The role of glutathione peroxidases in trypanosomatids.

Shane R Wilkinson; John M Kelly ORCID logo; (2003) The role of glutathione peroxidases in trypanosomatids. Biological chemistry, 384 (4). pp. 517-525. ISSN 1431-6730 DOI: 10.1515/BC.2003.060
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Reactive oxygen species are the unwanted by-products of aerobic metabolism. To protect cells against their potentially lethal effects a series of pathways have evolved that are collectively called the oxidative defence system. In most eukaryotes, catalases and selenium-dependent glutathione peroxidases form the front line of defence against hydroperoxide-mediated damage. However, these activities are lacking in members of the Trypanosomatidae family of protozoan parasites. Instead these organisms contain several enzyme-mediated pathways for removal of hydroperoxides that are centred upon the unusual thiol trypanothione. Here we discuss the biochemical properties of one group of these enzymes, the non-selenium glutathione-dependent peroxidases, and outline the roles that they play in protecting the parasite against hydroperoxides associated with biological membranes.

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