Items where Author is "Lewis, Michael D"

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Bibliographic data only

Analysis of molecular diversity of the Trypanosoma cruzi trypomastigote small surface antigen reveals novel epitopes, evidence of positive selection and potential implications for lineage-specific serology. (2010) Bhattacharyya, Tapan; Brooks, Jessica; Yeo, Matthew; Carrasco, Hernan J; Lewis, Michael D; Llewellyn, Martin S; Miles, Michael A

Identification and lineage genotyping of South American trypanosomes using fluorescent fragment length barcoding. (2011) Hamilton, PB; Lewis, MD; Cruickshank, C; Gaunt, MW; Yeo, M; Llewellyn, MS; Valente, SA; Maia da Silva, F; Stevens, JR; Miles, MA; Teixeira, MMG

Candidate targets for Multilocus Sequence Typing of Trypanosoma cruzi: validation using parasite stocks from the Chaco Region and a set of reference strains. (2012) Lauthier, Juan J; Tomasini, Nicolás; Barnabé, Christian; Rumi, María M Monje; D'Amato, Anahí M Alberti; Ragone, Paula G; Yeo, Matthew; Lewis, Michael D; Llewellyn, Martin S; Basombrío, Miguel A; Miles, Michael A; Tibayrenc, Michel; Diosque, Patricio

The midgut microbiota plays an essential role in sand fly vector competence for Leishmania major. (2017) Louradour, Isabelle; Monteiro, Carolina Cunha; Inbar, Ehud; Ghosh, Kashinath; Merkhofer, Richard; Lawyer, Phillip; Paun, Andrea; Smelkinson, Margery; Secundino, Nagila; Lewis, Michael; Erram, Dinesh; Zurek, Ludek; Sacks, David

Comparative phylogeography of Trypanosoma cruzi TCIIc: new hosts, association with terrestrial ecotopes, and spatial clustering. (2009) Marcili, Arlei; Lima, Luciana; Valente, Vera C; Valente, Sebastião A; Batista, Jael S; Junqueira, Angela CV; Souza, Alda I; da Rosa, João A; Campaner, Marta; Lewis, Michael D; Llewellyn, Martin S; Miles, Michael A; Teixeira, Marta MG

Molecular Genotyping of Trypanosoma cruzi for Lineage Assignment and Population Genetics. (2015) Messenger, LA; Yeo, M; Lewis, MD; Llewellyn, MS; Miles, MA

Molecular genotyping of Trypanosoma cruzi for lineage assignment and population genetics. (2015) Messenger, Louisa A; Yeo, Matthew; Lewis, Michael D; Llewellyn, Martin S; Miles, Michael A

The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia. (2002) Seedhouse, Claire; Bainton, Rowena; Lewis, Michael; Harding, Alexander; Russell, Nigel; Das-Gupta, Emma

Resolution of multiclonal infections of Trypanosoma cruzi from naturally infected triatomine bugs and from experimentally infected mice by direct plating on a sensitive solid medium. (2006) Yeo, Matthew; Lewis, Michael D; Carrasco, Hernan J; Acosta, Nidia; Llewellyn, Martin; da Silva Valente, Sebastião Aldo; de Costa Valente, Vera; de Arias, Antonieta Rojas; Miles, Michael A

Public

Hosts and vectors of Trypanosoma cruzi discrete typing units in the Chagas disease endemic region of the Paraguayan Chaco. (2017) Acosta, Nidia; López, Elsa; Lewis, Michael D; Llewellyn, Martin S; Gómez, Ana; Román, Fabiola; Miles, Michael A; Yeo, Matthew

Development of peptide-based lineage-specific serology for chronic Chagas disease: geographical and clinical distribution of epitope recognition. (2014) Bhattacharyya, Tapan; Falconar, Andrew K; Luquetti, Alejandro O; Costales, Jaime A; Grijalva, Mario J; Lewis, Michael D; Messenger, Louisa A; Tran, Trang T; Ramirez, Juan-David; Guhl, Felipe; Carrasco, Hernan J; Diosque, Patricio; Garcia, Lineth; Litvinov, Sergey V; Miles, Michael A

Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole. (2017) Campos, Mônica C; Phelan, Jody; Francisco, Amanda F; Taylor, Martin C; Lewis, Michael D; Pain, Arnab; Clark, Taane G; Kelly, John M

Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. (2015) Carnes, Jason; Anupama, Atashi; Balmer, Oliver; Jackson, Andrew; Lewis, Michael; Brown, Rob; Cestari, Igor; Desquesnes, Marc; Gendrin, Claire; Hertz-Fowler, Christiane; Imamura, Hideo; Ivens, Alasdair; Kořený, Luděk; Lai, De-Hua; MacLeod, Annette; McDermott, Suzanne M; Merritt, Chris; Monnerat, Severine; Moon, Wonjong; Myler, Peter; Phan, Isabelle; Ramasamy, Gowthaman; Sivam, Dhileep; Lun, Zhao-Rong; Lukeš, Julius; Stuart, Ken; Schnaufer, Achim

Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping. (2018) Costa, Fernanda Cristina; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Calderano, Simone Guedes; Lewis, Michael D; Olmo, Francisco; Beneke, Tom; Gluenz, Eva; Sunter, Jack; Dean, Samuel; Kelly, John Morrison; Taylor, Martin Craig

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection. (2016) Cuypers, Bart; Lecordier, Laurence; Meehan, Conor J; Van den Broeck, Frederik; Imamura, Hideo; Büscher, Philippe; Dujardin, Jean-Claude; Laukens, Kris; Schnaufer, Achim; Dewar, Caroline; Lewis, Michael; Balmer, Oliver; Azurago, Thomas; Kyei-Faried, Sardick; Ohene, Sally-Ann; Duah, Boateng; Homiah, Prince; Mensah, Ebenezer Kofi; Anleah, Francis; Franco, Jose Ramon; Pays, Etienne; Deborggraeve, Stijn

Optimized multilocus sequence typing (MLST) scheme for Trypanosoma cruzi. (2014) Diosque, Patricio; Tomasini, Nicolás; Lauthier, Juan José; Messenger, Louisa Alexandra; Monje Rumi, María Mercedes; Ragone, Paula Gabriela; Alberti-D'Amato, Anahí Maitén; Pérez Brandán, Cecilia; Barnabé, Christian; Tibayrenc, Michel; Lewis, Michael David; Llewellyn, Martin Stephen; Miles, Michael Alexander; Yeo, Matthew

Biological factors that impinge on Chagas disease drug development. (2017) Francisco, Amanda F; Jayawardhana, Shiromani; Lewis, Michael D; Taylor, Martin C; Kelly, John M

Challenges in Chagas Disease Drug Development. (2020) Francisco, Amanda F; Jayawardhana, Shiromani; Olmo, Francisco; Lewis, Michael D; Wilkinson, Shane R; Taylor, Martin C; Kelly, John M

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage. (2016) Francisco, Amanda Fortes; Jayawardhana, Shiromani; Lewis, Michael D; White, Karen L; Shackleford, David M; Chen, Gong; Saunders, Jessica; Osuna-Cabello, Maria; Read, Kevin D; Charman, Susan A; Chatelain, Eric; Kelly, John M

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease. (2018) Francisco, Amanda Fortes; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Kelly, John M

Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs". (2015) Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M

Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. (2015) Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M

Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL Brener. (2011) Franzén, Oscar; Ochaya, Stephen; Sherwood, Ellen; Lewis, Michael D; Llewellyn, Martin S; Miles, Michael A; Andersson, Björn

Comparative genomic analysis of human infective Trypanosoma cruzi lineages with the bat-restricted subspecies T. cruzi marinkellei. (2012) Franzén, Oscar; Talavera-López, Carlos; Ochaya, Stephen; Butler, Claire E; Messenger, Louisa A; Lewis, Michael D; Llewellyn, Martin S; Marinkelle, Cornelis J; Tyler, Kevin M; Miles, Michael A; Andersson, Björn

Multilocus sequence and microsatellite identification of intra-specific hybrids and ancestor-like donors among natural Ethiopian isolates of Leishmania donovani. (2014) Gelanew, Tesfaye; Hailu, Asrat; Schőnian, Gabriele; Lewis, Michael D; Miles, Michael A; Yeo, Matthew

Metabolomics, lipidomics and proteomics profiling of myoblasts infected with Trypanosoma cruzi after treatment with different drugs against Chagas disease. (2019) Hennig, K; Abi-Ghanem, J; Bunescu, A; Meniche, X; Biliaut, E; Ouattara, AD; Lewis, MD; Kelly, JM; Braillard, S; Courtemanche, G; Chatelain, E; Béquet, F

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale. (2021) Khan, Archie A; Langston, Harry C; Costa, Fernanda C; Olmo, Francisco; Taylor, Martin C; McCann, Conor J; Kelly, John M; Lewis, Michael D

Impact of Visceral Leishmaniasis on Local Organ Metabolism in Hamsters. (2022) Lesani, Mahbobeh; Gosmanov, Camil; Paun, Andrea; Lewis, Michael D; McCall, Laura-Isobel

Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection. (2014) Lewis, Michael D; Fortes Francisco, Amanda; Taylor, Martin C; Burrell-Saward, Hollie; McLatchie, Alex P; Miles, Michael A; Kelly, John M

Imaging the development of chronic Chagas disease after oral transmission. (2018) Lewis, Michael D; Francisco, Amanda F; Jayawardhana, Shiromani; Langston, Harry; Taylor, Martin C; Kelly, John M

Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy. (2016) Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Jayawardhana, Shiromani; Kelly, John M

A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging. (2014) Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Kelly, John M

Putting Infection Dynamics at the Heart of Chagas Disease. (2016) Lewis, Michael D; Kelly, John M

Flow cytometric analysis and microsatellite genotyping reveal extensive DNA content variation in Trypanosoma cruzi populations and expose contrasts between natural and experimental hybrids. (2009) Lewis, Michael D; Llewellyn, Martin S; Gaunt, Michael W; Yeo, Matthew; Carrasco, Hernán J; Miles, Michael A

Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids. (2011) Lewis, Michael D; Llewellyn, Martin S; Yeo, Matthew; Acosta, Nidia; Gaunt, Michael W; Miles, Michael A

Genotyping of Trypanosoma cruzi: systematic selection of assays allowing rapid and accurate discrimination of all known lineages. (2009) Lewis, Michael D; Ma, Jonathan; Yeo, Matthew; Carrasco, Hernán J; Llewellyn, Martin S; Miles, Michael A

Fatal progression of experimental visceral leishmaniasis is associated with intestinal parasitism and secondary infection by commensal bacteria, and is delayed by antibiotic prophylaxis. (2020) Lewis, Michael D; Paun, Andrea; Romano, Audrey; Langston, Harry; Langner, Charlotte A; Moore, Ian N; Bock, Kevin W; Francisco, Amanda Fortes; Brenchley, Jason M; Sacks, David L

Trypanosoma cruzi IIc: phylogenetic and phylogeographic insights from sequence and microsatellite analysis and potential impact on emergent Chagas disease. (2009) Llewellyn, Martin S; Lewis, Michael D; Acosta, Nidia; Yeo, Matthew; Carrasco, Hernan J; Segovia, Maikell; Vargas, Jorge; Torrico, Faustino; Miles, Michael A; Gaunt, Michael W

Genome-scale multilocus microsatellite typing of Trypanosoma cruzi discrete typing unit I reveals phylogeographic structure and specific genotypes linked to human infection. (2009) Llewellyn, Martin S; Miles, Michael A; Carrasco, Hernan J; Lewis, Michael D; Yeo, Matthew; Vargas, Jorge; Torrico, Faustino; Diosque, Patricio; Valente, Vera; Valente, Sebastiao A; Gaunt, Michael W

Extraordinary Trypanosoma cruzi diversity within single mammalian reservoir hosts implies a mechanism of diversifying selection. (2011) Llewellyn, Martin S; Rivett-Carnac, John B; Fitzpatrick, Sinead; Lewis, Michael D; Yeo, Matthew; Gaunt, Michael W; Miles, Michael A

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery. (2018) MacLean, Lorna M; Thomas, John; Lewis, Michael D; Cotillo, Ignacio; Gray, David W; De Rycker, Manu

Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection. (2020) Mann, Gurdip Singh; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Olmo, Francisco; de Freitas, Elisangela Oliveira; Leoratti, Fabiana MS; López-Camacho, Cesar; Reyes-Sandoval, Arturo; Kelly, John M

Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification. (2022) Matos, Gabriel Machado; Lewis, Michael D; Talavera-López, Carlos; Yeo, Matthew; Grisard, Edmundo C; Messenger, Louisa A; Miles, Michael A; Andersson, Björn

Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase. (2013) McLatchie, Alex P; Burrell-Saward, Hollie; Myburgh, Elmarie; Lewis, Michael D; Ward, Theresa H; Mottram, Jeremy C; Croft, Simon L; Kelly, John M; Taylor, Martin C

Multiple mitochondrial introgression events and heteroplasmy in trypanosoma cruzi revealed by maxicircle MLST and next generation sequencing. (2012) Messenger, Louisa A; Llewellyn, Martin S; Bhattacharyya, Tapan; Franzén, Oscar; Lewis, Michael D; Ramírez, Juan David; Carrasco, Hernan J; Andersson, Björn; Miles, Michael A

The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future. (2009) Miles, MA; Llewellyn, MS; Lewis, MD; Yeo, M; Baleela, R; Fitzpatrick, S; Gaunt, MW; Mauricio, IL

