Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Sandra Gemma;
Gagan Kukreja;
Caterina Fattorusso;
Marco Persico;
Maria P Romano;
Maria Altarelli;
Luisa Savini;
Giuseppe Campiani;
Ernesto Fattorusso;
Nicoletta Basilico;
+3 more...
Donatella Taramelli;
Vanessa Yardley;
Stefania Butini;
(2006)
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Bioorganic & medicinal chemistry letters, 16 (20).
pp. 5384-5388.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2006.07.060
A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.
| Item Type | Article |
|---|---|
| ISI | 241344400027 |