Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Julieta Coro;
Richard Atherton;
Susan Little;
Hayley Wharton;
Vanessa Yardley;
Amaury Alvarez;
Margarita Súarez;
Rolando Pérez;
Hortensia Rodríguez;
(2006)
Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Bioorganic & medicinal chemistry letters, 16 (5).
pp. 1312-1315.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2005.11.060
The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b. rhodesiense with IC(50) values ranging between 0.3 and 4 microM for the most active compounds.
| Item Type | Article |
|---|---|
| ISI | 235284700044 |