Items where Author is "Fortes Francisco, Amanda"
Number of items: 37.
2023
Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection. (2023)
Tawaraishi, Taisuke; Ochida, Atsuko; Akao, Yuichiro; Itono, Sachiko; Kamaura, Masahiro; Akther, Thamina; Shimada, Mitsuyuki; Canan, Stacie; Chowdhury, Sanjoy; Cao, Yafeng; Condroski, Kevin; Engkvist, Ola; Francisco, Amanda; Ghosh, Sunil; Kaki, Rina; Kelly, John M; Kimura, Chiaki; Kogej, Thierry; Nagaoka, Kazuya; Naito, Akira; Pairaudeau, Garry; Radu, Constantin; Roberts, Ieuan; Shum, David; Watanabe, Nao-Aki; Xie, Huanxu; Yonezawa, Shuji; Yoshida, Osamu; Yoshida, Ryu; Mowbray, Charles; Perry, Benjamin
2022
Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection. (2022)
Ang, Chee Wei; Lee, Brendon M; Jackson, Colin J; Wang, Yuehong; Franzblau, Scott G; Francisco, Amanda F; Kelly, John M; Bernhardt, Paul V; Tan, Lendl; West, Nicholas P; Sykes, Melissa L; Hinton, Alexandra O; Bolisetti, Raghu; Avery, Vicky M; Cooper, Matthew A; Blaskovich, Mark AT
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Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitological cure. (2022)
Francisco, Amanda Fortes; Saade, Ursula; Jayawardhana, Shiromani; Pottel, Hans; Scandale, Ivan; Chatelain, Eric; Liehl, Peter; Kelly, John M; Zrein, Maan
Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor. (2022)
Macleod, Olivia JS; Cook, Alexander D; Webb, Helena; Crow, Mandy; Burns, Roisin; Redpath, Maria; Seisenberger, Stefanie; Trevor, Camilla E; Peacock, Lori; Schwede, Angela; Kimblin, Nicola; Francisco, Amanda F; Pepperl, Julia; Rust, Steve; Voorheis, Paul; Gibson, Wendy; Taylor, Martin C; Higgins, Matthew K; Carrington, Mark
2020
Challenges in Chagas Disease Drug Development. (2020)
Francisco, Amanda F; Jayawardhana, Shiromani; Olmo, Francisco; Lewis, Michael D; Wilkinson, Shane R; Taylor, Martin C; Kelly, John M
Fatal progression of experimental visceral leishmaniasis is associated with intestinal parasitism and secondary infection by commensal bacteria, and is delayed by antibiotic prophylaxis. (2020)
Lewis, Michael D; Paun, Andrea; Romano, Audrey; Langston, Harry; Langner, Charlotte A; Moore, Ian N; Bock, Kevin W; Francisco, Amanda Fortes; Brenchley, Jason M; Sacks, David L
Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection. (2020)
Mann, Gurdip Singh; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Olmo, Francisco; de Freitas, Elisangela Oliveira; Leoratti, Fabiana MS; López-Camacho, Cesar; Reyes-Sandoval, Arturo; Kelly, John M
Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity. (2020)
Taylor, Martin C; Ward, Alexander I; Olmo, Francisco; Francisco, Amanda F; Jayawardhana, Shiromani; Costa, Fernanda C; Lewis, Michael D; Kelly, John M
Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection. (2020)
Taylor, Martin C; Ward, Alexander; Olmo, Francisco; Jayawardhana, Shiromani; Francisco, Amanda F; Lewis, Michael D; Kelly, John M
Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy. (2020)
Thompson, Andrew M; O'Connor, Patrick D; Marshall, Andrew J; Francisco, Amanda F; Kelly, John M; Riley, Jennifer; Read, Kevin D; Perez, Catherine J; Cornwall, Scott; Thompson, RC Andrew; Keenan, Martine; White, Karen L; Charman, Susan A; Zulfiqar, Bilal; Sykes, Melissa L; Avery, Vicky M; Chatelain, Eric; Denny, William A
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In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution. (2020)
