Items where Author is "Shakur, Haleema"
Number of items: 131.
2023
Tranexamic acid for gastrointestinal bleeding: can a reduction in the risk of death be discounted? A systematic review and meta-analysis of individual patient data from 64 724 bleeding patients. (2023)
Ker, Katharine; Mansukhani, Raoul; Shakur-Still, Haleema; Arribas, Monica; Beaumont, Danielle; Roberts, Ian
Alternative routes for tranexamic acid treatment in obstetric bleeding (WOMAN-PharmacoTXA trial): a randomised trial and pharmacological study in caesarean section births. (2023)
Shakur-still, Haleema; Roberts, Ian; Grassin-Delyle, Stanislas; Chaudhri, Rizwana; Geer, Amber; Arribas, Monica; Lamy, Elodie; Mansukhani, Raoul; Lubeya, Mwansa Ketty; Javaid, Kiran; Kayani, Aasia; Israr, Naila; Mazhar, Syeda Batool; Urien, Saïk; Bouazza, Naïm; Foissac, Frantz; Prowse, Danielle; Carrington, Laura; Barrow, Collette; Onandia, Julio Gil; Balogun, Eni
Tranexamic acid for the prevention of postpartum bleeding: Protocol for a systematic review and individual patient data meta-analysis. (2023)
The Anti-fibrinolytics Trialists Collaborators – Obstetric Trial; Ker, Katharine; Shakur-still, Haleema; Sentilhes, Loïc; Pacheco, Luis; Saade, George; Deneux-Tharaux, Catherine; Brenner, Amy; Mansukhani, Raoul; Ageron, Francois; Prowse, Danielle; Chaudhri, Rizwana; Olayemi, Oladapo; Roberts, Ian
2022
Postpartum haemorrhage in anaemic women: assessing outcome measures for clinical trials. (2022)
Brenner, Amy; Roberts, Ian; Balogun, Eni; Bello, Folasade Adenike; Chaudhri, Rizwana; Fleming, Charlotte; Javaid, Kiran; Kayani, Aasia; Lubeya, Mwansa Ketty; Mansukhani, Raoul; Olayemi, Oladapo; Prowse, Danielle; Vwalika, Bellington; Shakur-Still, Haleema
Pharmacokinetics of tranexamic acid after intravenous, intramuscular, and oral routes: a prospective, randomised, crossover trial in healthy volunteers. (2022)
Grassin-Delyle, Stanislas; Semeraro, Michaela; Lamy, Elodie; Urien, Saïk; Runge, Iléana; Foissac, Frantz; Bouazza, Naim; Treluyer, Jean-Marc; Arribas, Monica; Roberts, Ian; Shakur-Still, Haleema
Use of tranexamic acid in major trauma: a sex-disaggregated analysis of the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2 and CRASH-3) trials and UK trauma registry (Trauma and Audit Research Network) data. (2022)
Nutbeam, Tim; Roberts, Ian; Weekes, Lauren; Shakur-Still, Haleema; Brenner, Amy; Ageron, Francois-Xavier
Alternative routes to intravenous tranexamic acid for postpartum hemorrhage: A systematic search and narrative review. (2022)
Shakur-Still, Haleema; Grassin-Delyle, Stanislas; Muhunthan, Kopalasuntharam; Ahmadzia, Homa K; Faraoni, David; Arribas, Monica; Roberts, Ian
A cost-effectiveness and value of information analysis to inform future research of tranexamic acid for older adults experiencing mild traumatic brain injury. (2022)
Williams, Jack; Ker, Katharine; Roberts, Ian; Shakur-Still, Haleema; Miners, Alec
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A cost-effectiveness and value of information analysis to inform future research of tranexamic acid for older adults experiencing mild traumatic brain injury. (2022)
Williams, Jack; Ker, Katharine; Roberts, Ian; Shakur-Still, Haleema; Miners, Alec
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2021
Tranexamic acid in trauma care : who should be treated, when and where? (2021)
Ageron, F-X D
WOMAN-PharmacoTXA trial: Study protocol for a randomised controlled trial to assess the pharmacokinetics and pharmacodynamics of intramuscular, intravenous and oral administration of tranexamic acid in women giving birth by caesarean section. (2021)
Arribas, Monica; Roberts, Ian; Chaudhri, Rizwana; Geer, Amber; Prowse, Danielle; Lubeya, Mwansa Ketty; Kayani, Aasia; Javaid, Kiran; Grassin-Delyle, Stanislas; Shakur-Still, Haleema
Clinical Validation of a Volumetric Absorptive Micro-Sampling Device for Pharmacokinetic Studies With Tranexamic Acid. (2021)
Grassin-Delyle, Stanislas; Lamy, Elodie; Semeraro, Michaela; Runge, Iléana; Treluyer, Jean-Marc; Mansukhani, Raoul; Arribas, Monica; Roberts, Ian; Shakur-Still, Haleema
Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials. (2021)
Herrett, Emily; Williamson, Elizabeth; Brack, Kieran; Beaumont, Danielle; Perkins, Alexander; Thayne, Andrew; Shakur-Still, Haleema; Roberts, Ian; Prowse, Danielle; Goldacre, Ben; van Staa, Tjeerd; MacDonald, Thomas M; Armitage, Jane; Wimborne, Jon; Melrose, Paula; Singh, Jayshireen; Brooks, Lucy; Moore, Michael; Hoffman, Maurice; Smeeth, Liam; StatinWISE Trial Group
The effect of statins on muscle symptoms in primary care: the StatinWISE series of 200 N-of-1 RCTs. (2021)
Herrett, Emily; Williamson, Elizabeth; Brack, Kieran; Perkins, Alexander; Thayne, Andrew; Shakur-Still, Haleema; Roberts, Ian; Prowse, Danielle; Beaumont, Danielle; Jamal, Zahra; Goldacre, Ben; van Staa, Tjeerd; MacDonald, Thomas M; Armitage, Jane; Moore, Michael; Hoffman, Maurice; Smeeth, Liam
Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, sub-cutaneous and oral administration in healthy volunteers. (2021)
Kane, Zoe; Picetti, Roberto; Wilby, Alison; Standing, Joseph F; Grassin-Delyle, Stanislas; Roberts, Ian; Shakur-Still, Haleema
Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial. (2021)
Mansukhani, Raoul; Belli, Antonio; Brenner, Amy; Chaudhri, Rizwana; Frimley, Lauren; Faizah Jamaluddin, Sabariah; Jooma, Rashid; Shakur-Still, Haleema; Shokunbi, Temitayo; Roberts, Ian
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Development of a patient reported outcome questionnaire to measure the impact of postpartum blood loss in women with moderate and severe anaemia: A study using a multi-faceted approach. (2021)
Miller, Lori; Chaudhri, Shahana; Beaumont, Danielle; Kayani, Aasia; Javid, Kiran; Chaudhri, Rizwana; Edwards, Phil; Brenner, Amy; Roberts, Ian; Shakur-Still, Haleema
Development of a patient reported outcome questionnaire to measure the impact of postpartum blood loss in women with moderate and severe anaemia: A study using a multi-faceted approach. (2021)
Miller, Lori; Chaudhri, Shahana; Beaumont, Danielle; Kayani, Aasia; Javid, Kiran; Chaudhri, Rizwana; Edwards, Phil; Brenner, Amy; Roberts, Ian; Shakur-Still, Haleema
Tranexamic Acid Treatment for Trauma Victims. (2021)
Roberts, Ian; Brenner, Amy; Shakur-Still, Haleema
Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT. (2021)
Roberts, Ian; Shakur-Still, Haleema; Aeron-Thomas, Amy; Beaumont, Danielle; Belli, Antonio; Brenner, Amy; Cargill, Madeleine; Chaudhri, Rizwana; Douglas, Nicolas; Frimley, Lauren; Gilliam, Catherine; Geer, Amber; Jamal, Zahra; Jooma, Rashid; Mansukhani, Raoul; Miners, Alec; Pott, Jason; Prowse, Danielle; Shokunbi, Temitayo; Williams, Jack
A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT. (2021)
Roberts, Ian; Shakur-Still, Haleema; Afolabi, Adefemi; Akere, Adegboyega; Arribas, Monica; Austin, Emma; Bal, Kiran; Bazeer, Nuha; Beaumont, Danielle; Brenner, Amy; Carrington, Laura; Chaudhri, Rizwana; Coats, Timothy; Gilmore, Ian; Halligan, Kenneth; Hussain, Irshad; Jairath, Vipul; Javaid, Kiran; Kayani, Aasia; Lisman, Ton; Mansukhani, Raoul; Miners, Alec; Mutti, Muttiullah; Nadeem, Muhammad Arif; Pollok, Richard; Prowse, Danielle; Simmons, Jonathan; Stanworth, Simon; Veitch, Andrew; Williams, Jack
2020
Effect of tranexamic acid by baseline risk of death in acute bleeding patients: a meta-analysis of individual patient-level data from 28 333 patients. (2020)
Ageron, Francois-Xavier; Gayet-Ageron, Angele; Ker, Katharine; Coats, Timothy J; Shakur-Still, Haleema; Roberts, Ian; Antifibrinolytics Trials Collaboration
Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial. (2020)
Brenner, Amy; Belli, Antonio; Chaudhri, Rizwana; Coats, Timothy; Frimley, Lauren; Jamaluddin, Sabariah Faizah; Jooma, Rashid; Mansukhani, Raoul; Sandercock, Peter; Shakur-Still, Haleema; Shokunbi, Temitayo; Roberts, Ian; CRASH-3 trial collaborators
Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial. (2020)
Grassin-Delyle, Stanislas; Shakur-Still, Haleema; Picetti, Roberto; Frimley, Lauren; Jarman, Heather; Davenport, Ross; McGuinness, William; Moss, Phil; Pott, Jason; Tai, Nigel; Lamy, Elodie; Urien, Saïk; Prowse, Danielle; Thayne, Andrew; Gilliam, Catherine; Pynn, Harvey; Roberts, Ian
