Items where the Publication is Bioorganic & medicinal chemistry letters

Year Authors/Creators Item Type Full Text

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Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity. (2003) Bal, Gunther; Van der Veken, Pieter; Antonov, Dimitri; Lambeir, Anne-Marie; Grellier, Philippe; Croft, Simon L; Augustyns, Koen; Haemers, Achiel

Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo. (2010) Blackie, Margaret AL; Yardley, Vanessa; Chibale, Kelly

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine. (2001) Chibale, K; Haupt, H; Kendrick, H; Yardley, V; Saravanamuthu, A; Fairlamb, AH; Croft, SL

Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents. (2006) Coro, Julieta; Atherton, Richard; Little, Susan; Wharton, Hayley; Yardley, Vanessa; Alvarez, Amaury; Súarez, Margarita; Pérez, Rolando; Rodríguez, Hortensia

Antimalarial and cytotoxic activities of chiral triamines. (2013) Dellai, Afef; Appel, Jon; Bouraoui, Abderrahman; Croft, Simon; Nefzi, Adel

Praziquantel analogs with activity against juvenile Schistosoma mansoni. (2010) Dong, Yuxiang; Chollet, Jacques; Vargas, Mireille; Mansour, Nuha R; Bickle, Quentin; Alnouti, Yazen; Huang, Jiangeng; Keiser, Jennifer; Vennerstrom, Jonathan L

Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1. (2012) Gemma, Sandra; Giovani, Simone; Brindisi, Margherita; Tripaldi, Pierangela; Brogi, Simone; Savini, Luisa; Fiorini, Isabella; Novellino, Ettore; Butini, Stefania; Campiani, Giuseppe; Penzo, Maria; Blackman, Michael J

Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. (2007) Gemma, Sandra; Kukreja, Gagan; Campiani, Giuseppe; Butini, Stefania; Bernetti, Matteo; Joshi, Bhupendra P; Savini, Luisa; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Bertamino, Alessia; Novellino, Ettore; Persico, Marco; Catalanotti, Bruno; Fattorusso, Caterina

Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. (2006) Gemma, Sandra; Kukreja, Gagan; Fattorusso, Caterina; Persico, Marco; Romano, Maria P; Altarelli, Maria; Savini, Luisa; Campiani, Giuseppe; Fattorusso, Ernesto; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Butini, Stefania

Rational design of the first difluorostatone-based PfSUB1 inhibitors. (2014) Giovani, Simone; Penzo, Maria; Brogi, Simone; Brindisi, Margherita; Gemma, Sandra; Novellino, Ettore; Savini, Luisa; Blackman, Michael J; Campiani, Giuseppe; Butini, Stefania

Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone. (2006) Gokhale, Nikhil H; Shirisha, K; Padhye, Subhash B; Croft, Simon L; Kendrick, Howard D; Mckee, Vickie

Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives. (2004) Jung, Mankil; Lee, Kyunghoon; Jung, Hochul; Kendrick, Howard; Yardley, Vanessa; Croft, Simon L

Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives. (2007) Khrizman, Alexander; Moulthrop, Jason S; Little, Susan; Wharton, Hayley; Yardley, Vanessa; Moyna, Guillermo

Design and synthesis of bioactive adamantane spiro heterocycles. (2007) Kolocouris, Nicolas; Zoidis, Grigoris; Foscolos, George B; Fytas, George; Prathalingham, S Radhika; Kelly, John M; Naesens, Lieve; De Clercq, Erik

Meclonazepam analogues as potential new antihelmintic agents. (2008) Mahajan, Aman; Kumar, Vipan; Mansour, Nuha RN; Bickle, Quentin; Chibale, Kelly

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases. (2012) McIver, Edward G; Bryans, Justin; Birchall, Kristian; Chugh, Jasveen; Drake, Thomas; Lewis, Stephen J; Osborne, Joanne; Smiljanic-Hurley, Ela; Tsang, William; Kamal, Ahmad; Levy, Alison; Newman, Michelle; Taylor, Debra; Arthur, J Simon C; Clark, Kristopher; Cohen, Philip

The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin. (2001) Murray, PJ; Kranz, M; Ladlow, M; Taylor, S; Berst, F; Holmes, AB; Keavey, KN; Jaxa-Chamiec, A; Seale, PW; Stead, P; Upton, RJ; Croft, SL; Clegg, W; Elsegood, MR

Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro. (2007) Musonda, Chitalu C; Little, Susan; Yardley, Vanessa; Chibale, Kelly

Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity. (2001) Ohkanda, J; Lockman, JW; Yokoyama, K; Gelb, MH; Croft, SL; Kendrick, H; Harrell, MI; Feagin, JE; Blaskovich, MA; Sebti, SM; Hamilton, AD

Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity. (2012) Peña, Stella; Scarone, Laura; Manta, Eduardo; Stewart, Lindsay; Yardley, Vanessa; Croft, Simon; Serra, Gloria

Design, synthesis, and biological evaluation of a series of simple and novel potential antimalarial compounds. (2001) Ren, H; Grady, S; Gamenara, D; Heinzen, H; Moyna, P; Croft, SL; Kendrick, H; Yardley, V; Moyna, G

Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives. (2011) Singh, Pardeep; Sachdeva, Shaveta; Raj, Raghu; Kumar, Vipan; Mahajan, Mohinder P; Nasser, Shereen; Vivas, Livia; Gut, Jiri; Rosenthal, Phillip J; Feng, Tzu-Shean; Chibale, Kelly

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. (2014) Sola, Irene; Artigas, Albert; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego

2,4-diarylthiazole antiprion compounds as a novel structural class of antimalarial leads. (2011) Thompson, Mark J; Louth, Jennifer C; Little, Susan M; Chen, Beining; Coldham, Iain

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Synthesis of diphenoxyadamantane alkylamines with pharmacological interest. (2019) Georgiadis, Markos-Orestis; Kourbeli, Violeta; Ioannidou, Vaya; Karakitsios, Evangelos; Papanastasiou, Ioannis; Tsotinis, Andrew; Komiotis, Dimitri; Vocat, Anthony; Cole, Stewart T; Taylor, Martin C; Kelly, John M

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei. (2012) Kelly, John M; Taylor, Martin C; Horn, David; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik

Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1. (2014) Kher, Samir S; Penzo, Maria; Fulle, Simone; Finn, Paul W; Blackman, Michael J; Jirgensons, Aigars description

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty. (2019) Large, Jonathan M; Birchall, Kristian; Bouloc, Nathalie S; Merritt, Andy T; Smiljanic-Hurley, Ela; Tsagris, Denise J; Wheldon, Mary C; Ansell, Keith H; Coombs, Peter J; Kettleborough, Catherine A; Whalley, David; Stewart, Lindsay B; Bowyer, Paul W; Baker, David A; Osborne, Simon A

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines. (2018) Large, Jonathan M; Birchall, Kristian; Bouloc, Nathalie S; Merritt, Andy T; Smiljanic-Hurley, Ela; Tsagris, Denise J; Wheldon, Mary C; Ansell, Keith H; Coombs, Peter J; Kettleborough, Catherine A; Whalley, David; Stewart, Lindsay B; Bowyer, Paul W; Baker, David A; Osborne, Simon A

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG). (2018) Tsagris, Denise J; Birchall, Kristian; Bouloc, Nathalie; Large, Jonathan M; Merritt, Andy; Smiljanic-Hurley, Ela; Wheldon, Mary; Ansell, Keith H; Kettleborough, Catherine; Whalley, David; Stewart, Lindsay B; Bowyer, Paul W; Baker, David A; Osborne, Simon A