Items where the Publication is Journal of medicinal chemistry

Number of items: 52.
2023
  • Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection. (2023) Tawaraishi, Taisuke; Ochida, Atsuko; Akao, Yuichiro; Itono, Sachiko; Kamaura, Masahiro; Akther, Thamina; Shimada, Mitsuyuki; Canan, Stacie; Chowdhury, Sanjoy; Cao, Yafeng; Condroski, Kevin; Engkvist, Ola; Francisco, Amanda; Ghosh, Sunil; Kaki, Rina; Kelly, John M; Kimura, Chiaki; Kogej, Thierry; Nagaoka, Kazuya; Naito, Akira; Pairaudeau, Garry; Radu, Constantin; Roberts, Ieuan; Shum, David; Watanabe, Nao-Aki; Xie, Huanxu; Yonezawa, Shuji; Yoshida, Osamu; Yoshida, Ryu; Mowbray, Charles; Perry, Benjamin
  • 2022
  • Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis. (2022) Smith, Alasdair; Wall, Richard J; Patterson, Stephen; Rowan, Tim; Rico Vidal, Eva; Stojanovski, Laste; Huggett, Margaret; Hampton, Shahienaz E; Thomas, Michael G; Corpas Lopez, Victoriano; Gillingwater, Kirsten; Duke, Jeff; Napier, Grant; Peter, Rose; Vitouley, Hervé S; Harrison, Justin R; Milne, Rachel; Jeacock, Laura; Baker, Nicola; Davis, Susan H; Simeons, Frederick; Riley, Jennifer; Horn, David; Brun, Reto; Zuccotto, Fabio; Witty, Michael J; Wyllie, Susan; Read, Kevin D; Gilbert, Ian H
  • 2020
  • Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials. (2020) Mahindra, Amit; Janha, Omar; Mapesa, Kopano; Sanchez-Azqueta, Ana; Alam, Mahmood M; Amambua-Ngwa, Alfred; Nwakanma, Davis C; Tobin, Andrew B; Jamieson, Andrew G picture_as_pdf
  • 2019
  • Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites. (2019) Matralis, Alexios N; Malik, Adnan; Penzo, Maria; Moreno, Inmaculada; Almela, Maria J; Camino, Isabel; Crespo, Benigno; Saadeddin, Anas; Ghidelli-Disse, Sonja; Rueda, Lourdes; Calderon, Felix; Osborne, Simon A; Drewes, Gerard; Böesche, Markus; Fernández-Álvaro, Elena; Martin Hernando, Jose Ignacio; Baker, David A
  • Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes. (2019) Rueda-Zubiaurre, Ainoa; Yahiya, Sabrina; Fischer, Oliver J; Hu, Xiaojun; Saunders, Charlie N; Sharma, Sachi; Straschil, Ursula; Shen, Junting; Tate, Edward W; Delves, Michael J; Baum, Jake; Barnard, Anna; Fuchter, Matthew J
  • 2018
  • Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis. (2018) Thompson, Andrew M; O'Connor, Patrick D; Marshall, Andrew J; Blaser, Adrian; Yardley, Vanessa; Maes, Louis; Gupta, Suman; Launay, Delphine; Braillard, Stephanie; Chatelain, Eric; Wan, Baojie; Franzblau, Scott G; Ma, Zhenkun; Cooper, Christopher B; Denny, William A
  • 2017
  • Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. (2017) Brand, Stephen; Ko, Eun Jung; Viayna, Elisabet; Thompson, Stephen; Spinks, Daniel; Thomas, Michael; Sandberg, Lars; Francisco, Amanda F; Jayawardhana, Shiromani; Smith, Victoria C; Jansen, Chimed; De Rycker, Manu; Thomas, John; MacLean, Lorna; Osuna-Cabello, Maria; Riley, Jennifer; Scullion, Paul; Stojanovski, Laste; Simeons, Frederick RC; Epemolu, Ola; Shishikura, Yoko; Crouch, Sabrinia D; Bakshi, Tania S; Nixon, Christopher J; Reid, Iain H; Hill, Alan P; Underwood, Tim Z; Hindley, Sean J; Robinson, Sharon A; Kelly, John M; Fiandor, Jose M; Wyatt, Paul G; Marco, Maria; Miles, Timothy J; Read, Kevin D; Gilbert, Ian H