Stillbirths and neonatal deaths among 18 942 women with postpartum hemorrhage: Analysis of perinatal outcomes in the WOMAN trial. (2020)
Hough, Amy; Shakur-Still, Haleema; Roberts, Ian; Koukounari, Artemis; Lawn, Joy E; WOMAN Trial Collaborators
Risk factors for blood transfusion in traumatic and postpartum hemorrhage patients: Analysis of the CRASH-2 and WOMAN trials. (2020)
Kolin, David A; Shakur-Still, Haleema; Bello, Adenike; Chaudhri, Rizwana; Bates, Imelda; Roberts, Ian
Tranexamic acid quantification in human whole blood using liquid samples or volumetric absorptive microsampling devices. (2020)
Lamy, Elodie; Runge, Ileana; Roberts, Ian; Shakur-Still, Haleema; Grassin-Delyle, Stanislas
Effect of tranexamic acid on intracranial haemorrhage and infarction in patients with traumatic brain injury: a randomised trial. (2020)
Mahmood, A
Effect of tranexamic acid on intracranial haemorrhage and infarction in patients with traumatic brain injury: a pre-planned substudy in a sample of CRASH-3 trial patients. (2020)
Mahmood, Abda; Needham, Kelly; Shakur-Still, Haleema; Harris, Tim; Jamaluddin, Sabariah Faizah; Davies, David; Belli, Antonio; Mohamed, Fatahul Laham; Leech, Caroline; Lotfi, Hamzah Mohd; Moss, Phil; Lecky, Fiona; Hopkins, Philip; Wong, Darin; Boyle, Adrian; Wilson, Mark; Darwent, Melanie; Roberts, Ian
Accuracy of time to treatment estimates in the CRASH-3 clinical trial: impact on the trial results. (2020)
Mansukhani, Raoul; Frimley, Lauren; Shakur-Still, Haleema; Sharples, Linda; Roberts, Ian
The WOMAN Trial: Clinical and Contextual Factors Surrounding the Deaths of 483 Women Following Post-Partum Hemorrhage in Developing Countries. (2020)
Picetti, Roberto; Miller, Lori; Shakur-Still, Haleema; Pepple, Tracey; Beaumont, Danielle; Balogun, Eni; Asonganyi, Etienne; Chaudhri, Rizwana; El-Sheikh, Mohamed; Vwalika, Bellington; Arulkumaran, Sabaratnam; Roberts, Ian
The WOMAN trial: clinical and contextual factors surrounding the deaths of 483 women following post-partum haemorrhage in developing countries. (2020)
Picetti, Roberto; Miller, Lori; Shakur-Still, Haleema; Pepple, Tracey; Beaumont, Danielle; Balogun, Eni; Asonganyi, Etienne; Chaudhri, Rizwana; El-Sheikh, Mohamed; Vwalika, Bellington; Arulkumaran, Sabaratnam; Roberts, Ian; WOMAN trial collaborators
Cost-effectiveness analysis of tranexamic acid for the treatment of traumatic brain injury, based on the results of the CRASH-3 randomised trial: a decision modelling approach. (2020)
Williams, Jack; Roberts, Ian; Shakur-Still, Haleema; Lecky, Fiona E; Chaudhri, Rizwana; Miners, Alec
2019
Trial management: we need a cadre of high-class triallists to deliver the answers that patients need. (2019)
Beaumont, Danielle; Arribas, Monica; Frimley, Lauren; Balogun, Eni; Roberts, Ian; Shakur-Still, Haleema
Tranexamic acid for acute gastrointestinal bleeding (the HALT-IT trial): statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. (2019)
Brenner, Amy; Afolabi, Adefemi; Ahmad, Syed Masroor; Arribas, Monica; Chaudhri, Rizwana; Coats, Timothy; Cuzick, Jack; Gilmore, Ian; Hawkey, Christopher; Jairath, Vipul; Javaid, Kiran; Kayani, Aasia; Mutti, Muttiullah; Nadeem, Muhammad Arif; Shakur-Still, Haleema; Stanworth, Simon; Veitch, Andrew; Roberts, Ian; HALT-IT Trial Collaborators
Tranexamic acid for post-partum haemorrhage: What, who and when. (2019)
Brenner, Amy; Ker, Katharine; Shakur-Still, Haleema; Roberts, Ian
Secondary analysis of the WOMAN trial to explore the risk of sepsis after invasive treatments for postpartum hemorrhage. (2019)
Cornelissen, Laura; Woodd, Susannah; Shakur-Still, Haleema; Fawole, Bukola; Noor, Shehla; Etuk, Saturday; Akintan, Adesina Lawrence; Chaudhri, Rizwana; Roberts, Ian
No effect of tranexamic acid on platelet function and thrombin generation (ETAPlaT) in postpartum haemorrhage: a randomised placebo-controlled trial. (2019)
Dallaku, Kastriot; Shakur-Still, Haleema; Beaumont, Danielle; Roberts, Ian; Huque, Sumaya; Delius, Maria; Holdenrieder, Stefan; Gliozheni, Orion; Mansmann, Ulrich
