IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.
Luzia H Carvalho;
Gen-Ichiro Sano;
Julius CR Hafalla ;
Alexandre Morrot;
Maria A Curotto de Lafaille;
Fidel Zavala;
(2002)
IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.
Nature medicine, 8 (2).
pp. 166-170.
ISSN 1078-8956
DOI: 10.1038/nm0202-166
CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days after immunization. However, this response fails to develop further and is reduced by more than 90%, compared to that observed in the presence of CD4+ T cells. We report here that interleukin-4 (IL-4) secreted by CD4+ T cells is essential to the full development of this CD8+ T cell response. This is the first demonstration that IL-4 is a mediator of CD4/CD8 cross-talk leading to the development of immunity against an infectious pathogen.
Item Type | Article |
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Keywords | Animals, Antigens, CD4, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Differentiation, Hepatocytes, Interleukin-4, Malaria, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Plasmodium yoelii, Animals, Antigens, CD4, immunology, CD4-Positive T-Lymphocytes, cytology, immunology, CD8-Positive T-Lymphocytes, cytology, immunology, Cell Differentiation, immunology, Hepatocytes, immunology, Interleukin-4, secretion, Malaria, immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Plasmodium yoelii |
ISI | 173600600026 |
ORCID: https://orcid.org/0000-0002-5452-9263