  • 3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally. (2017) Leven, Michael; Knaab, Tanja C; Held, Jana; Duffy, Sandra; Meister, Stephan; Fischli, Christoph; Meitzner, Diane; Lehmann, Ursula; Lungerich, Beate; Kuna, Krystina; Stahlke, Petra; Delves, Michael J; Buchholz, Mirko; Winzeler, Elizabeth A; Avery, Vicky M; Mordmüller, Benjamin; Wittlin, Sergio; Kurz, Thomas
  • 7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis. (2017) Thompson, AM; O'Connor, PD; Marshall, AJ; Yardley, V; Maes, L; Gupta, S; Launay, D; Braillard, S; Chatelain, E; Franzblau, SG; Wan, B; Wang, Y; Ma, Z; Cooper, CB; Denny, WA
  • 2016
  • Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. (2016) Baragaña, Beatriz; Norcross, Neil R; Wilson, Caroline; Porzelle, Achim; Hallyburton, Irene; Grimaldi, Raffaella; Osuna-Cabello, Maria; Norval, Suzanne; Riley, Jennifer; Stojanovski, Laste; Simeons, Frederick RC; Wyatt, Paul G; Delves, Michael J; Meister, Stephan; Duffy, Sandra; Avery, Vicky M; Winzeler, Elizabeth A; Sinden, Robert E; Wittlin, Sergio; Frearson, Julie A; Gray, David W; Fairlamb, Alan H; Waterson, David; Campbell, Simon F; Willis, Paul; Read, Kevin D; Gilbert, Ian H
  • Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening. (2016) Neves, BJ; Dantas, RF; Senger, MR; Melo-Filho, CC; Valente, WC; de Almeida, AC; Rezende-Neto, JM; Lima, EF; Paveley, R; Furnham, N; Muratov, E; Kamentsky, L; Carpenter, AE; Braga, RC; Silva-Junior, FP; Andrade, CH description
  • Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. (2016) Thompson, Andrew M; O'Connor, Patrick D; Blaser, Adrian; Yardley, Vanessa; Maes, Louis; Gupta, Suman; Launay, Delphine; Martin, Denis; Franzblau, Scott G; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A
  • 2014
  • Synthesis and biological evaluation of N,N'-squaramides with high in vivo efficacy and low toxicity: toward a low-cost drug against Chagas disease. (2014) Olmo, Francisco; Rotger, Carmen; Ramírez-Macías, Inmaculada; Martínez, Luis; Marín, Clotilde; Carreras, Lucas; Urbanová, Kristína; Vega, Manel; Chaves-Lemaur, Guillermo; Sampedro, Angel; Rosales, María Jose; Sánchez-Moreno, Manuel; Costa, Antonio
  • 2012
  • Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection. (2012) Sánchez-Moreno, Manuel; Gómez-Contreras, Fernando; Navarro, Pilar; Marín, Clotilde; Olmo, Francisco; Yunta, María JR; Sanz, Ana María; Rosales, María José; Cano, Carmen; Campayo, Lucrecia
  • In vitro and in vivo trypanosomicidal activity of pyrazole-containing macrocyclic and macrobicyclic polyamines: their action on acute and chronic phases of Chagas disease. (2012) Sánchez-Moreno, Manuel; Marín, Clotilde; Navarro, Pilar; Lamarque, Laurent; García-España, Enrique; Miranda, Carlos; Huertas, Oscar; Olmo, Francisco; Gómez-Contreras, Fernando; Pitarch, Javier; Arrebola, Francisco
  • 2011
  • Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity. (2011) Fytas, Christos; Zoidis, Grigoris; Tzoutzas, Nikolaos; Taylor, Martin C; Fytas, George; Kelly, John M
  • In vivo trypanosomicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against acute and chronic phases of Chagas disease. (2011) Sánchez-Moreno, Manuel; Sanz, Ana M; Gómez-Contreras, Fernando; Navarro, Pilar; Marín, Clotilde; Ramírez-Macias, Inmaculada; Rosales, María Jose; Olmo, Francisco; Garcia-Aranda, Isabel; Campayo, Lucrecia; Cano, Carmen; Arrebola, Francisco; Yunta, María JR
