Prevalence, incidence, and mother-to-child transmission of HIV-1 in rural South Africa.
NC Rollins;
M Dedicoat;
S Danaviah;
T Page;
K Bishop;
I Kleinschmidt;
HM Coovadia;
SA Cassol;
Child Health Group;
(2002)
Prevalence, incidence, and mother-to-child transmission of HIV-1 in rural South Africa.
Lancet, 360 (9330).
389-.
ISSN 0140-6736
DOI: 10.1016/s0140-6736(02)09599-5
Simple, robust approaches are needed to monitor prevalence, incidence, and mother-to-child transmission of HIV-1 in rural Africa. We have designed a method that uses antibody and viral RNA testing of dried blood spots obtained from mother-infant pairs attending routine immunisation clinics. In our study, prevalence and incidence of HIV-1 was highest in young women in their late teens and early twenties. In children born to infected mothers, prevalence increased from 14% in infants younger than 6 weeks of age to 24% at 3-6 months. The blood-spot approach is an effective method for surveillance of HIV-1 in women and children, and for early identification of incidence of this infection in women of child-bearing age.
| Item Type | Article |
|---|---|
| Keywords | Adolescent, Adult, *Disease Transmission, Vertical, Female, HIV Infections/diagnosis/epidemiology/*transmission, *Hiv-1, Humans, Incidence, Infant, Infant, Newborn, Pregnancy, Prevalence, *Rural Health, South Africa/epidemiology, Adolescent, Adult, Disease Transmission, Vertical, Female, HIV Infections, diagnosis, epidemiology, transmission, HIV-1, Humans, Incidence, Infant, Infant, Newborn, Pregnancy, Prevalence, Rural Health, South Africa, epidemiology |
| ISI | 177255600017 |