Identification of CRF10_CD viruses among bar and hotel workers in Moshi, Northern Tanzania.
We recently identified an HIV-1 subtype C and D circulating recombinant form (CRF10_CD) in infants in Dar es Salaam, Tanzania. So far, this is the only reported HIV-1 CRF in East Africa. However, evidence for its spread in the adult population is scarce. Here we describe the presence of CRF10_CD in two asymptomatic bar and hotel workers in Moshi, Northern Tanzania. Subgenomic sequences from gag (3'p24-5'p7), env (C2-C5), and the 5' LTR were used for phylogenetic analysis and identification of recombination. Genetic divergence between the CRF10_CD sequences from Moshi suggested that they were contracted from independent sources. A third bar worker was infected with an apparent CRF10_CD/subtype A recombinant virus. Our data indicate that CRF10_CD genomes can be transmitted both vertically and heterosexually.
Item Type | Article |
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Keywords | Genome, Viral, HIV-1/classification/genetics/*isolation & purification, Humans, Phylogeny, Recombination, Genetic, Tanzania, Variation (Genetics), Genome, Viral, HIV-1, classification, genetics, isolation & purification, Humans, Phylogeny, Recombination, Genetic, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Tanzania, Variation (Genetics) |
ISI | 232965200011 |