Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria.
Anja TR Jensen;
Hanne D Zornig;
Caecilie Buhmann;
Ali Salanti;
Kwadwo A Koram;
Eleanor M Riley;
Thor G Theander;
Lars Hviid;
Trine Staalsoe;
(2003)
Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria.
Infection and immunity, 71 (7).
pp. 4193-4196.
ISSN 0019-9567
DOI: 10.1128/IAI.71.7.4193-4196.2003
Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.
| Item Type | Article |
|---|---|
| Keywords | chondroitin sulfate-a, erythrocyte-membrane protein-1, variant, surface-antigens, infected erythrocytes, cytoadherence, characteristics, human placenta, adhesion, receptor, identification, adherence, Animal, Antibodies, Protozoan, blood, Chondroitin Sulfates, physiology, Female, Human, Immunoglobulin G, blood, Malaria, Falciparum, immunology, Male, Parity, Plasmodium falciparum, genetics, immunology, Pregnancy, Pregnancy Complications, Parasitic, immunology, Protozoan Proteins, genetics, Sex Factors, Support, Non-U.S. Gov't |
| ISI | 183797200071 |
Explore Further
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC162013 (OA Location)
- 10.1128/IAI.71.7.4193-4196.2003 (DOI)
- 12819117 (PubMed)