, Mice, Inbred BALB C, Prodrugs/pharmacology, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S., Survival Analysis, Toxoplasma/*drug effects/*enzymology, Toxoplasmosis, Animal/*drug therapy/*parasitology, Administration, Oral, Alendronate, pharmacology, Alkyl and Aryl Transferases, antagonists & inhibitors, Animal, Diphosphonates, administration & dosage, therapeutic use, Enzyme Inhibitors, administration & dosage, adverse effects, therapeutic use, Female, Hamsters, Injections, Intraperitoneal, Leishmania donovani, drug effects, enzymology, Leishmaniasis, Visceral, drug therapy, parasitology, Mesocricetus, Mice, Mice, Inbred BALB C, Prodrugs, pharmacology, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S., Survival Analysis, Toxoplasma, drug effects, enzymology, Toxoplasmosis, Animal, drug therapy, parasitology
ISI 173908900054

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