  • 2010
  • In vitro and in vivo trypanocidal evaluation of nickel complexes with an azapurine derivative against Trypanosoma cruzi. (2010) Maldonado, Carmen R; Marín, Clotilde; Olmo, Francisco; Huertas, Oscar; Quirós, Miguel; Sánchez-Moreno, Manuel; Rosales, María J; Salas, Juan M
  • Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin. (2010) Pacorel, Bénédicte; Leung, Suet C; Stachulski, Andrew V; Davies, Jill; Vivas, Livia; Lander, Hollie; Ward, Stephen A; Kaiser, Marcel; Brun, Reto; O'Neill, Paul M
  • Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL). (2010) Yang, Mei; Arai, Chika; Bakar Md, Abu; Lu, Jun; Ge, Jian-Feng; Pudhom, Khanitha; Takasu, Kiyosei; Kasai, Kazuki; Kaiser, Marcel; Brun, Reto; Yardley, Vanessa; Itoh, Isamu; Ihara, Masataka
  • 2009
  • Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. (2009) Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, Bhupendra P; Kukreja, Gagan; Coccone, Salvatore Sanna; Bernetti, Matteo; Persico, Marco; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Taramelli, Donatella; Basilico, Nicoletta; Parapini, Silvia; Yardley, Vanessa; Croft, Simon; Keller-Maerki, Sonja; Rottmann, Matthias; Brun, Reto; Coletta, Massimiliano; Marini, Stefano; Guiso, Giovanna; Caccia, Silvio; Fattorusso, Caterina
  • Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine. (2009) O'Neill, Paul M; Shone, Alison E; Stanford, Deborah; Nixon, Gemma; Asadollahy, Eghbaleh; Park, B Kevin; Maggs, James L; Roberts, Phil; Stocks, Paul A; Biagini, Giancarlo; Bray, Patrick G; Davies, Jill; Berry, Neil; Hall, Charlotte; Rimmer, Karen; Winstanley, Peter A; Hindley, Stephen; Bambal, Ramesh B; Davis, Charles B; Bates, Martin; Gresham, Stephanie L; Brigandi, Richard A; Gomez-de-Las-Heras, Federico M; Gargallo, Domingo V; Parapini, Silvia; Vivas, Livia; Lander, Hollie; Taramelli, Donatella; Ward, Stephen A
  • 2008
  • Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. (2008) Ellis, GL; Amewu, R; Sabbani, S; Stocks, PA; Shone, A; Stanford, D; Gibbons, P; Davies, J; Vivas, L; Charnaud, S; Bongard, E; Hall, C; Rimmer, K; Lozanom, S; Jesus, M; Gargallo, D; Ward, SA; O'Neill, PM
  • Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. (2008) Ellis, Gemma L; Amewu, Richard; Sabbani, Sunil; Stocks, Paul A; Shone, Alison; Stanford, Deborah; Gibbons, Peter; Davies, Jill; Vivas, Livia; Charnaud, Sarah; Bongard, Emily; Hall, Charlotte; Rimmer, Karen; Lozanom, Sonia; Jesús, María; Gargallo, Domingo; Ward, Stephen A; O'Neill, Paul M
  • Targeting the lysosome: fluorescent iron(III) chelators to selectively monitor endosomal/lysosomal labile iron pools. (2008) Fakih, Sarah; Podinovskaia, Maria; Kong, Xiaole; Collins, Helen L; Schaible, Ulrich E; Hider, Robert C
  • Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. (2008) Fattorusso, Caterina; Campiani, Giuseppe; Kukreja, Gagan; Persico, Marco; Butini, Stefania; Romano, Maria Pia; Altarelli, Maria; Ros, Sindu; Brindisi, Margherita; Savini, Luisa; Novellino, Ettore; Nacci, Vito; Fattorusso, Ernesto; Parapini, Silvia; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Croft, Simon; Borriello, Marianna; Gemma, Sandra
  • Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. (2008) Friebolin, Wolfgang; Jannack, Beate; Wenzel, Nicole; Furrer, Julien; Oeser, Thomas; Sanchez, Cecilia P; Lanzer, Michael; Yardley, Vanessa; Becker, Katja; Davioud-Charvet, Elisabeth
  • Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies. (2008) Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, Gagan; Coccone, Salvatore Sanna; Joshi, Bhupendra P; Persico, Marco; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Fattorusso, Ernesto; Taglialatela-Scafati, Orazio; Savini, Luisa; Taramelli, Donatella; Basilico, Nicoletta; Parapini, Silvia; Morace, Giulia; Yardley, Vanessa; Croft, Simon; Coletta, Massimiliano; Marini, Stefano; Fattorusso, Caterina
  • Design, synthesis, and trypanocidal activity of new aminoadamantane derivatives. (2008) Papanastasiou, Ioannis; Tsotinis, Andrew; Kolocouris, Nicolas; Prathalingam, S Radhika; Kelly, John M
  • 2007
  • Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore. (2007) Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, Gagan; Joshi, Bhupendra P; Persico, Marco; Catalanotti, Bruno; Novellino, Ettore; Fattorusso, Ernesto; Nacci, Vito; Savini, Luisa; Taramelli, Donatella; Basilico, Nicoletta; Morace, Giulia; Yardley, Vanessa; Fattorusso, Caterina
  • 2006
  • Evaluation of azasterols as anti-parasitics. (2006) Gros, Ludovic; Lorente, Silvia Orenes; Jimenez, Carmen Jimenez; Yardley, Vanessa; Rattray, Lauren; Wharton, Hayley; Little, Susan; Croft, Simon L; Ruiz-Perez, Luis M; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H
  • Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. (2006) Hudock, Michael P; Sanz-Rodríguez, CE; Song, Yongcheng; Chan, Julian MW; Zhang, Yonghui; Odeh, Sarah; Kosztowski, Thomas; Leon-Rossell, Annette; Concepción, JL; Yardley, Vanessa; Croft, Simon L; Urbina, Julio A; Oldfield, Eric
  • Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo. (2006) Stachulski, Andrew V; Berry, Neil G; Lilian Low, AC; Moores, Shelley L; Row, Eleanor; Warhurst, David C; Adagu, Ipemida S; Rossignol, Jean-François
  • 2005
  • Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites. (2005) Baliani, Alessandro; Bueno, Gorka Jimenez; Stewart, Mhairi L; Yardley, Vanessa; Brun, Reto; Barrett, Michael P; Gilbert, Ian H
  • Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. (2005) Ersmark, Karolina; Nervall, Martin; Hamelink, Elizabeth; Janka, Linda K; Clemente, Jose C; Dunn, Ben M; Blackman, Michael J; Samuelsson, Bertil; Aqvist, Johan; Hallberg, Anders
  • Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II. (2005) Johansson, Per-Ola; Lindberg, Jimmy; Blackman, Michael J; Kvarnström, Ingemar; Vrang, Lotta; Hamelink, Elizabeth; Hallberg, Anders; Rosenquist, Asa; Samuelsson, Bertil
  • Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. (2005) Lee, Brittany; Bauer, Holger; Melchers, Johannes; Ruppert, Thomas; Rattray, Lauren; Yardley, Vanessa; Davioud-Charvet, Elisabeth; Krauth-Siegel, R Luise
  • Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. (2005) Onyeibor, Onyeka; Croft, Simon L; Dodson, Hilary I; Feiz-Haddad, Mohammad; Kendrick, Howard; Millington, Nicola J; Parapini, Silvia; Phillips, Roger M; Seville, Scott; Shnyder, Steven D; Taramelli, Donatella; Wright, Colin W
  • Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide. (2005) Parveen, Seheli; Khan, Mohammed OF; Austin, Susan E; Croft, Simon L; Yardley, Vanessa; Rock, Peter; Douglas, Kenneth T