Ward, Alexander I; Lewis, Michael D; Khan, Archie A; McCann, Conor J; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Kelly, John M
Revisiting aminocoumarins for the treatment of melioidosis. (2020)
Willcocks, SJ; Cia, F; Francisco, AF; Wren, BW
2019
A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis. (2019)
MacGregor, Paula; Gonzalez-Munoz, Andrea L; Jobe, Fatoumatta; Taylor, Martin C; Rust, Steven; Sandercock, Alan M; Macleod, Olivia JS; Van Bocxlaer, Katrien; Francisco, Amanda F; D'Hooge, Francois; Tiberghien, Arnaud; Barry, Conor S; Howard, Philip; Higgins, Matthew K; Vaughan, Tristan J; Minter, Ralph; Carrington, Mark
Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions. (2019)
Taylor, Martin C; Francisco, Amanda F; Jayawardhana, Shiromani; Mann, Gurdip Singh; Ward, Alexander I; Olmo, Francisco; Lewis, Michael D; Kelly, John M
Intestinal microbiota - A modulator of the Trypanosoma cruzi-vector-host triad. (2019)
Teotônio, Isabella Márcia Soares Nogueira; Dias, Nayra; Hagström-Bex, Luciana; Nitz, Nadjar; Francisco, Amanda Fortes; Hecht, Mariana
2018
Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping. (2018)
Costa, Fernanda Cristina; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Calderano, Simone Guedes; Lewis, Michael D; Olmo, Francisco; Beneke, Tom; Gluenz, Eva; Sunter, Jack; Dean, Samuel; Kelly, John Morrison; Taylor, Martin Craig
Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease. (2018)
Francisco, Amanda Fortes; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Kelly, John M
Imaging the development of chronic Chagas disease after oral transmission. (2018)
Lewis, Michael D; Francisco, Amanda F; Jayawardhana, Shiromani; Langston, Harry; Taylor, Martin C; Kelly, John M
Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B. (2018)
Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Fortes Francisco, Amanda; Yardley, Vanessa; Harris, Andy; Alavijeh, Mo; Murdan, Sudaxshina; Croft, Simon L
2017
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. (2017)
Brand, Stephen; Ko, Eun Jung; Viayna, Elisabet; Thompson, Stephen; Spinks, Daniel; Thomas, Michael; Sandberg, Lars; Francisco, Amanda F; Jayawardhana, Shiromani; Smith, Victoria C; Jansen, Chimed; De Rycker, Manu; Thomas, John; MacLean, Lorna; Osuna-Cabello, Maria; Riley, Jennifer; Scullion, Paul; Stojanovski, Laste; Simeons, Frederick RC; Epemolu, Ola; Shishikura, Yoko; Crouch, Sabrinia D; Bakshi, Tania S; Nixon, Christopher J; Reid, Iain H; Hill, Alan P; Underwood, Tim Z; Hindley, Sean J; Robinson, Sharon A; Kelly, John M; Fiandor, Jose M; Wyatt, Paul G; Marco, Maria; Miles, Timothy J; Read, Kevin D; Gilbert, Ian H
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole. (2017)
Campos, Mônica C; Phelan, Jody; Francisco, Amanda F; Taylor, Martin C; Lewis, Michael D; Pain, Arnab; Clark, Taane G; Kelly, John M
Biological factors that impinge on Chagas disease drug development. (2017)
Francisco, Amanda F; Jayawardhana, Shiromani; Lewis, Michael D; Taylor, Martin C; Kelly, John M
2016
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage. (2016)
Francisco, Amanda Fortes; Jayawardhana, Shiromani; Lewis, Michael D; White, Karen L; Shackleford, David M; Chen, Gong; Saunders, Jessica; Osuna-Cabello, Maria; Read, Kevin D; Charman, Susan A; Chatelain, Eric; Kelly, John M
Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds. (2016)
