Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.
Arnab Pain;
Hubert Renauld;
Matthew Berriman;
Lee Murphy;
Corin A Yeats;
William Weir;
Arnaud Kerhornou;
Martin Aslett;
Richard Bishop;
Christiane Bouchier;
+40 more...
Madeleine Cochet;
Richard MR Coulson;
Ann Cronin;
Etienne P de Villiers;
Audrey Fraser;
Nigel Fosker;
Malcolm Gardner;
Arlette Goble;
Sam Griffiths-Jones;
David E Harris;
Frank Katzer;
Natasha Larke;
Angela Lord;
Pascal Maser;
Sue McKellar;
Paul Mooney;
Fraser Morton;
Vishvanath Nene;
Susan O'Neil;
Claire Price;
Michael A Quail;
Ester Rabbinowitsch;
Neil D Rawlings;
Simon Rutter;
David Saunders;
Kathy Seeger;
Trushar Shah;
Robert Squares;
Steven Squares;
Adrian Tivey;
Alan R Walker;
John Woodward;
Dirk AE Dobbelaere;
Gordon Langsley;
Marie-Adele Rajandream;
Declan McKeever;
Brian Shiels;
Andrew Tait;
Bart Barrell;
Neil Hall;
(2005)
Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.
Science (New York, NY), 309 (5731).
pp. 131-133.
ISSN 0036-8075
DOI: 10.1126/science.1110418
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
| Item Type | Article |
|---|---|
| ISI | 230212800075 |