No effect of tranexamic acid on platelet function and thrombin generation (ETAPlaT) in postpartum haemorrhage: a randomised placebo-controlled trial. (2019)
Dallaku, Kastriot; Shakur-Still, Haleema; Beaumont, Danielle; Roberts, Ian; Huque, Sumaya; Delius, Maria; Holdenrieder, Stefan; Gliozheni, Orion; Mansmann, Ulrich
A nested randomised trial of the effect of tranexamic acid on intracranial haemorrhage and infarction in traumatic brain injury (CRASH-3 trial intracranial bleeding mechanistic study): Statistical analysis plan. (2019)
Mahmood, Abda; Roberts, Ian; Shakur-Still, Haleema
2018
Outcome measures in clinical trials of treatments for acute severe haemorrhage. (2018)
Brenner, Amy; Arribas, Monica; Cuzick, Jack; Jairath, Vipul; Stanworth, Simon; Ker, Katharine; Shakur-Still, Haleema; Roberts, Ian
The impact of early outcome events on the effect of tranexamic acid in post-partum haemorrhage: an exploratory subgroup analysis of the WOMAN trial. (2018)
Brenner, Amy; Shakur-Still, Haleema; Chaudhri, Rizwana; Fawole, Bukola; Arulkumaran, Sabaratnam; Roberts, Ian; WOMAN Trial Collaborators
Post-partum haemorrhage and tranexamic acid: a global issue. (2018)
Hibbs, Stephen P; Roberts, Ian; Shakur-Still, Haleema; Hunt, Beverley J
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What women think about consent to research at the time of an obstetric emergency: a qualitative study of the views of a cohort of World Maternal Antifibrinolytic Trial participants. (2018)
Houghton, G; Kingdon, C; Dower, M; Shakur-Still, H; Alfirevic, Z
Risk factors for peripartum hysterectomy among women with postpartum haemorrhage: analysis of data from the WOMAN trial. (2018)
Huque, Sumaya; Roberts, Ian; Fawole, Bukola; Chaudhri, Rizwana; Arulkumaran, Sabaratnam; Shakur-Still, Haleema
Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: study protocol for an international, randomised, double-blind, placebo-controlled trial. (2018)
Ker, Katharine; Roberts, Ian; Chaudhri, Rizwana; Fawole, Bukola; Beaumont, Danielle; Balogun, Eni; Prowse, Danielle; Pepple, Tracey; Javaid, Kiran; Kayani, Aasia; Arulkumaran, Sabaratnam; Bates, Imelda; Shakur-Still, Haleema; WOMAN-2 trial collaborators
Tranexamic acid for treatment of women with post-partum haemorrhage in Nigeria and Pakistan: a cost-effectiveness analysis of data from the WOMAN trial. (2018)
Li, Bernadette; Miners, Alec; Shakur, Haleema; Roberts, Ian; WOMAN Trial Collaborators
What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies. (2018)
Picetti, Roberto; Shakur-Still, Haleema; Medcalf, Robert L; Standing, Joseph F; Roberts, Ian
Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. (2018)
Roberts, Ian; Belli, Antonio; Brenner, Amy; Chaudhri, Rizwana; Fawole, Bukola; Harris, Tim; Jooma, Rashid; Mahmood, Abda; Shokunbi, Temitayo; Shakur, Haleema
Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. (2018)
Roberts, Ian; Belli, Antonio; Brenner, Amy; Chaudhri, Rizwana; Fawole, Bukola; Harris, Tim; Jooma, Rashid; Mahmood, Abda; Shokunbi, Temitayo; Shakur, Haleema
Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. (2018)
Roberts, Ian; Belli, Antonio; Brenner, Amy; Chaudhri, Rizwana; Fawole, Bukola; Harris, Tim; Jooma, Rashid; Mahmood, Abda; Shokunbi, Temitayo; Shakur, Haleema; CRASH-3 trial collaborators
Hydroxyethyl starch solutions and patient harm. (2018)
Roberts, Ian; Shakur, Haleema; Bellomo, Rinaldo; Bion, Julian; Finfer, Simon; Hunt, Beverley; Myburgh, John; Perner, Anders; Reinhart, Konrad
Should hydroxyethyl starch be banned? - Authors' reply. (2018)
Roberts, Ian; Shakur, Haleema; Bellomo, Rinaldo; Bion, Julian; Finfer, Simon; Hunt, Beverley; Myburgh, John; Perner, Anders; Reinhart, Konrad
Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage. (2018)
Roberts, Ian; Shakur, Haleema; Fawole, Bukola; Kuti, Modupe; Olayemi, Oladapo; Bello, Adenike; Ogunbode, Olayinka; Kotila, Taiwo; Aimakhu, Chris O; Olutogun, Tolulase; Hunt, Beverley J; Huque, Sumaya
Antifibrinolytic drugs for treating primary postpartum haemorrhage. (2018)
Shakur, Haleema; Beaumont, Danielle; Pavord, Sue; Gayet-Ageron, Angele; Ker, Katharine; Mousa, Hatem A