Kishore, Kranti G; Ghashghaei, Ouldouz; Estarellas, Carolina; Mestre, M Mar; Monturiol, Cristina; Kielland, Nicola; Kelly, John M; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Muñoz-Torrero, Diego; Pérez, Belén; Luque, F Javier; Gámez-Montaño, Rocío; Lavilla, Rodolfo
Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds. (2016)
Kishore, Kranti G; Ghashghaei, Ouldouz; Estarellas, Carolina; Mestre, M Mar; Monturiol, Cristina; Kielland, Nicola; Kelly, John M; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Muñoz-Torrero, Diego; Pérez, Belén; Luque, F Javier; Gámez-Montaño, Rocío; Lavilla, Rodolfo
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy. (2016)
Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Jayawardhana, Shiromani; Kelly, John M
2015
Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs". (2015)
Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. (2015)
Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M
The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence. (2015)
Taylor, Martin C; Lewis, Michael D; Fortes Francisco, Amanda; Wilkinson, Shane R; Kelly, John M
2014
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection. (2014)
Lewis, Michael D; Fortes Francisco, Amanda; Taylor, Martin C; Burrell-Saward, Hollie; McLatchie, Alex P; Miles, Michael A; Kelly, John M
A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging. (2014)
Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Kelly, John M
2012
Different infective forms trigger distinct immune response in experimental Chagas disease. (2012)
Vieira, Paula Melo de Abreu; Francisco, Amanda Fortes; Machado, Evandro Marques de Meneses; Nogueira, Nívia Carolina; Fonseca, Kátia da Silva; Reis, Alexandre Barbosa; Teixeira-Carvalho, Andrea; Martins-Filho, Olindo Assis; Tafuri, Washington Luiz; Carneiro, Cláudia Martins
2011
Trypanosoma cruzi: desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect. (2011)
Arantes, Jerusa Marilda; Francisco, Amanda Fortes; de Abreu Vieira, Paula Melo; Silva, Maisa; Araújo, Márcio Sobreira Silva; de Carvalho, Andréa Teixeira; Pedrosa, Maria Lúcia; Carneiro, Cláudia Martins; Tafuri, Washington Luiz; Martins-Filho, Olindo Assis; Elói-Santos, Silvana Maria
2010
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. (2010)
Francisco, Amanda Fortes; de Abreu Vieira, Paula Melo; Arantes, Jerusa Marilda; Silva, Maisa; Pedrosa, Maria Lúcia; Elói-Santos, Silvana Maria; Martins-Filho, Olindo Assis; Teixeira-Carvalho, Andréa; Araújo, Márcio Sobreira Silva; Tafuri, Washington Luiz; Carneiro, Cláudia Martins
Coinfection with different Trypanosoma cruzi strains interferes with the host immune response to infection. (2010)
Rodrigues, Claudiney Melquíades; Valadares, Helder Magno Silva; Francisco, Amanda Fortes; Arantes, Jerusa Marilda; Campos, Camila França; Teixeira-Carvalho, Andréa; Martins-Filho, Olindo Assis; Araujo, Márcio Sobreira Silva; Arantes, Rosa Maria Esteves; Chiari, Egler; Franco, Glória Regina; Machado, Carlos Renato; Pena, Sérgio Danilo Junho; Faria, Ana Maria Caetano; Macedo, Andréa Mara
2009
Trypanosoma cruzi: Serum levels of nitric oxide and expression of inducible nitric oxide synthase in myocardium and spleen of dogs in the acute stage of infection with metacyclic or blood trypomastigotes. (2009)
Vieira, Paula Melo de Abreu; Francisco, Amanda Fortes; de Souza, Sheler Martins; Malaquias, Luiz Cosme Cotta; Reis, Alexandre Barbosa; Giunchetti, Rodolfo Cordeiro; Veloso, Vanja Maria; de Lana, Marta; Tafuri, Washington Luiz; Carneiro, Cláudia Martins
