Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic.
Matthew J Burton 
;
Robin L Bailey ;
David Jeffries ;
David CW Mabey ;
Martin J Holland ;
(2004)
Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic.
Infection and immunity, 72 (12).
pp. 7352-7356.
ISSN 0019-9567
DOI: 10.1128/IAI.72.12.7352-7356.2004
;
Robin L Bailey ;
David Jeffries ;
David CW Mabey ;
Martin J Holland ;
(2004)
Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic.
Infection and immunity, 72 (12).
pp. 7352-7356.
ISSN 0019-9567
DOI: 10.1128/IAI.72.12.7352-7356.2004
The role of immunity in blinding trachoma is unclear. Conjunctival gene expression was measured in a population where trachoma is endemic. Proinflammatory (tumor necrosis factor alpha and interleukin-1beta [IL-1beta]), anti-inflammatory (IL-10), and fibrogenic (matrix metalloprotease 9) gene expression was increased in active trachoma. Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present.
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- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC529133 (OA Location)
- 10.1128/IAI.72.12.7352-7356.2004 (DOI)
- 15557667 (PubMed)