Antifibrinolytic drugs for treating primary postpartum hemorrhage. (2018)
Shakur, Haleema; Beaumont, Danielle; Pavord, Sue; Gayet-Ageron, Angele; Ker, Katharine; Mousa, Hatem A
Finding Better Ways to Prevent Postpartum Hemorrhage. (2018)
Shakur-Still, Haleema; Roberts, Ian
Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial. (2018)
Shakur-Still, Haleema; Roberts, Ian; Fawole, Bukola; Kuti, Modupe; Olayemi, Oladapo O; Bello, Adenike; Huque, Sumaya; Ogunbode, Olayinka; Kotila, Taiwo; Aimakhu, Chris; Okunade, Olujide A; Olutogun, Tolulase; Adetayo, Cecilia O; Dallaku, Kastriot; Mansmann, Ulrich; Hunt, Beverley J; Pepple, Tracey; Balogun, Eni
Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial. (2018)
Shakur-Still, Haleema; Roberts, Ian; Fawole, Bukola; Kuti, Modupe; Olayemi, Oladapo; Bello, Adenike; Huque, Sumaya; Ogunbode, Olayinka; Kotila, Taiwo; Aimakhu, Chris; Okunade, Olujide; Olutogun, Tolulase; Adetayo, Cecilia; Dallaku, Kastriot; Mansmann, Ulrich; Hunt, Beverley; Pepple, Tracey; Balogun, Eni
2017
Statistical analysis plan for the WOMAN-ETAPlaT study: Effect of tranexamic acid on platelet function and thrombin generation. (2017)
Dallaku, Kastriot; Shakur, Haleema; Edwards, Phil; Beaumont, Danielle; Roberts, Ian; Huque, Sumaya; Delius, Maria; Mansmann, Ulrich
Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients. (2017)
Gayet-Ageron, Angèle; Prieto-Merino, David; Ker, Katharine; Shakur, Haleema; Ageron, François-Xavier; Roberts, Ian; Antifibrinolytic Trials Collaboration
Study protocol for statin web-based investigation of side effects (StatinWISE): a series of randomised controlled N-of-1 trials comparing atorvastatin and placebo in UK primary care. (2017)
Herrett, Emily; Williamson, Elizabeth; Beaumont, Danielle; Prowse, Danielle; Youssouf, Nabila; Brack, Kieran; Armitage, Jane; Goldacre, Ben; MacDonald, Thomas; Staa, Tjeerd van; Roberts, Ian; Shakur-Still, Haleema; Smeeth, Liam
A nested mechanistic sub-study into the effect of tranexamic acid versus placebo on intracranial haemorrhage and cerebral ischaemia in isolated traumatic brain injury: study protocol for a randomised controlled trial (CRASH-3 Trial Intracranial Bleeding Mechanistic Sub-Study [CRASH-3 IBMS]). (2017)
Mahmood, Abda; Roberts, Ian; Shakur, Haleema
Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms. (2017)
Roberts, Ian; Edwards, Phil; Prieto, David; Joshi, Miland; Mahmood, Abda; Ker, Katharine; Shakur, Haleema
Tranexamic acid for post-partum haemorrhage in the WOMAN trial - Authors' reply. (2017)
Roberts, Ian; Shakur, Haleema
2016
Haleem Shakur: The WOMAN Trial. (2016)
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Statistical analysis plan for the WOMAN-ETAPlaT study: Effect of tranexamic acid on platelet function and thrombin generation. (2016)
Dallaku, Kastriot; Shakur, Haleema; Edwards, Phil; Beaumont, Danielle; Roberts, Ian; Huque, Sumaya; Delius, Maria; Mansmann, Ulrich
Effects of tranexamic acid on platelet function and thrombin generation (ETAPlaT): WOMAN trial sub-study. (2016)
Dallaku, Kastriot; Shakur, Haleema; Roberts, Ian; Edwards, Phil; Beaumont, Danielle; Delius, Maria; Siegmund, Braun; Gliozheni, Orion; Tasha, Ilir; Cenameri, Saimir; Mansmann, Ulrich
Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials. (2016)
Ker, K; Shakur, H; Roberts, I
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Does tranexamic acid improve outcomes in traumatic brain injury? (2016)
Mahmood, Abda; Roberts, Ian; Shakur, Haleema; Harris, Tim; Belli, Antonio
Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): protocol and statistical analysis plan for a randomized controlled trial. (2016)
Shakur, Haleema; Fawole, Bukola; Kuti, Modupe; Olayemi, Oladapo; Bello, Adenike; Ogunbode, Olayinka; Kotila, Taiwo; Aimakhu, Chris O; Huque, Sumaya; Gregg, Meghann; Roberts, Ian
The effect of tranexamic acid on the risk of death and hysterectomy in women with post-partum haemorrhage: statistical analysis plan for the WOMAN trial. (2016)
Shakur, Haleema; Roberts, Ian; Edwards, Philip; Elbourne, Diana; Alfirevic, Zarko; Ronsmans, Carine