  • 2004
  • Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity. (2004) Ersmark, Karolina; Feierberg, Isabella; Bjelic, Sinisa; Hamelink, Elizabeth; Hackett, Fiona; Blackman, Michael J; Hultén, Johan; Samuelsson, Bertil; Aqvist, Johan; Hallberg, Anders
  • Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. (2004) Ghosh, Subhash; Chan, Julian MW; Lea, Christopher R; Meints, Gary A; Lewis, Jared C; Tovian, Zev S; Flessner, Ryan M; Loftus, Timothy C; Bruchhaus, Iris; Kendrick, Howard; Croft, Simon L; Kemp, Robert G; Kobayashi, Seiki; Nozaki, Tomoyoshi; Oldfield, Eric
  • Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs. (2004) Johansson, Per-Ola; Chen, Yantao; Belfrage, Anna Karin; Blackman, Michael J; Kvarnström, Ingemar; Jansson, Katarina; Vrang, Lotta; Hamelink, Elizabeth; Hallberg, Anders; Rosenquist, Asa; Samuelsson, Bertil
  • Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone. (2004) Mäntylä, Antti; Garnier, Tracy; Rautio, Jarkko; Nevalainen, Tapio; Vepsälainen, Jouko; Koskinen, Ari; Croft, Simon L; Järvinen, Tomi
  • Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. (2004) Ohkanda, Junko; Buckner, Frederick S; Lockman, Jeffrey W; Yokoyama, Kohei; Carrico, Dora; Eastman, Richard; de Luca-Fradley, Kate; Davies, Wendy; Croft, Simon L; Van Voorhis, Wesley C; Gelb, Michael H; Sebti, Saïd M; Hamilton, Andrew D
  • 2003
  • Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead. (2003) Chauvière, Gérard; Bouteille, Bernard; Enanga, Bertin; de Albuquerque, Cristina; Croft, Simon L; Dumas, Michel; Périé, Jacques
  • Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi. (2003) Magaraci, Filippo; Jimenez, Carmen Jimenez; Rodrigues, Carlos; Rodrigues, Juliany CF; Braga, Marina Vianna; Yardley, Vanessa; de Luca-Fradley, Kate; Croft, Simon L; de Souza, Wanderley; Ruiz-Perez, Luis M; Urbina, Julio; Gonzalez Pacanowska, Dolores; Gilbert, Ian H
  • 2002
  • Synthesis, stability, and antimalarial activity of new hydrolytically stable and water-soluble (+)-deoxoartelinic acid. (2002) Jung, Mankil; Lee, Kyunghoon; Kendrick, Howard; Robinson, Brian L; Croft, Simon L
  • Activity of bisphosphonates against Trypanosoma brucei rhodesiense. (2002) Martin, Michael B; Sanders, John M; Kendrick, Howard; de Luca-Fradley, Kate; Lewis, Jared C; Grimley, Joshua S; Van Brussel, Erin M; Olsen, Jeffrey R; Meints, Gary A; Burzynska, Agnieszka; Kafarski, Pawel; Croft, Simon L; Oldfield, Eric
  • 2001
  • QSAR study on the contribution of log P and E(s) to the in vitro antiprotozoal activity of glutathione derivatives. (2001) Daunes, S; D'Silva, C; Kendrick, H; Yardley, V; Croft, SL
  • Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. (2001) Martin, MB; Grimley, JS; Lewis, JC; Heath, HT; Bailey, BN; Kendrick, H; Yardley, V; Caldera, A; Lira, R; Urbina, JA; Moreno, SN; Docampo, R; Croft, SL; Oldfield, E
  • 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity. (2001) Salmon-Chemin, L; Buisine, E; Yardley, V; Kohler, S; Debreu, MA; Landry, V; Sergheraert, C; Croft, SL; Krauth-Siegel, RL; Davioud-Charvet, E
  • Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents. (2001) Wright, CW; Addae-Kyereme, J; Breen, AG; Brown, JE; Cox, MF; Croft, SL; Gökçek, Y; Kendrick, H; Phillips, RM; Pollet, PL