Indole and beta-carboline alkaloids from Geissospermum sericeum.
Jonathan CP Steele;
Nigel C Veitch;
Geoffrey C Kite;
Monique SJ Simmonds;
David C Warhurst;
(2002)
Indole and beta-carboline alkaloids from Geissospermum sericeum.
Journal of natural products, 65 (1).
pp. 85-88.
ISSN 0163-3864
DOI: 10.1021/np0101705
The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.
| Item Type | Article |
|---|---|
| Keywords | Antimalarial, Animal, Antimalarials, chemistry, isolation & purification, pharmacology, Brazil, Carbolines, chemistry, isolation & purification, pharmacology, Chloroquine, pharmacology, Chromatography, Thin Layer, Drug Resistance, Human, Inhibitory Concentration 50, KB Cells, drug effects, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Bark, chemistry, Plants, Medicinal, chemistry, Plasmodium falciparum, drug effects, Spectrophotometry, Ultraviolet, Support, Non-U.S. Gov't, Tumor Cells, Cultured, drug effects |
| ISI | 173618200023 |