2015
Good clinical practice in trauma care research: considerations for inter-hospital patient transfers. (2015)
Bryceland, Catriona; Ellis, Sophie; Beaumont, Danielle; Shakur, Haleema; Coats, Timothy J
Comparison of routes for achieving parenteral access with a focus on the management of patients with Ebola virus disease. (2015)
Ker, K; Tansley, G; Beecher, D; Perner, A; Shakur, H; Harris, T; Roberts, I
Antifibrinolytic drugs for acute traumatic injury. (2015)
Ker, Katharine; Roberts, Ian; Shakur, Haleema; Coats, Tim J
Comparison of routes for achieving parenteral access with a focus on the management of patients with Ebola virus disease. (2015)
Ker, Katharine; Tansley, Gavin; Beecher, Deirdre; Perner, Anders; Shakur, Haleema; Harris, Tim; Roberts, Ian
Extending evidence for the use of tranexamic acid from traumatic haemorrhage to other patients with major bleeding: do we need more than one haemorrhage protocol? The case of gastrointestinal bleeding. (2015)
Stanworth, SJ; Manno, D; Shakur, H; Coats, T; Edwards, P; Gilmore, I; Jairath, V; Veitch, A; Roberts, I
2014
Living Library special - Saving the lives of trauma victims and using Big Data. (2014)
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Guide to the design and review of emergency research when it is proposed that consent and consultation be waived. (2014)
Davies, Hugh; Shakur, Haleema; Padkin, Andrew; Roberts, Ian; Slowther, Anne-Marie; Perkins, Gavin D
PTU-185 Update On The Halt-it Trial Progress: Tranexamic Acid For The Treatment Of Gastrointestinal Haemorrhage – An International, Randomised, Double Blind Placebo Controlled Trial. (2014)
Jairath, V; Shakur, H; Edwards, P; Ker, K; Manno, D; Gilmore, I; Veitch, A; Stanworth, S; Coats, T; Roberts, I
Treatment for primary postpartum haemorrhage. (2014)
Mousa, Hatem A; Blum, Jennifer; Abou El Senoun, Ghada; Shakur, Haleema; Alfirevic, Zarko
HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial. (2014)
Roberts, Ian; Coats, Timothy; Edwards, Phil; Gilmore, Ian; Jairath, Vipul; Ker, Katharine; Manno, Daniela; Shakur, Haleema; Stanworth, Simon; Veitch, Andrew
2013
Tranexamic acid in trauma: we need stronger global health policy. (2013)
Alvarado, José Caballero; Dewan, Yashbir; Elsayed, Hesham Fathy; Gogichaishvili, Tamar; Gupta, Sanjay; Hunt, BJ; Iribhogbe, Pius; Izurieta, Mario; Khamis, Hussein; Komolafe, Edward O; Mantilla, Jorge H Mejía; Miranda, Jaime; Uribe, Carlos H Morales; Olaomi, Oluwole; Olldashi, Fatos; Perel, Pablo; Ramana, PV; Ravi, RR; Roberts, Ian; Shakur, Haleema
Central and statistical data monitoring in the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2) trial. (2013)
Edwards, Phil; Shakur, Haleema; Barnetson, Lin; Prieto, David; Evans, Stephen; Roberts, Ian
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. (2013)
Roberts, I; Shakur, H; Coats, T; Hunt, B; Balogun, E; Barnetson, L; Cook, L; Kawahara, T; Perel, P; Prieto-Merino, D; Ramos, M; Cairns, J; Guerriero, C
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. (2013)
Roberts, I; Shakur, H; Coats, T; Hunt, B; Balogun, E; Barnetson, L; Cook, L; Kawahara, T; Perel, P; Prieto-Merino, D; Ramos, M; Cairns, J; Guerriero, C
A promise to save 100,000 trauma patients. (2013)
Shakur, Haleema; Roberts, Ian; Piot, Peter; Horton, Richard; Krug, Etienne; Mersch, Jeannot
2012
Tranexamic acid in trauma: we need stronger global health policy. (2012)
Alvarado, JC; Dewan, Y; Elsayed, HF; Gogichaishvili, T; Gupta, S; Hunt, BJ; Iribhogbe, P; Izurieta, M; Khamis, H; Komolafe, EO; Mejía Mantilla, JH; Miranda, J; Morales Uribe, CH; Olaomi, O; Olldashi, F; Perel, P; Ramana, PV; Ravi, RR; Roberts, IR; Shakur, H
CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial. (2012)
Dewan, Yashbir; Komolafe, Edward O; Mejía-Mantilla, Jorge H; Perel, Pablo; Roberts, Ian; Shakur, Haleema; CRASH-3 Collaborators
Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. (2012)
Ker, Katharine; Edwards, Phil; Perel, Pablo; Shakur, Haleema; Roberts, Ian
Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial. (2012)
