Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic.

Matthew J Burton ORCID logo; Robin L Bailey ORCID logo; David Jeffries ORCID logo; David CW Mabey ORCID logo; Martin J Holland ORCID logo; (2004) Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic. Infection and immunity, 72 (12). pp. 7352-7356. ISSN 0019-9567 DOI: 10.1128/IAI.72.12.7352-7356.2004
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The role of immunity in blinding trachoma is unclear. Conjunctival gene expression was measured in a population where trachoma is endemic. Proinflammatory (tumor necrosis factor alpha and interleukin-1beta [IL-1beta]), anti-inflammatory (IL-10), and fibrogenic (matrix metalloprotease 9) gene expression was increased in active trachoma. Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present.

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