Host-parasite dynamics in Chagas disease from systemic to hyper-local scales. (2020) Pérez-Mazliah, Damián; Ward, Alexander I; Lewis, Michael D

Contemporary cryptic sexuality in Trypanosoma cruzi. (2012) Ramírez, Juan David; Guhl, Felipe; Messenger, Louisa A; Lewis, Michael D; Montilla, Marleny; Cucunuba, Zulma; Miles, Michael A; Llewellyn, Martin S

Visualisation of Leishmania donovani fluorescent hybrids during early stage development in the sand fly vector. (2011) Sadlova, Jovana; Yeo, Matthew; Seblova, Veronika; Lewis, Michael D; Mauricio, Isabel; Volf, Petr; Miles, Michael A

Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity. (2020) Schwabl, Philipp; Maiguashca Sánchez, Jalil; Costales, Jaime A; Ocaña-Mayorga, Sofía; Segovia, Maikell; Carrasco, Hernán J; Hernández, Carolina; Ramírez, Juan David; Lewis, Michael D; Grijalva, Mario J; Llewellyn, Martin S

Molecular epidemiologic source tracking of orally transmitted Chagas disease, Venezuela. (2013) Segovia, Maikell; Carrasco, Hernán J; Martínez, Clara E; Messenger, Louisa A; Nessi, Anaibeth; Londoño, Juan C; Espinosa, Raul; Martínez, Cinda; Alfredo, Mijares; Bonfante-Cabarcas, Rafael; Lewis, Michael D; de Noya, Belkisyolé A; Miles, Michael A; Llewellyn, Martin S

Molecular Diversity of Trypanosoma cruzi Detected in the Vector Triatoma protracta from California, USA. (2016) Shender, Lisa A; Lewis, Michael D; Rejmanek, Daniel; Mazet, Jonna AK

Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi. (2021) Talavera-López, Carlos; Messenger, Louisa A; Lewis, Michael D; Yeo, Matthew; Reis-Cunha, João Luís; Matos, Gabriel Machado; Bartholomeu, Daniella C; Calzada, José E; Saldaña, Azael; Ramírez, Juan David; Guhl, Felipe; Ocaña-Mayorga, Sofía; Costales, Jaime A; Gorchakov, Rodion; Jones, Kathryn; Nolan, Melissa S; Teixeira, Santuza MR; Carrasco, Hernán José; Bottazzi, Maria Elena; Hotez, Peter J; Murray, Kristy O; Grijalva, Mario J; Burleigh, Barbara; Grisard, Edmundo C; Miles, Michael A; Andersson, Björn

Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions. (2019) Taylor, Martin C; Francisco, Amanda F; Jayawardhana, Shiromani; Mann, Gurdip Singh; Ward, Alexander I; Olmo, Francisco; Lewis, Michael D; Kelly, John M

The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence. (2015) Taylor, Martin C; Lewis, Michael D; Fortes Francisco, Amanda; Wilkinson, Shane R; Kelly, John M

Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity. (2020) Taylor, Martin C; Ward, Alexander I; Olmo, Francisco; Francisco, Amanda F; Jayawardhana, Shiromani; Costa, Fernanda C; Lewis, Michael D; Kelly, John M

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection. (2020) Taylor, Martin C; Ward, Alexander; Olmo, Francisco; Jayawardhana, Shiromani; Francisco, Amanda F; Lewis, Michael D; Kelly, John M

In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution. (2020) Ward, Alexander I; Lewis, Michael D; Khan, Archie A; McCann, Conor J; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Kelly, John M

Incomplete Recruitment of Protective T Cells Is Associated with Trypanosoma cruzi Persistence in the Mouse Colon. (2022) Ward, Alexander I; Lewis, Michael D; Taylor, Martin C; Kelly, John M

Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi. (2011) Yeo, Matthew; Mauricio, Isabel L; Messenger, Louisa A; Lewis, Michael D; Llewellyn, Martin S; Acosta, Nidia; Bhattacharyya, Tapan; Diosque, Patricio; Carrasco, Hernan J; Miles, Michael A

North American import? Charting the origins of an enigmatic Trypanosoma cruzi domestic genotype. (2012) Zumaya-Estrada, Federico A; Messenger, Louisa A; Lopez-Ordonez, Teresa; Lewis, Michael D; Flores-Lopez, Carlos A; Martínez-Ibarra, Alejandro J; Pennington, Pamela M; Cordon-Rosales, Celia; Carrasco, Hernan V; Segovia, Maikel; Miles, Michael A; Llewellyn, Martin S