Ker, Katharine; Kiriya, Junko; Perel, Pablo; Edwards, Phil; Shakur, Haleema; Roberts, Ian
CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial. (2012)
Perel, P; Al-Shahi Salman, R; Kawahara, T; Morris, Z; Prieto-Merino, D; Roberts, I; Sandercock, P; Shakur, H; Wardlaw, J
Predicting early death in patients with traumatic bleeding: development and validation of prognostic model. (2012)
Perel, Pablo; Prieto-Merino, David; Shakur, Haleema; Clayton, Tim; Lecky, Fiona; Bouamra, Omar; Russell, Rob; Faulkner, Mark; Steyerberg, Ewout W; Roberts, Ian
CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury - a nested, randomised, placebo-controlled trial. (2012)
Perel, Pablo; Salman, RAS; Kawahara, T; Morris, Z; Prieto-merino, David; Roberts, Ian; Sandercock, P; Shakur-still, Haleema; Wardlaw, J
Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. (2012)
Roberts, Ian; Perel, Pablo; Prieto-Merino, David; Shakur, Haleema; Coats, Tim; Hunt, Beverley J; Lecky, Fiona; Brohi, Karim; Willett, Keith; CRASH-2 Collaborators
Antifibrinolytic drugs for acute traumatic injury. (2012)
Roberts, Ian; Shakur, Haleema; Ker, Katharine; Coats, Tim; CRASH-2 Trial collaborators
Covariate adjustment increased power in randomized controlled trials: an example in traumatic brain injury. (2012)
Turner, Elizabeth L; Perel, Pablo; Clayton, Tim; Edwards, Phil; Hernández, Adrian V; Roberts, Ian; Shakur, Haleema; Steyerberg, Ewout W; CRASH trial collaborators
Prognostic value of major extracranial injury in traumatic brain injury: an individual patient data meta-analysis in 39,274 patients. (2012)
van Leeuwen, Nikki; Lingsma, Hester F; Perel, Pablo; Lecky, Fiona; Roozenbeek, Bob; Lu, Juan; Shakur, Haleema; Weir, James; Steyerberg, Ewout W; Maas, Andrew IR; International Mission on Prognosis and Clinical Trial Design in ; Corticosteroid Randomization After Significant Head Injury Trial; Trauma Audit and Research Network
2011
European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial). (2011)
Andrews, Peter JD; Sinclair, Helen Louise; Battison, Claire G; Polderman, Kees H; Citerio, Giuseppe; Mascia, Luciana; Harris, Bridget A; Murray, Gordon D; Stocchetti, Nino; Menon, David K; Shakur, Haleema; De Backer, Daniel; Eurotherm3235Trial collaborators
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. (2011)
CRASH-2 collaborators; Roberts, Ian; Shakur, Haleema; Afolabi, Adefemi; Brohi, Karim; Coats, Tim; Dewan, Yashbir; Gando, Satoshi; Guyatt, Gordon; Hunt, BJ; Morales, Carlos; Perel, Pablo; Prieto-Merino, David; Woolley, Tom
Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial. (2011)
Guerriero, Carla; Cairns, John; Perel, Pablo; Shakur, Haleema; Roberts, Ian; CRASH 2 trial collaborators
Using a business model approach and marketing techniques for recruitment to clinical trials. (2011)
McDonald, Alison M; Treweek, Shaun; Shakur, Haleema; Free, Caroline; Knight, Rosemary; Speed, Chris; Campbell, Marion K
Comparative effectiveness, safety and acceptability of medical abortion at home and in a clinic: a systematic review. (2011)
Ngo, Thoai D; Park, Min Hae; Shakur, Haleema; Free, Caroline
Antifibrinolytic drugs for acute traumatic injury. (2011)
Roberts, I; Shakur, H; Ker, K; Coats, T; CRASH-2 Trial collaborators
Consent in emergency care research – Authors' reply. (2011)
Roberts, Ian; Chalmers, Iain; Shakur, Haleema; Prieto-Merino, David; Nicholl, Jon
Early administration of tranexamic acid in trauma patients – Authors' reply. (2011)
Roberts, Ian; Prieto-Merino, David; Perel, Pablo; Shakur, Haleema
Effect of consent rituals on mortality in emergency care research. (2011)
Roberts, Ian; Prieto-Merino, David; Shakur, Haleema; Chalmers, Iain; Nicholl, Jon
2010
Managing clinical trials. (2010)
Farrell, Barbara; Kenyon, Sara; Shakur, Haleema
Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluation. (2010)
Guerriero, Carla; Cairns, John; Jayaraman, Sudha; Roberts, Ian; Perel, Pablo; Shakur, Haleema
Haemostatic drugs for traumatic brain injury. (2010)
Perel, Pablo; Roberts, Ian; Shakur, Haleema; Thinkhamrop, Bandit; Phuenpathom, Nakornchai; Yutthakasemsunt, Surakrant
Tranexamic acid for trauma Reply. (2010)
Shakur, H; Roberts, I; Perel, P
The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial. (2010)
Shakur, Haleema; Elbourne, Diana; Gülmezoglu, Metin; Alfirevic, Zarko; Ronsmans, Carine; Allen, Elizabeth; Roberts, Ian
2009
Anti-fibrinolytic agents in post partum haemorrhage: a systematic review. (2009)
Ferrer, Pili; Roberts, Ian; Sydenham, Emma; Blackhall, Karen; Shakur, Haleema
The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury. (2009)
Shakur, Haleema; Andrews, Peter; Asser, Toomas; Balica, Laura; Boeriu, Cristian; Quintero, Juan Diego Ciro; Dewan, Yashbir; Druwé, Patrick; Fletcher, Olivia; Frost, Chris; Hartzenberg, Bennie; Mantilla, Jorge Mejia; Murillo-Cabezas, Francisco; Pachl, Jan; Ravi, Ramalingam R; Rätsep, Indrek; Sampaio, Cristina; Singh, Manmohan; Svoboda, Petr; Roberts, Ian
2008
Patient outcome after traumatic brain injury in high-, middle- and low-income countries: analysis of data on 8927 patients in 46 countries. (2008)
De Silva, Mary J; Roberts, Ian; Perel, Pablo; Edwards, Phil; Kenward, Michael G; Fernandes, Janice; Shakur, Haleema; Patel, Vikram; CRASH Trial Collaborators
Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients. (2008)
MRC CRASH Trial Collaborators; Perel, Pablo; Arango, Miguel; Clayton, Tim; Edwards, Phil; Komolafe, Edward; Poccock, Stuart; Roberts, Ian; Shakur, Haleema; Steyerberg, Ewout; Yutthakasemsunt, Surakrant
Use of the Oxford Handicap Scale at hospital discharge to predict Glasgow Outcome Scale at 6 months in patients with traumatic brain injury. (2008)
Perel, Pablo; Edwards, Phil; Shakur, Haleema; Roberts, Ian
2007
Marketing and clinical trials: a case study. (2007)
Francis, David; Roberts, Ian; Elbourne, Diana R; Shakur, Haleema; Knight, Rosemary C; Garcia, Jo; Snowdon, Claire; Entwistle, Vikki A; McDonald, Alison M; Grant, Adrian M; Campbell, Marion K
Prognosis following head injury: a survey of doctors from developing and developed countries. (2007)
Perel, Pablo; Wasserberg, Jonathan; Ravi, Ramalingam R; Shakur, Haleema; Edwards, Phil; Roberts, Ian
Clinical trials in emergency situations. (2007)
Shakur, Haleema; Roberts, Ian; Barnetson, Lin; Coats, Tim
2005
Consent in emergency research: new regulations. (2005)
Coats, TJ; Shakur, H
Antifibrinolytic agents in traumatic hemorrhage. (2005)
Coats, Tim; Hunt, Beverley; Roberts, Ian; Shakur, Haleema
Antifibrinolytic agents in traumatic hemorrhage: a large scale randomized controlled trial is needed. (2005)
Coats, Tim; Hunt, Beverley; Roberts, Ian; Shakur, Haleema
Antifibrinolytic agents in traumatic haemorrhage. (2005)
Coats, Tim; Hunt, Beverly; Roberts, Ian; Shakur, Haleema
Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. (2005)
Edwards, Phil; Arango, Miguel; Balica, Laura; Cottingham, Rowland; El-Sayed, Hesham; Farrell, Barbara; Fernandes, Janice; Gogichaisvili, Tamar; Golden, Nyoman; Hartzenberg, Bennie; Husain, Mazhar; Ulloa, Mario Izurieta; Jerbi, Zouheir; Khamis, Hussein; Komolafe, Edward; Laloë, Véronique; Lomas, Gabrielle; Ludwig, Silke; Mazairac, Guy; Muñoz Sanchéz, Maria de los Angeles; Nasi, Luis; Olldashi, Fatos; Plunkett, Patrick; Roberts, Ian; Sandercock, Peter; Shakur, Haleema; Soler, Caridad; Stocker, Reto; Svoboda, Petr; Trenkler, Stefan; Venkataramana, NK; Wasserberg, Jonathan; Yates, David; Yutthakasemsunt, Surakrant; CRASH trial collaborators
Possible explanations for the results of CRASH. (2005)
Roberts, I; Edwards, P; Shakur, H
Trauma care research and the war on uncertainty. (2005)
Roberts, Ian; Shakur, Haleema; Edwards, Phil; Yates, David; Sandercock, Peter
2004
Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. (2004)
Roberts, Ian; Yates, David; Sandercock, Peter; Farrell, Barbara; Wasserberg, Jonathan; Lomas, Gabrielle; Cottingham, Rowland; Svoboda, Petr; Brayley, Nigel; Mazairac, Guy; Laloë, Véronique; Muñoz-Sánchez, Angeles; Arango, Miguel; Hartzenberg, Bennie; Khamis, Hussein; Yutthakasemsunt, Surakrant; Komolafe, Edward; Olldashi, Fatos; Yadav, Yadram; Murillo-Cabezas, Francisco; Shakur, Haleema; Edwards, Phil; CRASH trial collaborators